Lovastatin inhibits mesangial cell proliferation via p27(Kip1)

Journal of the American Society of Nephrology

Volumn 9, Issue 12, 1998, Pages 2235-2243

  Terada, Yoshio ^a   Inoshita, Seiji ^a   Nakashima, Osamu ^a   Yamada, Takehisa ^a   Kuwahara, Michio ^a   Sasaki, Sei ^a   Marumo, Fumiaki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; ENDOTHELIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN P27; RETINOBLASTOMA PROTEIN; THYMIDINE; TRITIUM;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; MESANGIUM CELL; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT; TRANSLATION REGULATION;

EID: 0031751677     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Abboud HE: Growth factors in glomerulonephritis. Kidney Int 43: 252-267, 1993
2. Floege J, Eng E, Young BA, Johnson RJ: Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo. Kidney Int 43: S48-S54, 1993
3. Abboud HE: Growth factors and the mesangium. J Am Soc Nephrol 2: S185-S189, 1992
4. Johnson RJ, Floege J, Couser WG, Alpers CE: Role of platelet-derived growth factor in glomerular disease. J Am Soc Nephrol 4: 119-128, 1993
5. Johnson RJ, Raines EW, Floege J, Yoshimura A, Pritzl P, Alpers C, Ross R: Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 175: 1413-1416, 1992
6. Isaka Y, Fujiwara Y, Ueda N, Kaneda Y, Kamada T, Imai E: Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney. J Clin Invest 92: 2597-2601, 1993
7. Fukuda K, Yanagida T, Okuda S, Tamaki K, Ando T, Fujishima M: Role of endothelin as a mitogen in experimental glomerulonephritis in rats. Kidney Int 49: 1320-1329, 1996
8. Yoshimura A, Iwasaki S, Inui K, Ideura T, Koshikawa S, Yanagisawa M, Masaki T: Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat. Kidney Int 48: 1290-1297, 1995
9. Hunter T, Pines J: Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell 79: 573-582, 1994
10. Sherr CJ: Mammalian G1 cyclins. Cell 73: 1059-1065, 1993
11. Hunter T: Braking the cycle. Cell 75: 839-841, 1993
12. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81: 323-330, 1995
13. Kip1) of cyclin-dependent kinase 4 activation. Cell 79: 487-496, 1994
14. Sherr CJ, Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163, 1995
15. Noda A, Ning Y, Venable SF, Pereira SO, Smith JR: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211: 90-98, 1994
16. Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y: Growth suppression by p18, a p16INK4/ MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev 8: 2939-2952, 1994
17. Shankland SJ, Hugo C, Coats SR, Nangaku M, Pichler RH, Gordon KL, Pippin J, Roberts JM, Couser WG, Johnson RJ: Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis. Kidney Int 50: 1230-1239, 1996
18. Cip1) and cyclin D1 using adenovirus vectors regulates proliferation of rat mesangial cells. J Am Soc Nephrol 8: 51-60, 1997
19. O'Donnell MP, Kasiske BL, Kim Y, Atluru D, Keane WF: Lovastatin inhibits proliferation of rat mesangial cells. J Clin Invest 91: 83-87, 1993
20. Grandaliano G, Biswas P, Choudhury GG, Abboud HE: Simvastatin inhibits PDGF-induced DNA synthesis in human glomerular mesangial cells. Kidney Int 44: 503-508, 1993
21. Sebti SM, Tkalcevic GT, Jani JP: Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human H-ras oncogene transformed cells in nude mice. Cancer Commun 3: 141-147, 1991
22. McGuire TF, Corey SJ, Sebti SM: Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor. J Biol Chem 268: 22227-22230, 1993
23. Ishikawa S, Kawasumi M, Saito T: Simvastatin inhibits the cellular signaling and proliferative action of arginine vasopressin in cultured rat glomerular mesangial cells. Endocrinology 136: 1954-1961, 1995
24. Kip1 accumulation during the cell cycle. Science 271: 1861-1864, 1996
25. Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 272: 13-16, 1997
26. Owada A, Tomita K, Terada Y, Sakamoto H, Nonoguchi H, Marumo F: Endothelin (ET)-3 stimulates cyclic guanosine 3′,5′-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. J Clin Invest 93: 556-563, 1994
27. Kita T, Brown MS, Goldstein JL: Feedback regulation of 3-hydroxy-3-methylglutaryl Coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. J Clin Invest 66: 1094-1100, 1980
28. Toyoshima H, Hunter T: p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67-74, 1994
29. Swafford DS, Middleton SK, Palmisano WA. Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG, Belinsky SA: Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Mol Cell Biol 7: 1366-1374, 1997
30. El-Deiry WS, Tokino T, Waldman T, Oliner JD, Velculescu VE, Burrell M, Hill DE, Healy E, Rees JL, Hamilton SR, Kinzler KW, Vogelstein B: Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res 55: 2910-2919, 1995
31. Terada Y, Tomita K, Nonoguchi H, Marumo F: Different localization of two types of endothelin receptor mRNA in microdissected rat nephron segments using reverse transcription and polymerase chain reaction assay. J Clin Invest 90: 107-112, 1992
32. Wolf G, Thaiss F, Schoeppe W, Stahl RAK: Angiotensin II-induced proliferation of cultured murine mesangial cells: Inhibitory role of the atrial natriuretic peptide. J Am Soc Nephrol 3: 1270-1278, 1992
33. Terada Y, Tomita K, Homma MK, Nonoguchi H, Yang T, Yamada T, Yuasa Y, Krebs EG, Sasaki S, Marumo F: Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. J Biol Chem 269: 31296-31301, 1994
34. Kip1 for restriction point control of the fibroblast cell cycle. Science 272: 877-880, 1996
35. Kip1. Kidney Int 50: 2112-2119, 1996
36. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ: Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701-713, 1991