A comparison of the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors simvastatin, lovastatin and pravastatin on leukaemic and normal bone marrow progenitors

Leukemia and Lymphoma

Volumn 24, Issue 5-6, 1997, Pages 533-537

  Newman, Ann ^a   Clutterbuck, Robyn D ^a   Powles, Ray L ^a   Catovsky, Daniel ^a   Millar, John L ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

AML; Colonies; Lovastatin; Normal bone marrow; Pravastatin; Simvastatin

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PRAVASTATIN; SIMVASTATIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BONE MARROW CELL; CANCER INHIBITION; CELL GROWTH; CELL STRAIN HL 60; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; STEM CELL;

EID: 0030993888     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199709055590     Document Type: Article

References (7)

1. Newman, A , Clutterbuck, R. D., Powles, R. L and Millar, J. L. (1994). Selective inhibition of primary acute myeloid leukaemia cell growth by simvastatin. Leukemia, 8, 2023-2029.
2. Newman, A., Clutterbuck, R. D., DeLord, C., Powles, R. L., Catovsky, D. and Millar, J. L. (1995) The sensitivity of leukemic bone marrow to simvastatin is lost at remission: A potential purging agent for autologous bone marrow transplantation. J. Investig. Med., 43, 269-274.
3. Chapuis, B., Summersgill, B. M., Cocks, P., Howard, P., Lawler, S. D., Alexander, P. and Powles, R. (1977). Test for cryopreservation efficiency of human acute myelogenous leukaemia cells relevant to clinical requirements. Cryobiology, 14, 637-648.
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7. Pentikainen, P. J., Saraheimo, M., Schwartz, J. I., Amin, R. D., Schwartz, M. S., Brunner-Ferber, F. and Rogers, J. D. (1992). Comparative Pharmacokinetics of lovastatin, simvastatin and pravastatin in humans. J. Clin. Pharmacol , 32, 136-140.