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Volumn 573, Issue 1-2, 2005, Pages 54-69

Genetic association studies of complex traits: Design and analysis issues

Author keywords

Association study; Complex trait; Genetics; Genomics; Review; Single nucleotide polymorphism

Indexed keywords

ALLELE; COMPARATIVE STUDY; DISEASE PREDISPOSITION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPE; HUMAN; MEASUREMENT; MEDICAL RESEARCH; NONHUMAN; PHENOTYPE; POPULATION DYNAMICS; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 17044419163     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.01.006     Document Type: Review
Times cited : (240)

References (84)
  • 1
    • 84965339061 scopus 로고
    • ABO blood groups and secretor character in duodenal ulcer: Population and sibship studies
    • C. Clarke, J. Edwards, D. Haddock, A. Howel-Evans, R. McConnell, and P. Sheppard ABO blood groups and secretor character in duodenal ulcer: population and sibship studies BMJ 1956 725 731
    • (1956) BMJ , pp. 725-731
    • Clarke, C.1    Edwards, J.2    Haddock, D.3    Howel-Evans, A.4    McConnell, R.5    Sheppard, P.6
  • 2
    • 17044367137 scopus 로고
    • Enzyme and protein diversity in human populations
    • American Elsevier Publishing Company New York
    • H. Harris Enzyme and protein diversity in human populations The Principle of Human Biochemical Genetics 1970 American Elsevier Publishing Company New York 211-242
    • (1970) The Principle of Human Biochemical Genetics
    • Harris, H.1
  • 5
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • K.E. Lohmueller, C.L. Pearce, M. Pike, E.S. Lander, and J.N. Hirschhorn Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease Nat. Genet. 33 2003 177 182
    • (2003) Nat. Genet. , vol.33 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 8
    • 0032231877 scopus 로고    scopus 로고
    • Comprehensive human genetic maps: Individual and sex-specific variation in recombination
    • K.W. Broman, J.C. Murray, V.C. Sheffield, R.L. White, and J.L. Weber Comprehensive human genetic maps: individual and sex-specific variation in recombination Am. J. Hum. Genet. 63 1998 861 869
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 861-869
    • Broman, K.W.1    Murray, J.C.2    Sheffield, V.C.3    White, R.L.4    Weber, J.L.5
  • 9
    • 0036403779 scopus 로고    scopus 로고
    • Linkage analysis in psychiatric disorders: The emerging picture
    • P. Sklar Linkage analysis in psychiatric disorders: the emerging picture Annu. Rev. Genomics Hum. Genet. 3 2002 371 413
    • (2002) Annu. Rev. Genomics Hum. Genet. , vol.3 , pp. 371-413
    • Sklar, P.1
  • 10
    • 0242524453 scopus 로고    scopus 로고
    • The inherited basis of diabetes mellitus: Implications for the genetic analysis of complex traits
    • J.C. Florez, J. Hirschhorn, and D. Altshuler The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits Annu. Rev. Genomics Hum. Genet. 4 2003 257 291
    • (2003) Annu. Rev. Genomics Hum. Genet. , vol.4 , pp. 257-291
    • Florez, J.C.1    Hirschhorn, J.2    Altshuler, D.3
  • 11
    • 0034758045 scopus 로고    scopus 로고
    • Genome-wide scans of complex human diseases: True linkage is hard to find
    • J. Altmuller, L.J. Palmer, G. Fischer, H. Scherb, and M. Wjst Genome-wide scans of complex human diseases: true linkage is hard to find Am. J. Hum. Genet. 69 2001 936 950
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 936-950
    • Altmuller, J.1    Palmer, L.J.2    Fischer, G.3    Scherb, H.4    Wjst, M.5
  • 21
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • N. Risch, and K. Merikangas The future of genetic studies of complex human diseases Science 273 1996 1516 1517
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 22
    • 0037432755 scopus 로고    scopus 로고
    • The Human Genome Project: Lessons from large-scale biology
    • F.S. Collins, M. Morgan, and A. Patrinos The Human Genome Project: lessons from large-scale biology Science 300 2003 286 290
    • (2003) Science , vol.300 , pp. 286-290
    • Collins, F.S.1    Morgan, M.2    Patrinos, A.3
  • 25
    • 0036208832 scopus 로고    scopus 로고
    • Patterns of linkage disequilibrium in the human genome
    • K.G. Ardlie, L. Kruglyak, and M. Seielstad Patterns of linkage disequilibrium in the human genome Nat. Rev. Genet. 3 2002 299 309
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 299-309
    • Ardlie, K.G.1    Kruglyak, L.2    Seielstad, M.3
  • 27
    • 0033927466 scopus 로고    scopus 로고
    • Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data
    • P.C. Sham, S.S. Cherny, S. Purcell, and J.K. Hewitt Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data Am. J. Hum. Genet. 66 2000 1616 1630
    • (2000) Am. J. Hum. Genet. , vol.66 , pp. 1616-1630
    • Sham, P.C.1    Cherny, S.S.2    Purcell, S.3    Hewitt, J.K.4
  • 29
    • 0025008677 scopus 로고
    • Linkage strategies for genetically complex traits. Part II: The power of affected relative pairs
    • N. Risch Linkage strategies for genetically complex traits. Part II: the power of affected relative pairs Am. J. Hum. Genet. 46 1990 229 241
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 229-241
    • Risch, N.1
  • 30
    • 11944263528 scopus 로고
    • Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis
    • M.I. Harris, R. Klein, T.A. Welborn, and M.W. Knuiman Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis Diabetes Care 15 1992 815 819
    • (1992) Diabetes Care , vol.15 , pp. 815-819
    • Harris, M.I.1    Klein, R.2    Welborn, T.A.3    Knuiman, M.W.4
  • 31
    • 0033770421 scopus 로고    scopus 로고
    • Evidence for a gene influencing blood pressure on chromosome 17: Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study
    • D. Levy, A.L. DeStefano, M.G. Larson, C.J. O'Donnell, R.P. Lifton, H. Gavras, L.A. Cupples, and R.H. Myers Evidence for a gene influencing blood pressure on chromosome 17: genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study Hypertension 36 2000 477 483
    • (2000) Hypertension , vol.36 , pp. 477-483
    • Levy, D.1    Destefano, A.L.2    Larson, M.G.3    O'Donnell, C.J.4    Lifton, R.P.5    Gavras, H.6    Cupples, L.A.7    Myers, R.H.8
  • 32
    • 0035094764 scopus 로고    scopus 로고
    • Variation is the spice of life
    • L. Kruglyak, and D.A. Nickerson Variation is the spice of life Nat. Genet. 27 2001 234 236
    • (2001) Nat. Genet. , vol.27 , pp. 234-236
    • Kruglyak, L.1    Nickerson, D.A.2
  • 33
    • 0034924997 scopus 로고    scopus 로고
    • Positive and negative selection on the human genome
    • J.C. Fay, G.J. Wyckoff, and C.I. Wu Positive and negative selection on the human genome Genetics 158 2001 1227 1234
    • (2001) Genetics , vol.158 , pp. 1227-1234
    • Fay, J.C.1    Wyckoff, G.J.2    Wu, C.I.3
  • 35
    • 0037373275 scopus 로고    scopus 로고
    • Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease
    • D. Botstein, and N. Risch Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease Nat. Genet. 33 Suppl. 2003 228 237
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 228-237
    • Botstein, D.1    Risch, N.2
  • 36
    • 0035261381 scopus 로고    scopus 로고
    • Genomic strategies to identify mammalian regulatory sequences
    • L.A. Pennacchio, and E.M. Rubin Genomic strategies to identify mammalian regulatory sequences Nat. Rev. Genet. 2 2001 100 109
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 100-109
    • Pennacchio, L.A.1    Rubin, E.M.2
  • 37
    • 0030444451 scopus 로고    scopus 로고
    • Human type 1 diabetes and the insulin gene: Principles of mapping polygenes
    • S.T. Bennett, and J.A. Todd Human type 1 diabetes and the insulin gene: principles of mapping polygenes Annu. Rev. Genet. 30 1996 343 370
    • (1996) Annu. Rev. Genet. , vol.30 , pp. 343-370
    • Bennett, S.T.1    Todd, J.A.2
  • 45
    • 0036775432 scopus 로고    scopus 로고
    • Once and again-issues surrounding replication in genetic association studies
    • J.N. Hirschhorn, and D. Altshuler Once and again-issues surrounding replication in genetic association studies J. Clin. Endocrinol. Metab. 87 2002 4438 4441
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4438-4441
    • Hirschhorn, J.N.1    Altshuler, D.2
  • 46
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • R.S. Spielman, R.E. McGinnis, and W.J. Ewens Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am. J. Hum. Genet. 52 1993 506 516
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 47
    • 0028944305 scopus 로고
    • A note on the application of the transmission disequilibrium test when a parent is missing
    • D. Curtis, and P.C. Sham A note on the application of the transmission disequilibrium test when a parent is missing Am. J. Hum. Genet. 56 1995 811 812
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 811-812
    • Curtis, D.1    Sham, P.C.2
  • 48
    • 0029858544 scopus 로고    scopus 로고
    • The TDT and other family-based tests for linkage disequilibrium and association
    • R.S. Spielman, and W.J. Ewens The TDT and other family-based tests for linkage disequilibrium and association Am. J. Hum. Genet. 59 1996 983 989
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 983-989
    • Spielman, R.S.1    Ewens, W.J.2
  • 49
    • 0033910787 scopus 로고    scopus 로고
    • A test for linkage and association in general pedigrees: The pedigree disequilibrium test
    • E.R. Martin, S.A. Monks, L.L. Warren, and N.L. Kaplan A test for linkage and association in general pedigrees: the pedigree disequilibrium test Am. J. Hum. Genet. 67 2000 146 154
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 146-154
    • Martin, E.R.1    Monks, S.A.2    Warren, L.L.3    Kaplan, N.L.4
  • 50
    • 0037371453 scopus 로고    scopus 로고
    • Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test
    • A.A. Mitchell, D.J. Cutler, and A. Chakravarti Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test Am. J. Hum. Genet. 72 2003 598 610
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 598-610
    • Mitchell, A.A.1    Cutler, D.J.2    Chakravarti, A.3
  • 51
    • 0031912715 scopus 로고    scopus 로고
    • A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test
    • R.S. Spielman, and W.J. Ewens A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test Am. J. Hum. Genet. 62 1998 450 458
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 450-458
    • Spielman, R.S.1    Ewens, W.J.2
  • 52
    • 0031949273 scopus 로고    scopus 로고
    • Genetic association mapping based on discordant sib pairs: The discordant-alleles test
    • M. Boehnke, and C.D. Langefeld Genetic association mapping based on discordant sib pairs: the discordant-alleles test Am. J. Hum. Genet. 62 1998 950 961
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 950-961
    • Boehnke, M.1    Langefeld, C.D.2
  • 53
    • 0031028361 scopus 로고    scopus 로고
    • Transmission-disequilibrium tests for quantitative traits
    • D.B. Allison Transmission-disequilibrium tests for quantitative traits Am. J. Hum. Genet. 60 1997 676 690
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 676-690
    • Allison, D.B.1
  • 54
    • 0344033602 scopus 로고    scopus 로고
    • Detecting disease associations due to linkage disequilibrium using haplotype tags: A class of tests and the determinants of statistical power
    • J.M. Chapman, J.D. Cooper, J.A. Todd, and D.G. Clayton Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power Hum. Hered. 56 2003 18 31
    • (2003) Hum. Hered. , vol.56 , pp. 18-31
    • Chapman, J.M.1    Cooper, J.D.2    Todd, J.A.3    Clayton, D.G.4
  • 55
    • 0035257236 scopus 로고    scopus 로고
    • Association study designs for complex diseases
    • L.R. Cardon, and J.I. Bell Association study designs for complex diseases Nat. Rev. Genet. 2 2001 91 99
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 91-99
    • Cardon, L.R.1    Bell, J.I.2
  • 56
    • 0036255811 scopus 로고    scopus 로고
    • Opinion: Candidate-gene approaches for studying complex genetic traits. Practical considerations
    • H.K. Tabor, N.J. Risch, and R.M. Myers Opinion: candidate-gene approaches for studying complex genetic traits. Practical considerations Nat. Rev. Genet. 3 2002 391 397
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 391-397
    • Tabor, H.K.1    Risch, N.J.2    Myers, R.M.3
  • 58
    • 0030052609 scopus 로고    scopus 로고
    • Permutation tests for multiple loci affecting a quantitative character
    • R.W. Doerge, and G.A. Churchill Permutation tests for multiple loci affecting a quantitative character Genetics 142 1996 285 294
    • (1996) Genetics , vol.142 , pp. 285-294
    • Doerge, R.W.1    Churchill, G.A.2
  • 59
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J. R. Stat. Soc. 57 1995 289 300
    • (1995) J. R. Stat. Soc. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 60
    • 4143076901 scopus 로고    scopus 로고
    • Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies
    • F. Dudbridge, and B.P. Koeleman Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies Am. J. Hum. Genet. 75 2004 424 435
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 424-435
    • Dudbridge, F.1    Koeleman, B.P.2
  • 61
    • 1642295096 scopus 로고    scopus 로고
    • Assessing the probability that a positive report is false: An approach for molecular epidemiology studies
    • S. Wacholder, S. Chanock, M. Garcia-Closas, L. El Ghormli, and N. Rothman Assessing the probability that a positive report is false: an approach for molecular epidemiology studies J. Natl. Cancer Inst. 96 2004 434 442
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 434-442
    • Wacholder, S.1    Chanock, S.2    Garcia-Closas, M.3    El Ghormli, L.4    Rothman, N.5
  • 62
    • 0032530165 scopus 로고    scopus 로고
    • Tests and estimates of allelic association in complex inheritance
    • N.E. Morton, and A. Collins Tests and estimates of allelic association in complex inheritance Proc. Natl. Acad. Sci. U.S.A. 95 1998 11389 11393
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 11389-11393
    • Morton, N.E.1    Collins, A.2
  • 63
    • 0036071296 scopus 로고    scopus 로고
    • Testing for population subdivision and association in four case-control studies
    • K.G. Ardlie, K.L. Lunetta, and M. Seielstad Testing for population subdivision and association in four case-control studies Am. J. Hum. Genet. 71 2002 304 311
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 304-311
    • Ardlie, K.G.1    Lunetta, K.L.2    Seielstad, M.3
  • 65
    • 2442585696 scopus 로고    scopus 로고
    • The effects of human population structure on large genetic association studies
    • J. Marchini, L.R. Cardon, M.S. Phillips, and P. Donnelly The effects of human population structure on large genetic association studies Nat. Genet. 36 2004 512 517
    • (2004) Nat. Genet. , vol.36 , pp. 512-517
    • Marchini, J.1    Cardon, L.R.2    Phillips, M.S.3    Donnelly, P.4
  • 66
    • 0032714352 scopus 로고    scopus 로고
    • Genomic control for association studies
    • B. Devlin, and K. Roeder Genomic control for association studies Biometrics 55 1999 997 1004
    • (1999) Biometrics , vol.55 , pp. 997-1004
    • Devlin, B.1    Roeder, K.2
  • 67
    • 0033358548 scopus 로고    scopus 로고
    • Use of unlinked genetic markers to detect population stratification in association studies
    • J.K. Pritchard, and N.A. Rosenberg Use of unlinked genetic markers to detect population stratification in association studies Am. J. Hum. Genet. 65 1999 220 228
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 220-228
    • Pritchard, J.K.1    Rosenberg, N.A.2
  • 68
    • 0035185344 scopus 로고    scopus 로고
    • Detecting association in a case-control study while correcting for population stratification
    • D.E. Reich, and D.B. Goldstein Detecting association in a case-control study while correcting for population stratification Genet. Epidemiol. 20 2001 4 16
    • (2001) Genet. Epidemiol. , vol.20 , pp. 4-16
    • Reich, D.E.1    Goldstein, D.B.2
  • 69
    • 0347362518 scopus 로고    scopus 로고
    • Informativeness of genetic markers for inference of ancestry
    • N.A. Rosenberg, L.M. Li, R. Ward, and J.K. Pritchard Informativeness of genetic markers for inference of ancestry Am. J. Hum. Genet. 73 2003 1402 1422
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 1402-1422
    • Rosenberg, N.A.1    Li, L.M.2    Ward, R.3    Pritchard, J.K.4
  • 70
  • 72
    • 0037195149 scopus 로고    scopus 로고
    • Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: Evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study
    • J.M. Ordovas, D. Corella, S. Demissie, L.A. Cupples, P. Couture, O. Coltell, P.W. Wilson, E.J. Schaefer, and K.L. Tucker Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study Circulation 106 2002 2315 2321
    • (2002) Circulation , vol.106 , pp. 2315-2321
    • Ordovas, J.M.1    Corella, D.2    Demissie, S.3    Cupples, L.A.4    Couture, P.5    Coltell, O.6    Wilson, P.W.7    Schaefer, E.J.8    Tucker, K.L.9
  • 73
    • 0242410130 scopus 로고    scopus 로고
    • Dietary fat interacts with the -514C > T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: The 1998 Singapore National Health Survey
    • E.S. Tai, D. Corella, M. Deurenberg-Yap, J. Cutter, S.K. Chew, C.E. Tan, and J.M. Ordovas Dietary fat interacts with the -514C > T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey J. Nutr. 133 2003 3399 3408
    • (2003) J. Nutr. , vol.133 , pp. 3399-3408
    • Tai, E.S.1    Corella, D.2    Deurenberg-Yap, M.3    Cutter, J.4    Chew, S.K.5    Tan, C.E.6    Ordovas, J.M.7
  • 74
    • 0345306138 scopus 로고    scopus 로고
    • Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass
    • A. Memisoglu, F.B. Hu, S.E. Hankinson, J.E. Manson, V. De, I.W.C. Willett, and D.J. Hunter Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass Hum. Mol. Genet. 12 2003 2923 2929
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2923-2929
    • Memisoglu, A.1    Hu, F.B.2    Hankinson, S.E.3    Manson, J.E.4    De, V.5    Willett, I.W.C.6    Hunter, D.J.7
  • 75
    • 0041630975 scopus 로고    scopus 로고
    • The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: Results from the Quebec Family Study
    • J. Robitaille, J.P. Despres, L. Perusse, and M.C. Vohl The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Quebec Family Study Clin. Genet. 63 2003 109 116
    • (2003) Clin. Genet. , vol.63 , pp. 109-116
    • Robitaille, J.1    Despres, J.P.2    Perusse, L.3    Vohl, M.C.4
  • 78
    • 0038389762 scopus 로고    scopus 로고
    • IBD5 is a general risk factor for inflammatory bowel disease: Replication of association with Crohn disease and identification of a novel association with ulcerative colitis
    • C. Giallourakis, M. Stoll, K. Miller, J. Hampe, E.S. Lander, M.J. Daly, S. Schreiber, and J.D. Rioux IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis Am. J. Hum. Genet. 73 2003 205 211
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 205-211
    • Giallourakis, C.1    Stoll, M.2    Miller, K.3    Hampe, J.4    Lander, E.S.5    Daly, M.J.6    Schreiber, S.7    Rioux, J.D.8


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