Positive and negative selection on the human genome

Genetics

Volumn 158, Issue 3, 2001, Pages 1227-1234

  Fay, Justin C ^a   Wyckoff, Gerald J ^a   Wu, Chung I ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; DIPLOIDY; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC SELECTION; HUMAN; MOLECULAR EVOLUTION; MONKEY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

GENOME, HUMAN; HUMANS; MODELS, GENETIC; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SELECTION (GENETICS);

DARWINIA;

EID: 0034924997     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Within- and between-species DNA sequence variation and the "footprint" of natural selection
2. Linkage and the limits to natural selection
3. The costs of human inbreeding and their implications for variations at the DNA level
4. Characterization of single-nucleotide polymorphisms in coding regions of human genes
5. Genetic loads and the cost of natural selection
6. Evidence of selection on silent site base composition in mammals: Potential implications for the evolution of isochores and junk DNA
7. High genomic deleterious mutation rates in hominids
8. Hitchhiking under positive Darwinian selection
9. Statistical properties of segregating sites
10. Amino acid difference formula to help explain protein evolution
11. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
12. Adaptive protein evolution at the Adh locus in Drosophila
13. The effects of Hill-Robertson interference between weakly selected mutations on patterns of molecular evolution and variation
14. An estimate of the mutational damage in man from data on consanguineous marriages
15. Our load of mutations
16. Population genetics of polymorphism and divergence
17. Pattern of selective constraint in C. elegans and C. briggsae genomes
18. SNP frequencies in human genes an excess of rare alleles and differing modes of selection
19. Contingency tests of neutrality using intra/ interspecific gene trees: The rejection of neutrality for the evolution of the mitochondrial cytochrome oxidase II gene in the hominoid primates
20. On the number of segregating sites
21. Estimating the proportion of neutral mutants
22. Rapid evolution of male reproductive genes in the descent of man