Genetic association mapping based on discordant sib pairs: The discordant-alleles test

American Journal of Human Genetics

Volumn 62, Issue 4, 1998, Pages 950-961

  Boehnke, Michael ^a   Langefeld, Carl D ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ALZHEIMER DISEASE; ARTICLE; COMPUTER SIMULATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ASSOCIATION; GENETIC LINKAGE; HUMAN; HYPERLIPOPROTEINEMIA TYPE 3; PRIORITY JOURNAL; SIBLING;

EID: 0031949273     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301787     Document Type: Article

References (23)

1. Agresti A (1990) Categorical data analysis. Wiley, New York
2. Besag J, Clifford P (1991) Sequential Monte Carlo p-values. Biometrika 78:301-304
3. Bowker AH (1948) A test for symmetry in contingency tables. J Am Stat Assoc 43:572-574
4. Chee M, Yang R, Hubbell E, Berno A, Huang XC, Stern D, Winkler J, et al (1996) Accessing genetic information with high-density DNA arrays. Science 274:610-614
5. Clarke CA, Edwards JW, Haddock DRW, Howel-Evans AW, McConnell RB, Sheppard PM (1956) ABO blood groups and secretor character in duodenal ulcer. Br Med J:725-731
6. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC Jr, Rimmler JB, et al (1994) Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 7:180-184
7. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923
8. Curtis D (1997) Use of siblings as controls in case-control association studies. Ann Hum Genet 61:319-333
9. Curtis D, Sham PC (1995) A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet 56:811-812
10. Efron B, Tibshirani RJ (1993) An introduction to the bootstrap. Chapman and Hall, New York, pp 202-219
11. Falk CT, Rubenstein P (1987) Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227-233
12. Knapp M, Seuchter SA, Baur MP (1993) The haplotype-relative-risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet 52:1085-1093
13. Ott J (1989) Statistical properties of the haplotype relative risk. Genet Epidemiol 6:127-130
14. Risch N (1987) Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 40:1-14
15. Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273:1516-1517
16. Risch N, Zhang H (1995) Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268: 1584-1589
17. Rogus JJ, Krolewski AS (1996) Using discordant sib pairs to map loci for qualitative traits with high sibling recurrence risk. Am J Hum Genet 59:1376-1381
18. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, et al (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467-1472
19. Schaid DJ (1996) General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-449
20. Spielman RS, Ewens WJ (1996) The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989
21. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516
22. Thomson G (1995) Mapping disease genes: family-based association studies. Am J Hum Genet 57:487-498
23. Utermann G, Langenbeck U, Beisiegel U, Weber W (1980) Genetics of the apolipoprotein E system in man. Am J Hum Genet 32:339-347