Mouse models of pancreatic cancer: The fur is finally flying!

Cancer Cell

Volumn 5, Issue 1, 2004, Pages 7-11

  Leach, Steven D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; ELASTASE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; NOTCH RECEPTOR; PROTEIN P16; PROTEIN P53; SMAD4 PROTEIN; SONIC HEDGEHOG PROTEIN; VIRUS T ANTIGEN; VIRUS VECTOR;

ALLELE; BRANCHING MORPHOGENESIS; CANCER MODEL; CANCER PREVENTION; CANCER SUSCEPTIBILITY; CELL DIFFERENTIATION; CELL LINEAGE; CELL TYPE; CHEMICAL MUTAGENESIS; CHEMOPROPHYLAXIS; CYCLIC AMP RESPONSIVE ELEMENT; DISEASE MODEL; EARLY DIAGNOSIS; ENHANCER REGION; EVALUATION; EXPERIMENTAL MOUSE; GENE LOCUS; HUMAN; KNOCKOUT MOUSE; LETHALITY; MORPHOGENESIS; NONHUMAN; ONCOGENE C MYC; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROMOTER REGION; SHORT SURVEY; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; TRANSGENE; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

ANIMALIA; ERINACEIDAE; SIMIAE; SIMIAN VIRUS 40;

EID: 1642512647     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(03)00337-4     Document Type: Review

References (55)

1. Aguirre A.J., Bardeesy N., Sinha M., Lopez L., Tuveson D.A., Horner J., Redston M.S., DePinho R.A. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 17:2003;3112-3126.
2. Ahlgren U., Jonsson J., Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development. 122:1996;1409-1416.
3. Apelqvist A., Ahlgren U., Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol. 7:1997;801-804.
4. Apelqvist A., Li H., Sommer L., Beatus P., Anderson D.J., Honjo T., Hrabe de Angelis M., Lendahl U., Edlund H. Notch signalling controls pancreatic cell differentiation. Nature. 400:1999;877-881.
5. Berman D.M., Karhadkar S.S., Maitra A., Montes De Oca R., Gerstenblith M.R., Briggs K., Parker A.R., Shimada Y., Eshleman J.R., Watkins D.N., Beachy P.A. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 425:2003;846-851.
6. Bolt A.B., Papanikolaou A., Delker D.A., Wang Q.S., Rosenberg D.W. Azoxymethane induces KI-ras activation in the tumor resistant AKR/J mouse colon. Mol. Carcinog. 27:2000;210-218.
7. Brat D.J., Lillemoe K.D., Yeo C.J., Warfield P.B., Hruban R.H. Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas. Am. J. Surg. Pathol. 22:1998;163-169.
8. Brembeck F.H., Schreiber F.S., Deramaudt T.B., Craig L., Rhoades B., Swain G., Grippo P., Stoffers D.A., Silberg D.G., Rustgi A.K. The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. Cancer Res. 63:2003;2005-2009.
9. Chiang M.K., Melton D.A. Single-cell transcript analysis of pancreas development. Dev. Cell. 4:2003;383-393.
10. Cras-Meneur C., Elghazi L., Czernichow P., Scharfmann R. Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro. a balance between proliferation and differentiation Diabetes. 50:2001;1571-1579.
11. Crawford H.C., Scoggins C.R., Washington M.K., Matrisian L.M., Leach S.D. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J. Clin. Invest. 109:2002;1437-1444.
12. Deutsch G., Jung J., Zheng M., Lora J., Zaret K.S. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development. 128:2001;871-881.
13. Edlund H. Pancreas. how to get there from the gut? Curr. Opin. Cell Biol. 11:1999;663-668.
14. Ewart-Toland A., Briassouli P., de Koning J.P., Mao J.H., Yuan J., Chan F., MacCarthy-Morrogh L., Ponder B.A., Nagase H., Burn J.et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat. Genet. 34:2003;403-412.
15. Grippo P.J., Nowlin P.S., Demeure M.J., Longnecker D.S., Sandgren E.P. Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice. Cancer Res. 63:2003;2016-2019.
16. Gu G., Brown J.R., Melton D.A. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech. Dev. 120:2003;35-43.
17. Hald J., Hjorth J.P., German M.S., Madsen O.D., Serup P., Jensen J. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev. Biol. 260:2003;426-437.
18. Hebrok M., Kim S.K., St Jacques B., McMahon A.P., Melton D.A. Regulation of pancreas development by hedgehog signaling. Development. 127:2000;4905-4913.
19. Hingorani S.R., Petricoin E.F., Maitra A., Rajapakse V., King C., Jacobetz M.A., Ross S., Conrads T.P., Veenstra T.D., Hitt B.A.et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4:2003;437-450.
20. Hook L.M., Agafonova Y., Ross S.R., Turner S.J., Golovkina T.V. Genetics of mouse mammary tumor virus-induced mammary tumors. linkage of tumor induction to the gag gene J. Virol. 74:2000;8876-8883.
21. Hruban R.H., Wilentz R.E., Goggins M., Offerhaus G.J., Yeo C.J., Kern S.E. Pathology of incipient pancreatic cancer. Ann. Oncol. 10(Suppl 4):1999;9-11.
22. Hruban R.H., Adsay N.V., Albores-Saavedra J., Compton C., Garrett E.S., Goodman S.N., Kern S.E., Klimstra D.S., Kloppel G., Longnecker D.S.et al. Pancreatic intraepithelial neoplasia. a new nomenclature and classification system for pancreatic duct lesions Am. J. Surg. Pathol. 25:2001;579-586. a.
23. Hruban R.H., Iacobuzio-Donahue C., Wilentz R.E., Goggins M., Kern S.E. Molecular pathology of pancreatic cancer. Cancer J. 7:2001;251-258. b.
24. Hutchinson J.N., Muller W.J. Transgenic mouse models of human breast cancer. Oncogene. 19:2000;6130-6137.
25. Jacoby R.F., Marshall D.J., Newton M.A., Novakovic K., Tutsch K., Cole C.E., Lubet R.A., Kelloff G.J., Verma A., Moser A.R., Dove W.F. Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam. Cancer Res. 56:1996;710-714.
26. Jemal A., Murray T., Samuels A., Ghafoor A., Ward E., Thun M.J. Cancer statistics, 2003. CA Cancer J. Clin. 53:2003;5-26.
27. Jensen J., Pedersen E.E., Galante P., Hald J., Heller R.S., Ishibashi M., Kageyama R., Guillemot F., Serup P., Madsen O.D. Control of endodermal endocrine development by Hes-1. Nat. Genet. 24:2000;36-44.
28. Kasper S., Sheppard P.C., Yan Y., Pettigrew N., Borowsky A.D., Prins G.S., Dodd J.G., Duckworth M.L., Matusik R.J. Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice. a model for prostate cancer Lab. Invest. 78:1998;i-xv.
29. Kawaguchi Y., Cooper B., Gannon M., Ray M., MacDonald R.J., Wright C.V. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet. 32:2002;128-134.
30. Kim S.K., MacDonald R.J. Signaling and transcriptional control of pancreatic organogenesis. Curr. Opin. Genet. Dev. 12:2002;540-547.
31. Krapp A., Knofler M., Ledermann B., Burki K., Berney C., Zoerkler N., Hagenbuchle O., Wellauer P.K. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12:1998;3752-3763.
32. Lewis B.C., Klimstra D.S., Varmus H.E. The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes Dev. 17:2003;3127-3138.
33. Maitra A., Ashfaq R., Gunn C.R., Rahman A., Yeo C.J., Sohn T.A., Cameron J.L., Hruban R.H., Wilentz R.E. Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia. an immunohistochemical analysis with automated cellular imaging Am. J. Clin. Pathol. 118:2002;194-201.
34. Maitra A., Adsay N.V., Argani P., Iacobuzio-Donahue C., De Marzo A., Cameron J.L., Yeo C.J., Hruban R.H. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod. Pathol. 16:2003;902-912.
35. Malkinson A.M. Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung. Lung Cancer. 32:2001;265-279.
36. Meszoely I.M., Means A.L., Scoggins C.R., Leach S.D. Developmental aspects of early pancreatic cancer. Cancer J. 7:2001;242-250.
37. Miyamoto Y., Maitra A., Ghosh B., Zechner U., Argani P., Iacobuzio-Donahue C.A., Sriuranpong V., Iso T., Meszoely I.M., Wolfe M.S.et al. Notch mediates TGFalpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell. 3:2003;565-576.
38. Moser A.R., Dove W.F., Roth K.A., Gordon J.I. The Min (multiple intestinal neoplasia) mutation. its effect on gut epithelial cell differentiation and interaction with a modifier system J. Cell Biol. 116:1992;1517-1526.
39. Offield M.F., Jetton T.L., Labosky P.A., Ray M., Stein R.W., Magnuson M.A., Hogan B.L., Wright C.V. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 122:1996;983-995.
40. Ornitz D.M., Palmiter R.D., Hammer R.E., Brinster R.L., Swift G.H., MacDonald R.J. Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature. 313:1985;600-602.
41. Ornitz D.M., Hammer R.E., Messing A., Palmiter R.D., Brinster R.L. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science. 238:1987;188-193.
42. Quaife C.J., Pinkert C.A., Ornitz D.M., Palmiter R.D., Brinster R.L. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell. 48:1987;1023-1034.
43. Rangarajan A., Weinberg R.A. Comparative biology of mouse versus human cells. modelling human cancer in mice Nat. Rev. Cancer. 3:2003;952-959.
44. Roberts R.B., Min L., Washington M.K., Olsen S.J., Settle S.H., Coffey R.J., Threadgill D.W. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc. Natl. Acad. Sci. USA. 99:2002;1521-1526.
45. Sandgren E.P., Quaife C.J., Paulovich A.G., Palmiter R.D., Brinster R.L. Pancreatic tumor pathogenesis reflects the causative genetic lesion. Proc. Natl. Acad. Sci. USA. 88:1991;93-97.
46. Saran A., Neveu T., Covelli V., Mouton D., Pazzaglia S., Rebessi S., Doria G., Biozzi G. Genetics of chemical carcinogenesis. analysis of bidirectional selective breeding inducing maximal resistance or maximal susceptibility to 2-stage skin tumorigenesis in the mouse Int. J. Cancer. 88:2000;424-431.
47. Su L.K., Kinzler K.W., Vogelstein B., Preisinger A.C., Moser A.R., Luongo C., Gould K.A., Dove W.F. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science. 256:1992;668-670.
48. Swift G.H., Hammer R.E., MacDonald R.J., Brinster R.L. Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell. 38:1984;639-646.
49. Thayer S.P., Di Magliano M.P., Heiser P.W., Nielsen C.M., Roberts D.J., Lauwers G.Y., Qi Y.P., Gysin S., Castillo C.F., Yajnik V.et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 425:2003;851-856.
50. Torrance C.J., Jackson P.E., Montgomery E., Kinzler K.W., Vogelstein B., Wissner A., Nunes M., Frost P., Discafani C.M. Combinatorial chemoprevention of intestinal neoplasia. Nat. Med. 6:2000;1024-1028.
51. Van Dyke T., Jacks T. Cancer modeling in the modern era. progress and challenges Cell. 108:2002;135-144.
52. van Heek N.T., Meeker A.K., Kern S.E., Yeo C.J., Lillemoe K.D., Cameron J.L., Offerhaus G.J., Hicks J.L., Wilentz R.E., Goggins M.G.et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am. J. Pathol. 161:2002;1541-1547.
53. Wagner M., Greten F.R., Weber C.K., Koschnick S., Mattfeldt T., Deppert W., Kern H., Adler G., Schmid R.M. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev. 15:2001;286-293.
54. Wagner M., Weber C.K., Bressau F., Greten F.R., Stagge V., Ebert M., Leach S.D., Adler G., Schmid R.M. Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells. Gastroenterology. 122:2002;1898-1912.
55. Yeo T.P., Hruban R.H., Leach S.D., Wilentz R.E., Sohn T.A., Kern S.E., Iacobuzio-Donahue C.A., Maitra A., Goggins M., Canto M.I.et al. Pancreatic cancer. Curr. Probl. Cancer. 26:2002;176-275.