Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

Journal of Clinical Investigation

Volumn 109, Issue 11, 2002, Pages 1437-1444

  Crawford, Howard C ^a,d   Scoggins, Charles R ^b   Kay Washington, M ^b   Matrisian, Lynn M ^a   Leach, Steven D ^c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS LIGAND; MATRILYSIN;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER RISK; CARCINOGENESIS; CELL TYPE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; INTESTINE EPITHELIUM; MALE; METAPLASIA; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREAS DUCT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLUBILIZATION;

EID: 0036266409     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215051     Document Type: Article

References (49)

1. Risk factors For cancer in hereditary pancreatitis
2. Pancreatitis and the risk of pancreatic cancer
3. The genetics of pancreatic adenocarcinoma: A roadmap for a mouse model
4. Helicobacter pylori infection and the development of gastric cancer
5. Helicobacter pylori-not a good bug after all!
6. The risk of colorectal cancer in ulcerative colitis: A meta-analysis
7. Barrett's metaplasia
8. Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice
9. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
10. Complex roles of matrix metalloproteinases in tumor progression
11. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin
12. The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis
13. Stromelysin-3 expression promotes tumor take in nude mice
14. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
15. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
16. ECM and cell surface proteolysis: Regulating cellular ecology
17. Release of an invasion promoter E-cadherin Fragment by matrilysin and stromelysin-1
18. Cleavage of beta 4 integrin by matrilysin
19. Processing of tumour necrosis factor-alpha precursor by metalloproteinases
20. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-α in a model of herniated disc resorption
21. The metalloproteinase matrilysin (MMP-7) proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
22. Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract
23. Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis
24. Overexpression of TGF alpha in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
25. p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas
26. Matrilysin and cyclooxygenase-2 are differentially expressed in intestinal and colorecral neoplasms
27. Pathology of incipient pancreatic cancer
28. TGF-alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas
29. A new model for pancreatitis
30. Expansion of Pdxl-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth Factor alpha
31. Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects rumor cells from chemotherapeutic drug cytotoxicity
32. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling
33. Coexpression of FAS and FAS-ligand in chronic pancreatitis: Correlation with apoptosis
34. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
35. Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax
36. STAT3 mediates the survival signal in oncogenic rastransfected intestinal epithelial cells
37. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: Clinicopathologic and prognostic significance of matrilysin expression
38. Identification of genes showing differential expression in antisense K-ras-transduced pancreatic cancer cells with suppressed tumorigenicity
39. Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas
40. Molecular pathology of pancreatic cancer
41. Interleukin-1 beta-induced promatrilysin expression is mediated by NFkappaB-regulated synthesis of interleukin-6 in the prostate carcinoma cell line LNCaP
42. Apoptotic and proliferative activity in the neoplastic progression of Barrett's oesophagus: A comparative study
43. Apoptosis of crypt epithelial cells in ulcerative colitis
44. Induction of gastric epithelial apoptosis by Helicobacter pylori
45. Overexpression of Fas ligand (FasL) during malignant transformation in the large bowel and in Barrett's metaplasia of the esophagus
46. Apoptosis of crypt epithelial cells in ulcerative colitis
47. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis
48. Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma
49. Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers