Azoxymethane induces Ki-ras activation in the tumor resistant AKR/J mouse colon

Molecular Carcinogenesis

Volumn 27, Issue 3, 2000, Pages 210-218

  Bolt, Andrew B ^a   Papanikolaou, Alexandros ^a   Delker, Don A ^a   Wang, Qian Shu ^a   Rosenberg, Daniel W ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Azoxymethane; Colon cancer; Mouse colon; Tumor susceptibility

Indexed keywords

AZOXYMETHANE; CARCINOGEN; DNA; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DNA SEQUENCE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AZOXYMETHANE; BASE SEQUENCE; COLON; DNA PRIMERS; EXONS; GENE EXPRESSION REGULATION; GENES, RAS; IMMUNOHISTOCHEMISTRY; MALE; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA; MURINAE;

EID: 0034099934     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(200003)27:3<210::AID-MC8>3.0.CO;2-3     Document Type: Article

References (47)

1. Diwan BA, Meier H, Blackman KE. Genetic differences in the induction of colorectal tumors by 1,2-dimethylhydrazine in inbred mice. J Natl Cancer Inst 1977;59:455-458.
2. Evans JT, Hauschka TS, Mittelman A. Differential susceptibility of four mouse strains to induction of multiple large-bowel neoplasms by 1,2-dimethylhydrazine. J Natl Cancer Inst 1974;52:999-1000.
3. Papanikolaou A, Wang QS, Delker DA, Rosenberg DW. Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility. Cancer Lett 1998;130:29-34.
4. Wang Q-S, Walsh A, Goldsby JS, Papanikolaou A, Bolt AB, Rosenberg, DW. Preliminary analysis of azoxymethane-induced colon tumorigenesis in mouse aggregation chimeras. Carcinogenesis 1999;20:691-697.
5. Moen CJA, Groot PC, Hart AAM, Snoek M, Demant P. Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. Proc Natl Acad Sci USA 1996;93: 1082-1086.
6. Jacoby RF, Hohman C, Marshall DJ, et al. 1994. Genetic analysis of colon cancer susceptibility in mice. Genomics 1994;22:381-387.
7. Delker DA, Wang Q-S, Papanikolaou A, Whiteley HE, Rosenberg, DW. Quantitative assessment of azoxymethane-induced aberrant crypt foci in inbred mice. Exp Mol Pathol 1998;65:141-149.
8. Rosenberg DW, Liu Y. Induction of aberrant crypts in murine colon with varying sensitivity to colon carcinogenesis. Cancer Letters 1995;92:209-215.
9. McLellan EA, Bird RP. Aberrant crypts: Potential preneoplastic lesions in the murine colon. Cancer Res 1998;48: 6187-6192.
10. McLellan EA, Medline A, Bird RP. Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: Putative preneoplastic lesions. Cancer Res 1991;51: 5270-5274.
11. Pretlow TP, Barrow BJ, Ashton WS, O'Riordan MA, Pretlow TG, Jurcisek JA, Stellato TA. Aberrant crypts: Putative preneoplastic foci in human colonic mucosa. Cancer Res. 1991;51:1564-1567.
12. Deschner EE, Long FC, Hakissian M, Herman SL. Differential susceptibility of AKR/J, C57BL/6J and CF1 to 1,2-dimethylhydrazine-induced colonic tumor formation predicted by proliferate characteristics of colonic epithelial cells. J Natl Cancer Inst 1983;72:196-198
13. Pretlow TP, O'Riordan MA, Spancake KM, Pretlow TG. Two types of putative preneoplastic lesions identified by hexosaminidase activity in whole-mounts of colons from F344 rats treated with carcinogen. Am J Pathol 1993;142: 1695-1700.
14. Jen J, Powell SM, Papadopoulos N, Smith KJ, Hamilton SR, Vogelstein B, Kinzler KW. Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994;54: 5523-5526.
15. Stopera SA, Bird RP. Expression of ras oncogene m RNA and protein in aberrant crypt foci. Carcinogenesis 1992;13: 1863-1868.
16. Vivona AA, Shpitz B, Medline A, et al. Ki-ras mutations in aberrant crypt foci, adenomas, and adenocarcinomas during azoxymethane-induced colon carcinogenesis. Carcinogenesis 1993;14:1777-1781.
17. Stopera SA, Murphy LC, Bird RP. Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: Earliest recognizable precursor lesions of experimental colon cancer. Carcinogenesis 1992;13:2081-2085.
18. Jacoby RF, Llor X, Ba-Bie T, Davidson NO, Brasitus TA. Mutations in the Ki-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. J Clin Invest 1991;87:624-630.
19. Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H. Frequent and characteristic Ki-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon. Gastroenterology 1995;108:434-440.
20. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170.
21. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-767.
22. Whiteley LO, Anver MR, Botts S, Jokinen MP. Proliferate lesions of the intestine, salivary glands, oral cavity and esophogus in rats. In: Guides for toxicologic pathology, Washington, DC: STP/ARP/AFIP, 1996. p. 1-18.
23. Wang QS, Papanikolaou A, Sabourin CLK, Rosenberg DW. Altered expression of cyclin D1 and cyclin-dependent kinase 4 in azoxythane-induced mouse colon tumorigenesis. Carcinogenesis 1998;19:2001-2006.
24. Maltzman T, Whittington J, Driggers L, Stephens J, Ahnen D. 1997. AOM-induced mouse colon tumors do not express full-length APC protein. Carcinogenesis 1997; 18:2435-2439.
25. Wong MH, Hermiston ML, Syder AJ, Gordon JI. Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium. Proc Natl Acad Sci USA 1996;93: 9588-9593.
26. Miyashiro I, Senda T, Matsumine A, et al. Subcellular localization of the APC protein: Immunoelectron microscopic study of the association of the APC protein with catenin. Oncogene 1995;11:89-96.
27. Neufeld KL, White RL. Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein. Proc Natl Acad Sci USA 1997,94:3034-3039.
28. Erdman SH, Wu HD, Hixson LJ, Ahnen DJ, Gerner EW. Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane-and dimethylhydrazine-treated rats. Mol Carcinog 1997;19:137-144.
29. Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations In human colorectal cancer. Nature 1987;327: 293-297.
30. Forrester K, Almoguera C, Han K, Grizzle WE, Perucho, M. Detection of high incidence of Ki-ras oncogenes during human colon tumorigenesis. Nature 1987;327: 298-303.
31. Jackson PE, Cooper DP, O'Connor PJ, Povey AC. The relationship between 1,2-dimethylhydrazine dose and the nduction of colon tumors: tumor development in female SWR mice does not require a Ki-ras mutational event. Carcinogenesis 1999;20:509-513.
32. Zaidi NH, Pretlow TP, O'Riordan MA, Dumenco LL, Allay E, Gerson SL. Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the Ki-ras oncogene of mouse colon. Carcinogenesis 1995;16:451-456.
33. Papanikolaou A, Shank RC, Delker DA, Rosenberg DW. Initial levels of azoxymethane-induced DNA methyl adducts are not predictive of tumor susceptibility in inbred mice. Toxicol Appl Pharmacol 1998;150:196-203.
34. Cooper HK, Buecheler J, Kleihues P. DNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis. Cancer Res 1978;38: 3063-3065.
35. Chen B, You L, Wang Y, Stoner GD, You M. 1994. Allele-specific activation and expression of the Ki-ras gene in hybrid mouse lung tumors induced by chemical carcinogens. Carcinogenesis 1994;15:2031-2035.
36. Jones-Bolin SE, Johansson E, Palmisano MW, Wiest JS, Belinksy SA. Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression. Carcinogenesis 1998;19:1503-1508.
37. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe, SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88:593-602.
38. Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in reponse to constitutive MEK/MAPK mitogenic signalling. Genes Dev 1998;12:3008-3019.
39. Okamoto M, Ohtsu H, Miyaki M, Yonekawa, H. No allelic loss at the p53 locus in 1,2-dimethylhydrazine-induced mouse colon tumors: PCR-SSCP analysis with sequence-tagged microsatellite site primers. Carcinogenesis 1993;14: 1483-1486.
40. Okamoto M, Ohtsu H, Kominami R, Yonekawa H. 1995. Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice. Carcinogenesis 1995;16:2659-2666.
41. Shivapurkar N, Belinksy SA, Wolf DC, Tang Z, Alabaster O. Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane. Cancer Lett. 1995;96:63-70.
42. De Fillipo C, Caderni G, Bazzicalupo M, et al. Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats. Br J Cancer 1998;77:2148-2151.
43. Gruber SB, Petersen GM, Kinzler KW, Vogelstein B. Cancer, crash sites, and the new genetics of neoplasia. Gastroenterology 1999;116:210-212.
44. Bolognesi C, Mariani MR, Boffa LC. Target tissue DNA damage in inbred mouse strains with differing susceptibility to the colon carcinogen, 1,2-dimethylhydrazine. Carcinogenesis 1988;9:1347-1350.
45. Fiala ES, Joseph C, Sohn OS, Bayoumy KE, Reddy BS. Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Res 1991;51:2826-2830.
46. 6-methylguanine and 7-methylguanine formation and persistence in DNA of rats treated with symmetrical dimethylhydrazine. Cancer Res 1981;41:3967-3972
47. Delker DA, McKnight SJ, Rosenberg DW. The role of alcohol dehydrogenase in the metabolism of the colon carcinogen, methylazoxymethanol. Toxicol Sci 1998;45: 66-71.