Signaling and transcriptional control of pancreatic organogenesis

Current Opinion in Genetics and Development

Volumn 12, Issue 5, 2002, Pages 540-547

  Kim, Seung K ^a   MacDonald, Raymond J ^b  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; PROTEIN; PROTEIN P48; PROTEIN PTF1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

ACINAR CELL; BUDDING; CELL ASSAY; CELL DIFFERENTIATION; CELL FATE; CELL LINE; CELL MATURATION; CELLULAR PARAMETERS; EMBRYO DEVELOPMENT; ENDOCRINE CELL; GENE EXPRESSION; IPF1 GENE; MESODERM; MOLECULAR MECHANICS; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; PANCREAS; PANCREAS ISLET CELL; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0036777339     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00338-6     Document Type: Review

References (60)

1. Development of the embryonic endocrine pancreas
2. An ultrastructural analysis of the developing embryonic pancreas
3. Programming of the pancreas
4. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
5. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
6. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
7. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
8. Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)
9. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
10. The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein
11. Early mouse endoderm is patterned by soluble factors from adjacent germ layers
12. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
13. Notochord to endoderm signaling is required for pancreas development
14. Regulation of pancreas development by hedgehog signaling
15. A bipotential precursor population for pancreas and liver within the embryonic endoderm
16. Induction of pancreatic differentiation by signals from blood vessels
17. Notochord repression of endodermal Sonic hedgehog permits pancreas development
18. Liver organogenesis promoted by endothelial cells prior to vascular function
19. Expression of alternatively spliced bFGF first coding exons and antisense mRNAs during chicken embryogenesis
20. AltFGF-2, a novel ER-associated FGF-2 protein isoform: Its embryonic distribution and functional analysis during neural tube development
21. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
22. Hepatic transdifferentiation in the pancreas
23. Molecular basis of transdifferentiation of pancreas to liver
24. Insulin-promoter-factor 1 is required for pancreas development in mice
25. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes
26. Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
27. Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo
28. Sonic hedgehog is required early in pancreatic islet development
29. Hedgehog signaling in pancreas development
30. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: Importance of the FPWMK motif and of the homeodomain
31. A endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2)
32. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development
33. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
34. Nuclear import of the homeodomain protein extradenticle in response to Wg and Dpp signalling
35. Antagonism between extradenticle function and Hedgehog signalling in the developing limb
36. The control of trunk Hox specificity and activity by Extradenticle
37. Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning
38. The role of PTF1-P48 in pancreatic acinar gene expression
39. P48 subunit of mouse PTF1 binds to RBP-Kl/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos
40. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas
41. The role of the transcriptional regulator PTF1-p48 in converting intestinal to pancreatic progenitors
42. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
43. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
44. Z/AP, a double reporter for cre-mediated recombination
45. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
46. Notch signalling controls pancreatic cell differentiation
47. Control of endodermal endocrine development by Hes-1
48. Experimental control of pancreatic development and maintenance
49. Beta-cell specific inactivation of the mouse Ipf1/Pdx1 gene results in impaired glucose transporter expression and late onset diabetes
50. The Tet-On system in transgenic mice: Inhibition of the mouse Pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells
51. Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1
52. Ultrastructural studies of early morphogenesis and cytodifferentiation in the embryonic mammalian pancreas
53. On the development of the islets of Langerhans
54. Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development
55. Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
56. Phylogeny and ontogeny of the neuroendocrine cells of the gastrointestinal tract
57. Ablation of insulin-producing neurons in flies: Growth and diabetic phenotypes
58. Islet transplantation in seven patients with type I diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
59. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA
60. Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas