Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam

Cancer Research

Volumn 56, Issue 4, 1996, Pages 710-714

  Jacoby, Russell F ^a,b,c,g   Marshall, David J ^a,c   Newton, Michael A ^b,d   Novakovic, Kristian ^a   Tutsch, Kendra ^b   Cole, Carolyn E ^b,c   Lubet, Ronald A ^e   Kelloff, Gary J ^e   Verma, Ajit ^a,b   Moser, Amy R ^a,b,f   Dove, William F ^f  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

^g University of Wisconsin Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; THROMBOXANE B2;

ADENOMA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MEGADOSE; FEMALE; INTESTINE CANCER; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICARCINOGENIC AGENTS; COLONIC NEOPLASMS; CROSSES, GENETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENES, APC; HETEROZYGOTE; INTESTINAL NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUTATION; PIROXICAM; RANDOM ALLOCATION; THROMBOXANE B2;

EID: 0030019753     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Winawer, S. J., Zauber, A. G., and Stewart, E The natural history of colorectal cancer: opportunities for intervention. Cancer (Phila), 67: 1143-1149, 1991.
2. Maskens, A P., and Dujardin-Loits, R. M. Experimental adenomas and carcinomas of the large intestine behave as distinct entities: most carcinomas arise de novo in flat mucosa. Cancer (Phila), 47: 81-89, 1981
3. Aaltonen, L., Peltomaki, P., Leach, F , Sistonen, P., Pylkkanen, L., Mecklin, J P., Jarvinen, H., Powell, S., Jen, J., Hamilton, S , Petersen, G., Kinzler, K. W., Vogelstein, B., and DeLaChapelle, A. Clues to the pathogenesis of familial cancer. Science (Washington DC), 260: 812-816, 1993
4. Jacoby, R. F., Marshall, D J , Schlack, S., Kailas, S , Harms, B., and Love, R. Genetic instability associated with adenoma to carcinoma progression in hereditary non-polyposis colon cancer. Gastroenterology, 109: 73-82, 1994.
5. Moser, A. R., Pitot, H. C., and Dove, W F. A dominant mutation that predisposes to intestinal neoplasia in the mouse. Science (Washington DC), 247. 322-324, 1990.
6. Su, L K , Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A., and Dove, W. F Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (Washington DC), 256 668-670, 1992.
7. Dietrich, W F , Lander, E. S , Smith, J. S., Moser, A. R., Gouid, K A., Luongo, C., Borenstein, N., and Dove, W. Genetic identification of Mom-I, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell, 75: 631-639, 1993.
8. Reddy, B. S., Naylor, S., Tokumo, K , Rigotty, J., Zang, E., and Kelloff, G. Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal anti-inflammatory drug with D,L-α-difluoromethyornithine, an ornithine decarboxylase inhibitor, in diet. Cancer Res., 50, 2562-2568, 1991.
9. Marnett, L. J Aspirin and the potential role of prostaglandins in colon cancer Cancer Res., 52: 5575-5589, 1992.
10. Giardiello, F. M., Hamilton, S. R , Krush, A. J., Piantadosi, S., Hylind, L. M , Celano, P , Booker, S V , Robinson, C R., and Offerhaus, G. J. A. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis N Engl. J. Med., 328: 1313-1316, 1993.
11. Rao, C. V., Rivenson, A., Simi, B., Zang, E., Kelloff, G., Steele, V , and Reddy, B S Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Res., 55: 1464-1472, 1995.
12. Shiff, S J., Qiao, L., Tsai, L., and Rigas, B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J Clin. Invest., 96: 491-503, 1995.
13. Merritt, A J , Potten, C. S , Watson, A J. M., and Hickman, J. A. Differential expression of Bcl-2 in intestinal epithelia: correlation with attenuation of apoptosis in colonic crypts J Cell Sci., 108. 2261-2271, 1995.
14. Dove, W. F., Gould, K. A., Luongo, C., Moser, A. R., and Shoemaker, A. R Emergent issues in the genetics of intestinal neoplasia. Cancer Surv , 25: 335-355, 1995
15. Tudek, B., Bird, R. P., and Bruce, W. R. Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods Cancer Res , 49: 1236-1240, 1989.
16. Macek, J., and Vacha, J. Rapid and sensitive method for determination of piroxicam in dog, rat and human plasma by high-performance liquid chromatography J Chromatogr., 420. 445-449, 1987.
17. Piazza, G. A., Kulchak Rahm, A L., Krutzsch, M., Sperl, G., Shipp Paranka, N , Gross, P. H., Brendel, K., Burt, R. W., Alberts, D S., Pamukcu, R., and Ahnen, D. J Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Res., 55: 3110-3116, 1995.
18. Dove, W. F., Luongo, C., Connelly, C. S., Gould, K. A., Shoemaker, A R., Moser, A. R., and Gardner, R. L. The adenomatous polyposis coli gene of the mouse in development and neoplasia. Cold Spring Harbor Symp Quant. Biol., 59: 501-508, 1994.
19. Jacoby, R. F., Llor, X , Teng, B. B., Davidson, N. O., and Brasitus, T. A Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. J. Clin. Invest., 87: 624-630, 1991.
20. + in intestinal adenomas from Min mice. Cancer Res., 54: 5947-5952, 1994.