4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1α and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells

Toxicology and Applied Pharmacology

Volumn 196, Issue 1, 2004, Pages 124-135

  Gao, Ning ^a   Nester, Rebecca A ^a   Sarkar, Mohamadi A ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Philip Morris USA   (United States)

Author keywords

2 hydroxy estradiol; 2 OHE2; 4 Hydroxy estradiol; 4 hydroxy estradiol; 4 OHE2; Estrogen; HIF 1; Human ovarian carcinoma cells; Hypoxia inducible factor 1; MAPK; Phosphatidylinositol 3 kinase; PI3K; Vascular endothelial growth factor; VEGF A

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 HYDROXYESTRADIOL; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 HYDROXYESTRADIOL; ESTRADIOL DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; VASCULOTROPIN A; WORTMANNIN;

ARTICLE; CARCINOMA CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; OVARY CARCINOMA; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL LINE, TUMOR; ENZYME INHIBITORS; ESTRADIOL; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MITOGEN-ACTIVATED PROTEIN KINASES; OVARIAN NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 1642283086     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.12.002     Document Type: Article

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