A mouse model of Werner Syndrome: What can it tell us about aging and cancer?

International Journal of Biochemistry and Cell Biology

Volumn 37, Issue 5 SPEC. ISS., 2005, Pages 991-999

  Chang, Sandy ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Aging; Cancer; Mouse model; Telomeres; Werner Syndrome

Indexed keywords

TELOMERASE; TELOMERE BINDING PROTEIN;

AGING; CANCER; CARCINOGENESIS; CELL DEATH; DISEASE ASSOCIATION; DNA DAMAGE; ENZYME ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC ANALYSIS; GENOMIC INSTABILITY; MUTATION; NONHUMAN; PHENOTYPE; PREMATURE AGING; PROTEIN EXPRESSION; REVIEW; TELOMERE; TUMOR SUPPRESSOR GENE; WERNER SYNDROME;

EID: 14644432483     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2004.11.007     Document Type: Review

References (75)

1. S. Artandi, S. Chang, S. Lee, S. Alson, G. Gottlieb, and L. Chin Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice Nature 406 2000 641 645
2. G. Blander, N. Zalle, J.F. Leal, R.L. Bar-Or, C.E. Yu, and M. Oren The Werner syndrome protein contributes to induction of p53 by DNA damage The FASEB Journal 14 14 (November) 2000 2138 2140
3. M.A. Blasco, H.W. Lee, M.P. Hande, E. Samper, P.M. Lansdorp, and R.A. DePinho Telomere shortening and tumor formation by mouse cells lacking telomerase RNA Cell 91 1997 25 34
4. A.G. Bodnar, M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, and G.B. Morin Extension of life-span by introduction of telomerase into normal human cells Science 279 1998 349 352
5. T.M. Bryan, A. Englezou, L. Dalla-Pozza, M.A. Dunham, and R.R. Reddel Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines Nature Medicine 3 1997 1271 1274
6. S. Chang, A.S. Multani, N.G. Cabrera, M.L. Naylor, P. Laud, and D. Lombard Essential role of limiting telomeres in the pathogenesis of Werner syndrome Nature Genetics 36 8 2004 877 882
7. R.Z. Cheng, S. Murano, B. Kurz, and R.J. Shmookler Reis Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells Mutation Research 237 1990 259 269
8. D. Choi, P.S. Whittier, J. Oshima, and W.D. Funk Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains The FASEB Journal 15 6 (April) 2001 1014 1020
9. H. Cohen, and D.A. Sinclair Recombination-mediated lengthening of terminal telomeric repeats requires the sgs1 DNA helicase Proceedings of the National Academy of Sciences of the United States of America 98 6 2001 3174 3179
10. C.M. Counter, A.A. Avilion, C.E. LeFeuvre, N.G. Stewart, C.W. Greider, and C.B. Harley Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity The EMBO Journal 11 1992 1921 1929
11. F. d'Adda di Fagagna, P.M. Reaper, L. Clay-Farrace, H. Fiegler, P. Carr, and T. Von Zglinicki A DNA damage checkpoint response in telomere-initiated senescence Nature 426 6963 2003 194 198
12. R.A. DePinho The age of cancer Nature 408 6809 2000 248 254
13. X. Du, J. Shen, N. Kugan, E. Furth, D. Lombard, and C. Cheung Telomere shortening exposes functions for the Werner and Bloom syndrome genes in mice Molecular and Cellular Biology 24 19 2004 8437 8446
14. N.A. Ellis DNA helicases in inherited human disorders Current Opinion in Genetics Development 7 1997 354 363
15. N.A. Ellis, J. Groden, T.Z. Ye, J. Straughen, D.J. Lennon, and S. Ciocci The Bloom's syndrome gene product is homologous to RecQ helicases Cell 83 1995 655 666
16. C.J. Epstein, G.M. Martin, A. Schultz, and A.G. Motulsky Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process Medicine 45 1966 5893 5897
17. R.G. Faragher, I.R. Kill, J.A. Hunter, F.M. Pope, C. Tannock, and S. Shall The gene responsible for Werner syndrome may be a cell division "counting" gene Proceedings of the National Academy of Sciences of the United States of America 90 1993 12030 12034
18. S. Gangloff, J.P. McDonald, C. Bendixen, L. Arthur, and R. Rothstein The yeast type I topoisomerase Top3 interacts with sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase Molecular and Cellular Biology 14 1994 8391 8398
19. I. Garcia-Cao, M. Garcia-Cao, J. Martin-Caballero, L.M. Criado, P. Klatt, J.M. Flores, J.C. Weill, M.A. Blasco, and M. Serrano "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally The EMBO Journal 21 22 2002 6225 6235
20. J. German Bloom syndrome: A mendelian prototype of somatic mutational disease Medicine (Baltimore) 72 1993 393 406
21. M. Goto, R.W. Miller, Y. Ishikawa, and H. Sugano Excess of rare cancers in Werner syndrome (adult progeria) Cancer Epidemiology, Biomarkers and Prevention 5 1996 239 246
22. M.D. Gray, L. Wang, H. Youssoufian, G.M. Martin, and J. Oshima Werner helicase is localized to transcriptionally active nucleoli of cycling cells Experimental Cell Research 242 1998 487 494
23. M.D. Gray, J.C. Shen, A.S. Kamath-Loeb, A. Blank, B.L. Sopher, and G.M. Martin The Werner syndrome protein is a DNA helicase Nature Genetics 17 1 (September) 1997 100 103
24. R.A. Greenberg, R.C. Allsopp, L. Chin, G.B. Morin, and R.A. DePinho Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation Oncogene 16 1998 1723 1730
25. C.W. Greider Telomere length regulation Annual Review of Biochemistry 65 1996 337 365
26. J.D. Griffith, L. Comeau, S. Rosenfield, R.M. Stansel, A. Bianchi, and H. Moss Mammalian telomeres end in a large duplex loop Cell 97 1999 503 514 [see comments]
27. W.C. Hahn, C.M. Counter, A.S. Lundberg, R.L. Beijersbergen, M.W. Brooks, and R.A. Weinberg Creation of human tumour cells with defined genetic elements Nature 400 1999 464 468 [see comments]
28. E. Hara, H. Tsurui, A. Shinozaki, S. Nakada, and K. Oda Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1 Biochemical and Biophysical Research Communication 179 1991 528 534
29. C.B. Harley, A.B. Futcher, and C.W. Greider Telomeres shorten during ageing of human fibroblasts Nature 345 1990 458 460
30. L.A. Hayflick, and P.S. Moorhead The serial cultivation of human diploid cell strains Experimental Cell Research 25 1961 585 621
31. I.D. Hickson RecQ helicases: Caretakers of the genome Nature Reviews Cancer 3 2003 169 178
32. H. Hoehn, E.M. Bryant, K. Au, T.H. Norwood, H. Boman, and G.M. Martin Variegated translocation mosaicism in human skin fibroblast cultures Cytogenetics and Cell Genetics 15 1975 282 298
33. P. Huang, F.E. Pryde, D. Lester, R.L. Maddison, R.H. Borts, and I.D. Hickson SGS1 is required for telomere elongation in the absence of telomerase Current Biology 11 2 2001 125 129
34. S. Huang, B. Li, M.D. Gray, J. Oshima, I.S. Mian, and J. Campisi The premature ageing syndrome protein, WRN, is a 3′ → 5′ exonuclease Nature Genetics 20 1998 114 116
35. S.E. James, R.G. Faragher, J.F. Burke, S. Shall, and L.V. Mayne Werner's syndrome T lymphocytes display a normal in vitro life-span Mechanisms of Ageing and Development 121 2000 139 149
36. F.B. Johnson, R.A. Marciniak, M. McVey, S.A. Stewart, W.C. Hahn, and L. Guarente The Saccharomyces cerevisiae WRN homolog sgs1p participates in telomere maintenance in cells lacking telomerase The EMBO Journal 20 4 2001 905 913
37. H. Kaneko, E. Matsui, T. Fukao, K. Kasahara, W. Morimoto, and N. Kondo Expression of the BLM gene in human haematopoietic cells Clinical and Experimental Immunology 118 2 (November) 1999 285 289
38. D. Kipling, T. Davis, E.L. Ostler, and R.G. Faragher What can progeroid syndromes tell us about human aging? Science 305 5689 (September) 2004 1426 1431
39. K.J. Kyng, A. May, S. Kolvraa, and V.A. Bohr Gene expression profiling in Werner syndrome closely resembles that of normal aging Proceedings of the National Academy of Sciences of the United States of America 100 21 (October) 2003 12259 12264
40. M. Lebel, and P. Leder A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity Proceedings of the National Academy of Sciences of the United States of America 95 1998 13097 13102
41. H.W. Lee, M.A. Blasco, G.J. Gottlieb, J.W. Horner 2nd., C.W. Greider, and R.A. DePinho Essential role of mouse telomerase in highly proliferative organs Nature 392 1998 569 574
42. A.J. Levine p53, The cellular gatekeeper for growth and division Cell 88 1997 323 331
43. N.M. Lindor Rothmund-Thomson syndrome due to RecQ4 helicase mutations: Report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome American Journal of Medical Genetics 90 3 2000 223 228
44. D.B. Lombard, C. Beard, B. Johnson, R.A. Marciniak, J. Dausman, and R. Bronson Mutations in the WRN gene in mice accelerate mortality in a p53-null background Molecular and Cellular Biology 9 2000 3286 3291
45. R.A. Marciniak, D.B. Lombard, F.B. Johnson, and L. Guarente Nucleolar localization of the Werner syndrome protein in human cells Proceedings of the National Academy of Sciences of the United States of America 95 1998 6887 6892
46. G.M. Martin, and J. Oshima Lessons from human progeroid syndromes Nature 408 2000 263 266
47. T. Matsumoto, A. Shimamoto, M. Goto, and Y. Furuichi Impaired nuclear localization of defective DNA helicases in Werner's syndrome Nature Genetics 16 1997 335 336
48. B. McClintock The stability of broken ends of chromosomes in Zea mays Genetics 26 1941 234 245
49. K. Myung, A. Datta, C. Chen, and R.D. Kolodner SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination Nature Genetics 27 2001 113 116
50. C.E. Ogburn, J. Oshima, M. Poot, R. Chen, K.E. Hunt, and K.A. Gollahon An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants Human Genetics 101 1997 121 125
51. P.L. Opresko, M. Otterlei, J. Graakjaer, P. Bruheim, L. Dawut, and S. Kolvraa The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2 Molecules and Cells 14 6 2004 763 774
52. P.L. Opresko, C. von Kobbe, J.P. Laine, J. Harrigan, I.D. Hickson, and V.A. Bohr Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases The Journal of Biological Chemistry 277 43 2002 41110 41119
53. D.K. Orren, A. Machwe, P. Karmakar, J. Piotrowski, M.P. Cooper, and V.A. Bohr A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA NAR 29 9 2001 1926 1934
54. K.R. Prowse, A.A. Avilion, and C.W. Greider Identification of a nonprocessive telomerase activity from mouse cells Proceedings of the National Academy of Sciences of the United States of America 90 1993 1493 1497
55. K.R. Prowse, and C.W. Greider Developmental and tissue-specific regulation of mouse telomerase and telomere length Proceedings of the National Academy of Sciences of the United States of America 92 1995 4818 4822
56. A.M. Rodriguez-Lopez, D.A. Jackson, F. Iborra, and L.S. Cox Asymmetry of DNA replication fork progression in Werner's syndrome Aging Cells 1 1 2002 30 39
57. K.L. Rudolph, S. Chang, H.W. Lee, M. Blasco, G.J. Gottlieb, and C. Greider Longevity, stress response, and cancer in aging telomerase-deficient mice Cell 96 1999 701 712
58. D. Salk, K. Au, H. Hoehn, and G.M. Martin Cytogenetics of Werner's syndrome cultured skin fibroblasts: Variegated translocation mosaicism Cytogenetics and Cell Genetics 30 1981 92 107
59. V.P. Schulz, V.A. Zakian, C.E. Ogburn, J. McKay, A.A. Jarzebowicz, and S.D. Edland Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells Human Genetics 97 1996 750 754
60. J.W. Shay, O.M. Pereira-Smith, and Wright WE A role for both RB and p53 in the regulation of human cellular senescence Experimental Cell Research 196 1991 33 39
61. D.A. Sinclair, and L. Guarente Extrachromosomal rDNA circles - a cause of aging in yeast Cell 91 1997 1033 1042
62. D.A. Sinclair, K. Mills, and L. Guarente Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants Science 277 1997 1313 1316
63. E.A. Spillare, A.I. Robles, X.W. Wang, J.C. Shen, C.E. Yu, and G.D. Schellenberg p53-Mediated apoptosis is attenuated in Werner syndrome cells Genes Development 13 11 1999 1355 1360
64. N. Suzuki, A. Shimamoto, O. Imamura, J. Kuromitsu, S. Kitao, and M. Goto DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system Nucleic Acids Research 25 1997 2973 2978
65. H. Tahara, Y. Tokutake, S. Maeda, H. Kataoka, T. Watanabe, and M. Satoh Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus Oncogene 15 1997 1911 1920
66. H. Takai, A. Smogorzewska, and T. de Lange DNA damage foci at dysfunctional telomeres Current Biology 13 17 2003 1549 1556
67. S.J. Thannhauser Werner's syndrome (progeria of the adult) and Rothmund's syndrome: Two types of closely related heredofamilial atrophic dermatosis with juvenile cataracts and endocrine features. A critical study with five new cases Annals of Internal Medicine 23 1945 559 625
68. H. Vaziri, and S. Benchimol Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span Current Biology 8 1998 279 282
69. P.M. Watt, E.J. Louis, R.H. Borts, and I.D. Hickson Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation Cell 81 1995 253 260
70. F.S. Wyllie, C.J. Jones, J.W. Skinner, M.F. Haughton, C. Wallis, and D. Wynford-Thomas Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts Nature Genetics 24 2000 16 17
71. W.E. Wright, and J.W. Shay The two-stage mechanism controlling cellular senescence and immortalization Experimental Gerontology 27 1992 383 389
72. K. Yamagata, J. Kato, A. Shimamoto, M. Goto, Y. Furuichi, and H. Ikeda Bloom's and Werner's syndrome genes suppress hyper recombination in yeast sgs1 mutant: Implication for genomic instability in human diseases Proceedings of the National Academy of Sciences of the United States of America 95 1998 8733 8738
73. H. Yan, C.Y. Chen, R. Kobayashi, and J. Newport Replication focus-forming activity 1 and the Werner syndrome gene product Nature Genetics 19 1998 375 378
74. C.E. Yu, J. Oshima, Y.H. Fu, E.M. Wijsman, F. Hisama, and R. Alisch Positional cloning of the Werner's syndrome gene Science 272 5259 1996 258 262
75. J.M. Zijlmans, U.M. Martens, S.S. Poon, A.K. Raap, H.J. Tanke, and R.K. Ward Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats Proceedings of the National Academy of Sciences of the United States of America 94 1997 7423 7428