Werner helicase is localized to transcriptionally active nucleoli of cycling cells

Experimental Cell Research

Volumn 242, Issue 2, 1998, Pages 487-494

  Gray, Matthew D ^a   Wang, Lan ^a   Youssoufian, Hagop ^b   Martin, George M ^a   Oshima, Junko ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Helicase; Nucleolus; Progeroid sydrome; Werner's syndrome

Indexed keywords

HELICASE;

ARTICLE; CELL CYCLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NUCLEOLUS; PRIORITY JOURNAL; WERNER SYNDROME;

MAMMALIA;

EID: 0032146147     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4124     Document Type: Article

References (33)

1. Yu C. E., Oshima J., Fu Y. H., Wijsman E. M., Hisama F., Alisch R., Matthews S., Nakura J., Miki T., Ouais S., Martin G. M., Mulligan J., Schellenberg G. D. Positional cloning of the Werner's syndrome gene. Science. 272:1996;258-262.
2. Suzuki N., Shimamoto A., Imamura O., Kuromitsu J., Kitao S., Goto M., Furuichi Y. DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system. Nucleic Acids Res. 25:1997;2973-2978.
3. Gray M. D., Shen J. C., Kamath-Loeb A. S., Blank A., Sopher B. L., Martin G. M., Oshima J., Loeb L. A. The Werner syndrome protein is a DNA helicase. Nat. Genet. 17:1997;100-103.
4. Mushegian A. R., Bassett D. E. Jr., Boguski M. S., Bork P., Koonin E. V. Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs. Proc. Natl. Acad. Sci. USA. 94:1997;5831-5836.
5. Moser M. J., Holley W. R., Chatterjee A., Mian I. S. The proofreading domain of Escherichia coli. Nucleic Acids Res. 25:1997;5110-5118.
6. Matsumoto T., Shimamoto A., Goto M., Furuichi Y. Impaired nuclear localization of defective DNA helicases in Werner's syndrome. Nat. Genet. 16:1997;335-336.
7. Epstein C. J., Martin G. M., Schultz A. L., Motulsky A. G. Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine. 45:1966;177-221.
8. Martin G. M. Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig. Artic. Ser. 14:1978;5-39.
9. Goto M. Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing. Mech. Ageing Dev. 98:1997;239-254.
10. Tollefsbol T. O., Cohen H. J. The effect of age on the accumulation of labile triosephosphate isomerase and thymidine incorporation in pokeweed mitogen stimulated human lymphocytes. J. Gerontol. 39:1984;398-405.
11. Oshima J., Yu C. E., Piussan C., Klein G., Jabkowski J., Balci S., Miki T., Nakura J., Ogihara T., Ells J., Smith M., Melaragno M. I., Fraccaro M., Scappaticci S., Matthews J., Ouais S., Jarzebowicz A., Schellenberg G. D., Martin G. M. Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum. Mol. Genet. 5:1996;1909-1913.
12. Yu C. E., Oshima J., Wijsman E. M., Nakura J., Miki T., Piussan C., Matthews S., Fu Y. H., Mulligan J., Martin G. M., Schellenberg G. D. Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am. J. Hum. Genet. 60:1997;330-341.
13. Ogburn C. E., Oshima J., Poot M., Chen R., Hunt K. E., Gollahon K. A., Rabinovitch P. S., Martin G. M. An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild type and homozygous mutants. Hum. Genet. 101:1997;121-125.
14. Rodolfo C., Lanza A., Tornaletti S., Fronza G., Pedrini A. M. The ultimate carcinogen of 4-nitroquinoline 1-oxide does not react with Z-DNA and hyperreacts with B-Z junctions. Nucleic Acids Res. 22:1994;314-320.
15. Hoehn H., Bryant E. M., Au K., Norwood T. H., Boman H., Martin G. M. Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet. Cell Genet. 15:1975;282-298.
16. Salk D., Au K., Hoehn H., Martin G. M. Cytogenetic aspects of Werner syndrome. Adv. Exp. Med. Biol. 190:1985;541-546.
17. Fukuchi K., Martin G. M., Monnat R. J. Jr. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. USA. 86:1989;5893-5897.
18. Fukuchi K., Tanaka K., Kumahara Y., Marumo K., Pride M. B., Martin G. M., Monnat R. J. Jr. Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum. Genet. 84:1990;249-252.
19. Runger T. M., Bauer C., Dekant B., Moller K., Sobotta P., Czerny C., Poot M., Martin G. M. Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J. Invest. Dermatol. 102:1994;45-48.
20. Weirich-Schwaiger H., Weirich H. G., Gruber B., Schweiger M., Hirsch-Kauffmann M. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat. Res. 316:1994;37-48.
21. Watt P. M., Louis E. J., Borts R. H., Hickson I. D. Sgs1: A eukaryotic homolog ofE. coliin vivo. Cell. 81:1995;253-260.
22. Sinclair D. A., Mills K., Guarente L. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science. 277:1997;1313-1316.
23. Sinclair D. A., Guarente L. Extrachromosomal rDNA circles - A cause of aging in yeast. Cell. 91:1997;1033-1042.
24. Oshima J., Campisi J., Tannock T. C., Martin G. M. Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J. Cell. Physiol. 162:1995;277-283.
25. Stein G. H., Yanishevsky R. Autoradiography. Methods Enzymol. 58:1979;279-292.
26. Login G. R., Dvorak A. M. Methods of microwave fixation for microscopy. A review of research and clinical applications: 1970-1992. Prog. Histochem. Cytochem. 27:1994;1-127.
27. Pignolo R. J., Martin B. G., Horton J. H., Kalbach A. N., Cristofalo V. J. The pathway of cell senescence: WI38 cells arrest in late G1 and are unable to traverse the cell cycle from a true G0 state. Exp. Gerontol. 33:1998;67-80.
28. Halle J. P., Muller S., Simm A., Adam G. Copy number, epigenetic state and expression of the rRNA genes in young and senescent rat embryo fibroblasts. Eur. J. Cell. Biol. 74:1997;281-288.
29. Kowalczykowski S. C., Dixon D. A., Eggleston A. K., Lauder S. D., Rehrauer W. M. Biochemistry of homologous recombination inEscherichia coli. Microbiol. Rev. 58:1994;401-465.
30. Fronza G., Tornaletti S., Menichini P., Galiegue-Zouitina S., Bailleul B., Loucheux-Lefebvre M. H., Abbondandolo A., Pedrini A. M. Extent of helix perturbation associated with DNA modification by theO. Biochem. Biophys. Acta. 1087:1990;330-335.
31. Snyderwine E. G., Bohr V. A. Gene- and strand-specific damage and repair in Chinese hamster ovary cells treated with 4-nitroquinoline 1-oxide. Cancer Res. 52:1992;4183-4189.
32. Valdez B. C., Busch R. K., Busch H. Phosphorylation of the human cell proliferation-associated nucleolar protein p120. Biochem. Biophys. Res. Commun. 173:1990;423-430.
33. Peter M., Nakagawa J., Doree M., Labbe J. C., Nigg E. A. Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase. Cell. 60:1990;791-801.