An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

Human Genetics

Volumn 101, Issue 2, 1997, Pages 121-125

  Ogburn, Charles E ^a   Oshima, Junko ^a   Poot, Martin ^a   Chen, Ru ^a   Hunt, Kristin E ^a   Gollahon, Katherine A ^a   Rabinovitch, Peter S ^a   Martin, George M ^a  

^a Health Sciences Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; HELICASE; MUTAGENIC AGENT;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL IMMORTALIZATION; CHEMOSENSITIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENOTOXICITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; LYMPHOID CELL LINE; PRIORITY JOURNAL; WERNER SYNDROME;

4-NITROQUINOLINE-1-OXIDE; APOPTOSIS; B-LYMPHOCYTES; CELL LINE; DNA HELICASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MUTAGENS; MUTATION; PHENOTYPE; RECQ HELICASES; WERNER SYNDROME;

EID: 0031453968     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050599     Document Type: Article

References (24)

1. Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, Proytcheva M, German J (1995) The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 83:655-666
2. Epstein CJ, Motulsky AG (1996) Werner syndrome: entering the helicase era. Bioessays 18:1025-1027
3. Epstein CJ, Martin GM, Motulsky AG (1965) Werner's syndrome, caricature of aging: a genetic model for the study of degenerative diseases. Trans Assoc Am Physicians 78:73-81
4. Epstein CJ, Martin GM, Schultz AL, Motulsky AG (1966) Werner syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine 45:177-221
5. Fujiwara Y, Higashikawa T, Tatsumi M (1977) A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture. J Cell Physiol 92:365-374
6. Gebhardt E, Bauer R, Raub U, Schinzel M, Reuprecht KW, Jonas JB (1988) Spontaneous and induced chromosomal instability in Werner syndrome. Hum Genet 80:135-139
7. Gong J, Traganos F, Darzynkiewicz Z (1994) A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Ann Biochem 218:314-319
8. Goto M, Tanimoto K, Horiuchi Y, Sasazuki T (1981) Family analysis of Werner's syndrome: a survey of 42 Japanese families with a review of the literature. Clin Genet 19:8-15
9. Goto M, Miller RW, Ishikawa Y, Sugano H (1996) Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol Biomarkers Prev 5:239-246
10. Lombard DB, Guarente L (1996) Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging. Trends Genet 12:283-286
11. Martin GM (1978) Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects 14:5-9
12. Miller JA (1991) 4-Nitroquinoline 1-oxide. Jpn J Cancer Res 82: 1452-1453
13. Nagao M, Sugimura T (1976) Molecular biology of the carcinogen, 4-nitroquinoline-l-oxide. Adv Cancer Res 23:131-169
14. Nunoshiba T, Demple B (1993) Potent intracellular oxidative stress exerted by the carcinogen-4-nitroquinoline-N-oxide. Cancer Res 53:3250-3252
15. Oshima J, Yu CE, Piussan C, Klein G, Jabkowski J, Balci S, Miki T, Nakura J, Ogihara T, Ells J, Smith MA, Melaragno MI, Fraccaro M, Scappaticci S, Matthews J, Quais S, Jarzebowicz A, Schellenberg GD, Martin GM (1996) Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum Mol Genet 5:1909-1913
16. Poot M, Hoehn H, Runger TM, Martin GM (1992) Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res 202:267-273
17. Pool M, Gibson LL, Singer VL (1997) Detection of apoptosis in live cells by MitoTracker Red CMXRos and SYTO dye flow cytometry. Cytometry 27:1-7
18. Rodolfo C, Lanza A, Tornaletti S, Fronza G, Pedrini AM (1994) The ultimate carcinogen of 4-nitroquinoline 1-oxide does not react with Z-DNA and hyperreacts with B-Z junctions. Nucleic Acids Res 22:314-320
19. Stohr M, Vogt-Schaden M (1980) A new dual staining technique for simultaneous flow sytometric DNA analysis of living and dead cells. In: Laerum OD, Lindmo T, Thorud E (eds) Flow Cytometry IV, 96-99. Universitetsforlaget, Bergen
20. Takeuchi F, Hanaoka F, Goto M, Yamada M-A, Miyamoto T (1982) Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts. Exp Gerontol 17:473-480
21. Wall FE, Henkel RD, Stern MP, Jenson HB, Moyer MP (1995) An efficient method for routine Epstein-Barr virus immortalization of human B lymphocytes. In Vitro Cell Dev Biol 31:156-159
22. Ye L, Miki T, Nakura J, Oshima J, Kamino K, Rakugi H, Ikegami H, Higaki J, Edland SD, Martin GM, Ogihara T (1997) Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Med Genet 68:494-498
23. Yu C-E, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD (1996) Positional cloning of the Werner's syndrome gene. Science 272:258-262
24. Yu C-E, Oshima J, Wijsman EM, Nakura J, Miki T, Piussan C, Matthews S, Fu YH, Mulligan J, Martin GM, Schellenberg GD (1997) Mutations in the consensus helicase domains of the Werner syndrome gene. Am J Hum Genet 60:330-341