Control of IRF-3 activation by phosphorylation

Journal of Interferon and Cytokine Research

Volumn 22, Issue 1, 2002, Pages 73-76

  Yoneyama, Mitsutoshi ^a   Suhara, Wakako ^a   Fujita, Takashi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DIMER; DOUBLE STRANDED RNA; I KAPPA B KINASE; INTERFERON REGULATORY FACTOR 3; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN P300; SERINE; STRESS ACTIVATED PROTEIN KINASE;

BACTERIAL INFECTION; CYTOPLASM; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ANIMALS; DIMERIZATION; DNA-BINDING PROTEINS; FORECASTING; HUMANS; INTERFERON REGULATORY FACTOR-3; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; VIRUS DISEASES;

BACTERIA (MICROORGANISMS);

EID: 0036182036     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999002753452674     Document Type: Review

References (22)

1. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction
2. Downregulation of IRF-3 levels by ribozyme modulates the profile of IFNA subtypes expressed in infected human cells
3. Interferon regulatory factor 3 is required for viral induction of beta interferon in primary cardiac myocyte cultures
4. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
5. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes
6. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
7. Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7
8. Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
9. Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-β gene
10. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo
11. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
12. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1
13. Cytomegalo-virus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex
14. p38-dependent activation of interferon regulatory factor by lipopolysaccharide
15. Identification of distinct signaling pathways leading to the phos-phorylation of interferon regulatory factor 3
16. Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300
17. Structural and functional analysis of interferon regulatory factor 3: Localization of the transactivation and autoinhibitory domains
18. Induction of IRF-3/-7 kinase and NF-kB in response to double-stranded RNA and virus infection: Common and unique pathways
19. Activation of interferon regulatory factor 3 in response to DNA-damaging agents
20. Characterization of the DNA-binding and dimerization properties of the nuclear orphan receptor germ cell nuclear factor
21. JNK2 and IKKb are required for activating the innate response to viral infection
22. Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: Involvement of RNase L, protein kinase R, and alternative pathways