Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation

Nature Structural Biology

Volumn 10, Issue 11, 2003, Pages 913-921

  Qin, Bin Y ^a   Liu, Cheng ^b   Lam, Suvana S ^a   Srinath, Hema ^a   Delston, Rachel ^b   Correia, John J ^c   Derynck, Rik ^b   Lin, Kai ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; INTERFERON REGULATORY FACTOR 3; TRANSCRIPTION FACTOR;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DNA BINDING; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HYDROPHOBICITY; INHIBITION KINETICS; MOLECULAR MECHANICS; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SURFACE TENSION; TRANSCRIPTION REGULATION; VIRUS ACTIVATION; VIRUS INDUCTION; VIRUS INFECTION; VIRUS INHIBITION;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; ELECTROSTATICS; HUMANS; INTERFERON REGULATORY FACTOR-3; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTORS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0242574745     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb1002     Document Type: Article

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