The importance of LC-MS and LC-NMR in the discovery of new lead compounds from plants

Pharmaceutical Biology

Volumn 38, Issue SUPPL., 2000, Pages 41-54

  Wolfender, Jean Luc ^a   Terreaux, Christian ^a   Hostettmann, Kurt ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Antifungal; Bioautography; Dereplication; Gentianaceae; LC MS; LC NMR; LC UV; Leguminosae; Phytochemical investigation

Indexed keywords

EID: 0010649807     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.38.6.41.5957     Document Type: Article

References (33)

1. Albert K (1995): On-line use of NMR detection in separation chemistry. J Chromatogr A 703: 123-147.
2. Blakley CR, Vestal ML (1983): Thermospray interface for liquid chromatography/mass spectrometry. Anal Chem 55: 750-754.
3. Borel C, Hostettmann K (1987): Molluscicidal saponins from Swartzia madagascariensis Desvaux. Helv Chim Acta 70: 570-576.
4. Caprioli RM, Tan F, Cotrell JS (1986): Continuous-flow sample probe for fast atom bombardment mass spectrometry. Anal Chem 58: 2949-2954.
5. Cassady JM, Baird WM, Chang CJ (1990): Natural products as a source of potential cancer chemotherapeutic and chemopreventive agents. J Nat Prod 53: 23-41.
6. Chapman & Hall (2000). Dictionary of Natural Products on CD-ROM. Data © Chapman & Hall 1982-1999.
7. Fromtling RA (1998): Human mycoses and current antifungal therapy. Drug News Perspect 11: 185-190.
8. Garo E, Wolfender J-L, Hostettmann K, Hiller W, Antus S, Mavi S (1998): Prenylated fiavanones from Monotes engleri: On-line structure elucidation by LC/UV/NMR. Helv Chim Acta 81: 754-763.
9. Hamburger M, Hostettmann K (1991): Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry 30: 3864-3874.
10. Holt RM, Newman MJ, Pullen FS, Richards DS, Swanson AG (1998): High-performance liquid chromatography/NMR spectrometry/Mass spectrometry: Further advances in hyphenated technology. J Mass Spectrom 32: 64-70.
11. Hostettmann K, Marston A, Wolfender J-L (1995): Strategy in the search for new biologically active plant constituents. In: Hostettmann K, Marston M, Maillard M, Hamburger M, eds., Phytochemistry of Plants Used in Traditional Medicine. Oxford, Oxford Science Publications, pp. 17-45.
12. Hostettmann K, Potterat O (1997): Strategy for the isolation and analysis of antifungal, molluscicidal, and larvicidal agents from tropical plants. In: Hedin PA, Hollingworth RM, Masler EP, Miyamoto J, Thompson DG, eds., Phytochemical for Pest Control. Washington D.C., American Chemical Society, pp. 14-26.
13. Hostettmann K, Wolfender J-L, Rodriguez S (1997): Rapid detection and subsequent isolation of bioactive constituents of crude plant extracts. Planta Med 63: 2-10.
14. Hostettmann K, Schaller F (2000): Antimicrobial diterpenes. United States Patent No. 5,929,124.
15. Huber L, George SA (1993). Diode Array Detection in HPLC. Marcel Dekker, New York.
16. Lindon JC, Nicholson JK, Sidelmann UG, Wilson ID (1997): Directly coupled HPLC-NMR and its application to drug metabolism. Drug Metab Rev 29: 705-746.
17. Niessen WMA, Tinke AP (1995): Liquid chromatography-mass spectrometry, general principles and instrumentation. J Chromatogr A 703: 37-57.
18. Niessen WMA (1999). Liquid Chromatography-Mass Spectrometry (2nd ed). Marcel Dekker, New York.
19. Rodriguez S, Wolfender J-L, Hakizamungu E, Hostettmann K (1995a): An antifungal naphthoquinone, xanthones and secoiridoids from Swertia calycina. Planta Med 61: 362-364.
20. Rodriguez S, Wolfender J-L, Odontuya G, Purev O, Hostettmann K (1995b): Xanthones, secoiridoids and flavonoids from Halenia corniculata. Phytochemistry 40: 1265-1272.
21. Schaller F (1999). Composés antifongiques nouveaux issus de l'investigation phytochimique d'une plante africaine: Bobgunnia madagascariensis (Desv.) J.H. Kirkbr. et Wiersem (Leguminosae). Thesis, Lausanne University.
22. Schaller F, Rahalison L, Islam N, Potterat O, Hostettmann K, Stoeckli-Evans H, Mavi S (2000a): A new potent antifungal 'quinone methide' diterpene with a cassane skeleton from Bobgunnia madagascariensis. Helv Chim Acta 83: 407-413.
23. Schaller F, Wolfender J-L, Hostettmann K (2000b): New antifungal 'quinone methide' diterpene from Bobgunnia madagascariensis and study of their interconversion by LC/NMR. Helv Chim Acta (In press).
24. Smallcombe SH, Patt SL, Keiffer PA (1995): WET solvent suppression and its application to LC-NMR and high-resolution NMR spectroscopy. J Magn Reson A Series A 117: 295-303.
25. Sudmeier JL, Günther UL, Albert K, Bachovchin WW (1996): Sensitivity optimization in continuous-flow FTNMR. J Magn Reson A 118: 145-156.
26. Suffness M, Douros J (1982): Current status of the NCI plant and animal product program. J Nat Prod 45: 1-14.
27. Suzuki O, Katsumata Y, Oya M, Chari VM, Klapfenberger R, Wagner H, Hostettmann K (1981): Inhibition of type A and type B monoamine oxydases by naturally occurring xanthones. Planta Med 42: 17-21.
28. Whitehouse RC, Dreyer RN, Yamashita M, Fenn JB (1985): Electrospray interface for liquid chromatographs and mass spectrometers. Anal Chem 57: 675-679.
29. Wolfender J-L, Hostettmann K (1993): Liquid chromatographic-UV detection and liquid chromatographic-thermospray mass spectrometric analysis of Chironia (Gentianaceae) species. A rapid method for the screening of polyphenols in crude plant extracts. J Chromatogr 647: 191-202.
30. Wolfender J-L, Rodriguez S, Hostettmann K, Wagner-Redeker W (1995): Comparison of liquid chromatography/electrospray, atmospheric pressure chemical ionisation, thermospray and continuous-flow fast atom bombardment mass spectrometry for the determination of secondary metabolites in crude plant extracts. J Mass Spectrom and Rapid Commun Mass Spectrom S35-S46.
31. Wolfender J-L, Rodriguez S, Hiller W, Hostettmann K (1997): LC/UV/MS and LC/NMR analyses of crude extracts of Gentianaceae species. Phytochem Anal 8: 97-104.
32. Wolfender J-L, Ndjoko K, Hostettmann K (1998a): LC/NMR in natural products chemistry. Curr Org Chem 2: 575-596.
33. Wolfender J-L, Rodriguez S, Hostettmann K (1998b): Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents. J Chromatogr A 794: 299-316.