CpG methylation regulates the Igf2/H19 insulator

Current Biology

Volumn 11, Issue 14, 2001, Pages 1128-1130

  Holmgren, Claes ^a   Kanduri, Chandrasekhar ^a   Dell, Ghislaine ^b   Ward, Andrew ^b   Mukhopadhya, Rituparna ^a   Kanduri, Meena ^a   Lobanenkov, Victor ^c   Ohlsson, Rolf ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b University of Bath   (United Kingdom)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATIN STRUCTURE; DNA FLANKING REGION; ENHANCER REGION; EPISOME; GENE REPRESSION; GENETIC REGULATION; GENETIC TRANSFECTION; GERM LINE; HYPERSENSITIVITY; IGF2 H19 INSULATOR; METHYLATION; NUCLEASE; PROMOTER REGION;

RODENTIA;

EID: 0035943045     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00314-1     Document Type: Article

References (10)

1. The 5′-flank of the murine H19 gene in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication
2. Functional interaction of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
3. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
4. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
5. Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function
6. A transcriptional insulator at the imprinted H19/Igf2 locus
7. In vitro methylation of predetermined regions in recombinant DNA constructs by excision and religation
8. Two regulatory domains flank the mouse H19 gene
9. Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting
10. Cancer epigenetics takes center stage