Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma

Biochemical and Biophysical Research Communications

Volumn 307, Issue 1, 2003, Pages 52-63

  Cho, Bomsoo ^a   Lee, Hansoo ^b   Jeong, Shin Wu ^c   Bang, Yung Jue ^d   Lee, Hyun Joo ^d   Hwang, Kyu Sang ^d   Kim, Hae Yeong ^e   Lee, Yun Sil ^f   Kang, Gyeong Hoon ^d   Jeoung, Doo Il ^b  

^a In2Gen Co Ltd   (South Korea)

^b Kangwon National University   (South Korea)

^c LG Chemical Ltd   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e Kyung Hee University   (South Korea)

^f Kyung Hee University ^*

Author keywords

CAGE; Hypomethylation; Methylation specific PCR; Transcription

Indexed keywords

5' AZA 2' DEOXYCYTIDINE; BISULFITE; CYTIDINE DERIVATIVE; LUCIFERASE; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER STAGING; CHRONIC GASTRITIS; CHRONIC HEPATITIS; COLON; CORRELATION ANALYSIS; DRUG EFFECT; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LARYNX CARCINOMA; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LUNG CARCINOMA; METHYLATION; POLYMERASE CHAIN REACTION; PRECANCER; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CARCINOMA; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STOMACH CARCINOMA; TESTIS; UTERINE CERVIX CARCINOMA;

EID: 0038387946     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01121-5     Document Type: Article

References (52)

1. Cho B., Lim Y., Lee D.Y., Park S.Y., Lee H., Kim W.H., Yang H., Bang Y.J., Jeoung D.I. Identification and characterization of a novel cancer/testis antigen gene CAGE. Biochem. Biophys. Res. Commun. 292:2002;715-726.
2. Baylin S.B., Herman J.G. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 16:2000;168-174.
3. Esteller M., Corn O.G., Baylin S.B., Herman J.G. A gene hypermethylation profile of human cancers. Cancer Res. 61:2001;3225-3229.
4. Baylin S.B., Esteller M., Rountree M.R., Bachman K.E., Schuebel K., Herman J.G. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum. Mol. Genet. 10:2001;687-692.
5. Feinberg A.P., Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 301:1983;89-92.
6. Diala E.S., Cheah M.S.C., Rotwich D., Hoffman R.M. Extent of DNA methylation in tumor cells. J. Natl. Cancer Inst. 71:1983;755-764.
7. Feinberg A.P., Gehrke C.W., Kuo K.C., Ehrlich M. Reduced genomic 5-methylcytosine in human colonic neoplasia. Cancer Res. 48:1988;1159-1161.
8. Laird P.W., Jaenisch R. DNA methylation and cancer. Hum. Mol. Genet. 3:1994;1487-1495.
9. Laird P.W., Jackson-Grusby L., Fazeli A., Dickinson S.L., Jung W.E., Li E., Weinberg R.A., Jaenisch R. Suppression of intestinal neoplasia by DNA hypomethylation. Cell. 81:1995;197-205.
10. Counts J.L., Goodman J.I. Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell. 83:1995;13-15.
11. Smith S.S. Biological implications of the mechanism of action of human DNA (cytosine-5) methyltransferase. Prog. Nucleic Acid Res. Mol. Biol. 49:1994;65-111.
12. Li E., Bestor T.H., Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 69:1992;915-926.
13. Xu G.L., Bestor T.H., Bourc'his D., Hsieh C.L., Tommerup N., Bugge M., Hulten M., Qu X., Russo J.J., Viegas-Pequignot E. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 402:1999;187-191.
14. Li E., Beard C., Jaenisch R. Role for DNA methylation in genome imprinting. Nature. 366:1993;362-365.
15. Li E., Beard C., Forster A.C., Bestor T.H., Jaenisch R. DNA methylation, genomic imprinting, and mammalian development. Cold Spring Harbor Symp. Quant. Biol. 58:1993;297-305.
16. Bird A. The essentials DNA methylation. Cell. 70:1992;5-8.
17. Eden S., Cedar H. Role of DNA methylation in the regulation of transcription. Curr. Opin. Genet. Dev. 4:1994;255-259.
18. Jost J.P., Bruhat A. The formation of DNA methylations and the silencing of genes. Prog. Nucleic Acid Res. Mol. Biol. 57:1997;217-248.
19. Razin A. CpG methylation, chromatin structure and gene silencing - A three-way connection. EMBO J. 17:1998;4905-4908.
20. Grunstein M. Histone acetylation in chromatin structure and transcription. Nature. 389:1997;349-352.
21. Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12:1998;599-606.
22. Knoepfler P.S., Eisenman R.N. Sin meets NuRD and other tails of repression. Cell. 99:1999;447-450.
23. Nan X., Ng H.H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., Bird A. Transcriptional repression by the methyl-CpG-binding proteins MeCP2 involves a histone deacetylase complex. Nature. 393:1998;386-389.
24. Jones P.L., Veenstra G.J., Wade P.A., Vermaak D., Kass S.U., Landsberger N., Strouboulis J., Wolffe A.P. Methylated DNA and MeCP2 recruit histone deacetylases to repress transcription. Nature Genet. 19:1998;187-191.
25. Fuks F., Burgers W.A., Brehm A., Hughes-Davies L., Kouzarides T. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nature Genet. 24:2000;88-91.
26. Tate P.H., Bird A.P. Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet. Dev. 3:1993;226-231.
27. Lunyak V.V., Burgess R., Prefontaine G.G., Nelson C., Sze S.H., Chenoweth J., Schwartz P., Pevzner P.A., Glass C., Mandel G., Rosenfeld M.G. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science. 98:2002;1747-1752.
28. Kondo Y., Kania Y., Sakamoto M., Mizokami M., Ueda R., Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis-A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG bands in microdissected specimen from patients with hepatocellular carcinoma. Hepatology. 32:2000;970-979.
29. Kaneto H., Sasaki S., Yamamoto H., Itoh F., Toyota M., Suzuki H., Ozeki I., Iwata N., Ohmura T., Satoh T., Karino Y., Satoh T., Toyota J., Satoh M., Endo T., Omata M., Imai K. Detection of hypermethylation of the p16 (INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut. 48:2001;372-377.
30. Kanai Y., Ushijima S., Tsuda H., Sakamoto M., Hirohashi S. Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis. Cancer Lett. 148:2000;73-80.
31. Gonmyo Y., Osaki M., Kaibara N., Ito H. Numerical aberrations and point mutation of p53 gene in human gastric intestinal metaplasia and well-differentiated adenocarcinoma: analysis by fluorescence in situ hybridization (FISH) and PCR-SSCP. Int. J. Cancer. 66:1996;594-599.
32. Graff J.R., Herman J.G., Myohanen S., Baylin S.B., Vertino P.M. Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J. Biol. Chem. 272:1997;22322-22329.
33. Jang S.J., Soria J.C., Wang L., Hassan K.A., Morice R.C., Walsh G.L., Hong W.K., Mao L. Activation of melanoma tumor antigens occurs early in lung cancer carcinogenesis. Cancer Res. 61:2001;7559-7563.
34. Sigalotti L., Coral S., Nardi G., Spessotto A., Cortini E., Cattarossi I., Colizzi F., Altomonte M., Maio M. Promoter methylation controls the expression of MAGE 2, 3 and 4 genes in human cutaneous melanoma. J. Immunother. 25:2002;16-26.
35. Cho M., Uemura H., Kim S.C., Kawada Y., Yoshida K., Hirao Y., Konishi N., Saga S., Yoshikawa K. Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma. Br. J. Cancer. 85:2001;563-567.
36. Tao L., Yang S., Xie M., Kramer P.M., Pereira M.A. Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Cancer Lett. 158:2000;185-193.
37. Rosty C., Ueki T., Argani P., Jansen M., Yeo C.J., Cameron J.L., Hruban R.H., Goggins M. Overexpression of S100A in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am. J. Pathol. 160:2002;45-50.
38. Frommer M., McDonald L.E., Millar D.S., Collis C.M., Watt F., Grigg G.W., Molloy P.L., Paul C.L. A genome sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. 89:1992;1827-1831.
39. Herman J.G., Graff J.R., Myohanen S., Nelkin B.D., Baylin S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA. 93:1996;9821-9826.
40. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription inhibition by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
41. De Smet C., Courtois S.J., Faraoni I., Lurquin C., Szikora J.P., De Backer O., Boon T. Involvement of two Ets binding sites in the transcriptional activation of the MAGE gene. Immunogenetics. 42:1995;282-290.
42. ′ -deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemia and myelodysplastic syndromes: past, present, and future trends Leukemia. 7:1993;51-60.
43. De Smet C., De Backer O., Faraoni I., Lurquin C., Brasseur F., Boon T. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc. Natl. Acad. Sci. USA. 93:1996;7149-7153.
44. Gupta A., Godwin A.K., Vanderveer L., Lu A., Liu J. Hypomethylation of the synuclein γ gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma. Cancer Res. 63:2003;664-673.
45. Yuan L., Shan J., De Risi D., Broome J., Lovecchio J., Gal D., Vinciguerra V., Xu H.P. Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer. Cancer Res. 59:1999;3215-3221.
46. Ahrendt S.A., Chow J.T., Xu L.H., Yang S.C., Eisenber C.F., Esteller M., Herman J.G., Wu L., Decker A., Jen J., Sidransky D. Molecular detection of tumor cells in bronchioalveolar lavage from patients with early lung cancer. J. Natl. Cancer Inst. 91:1999;332-339.
47. Sigalotti L., Coral S., Altomonte M., Natali L., Gaudino G., Cacciotti P., Libener R., Colizzi F., Vianale G., Martini F., Tognon M., Jungbluth A., Cebon J., Maraskovsky E., Mutti L., Maio M. Cancer testis antigens expression in mesothelioma: role of DNA methylation and bioimmunotherapeutic implications. Br. J. Cancer. 86:2002;979-982.
48. Eads C.A., Lord R.V., Wickramasnghe K., Long T.I., Kurumboor S.K., Bernstein L., Peters J.H., De Meester S.R., De Meester T.R., Skinner K.A., Laird P.W. Epigenetic patterns in the progression of esophageal adenocarcinomas. Cancer Res. 61:2001;3410-3418.
49. Roncalli M., Bianchi P., Bruni B., Laghi L., Destro A., Di Gioia S., Gennari L., Tommasini M., Malesci A., Coggi G. Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. Hepatology. 36:2002;427-432.
50. Sato F., Shibata D., Harpaz N., Xu Y., Yin J., Mori Y., Wang S., Olaru A., Deacu E., Selaru F.M., Kimos M.C., Hytiroglou P., Young J., Leggett B., Gazdar A.F., Toyooka S., Abraham J.M., Meltzer S.J. Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma. Cancer Res. 62:2002;6820-6822.
51. Kang G.H., Shim Y.H., Jung H.Y., Kim W.H., Ro J.Y., Rhyu M.G. CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res. 161:2001;2847-2851.
52. Lorincz M.C., Groudine M. C(m) C(a/t) GG methylation: A new epigenetic mark in mammalian DNA? Proc. Natl. Acad. Sci. USA. 98:2001;10034-10036.