Insulin-Like Growth Factor (IGF)-I/IGF-Binding Protein-3 Complex: Therapeutic Efficacy and Mechanism of Protection against Type 1 Diabetes

Endocrinology

Volumn 145, Issue 2, 2004, Pages 627-638

  Chen, Wei ^a   Salojin, Konstantin V ^a   Mi, Qing Sheng ^a   Grattan, Marsha ^a   Meagher, T Craig ^a,b   Zucker, Peter ^a   Delovitch, Terry L ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CHEMOKINE; CHEMOKINE CCL4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; INSULIN DEPENDENT DIABETES MELLITUS; LYMPH NODE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CASPASE 9; CASPASES; CELL DIVISION; CHEMOKINES; DIABETES MELLITUS, TYPE 1; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; INFLAMMATION; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; ISLETS OF LANGERHANS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; MICE, SCID; PANCREAS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0842291575     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1274     Document Type: Article

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