Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes

Journal of Immunology

Volumn 165, Issue 2, 2000, Pages 1102-1110

  Cameron, Mark J ^a,b   Arreaza, Guillermo A ^a   Grattan, Marsha ^a   Meagher, Craig ^a,b   Sharif, Shayan ^a   Burdick, Marie D ^c   Strieter, Robert M ^c   Cook, Donald N ^d,e   Delovitch, Terry L ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CHEMOKINE RECEPTOR CCR5; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HELPER CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MOUSE; NONHUMAN; PANCREAS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034662271     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.2.1102     Document Type: Article

References (46)

1. Ward, S. G., K. Bacon, and J. Westwick. 1998. Chemokines and T lymphocytes: more than an attraction. Immunity 9:1.
2. Xia, Y., M. E. Pauza, L. Feng, and D. Lo. 1997. ReIB regulation of chemokine expression modulates local inflammation. Am. J. Pathol. 151:375.
3. Luster, A. D. 1998. Chemokines: chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338:436.
4. Karpus, W. J., and K. J. Kennedy. 1997. MIP-lα and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation. J. Leukocyte Biol. 62:681.
5. Karpus, W. J., N. W. Lukacs, B. L. McRae, R. M. Stricter, S. L. Kunkel, and S. D. Miller. 1995. An important role for the chemokine macrophage inflammatory protein-lα in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J. Immunol 155:5003.
6. Karpus, W. J., and R. M. Ransohoff. 1998. Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis. J. Immunol. 161:2667.
7. Kunkel, S. L. 1996. Th1-and Th2-type cytokines regulate chemokine expression. Biol. Signals 5:197.
8. Sallusto, F., C. R. Mackay, and A. Lanzavecchia. 1997. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277:2005.
9. Bonecchi, R., G. Bianchi, P. P. Bordignon, D. D'Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A. Mantovani, et al. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type I T helper cells (Th1s) and Th2s. J. Exp. Med. 187:129.
10. Sallusto, F. D. Lenig, C. R. Mackay, and A. Lanzavecchia. 1998. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187:875.
11. Loetscher, P., M. Uguccioni, L. Bordoli, M. Baggiolini, B. Moser, C. Chizzolini, and J. M. Dayer. 1998. CCR5 is characteristic of Th1 lymphocytes. Nature 391:344.
12. Mackay, C. R. 1996. Chemokine receptors and T cell chemotaxis. J. Exp. Med. 184:799.
13. Murphy, P. M. 1996. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Factor Rev. 7:47.
14. Delovitch, T. L., and B. Singh. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7:727.
15. Gill, B. M., A. Jaramillo, L. Ma, K. B. Laupland, and T. L. Delovitch. 1995. Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice: a possible role for chemokine genes. Diabetes 44:614.
16. Rapoport, M. J., A. Jaramillo, D. Zipris, A. H. Lazarus, D. V. Serreze, E. H. Leiter, P. Cyopick, J. S. Danska, and T. L. Delovitch. 1993. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178:87.
17. Arreaza, G. A., M. J. Cameron, A. Jaramillo, B. M. Gill, D. Hardy, K. B. Laupland, M. J. Rapoport, P. Zucker, S. Chakrabarti, S. W. Chensue, et al. 1997. Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism. J. Clin. Invest. 100:2243.
18. Cameron, M. J., G. A. Arreaza, P. Zucker, S. W. Chensue, R. M. Strieter, S. Chakrabarti, and T. L. Delovitch. 1997. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J. Immunol. 159:4686.
19. Standiford, T. J., S. L. Kunkel, J. M. Liebler, M. D. Burdick, A. R. Gilbert, and R. M. Strieter. 1993. Gene expression of macrophage inflammatory protein-1 alpha from human blood monocytes and alveolar macrophages is inhibited by interleukin-4. Am. J. Respir. Cell Mol. Biol. 9:192.
20. Herold, K. C., J. Lu, I. Rulifson, V. Vezys, D. Taub, M. J. Grusby, and J. A. Bluestone. 1997. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J. Immunol. 159:4150.
21. DiPietro, L. A., M. Burdick, Q. E. Low, S. L. Kunkel, and R. M. Strieter. 1998. MIP-lα as a critical macrophage chemoattractant in murine wound repair. J. Clin. Invest. 101:1693.
22. Wilborn, J., M. Bailie, M. Coffey, M. Burdick, R. Strieter, and M. Peters-Golden. 1996. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Invest. 97:1827.
23. Greenberger, M. J., R. M. Strieter, S. L. Kunkel, J. M. Danforth, R. E. Goodman, and T. J. Standiford. 1995. Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia. J. Immunol. 155:722.
24. Lukacs, N. W., S. L. Kunkel, R. M. Strieter, K. Warmington, and S. W. Chensue. 1993. The role of macrophage inflammatory protein lα in Schistosoma mansoni egg-induced granulomatous inflammation. J. Exp. Med. 177:1551.
25. Cook, D. N., M. A. Beck, T. M. Coffman, S. L. Kirby, J. F. Sheridan, I. B. Pragnell, and O. Smithies. 1995. Requirement of MIP-lα for an inflammatory response to viral infection. Science 269:1583.
26. Fox, C. J., and J. S. Danska. 1998. Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation. Diabetes 47:331.
27. Kagi, D., A. Ho, B. Odermatt, A. Zakarian, P. S. Ohashi, and T. W. Mak. 1999. TNF receptor I-dependent β cell toxicity as an effector pathway in autoimmune diabetes. J. Immunol. 162:4598.
28. Mora, C., F. S. Wong, C. H. Chang, and R. A. Flavell. 1999. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice. J. Immunol. 162:4576.
29. Grewal, I. S., B. J. Rutledge, J. A. Fiorillo, L. Gu, R. P. Gladue, R. A. Flavell, and B. J. Rollins. 1997. Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1. J. Immunol. 159:401.
30. Shimada, A., B. Charlton, C. Taylor-Edwards, and C. G. Fathman. 1996. β-Cell destruction may be a late consequence of the autoimmune process in nonobese diabetic mice. Diabetes 45:1063.
31. Pilstrom, B., L. Bjork, and J. Bohme. 1995. Demonstration of a TH1 cytokine profile in the late phase of NOD insulitis. Cytokine 7:806.
32. Wang, B., I. Andre, A. Gonzalez, J. D. Katz, M. Aguet, C. Benoist, and D. Mathis. 1997. Interferon-γ impacts at multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94:13844.
33. Youssef, S., G. Wildbaum, G. Maor, N. Lanir, A. Gour-Lavie, N. Grabie, and N. Karin. 1998. Long-lasting protective immunity to experimental autoimmune encephalomyelitis following vaccination with naked DNA encoding C-C chemokines. J. Immunol. 161:3870.
34. + T cells in response to MIP-lα and MIP-1β. Science 260:355.
35. Cook, D. N. 1996. The role of MIP-lα in inflammation and hematopoiesis. J. Leukocyte Biol. 59:61.
36. Fahey, T. J., K. J. Tracey, P. Tekamp-Olson, L. S. Cousens, W. G. Jones, G. T. Shires, A. Cerami, and B. Sherry. 1992. Macrophage inflammatory protein 1 modulates macrophage function. J. Immunol. 148:2764.
37. Stassi, G., R. D. Maria, G. Trucco, W. Rudert, R. Testi, A. Galluzzo, C. Giordano, and M. Trucco. 1997. Nitric oxide primes pancreatic β cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J. Exp. Med. 186:1193.
38. 2m null mice are diabetes and insulitis resistant. Diabetes 43:505.
39. + T cells are a biologically relevant source of macrophage inflammatory protein-1α in vivo. J. Immunol. 162:5423.
40. + regulatory T-cells induced by oral insulin treatment protect from type I diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T cells. Diabetes 48:1720.
41. Karpus, W. J., K. J. Kennedy, S. L. Kunkel, and N. W. Lukacs. 1998. Monocyte chemotactic protein 1 regulates oral tolerance induction by inhibition of T helper cell 1-related cytokines. J. Exp. Med. 187:733.
42. Rollins, B. J., and J. S. Pober. 1991. Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells. Am. J. Pathol. 138:1315.
43. + T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J. Clin. Invest. 104:49.
44. + T cells are increased in multiple sclerosis and their ligands MIP-lα and IP-10 are expressed in demyelinating brain lesions. Proc. Natl. Acad. Sci. USA 96:6873.
45. Lichtman, A. H., and A. K. Abbas. 1997. T-cell subsets: recruiting the right kind of help. Curr. Biol. 7:R242.
46. Bradley, L. M., V. C. Asensio, L. K. Schioetz, J. Harbertson, T. Krahl, G. Patstone, N. Woolf, I. L. Campbell, and N. Sarvetnick. 1999. Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J. Immunol. 162:2511.