메뉴 건너뛰기




Volumn 49, Issue 2, 2000, Pages 209-217

Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: Involvement of phosphatidylinositol 3-kinase

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN; WORTMANNIN;

EID: 0033969128     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.2.209     Document Type: Article
Times cited : (44)

References (55)
  • 1
    • 0032504211 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent: Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells
    • Hugl SR, White MF, Rhodes CJ: Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent: synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem 273:17771-17779, 1998
    • (1998) J Biol Chem , vol.273 , pp. 17771-17779
    • Hugl, S.R.1    White, M.F.2    Rhodes, C.J.3
  • 2
    • 0345222443 scopus 로고    scopus 로고
    • Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of langerhans from pre-diabetic non-obese diabetic mice
    • Hill DJ, Petrik J, Arany E, McDonald TJ, Delovitch TL: Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice. J Endocrinol 161:153-165, 1999
    • (1999) J Endocrinol , vol.161 , pp. 153-165
    • Hill, D.J.1    Petrik, J.2    Arany, E.3    McDonald, T.J.4    Delovitch, T.L.5
  • 3
    • 0030730904 scopus 로고    scopus 로고
    • Insulin-like growth factor I reverses interleukin-1β inhibition of insulin secretion, induction of nitric oxide synthase and cytokine-mediated apoptosis in rat islets of langerhans
    • Mabley JG, Belin V, John N, Green IC: Insulin-like growth factor I reverses interleukin-1β inhibition of insulin secretion, induction of nitric oxide synthase and cytokine-mediated apoptosis in rat islets of Langerhans. FEBS Lett 417:235-238, 1997
    • (1997) FEBS Lett , vol.417 , pp. 235-238
    • Mabley, J.G.1    Belin, V.2    John, N.3    Green, I.C.4
  • 4
    • 0031034574 scopus 로고
    • Antiapoptotic signalling by the insulin-like growth factor 1 receptor, phosphatidylinositol 3-kinase, and Akt
    • Kulik G, Klippel A, Weber MJ: Antiapoptotic signalling by the insulin-like growth factor 1 receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17:1595-1606, 1907
    • (1907) Mol Cell Biol , vol.17 , pp. 1595-1606
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 5
    • 0028890744 scopus 로고
    • The insulin-like growth factor I receptor: A key to tumor growth?
    • Baserga R: The insulin-like growth factor I receptor: a key to tumor growth? Cancer Res 55:249-252, 1995
    • (1995) Cancer Res , vol.55 , pp. 249-252
    • Baserga, R.1
  • 6
    • 0028036698 scopus 로고
    • Insulin receptor substrate-1 mediates phosphatidylinositol 3′-kinase and p70S6K signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation
    • Myers MGJ, Grammer TC, Wang LM, Sun XJ, Pierce JH, Blenis J, White MF: Insulin receptor substrate-1 mediates phosphatidylinositol 3′-kinase and p70S6K signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. J Biol Chem 269:28783-28789, 1994
    • (1994) J Biol Chem , vol.269 , pp. 28783-28789
    • Myers, M.G.J.1    Grammer, T.C.2    Wang, L.M.3    Sun, X.J.4    Pierce, J.H.5    Blenis, J.6    White, M.F.7
  • 7
    • 0028085078 scopus 로고
    • The insulin signaling system
    • White MF, Kahn CR: The insulin signaling system. J Biol Chem 269:1-4, 1994
    • (1994) J Biol Chem , vol.269 , pp. 1-4
    • White, M.F.1    Kahn, C.R.2
  • 8
    • 0031756168 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differentiation
    • Sarbassov DD, Peterson CA: Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differentiation. Mol Endocrinol 12:1870-1878, 1998
    • (1998) Mol Endocrinol , vol.12 , pp. 1870-1878
    • Sarbassov, D.D.1    Peterson, C.A.2
  • 10
    • 0028810236 scopus 로고
    • 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-dencient mice
    • Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CR: 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-dencient mice. J Biol Chem 270:24670-24673, 1995
    • (1995) J Biol Chem , vol.270 , pp. 24670-24673
    • Patti, M.E.1    Sun, X.J.2    Bruening, J.C.3    Araki, E.4    Lipes, M.A.5    White, M.F.6    Kahn, C.R.7
  • 12
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • Toker A, Cantley LC: Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673-676, 1997
    • (1997) Nature , vol.387 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 14
    • 0032143284 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
    • Shepherd PR, Withers DJ, Siddle K: Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 333:471-490, 1998
    • (1998) Biochem J , vol.333 , pp. 471-490
    • Shepherd, P.R.1    Withers, D.J.2    Siddle, K.3
  • 15
    • 0033563141 scopus 로고    scopus 로고
    • Negative regulation by phospliatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages
    • Diaz-Guerra MJM, Castrillo A, Martin-Sanz P, Bosca L: Negative regulation by phospliatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages. J Immunol 162:6184-6190, 1999
    • (1999) J Immunol , vol.162 , pp. 6184-6190
    • Diaz-Guerra, M.J.M.1    Castrillo, A.2    Martin-Sanz, P.3    Bosca, L.4
  • 16
    • 0033548627 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide-or cytokine-stimulated C6 glial cells
    • Pahan K, Raymond JR, Singh I: Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide-or cytokine-stimulated C6 glial cells. J Biol Chem 274:7528-7536, 1999
    • (1999) J Biol Chem , vol.274 , pp. 7528-7536
    • Pahan, K.1    Raymond, J.R.2    Singh, I.3
  • 17
    • 0027255749 scopus 로고
    • Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide
    • Xie QW, Whisnant R, Nathan C: Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J Exp Med 177:1779-1784, 1993
    • (1993) J Exp Med , vol.177 , pp. 1779-1784
    • Xie, Q.W.1    Whisnant, R.2    Nathan, C.3
  • 18
    • 0029860947 scopus 로고    scopus 로고
    • Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes: Requirement of NF-κB activation after stimulation with bacterial cell wall products and phorbol esters
    • Diaz-Guerra MJM, Velasco M, Martin-Sanz P, Bosca L: Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes: requirement of NF-κB activation after stimulation with bacterial cell wall products and phorbol esters. J Biol Chem 271:130114-30120, 1996
    • (1996) J Biol Chem , vol.271 , pp. 130114-130120
    • Diaz-Guerra, M.J.M.1    Velasco, M.2    Martin-Sanz, P.3    Bosca, L.4
  • 19
    • 0028850008 scopus 로고
    • The cytokine responsive vascular smooth muscle cell enhancer of inducible nitric oxide synthase: Activation by nuclear factor-κB
    • Spink J, Cohen J, Evans TJ: The cytokine responsive vascular smooth muscle cell enhancer of inducible nitric oxide synthase: activation by nuclear factor-κB. J Biol Chem 270:29541-29547, 1995
    • (1995) J Biol Chem , vol.270 , pp. 29541-29547
    • Spink, J.1    Cohen, J.2    Evans, T.J.3
  • 20
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB: NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260, 1998
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 21
    • 0033004242 scopus 로고    scopus 로고
    • Mechanisms of nitric oxide-dependent apoptosis: Involvement of mitochondrial mediators
    • Bosca L, Hortelano S: Mechanisms of nitric oxide-dependent apoptosis: involvement of mitochondrial mediators. Cell Signal 11:239-244, 1999
    • (1999) Cell Signal , vol.11 , pp. 239-244
    • Bosca, L.1    Hortelano, S.2
  • 22
    • 0031868114 scopus 로고    scopus 로고
    • Nitric oxide-induced apoptosis in human pancreatic carcinoma cell lines is associated with a G1-arrest and an increase of the cyclin-dependent kinase inhibitor p21WAF1/CIP1
    • Gansauge S, Nussler AK, Beger HG, Gansauge F: Nitric oxide-induced apoptosis in human pancreatic carcinoma cell lines is associated with a G1-arrest and an increase of the cyclin-dependent kinase inhibitor p21WAF1/CIP1. Cell Growth Differ 9:611-617, 1998
    • (1998) Cell Growth Differ , vol.9 , pp. 611-617
    • Gansauge, S.1    Nussler, A.K.2    Beger, H.G.3    Gansauge, F.4
  • 23
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB: Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130:167-178, 1992
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 24
    • 0030823758 scopus 로고    scopus 로고
    • Rapid up-regulation of IκBβ and abrogation of NF-κB activity in peritoneal macrophages stimulated with lipopolysaccharide
    • Velasco M, Diaz-Guerra MJ, Martin-Sanz P, Alvarez A, Bosca L: Rapid Up-regulation of IκBβ and abrogation of NF-κB activity in peritoneal macrophages stimulated with lipopolysaccharide. J Biol Chem 272:23025-23030, 1997
    • (1997) J Biol Chem , vol.272 , pp. 23025-23030
    • Velasco, M.1    Diaz-Guerra, M.J.2    Martin-Sanz, P.3    Alvarez, A.4    Bosca, L.5
  • 25
    • 0029777285 scopus 로고    scopus 로고
    • Multiple p21ras effector path ways regulate nuclear factor of activated T cells
    • Genot E, Cleverley S, Henning S, Cantrell D: Multiple p21ras effector path ways regulate nuclear factor of activated T cells. EMBO J 15:3923-3933, 1996
    • (1996) EMBO J , vol.15 , pp. 3923-3933
    • Genot, E.1    Cleverley, S.2    Henning, S.3    Cantrell, D.4
  • 28
    • 0344766073 scopus 로고    scopus 로고
    • Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages
    • Hortelano S, López-Collazo A, Boscá L: Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. Br J Pharmacol 126:1139-1146, 1999
    • (1999) Br J Pharmacol , vol.126 , pp. 1139-1146
    • Hortelano, S.1    López-Collazo, A.2    Boscá, L.3
  • 29
    • 0033023541 scopus 로고    scopus 로고
    • Suppression of nitric oxide synthase and the down-regulation of the activation of NFκB in macrophages by resveratrol
    • Tsai SH, Lui-Shiau SY, Lin JK: Suppression of nitric oxide synthase and the down-regulation of the activation of NFκB in macrophages by resveratrol. Br J Pharmacol 126:673-680, 1999
    • (1999) Br J Pharmacol , vol.126 , pp. 673-680
    • Tsai, S.H.1    Lui-Shiau, S.Y.2    Lin, J.K.3
  • 30
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
    • DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M: A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548-554, 1997
    • (1997) Nature , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 32
    • 0040973209 scopus 로고    scopus 로고
    • Differential signaling by insulin receptor substrate 1 (IRS-1) and 1RS- 2 in IRS-1-deficient cells
    • Bruning JC, Winnay J, Cheatham B, Kahn CR: Differential signaling by insulin receptor substrate 1 (IRS-1) and 1RS- 2 in IRS-1-deficient cells. Mol Cell Biol 17:1513-1521, 1997
    • (1997) Mol Cell Biol , vol.17 , pp. 1513-1521
    • Bruning, J.C.1    Winnay, J.2    Cheatham, B.3    Kahn, C.R.4
  • 33
    • 0031917412 scopus 로고    scopus 로고
    • Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: Dominant negative p85 expression blocks differentiation of L6E9 muscle cells
    • Kaliman P, Canicio J, Shepherd PR, Beeton CA, Testar X, Palacin M, Zorzano A: Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Mol Endocrinol 12:66-77, 1998
    • (1998) Mol Endocrinol , vol.12 , pp. 66-77
    • Kaliman, P.1    Canicio, J.2    Shepherd, P.R.3    Beeton, C.A.4    Testar, X.5    Palacin, M.6    Zorzano, A.7
  • 34
    • 0030037906 scopus 로고
    • Interleukin-10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine
    • Crawley JB, Williams IM, Mander T, Brennan FM, Foxwell BMJ: Interleukin-10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine. J Biol Chem 271:16357-16362, 1990
    • (1990) J Biol Chem , vol.271 , pp. 16357-16362
    • Crawley, J.B.1    Williams, I.M.2    Mander, T.3    Brennan, F.M.4    Foxwell, B.M.J.5
  • 35
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC: Mitochondria and apoptosis. Science 281:1309-1312, 1998
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 39
    • 0031871335 scopus 로고    scopus 로고
    • An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
    • Rabinovitch A: An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev 14:129-151, 1998
    • (1998) Diabetes Metab Rev , vol.14 , pp. 129-151
    • Rabinovitch, A.1
  • 40
    • 0033617148 scopus 로고    scopus 로고
    • Double-stranded RNA inhibits β-cell function and induces islet damage by stimulating β-cell production of nitric oxide
    • Heitmeier MR, Scarim AL, Corbett JA: Double-stranded RNA inhibits β-cell function and induces islet damage by stimulating β-cell production of nitric oxide. J Biol Chem 274:12531-12536, 1999
    • (1999) J Biol Chem , vol.274 , pp. 12531-12536
    • Heitmeier, M.R.1    Scarim, A.L.2    Corbett, J.A.3
  • 41
    • 0031586615 scopus 로고    scopus 로고
    • Interferon-γ inhibits insulin release and induces cell death in the pancreatic β-cell line INS-1 independently of nitric oxide production
    • Laffranchi R, Spinas GA: Interferon-γ inhibits insulin release and induces cell death in the pancreatic β-cell line INS-1 independently of nitric oxide production. Exp Cell Res 237:217-222, 1997
    • (1997) Exp Cell Res , vol.237 , pp. 217-222
    • Laffranchi, R.1    Spinas, G.A.2
  • 42
    • 0031850873 scopus 로고    scopus 로고
    • Aspects of the involvement of interleukin-1 and nitric oxide in the pathogenesis of insulin-dependent diabetes mellitus
    • Sjoholm A: Aspects of the involvement of interleukin-1 and nitric oxide in the pathogenesis of insulin-dependent diabetes mellitus. Cell Death Differ 5:461-468, 1998
    • (1998) Cell Death Differ , vol.5 , pp. 461-468
    • Sjoholm, A.1
  • 43
    • 0032579373 scopus 로고    scopus 로고
    • Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis
    • Takamura T, Kato I, Kimura N, Nakazawa T, Yonekura H, Takasawa S, Okamoto H: Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis. J Biol Chem 273:2493-2406, 1998
    • (1998) J Biol Chem , vol.273 , pp. 2493-12406
    • Takamura, T.1    Kato, I.2    Kimura, N.3    Nakazawa, T.4    Yonekura, H.5    Takasawa, S.6    Okamoto, H.7
  • 44
    • 0031426764 scopus 로고    scopus 로고
    • Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM?
    • Eizirik DL, Pavlovic D: Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? Diabetes Metab Rev 13:293-307, 1997
    • (1997) Diabetes Metab Rev , vol.13 , pp. 293-307
    • Eizirik, D.L.1    Pavlovic, D.2
  • 45
    • 0033041283 scopus 로고    scopus 로고
    • Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes
    • Flodstrom M, Tyrberg B, Eizirik DL, Sandler S: Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes. Diabetes 48:706-713, 1999
    • (1999) Diabetes , vol.48 , pp. 706-713
    • Flodstrom, M.1    Tyrberg, B.2    Eizirik, D.L.3    Sandler, S.4
  • 46
    • 0031969157 scopus 로고    scopus 로고
    • IGF-I and insulin amplify IL-1β-induced nitric oxide and prostaglandin biosynthesis
    • Guan Z, Buckman SY, Baier LD, Morrison AR: IGF-I and insulin amplify IL-1β-induced nitric oxide and prostaglandin biosynthesis. Am J Physiol 274:F673-F679, 1998
    • (1998) Am J Physiol , vol.274
    • Guan, Z.1    Buckman, S.Y.2    Baier, L.D.3    Morrison, A.R.4
  • 47
    • 0031757110 scopus 로고    scopus 로고
    • Heat shock inhibits cytokine-induced nitric oxide synthase expression by rat and human islets
    • Scarim AL, Heitmeier MR, Corbett JA: Heat shock inhibits cytokine-induced nitric oxide synthase expression by rat and human islets. Endocrinology 139:5050-5057, 1998
    • (1998) Endocrinology , vol.139 , pp. 5050-5057
    • Scarim, A.L.1    Heitmeier, M.R.2    Corbett, J.A.3
  • 48
    • 0031827241 scopus 로고    scopus 로고
    • Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells
    • Darville MI, Eizirik DL: Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41:1101-1108, 1998
    • (1998) Diabetologia , vol.41 , pp. 1101-1108
    • Darville, M.I.1    Eizirik, D.L.2
  • 49
    • 0033153484 scopus 로고    scopus 로고
    • Negative regulation by protein tyrosine phosphatase of IFN-γ-dependent expression of inducible nitric oxide synthase
    • Diaz-Guerra MJM, Castrillo A, Martin-Sanz P, Bosca L: Negative regulation by protein tyrosine phosphatase of IFN-γ-dependent expression of inducible nitric oxide synthase. J Immunol 162:6776-6783, 1999
    • (1999) J Immunol , vol.162 , pp. 6776-6783
    • Diaz-Guerra, M.J.M.1    Castrillo, A.2    Martin-Sanz, P.3    Bosca, L.4
  • 50
    • 0032545272 scopus 로고    scopus 로고
    • Insulin receptor substrate 2 and she play different roles in insulin-like growth factor I signaling
    • Kim B, Cheng HL, Margolis B, Feldman EL: Insulin receptor substrate 2 and She play different roles in insulin-like growth factor I signaling. J Biol Chem 273:34543-34550, 1998
    • (1998) J Biol Chem , vol.273 , pp. 34543-34550
    • Kim, B.1    Cheng, H.L.2    Margolis, B.3    Feldman, E.L.4
  • 51
    • 0033104502 scopus 로고    scopus 로고
    • Autophosphorylation of p110δ phosphoinositide 3-kinase: A new paradigm for the regulation of lipid kinases in vitro and in vivo
    • Vanhaesebroeck B, Higashi K, Raven C, Welham M, Anderson S, Brennan P, Ward SG, Waterfield MD: Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. EMBO J 18:1292-1302, 1999
    • (1999) EMBO J , vol.18 , pp. 1292-1302
    • Vanhaesebroeck, B.1    Higashi, K.2    Raven, C.3    Welham, M.4    Anderson, S.5    Brennan, P.6    Ward, S.G.7    Waterfield, M.D.8
  • 52
    • 0030731917 scopus 로고    scopus 로고
    • Nitric oxide primes pancreatic β-cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
    • Stassi G, De Maria R, Trucco G, Rudert W, Testi R, Galluzzo A, Giordano C, Trucco M: Nitric oxide primes pancreatic β-cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 186:1193-1200, 1997
    • (1997) J Exp Med , vol.186 , pp. 1193-1200
    • Stassi, G.1    De Maria, R.2    Trucco, G.3    Rudert, W.4    Testi, R.5    Galluzzo, A.6    Giordano, C.7    Trucco, M.8
  • 53
    • 0033561763 scopus 로고    scopus 로고
    • Phosphatidylinositol 3′-kinase, but not S6-kinase, is required for IGF-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid progenitors
    • Minshall C, Arkins S, Dantzer R, Freund GG, Kelley KW: Phosphatidylinositol 3′-kinase, but not S6-kinase, is required for IGF-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid progenitors. J Immunol 162:4542-4549, 1999
    • (1999) J Immunol , vol.162 , pp. 4542-4549
    • Minshall, C.1    Arkins, S.2    Dantzer, R.3    Freund, G.G.4    Kelley, K.W.5
  • 54
    • 0031570874 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3′-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes
    • Liu Q, Schacher D, Hurth C, Freund GG, Dantzer R, Kelley KW: Activation of phosphatidylinositol 3′-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes. J Immunol 159:820-837, 1997
    • (1997) J Immunol , vol.159 , pp. 820-837
    • Liu, Q.1    Schacher, D.2    Hurth, C.3    Freund, G.G.4    Dantzer, R.5    Kelley, K.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.