메뉴 건너뛰기




Volumn 22, Issue 12, 2002, Pages 1153-1166

Ingested type I interferon: A potential treatment for autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AUROTHIOMALATE; BETA1A INTERFERON; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GADOLINIUM; GAMMA INTERFERON; HYDROXYCHLOROQUINE; INSULIN; INTERFERON; INTERFERON BETA SERINE; INTERLEUKIN 1; INTERLEUKIN 2; METHOTREXATE; RECOMBINANT ALPHA2A INTERFERON; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0036975241     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/10799900260475669     Document Type: Review
Times cited : (16)

References (161)
  • 1
    • 0031852204 scopus 로고    scopus 로고
    • Hypothesis: Multiple sclerosis is a type I interferon deficiency syndrome
    • BROD, S.A. (1998). Hypothesis: multiple sclerosis is a type I interferon deficiency syndrome. Proc. Soc. Exp. Biol. Med. 218, 278-283.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.218 , pp. 278-283
    • Brod, S.A.1
  • 2
    • 0030824070 scopus 로고    scopus 로고
    • Gut response. Therapy with ingested immunomodulatory proteins
    • BROD, S.A. (1997). Gut response. Therapy with ingested immunomodulatory proteins. Arch. Neurol. 54, 1300-1302.
    • (1997) Arch. Neurol. , vol.54 , pp. 1300-1302
    • Brod, S.A.1
  • 3
    • 0032818247 scopus 로고    scopus 로고
    • Immunomodulation and therapeutic effects of the oral use of interferon-alpha: Mechanism of action
    • TOMPKINS, W.A. (1999). Immunomodulation and therapeutic effects of the oral use of interferon-alpha: mechanism of action. J. Interferon Cytokine Res. 19, 817-828.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 817-828
    • Tompkins, W.A.1
  • 4
    • 0025185153 scopus 로고
    • Is interferon effective after oral administration?
    • BOCCI, V. (1990). Is interferon effective after oral administration? J. Biol. Reg. Homeostasis Agents 4, 81-83.
    • (1990) J. Biol. Reg. Homeostasis Agents , vol.4 , pp. 81-83
    • Bocci, V.1
  • 5
    • 0000383435 scopus 로고
    • Multiple sclerosis
    • S. Appel (ed.) St. Louis: Mosby - Year Book, Inc.
    • WOLINSKY, J. (1993). Multiple sclerosis. In: Current Neurology. S. Appel (ed.) St. Louis: Mosby - Year Book, Inc. pp. 167-207.
    • (1993) Current Neurology , pp. 167-207
    • Wolinsky, J.1
  • 7
    • 0018305482 scopus 로고
    • Suppressor cell function in multiple sclerosis: Correlation with clinical disease activity
    • ANTEL, J.P., ARNASON, B.G.W., and MEDOF, M.E. (1979). Suppressor cell function in multiple sclerosis: correlation with clinical disease activity. Ann. Neurol. 5, 338-342.
    • (1979) Ann. Neurol. , vol.5 , pp. 338-342
    • Antel, J.P.1    Arnason, B.G.W.2    Medof, M.E.3
  • 8
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • THE IFNB MULTIPLE SCLEROSIS GROUP. (1993). Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43, 655-661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 10
    • 0037154192 scopus 로고    scopus 로고
    • Disease modifying therapies in multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines
    • GOODIN, D.S., FROHMAN, E.M., GARMANY, G.P., Jr., HALPER, J., LIKOSKY, W.H., LUBLIN, F.D., SILBERBERG, D.H., STUART, W.H., and VAN DEN NOORT, S. (2002). Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology 58, 169-178.
    • (2002) Neurology , vol.58 , pp. 169-178
    • Goodin, D.S.1    Frohman, E.M.2    Garmany G.P., Jr.3    Halper, J.4    Likosky, W.H.5    Lublin, F.D.6    Silberberg, D.H.7    Stuart, W.H.8    Van Den Noort, S.9
  • 12
    • 0028348216 scopus 로고
    • Chronic systemic high-dose recombinant interferon alfa-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon gamma production in relapsing-remitting multiple sclerosis
    • DURELLI, L., BONGIOANNI, M.R., CAVALLO, R., FERRERO, B., FERRI, R., FERRIO, M.F., BRADAC, G.B., RIVA, A., VAI, S., GEUNA, M., et al. (1994). Chronic systemic high-dose recombinant interferon alfa-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon gamma production in relapsing-remitting multiple sclerosis. Neurology 44, 406-413.
    • (1994) Neurology , vol.44 , pp. 406-413
    • Durelli, L.1    Bongioanni, M.R.2    Cavallo, R.3    Ferrero, B.4    Ferri, R.5    Ferrio, M.F.6    Bradac, G.B.7    Riva, A.8    Vai, S.9    Geuna, M.10
  • 13
    • 0033472729 scopus 로고    scopus 로고
    • Effect of interferon-beta1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: Results of a European multicenter, randomized, double-blind, placebo-controlled trial
    • European Study Group on Interferon-beta1b in secondary progressive multiple sclerosis
    • MILLER, D.H., MOLYNEUX, P.D., BARKER, G.J., MACMANUS, D.G., MOSELEY, I.F., and WAGNER, K. (1999). Effect of interferon-beta1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: results of a European multicenter, randomized, double-blind, placebo-controlled trial. European Study Group on Interferon-beta1b in secondary progressive multiple sclerosis. Ann. Neurol. 46, 850-859.
    • (1999) Ann. Neurol. , vol.46 , pp. 850-859
    • Miller, D.H.1    Molyneux, P.D.2    Barker, G.J.3    Macmanus, D.G.4    Moseley, I.F.5    Wagner, K.6
  • 14
    • 0030072651 scopus 로고    scopus 로고
    • Clinical and magnetic resonance imaging predictors of disability in primary and secondary progressive multiple sclerosis
    • LOSSEFF, N.A., KINGSLEY, D.P., McDONALD, W.I., MILLER, D.H., and THOMPSON, A.J. (1996). Clinical and magnetic resonance imaging predictors of disability in primary and secondary progressive multiple sclerosis. Mult. Scler. 1, 218-222.
    • (1996) Mult. Scler. , vol.1 , pp. 218-222
    • Losseff, N.A.1    Kingsley, D.P.2    McDonald, W.I.3    Miller, D.H.4    Thompson, A.J.5
  • 15
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
    • THE IFNB MULTIPLE SCLEROSIS STUDY GROUP and THE UNIVERSITY OF BRITISH COLUMBIA MS/MRI ANALYSIS GROUP. (1995). Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 45, 1277-1285.
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 16
    • 0005489101 scopus 로고    scopus 로고
    • Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: Experience during the first three years
    • THE IFNB MULTIPLE SCLEROSIS STUDY GROUP and THE UNIVERSITY OF BRITISH COLUMBIA MS/MRI ANALYSIS GROUP. (1996). Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years. Neurology 47, 889-894.
    • (1996) Neurology , vol.47 , pp. 889-894
  • 17
    • 0029950889 scopus 로고    scopus 로고
    • Interferon-beta 1b treatment decreases tumor necrosis factor-alpha and increases interleukin-6 production in multiple sclerosis
    • BROD, S.A., MARSHALL, G.D., Jr., HENNINGER, E.M., SRIRAM, S., KHAN, M., and WOLINSKY, J.S. (1996). Interferon-beta 1b treatment decreases tumor necrosis factor-alpha and increases interleukin-6 production in multiple sclerosis. Neurology 46, 1633-1638.
    • (1996) Neurology , vol.46 , pp. 1633-1638
    • Brod, S.A.1    Marshall G.D., Jr.2    Henninger, E.M.3    Sriram, S.4    Khan, M.5    Wolinsky, J.S.6
  • 18
    • 0022475906 scopus 로고
    • The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: A 25-year review of deaths in patients under 20 years of age in the United Kingdom
    • FOULIS, A.K., LIDDLE, C.N., FARQUHARSON, M.A., RICHMOND, J.A., and WEIR, R.S. (1986). The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29, 267-274.
    • (1986) Diabetologia , vol.29 , pp. 267-274
    • Foulis, A.K.1    Liddle, C.N.2    Farquharson, M.A.3    Richmond, J.A.4    Weir, R.S.5
  • 19
    • 0023735943 scopus 로고
    • Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus
    • SILVERSTEIN, J., MACLAREN, N., RILEY, W., SPILLAR, R., RADJENOVIC, D., and JOHNSON, S. (1988). Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus. N. Engl. J. Med. 319, 599-604.
    • (1988) N. Engl. J. Med. , vol.319 , pp. 599-604
    • Silverstein, J.1    Maclaren, N.2    Riley, W.3    Spillar, R.4    Radjenovic, D.5    Johnson, S.6
  • 20
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • THE DIABETES CONTROL AND COMPLICATIONS TRIAL RESEARCH GROUP. (1993). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977-986.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
  • 21
    • 0024504171 scopus 로고
    • A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus
    • SHAH, S., MALONE, J., and SIMPSON, N. (1989). A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N. Engl. J. Med. 320, 550-554.
    • (1989) N. Engl. J. Med. , vol.320 , pp. 550-554
    • Shah, S.1    Malone, J.2    Simpson, N.3
  • 22
    • 0023709376 scopus 로고
    • Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion
    • CANADIAN-EUROPEAN RANDOMIZED CONTROL TRIAL GROUP. (1988). Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. Diabetes 37, 1574-1582.
    • (1988) Diabetes , vol.37 , pp. 1574-1582
  • 23
    • 0022619110 scopus 로고
    • Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial
    • FEUTREN, G., PAPOZ, L., ASSAN, R., VIALETTES, B., KARSENTY, G., VEXIAU, P., DU ROSTU, H., RODIER, M., SIRMAI, J., and LALLEMAND, A. (1986). Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet 2, 119-124.
    • (1986) Lancet , vol.2 , pp. 119-124
    • Feutren, G.1    Papoz, L.2    Assan, R.3    Vialettes, B.4    Karsenty, G.5    Vexiau, P.6    Du Rostu, H.7    Rodier, M.8    Sirmai, J.9    Lallemand, A.10
  • 24
    • 0025049497 scopus 로고
    • Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin
    • BOUGNERES, P., LANDAIS, P., BOISSON, C., CAREL, J., FRAMENT, N., BOITARD, C., CHAUSSAIN, J., and BACH, J. (1990). Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin. Diabetes 39, 1264-1272.
    • (1990) Diabetes , vol.39 , pp. 1264-1272
    • Bougneres, P.1    Landais, P.2    Boisson, C.3    Carel, J.4    Frament, N.5    Boitard, C.6    Chaussain, J.7    Bach, J.8
  • 25
    • 0024813410 scopus 로고
    • Double-blind controlled trial of azathioprine in children with newly diagnosed type I diabetes
    • COOK, J., HUDSON, I., HARRISON, L., DEAN, B., COLMAN, P., WERTHER, G., WARNE, G., and COURT, J. (1989). Double-blind controlled trial of azathioprine in children with newly diagnosed type I diabetes. Diabetes 38, 779-783.
    • (1989) Diabetes , vol.38 , pp. 779-783
    • Cook, J.1    Hudson, I.2    Harrison, L.3    Dean, B.4    Colman, P.5    Werther, G.6    Warne, G.7    Court, J.8
  • 26
    • 0025294001 scopus 로고
    • A trial of nicotinamide in newly diagnosed patients with type 1 (insulin-dependent) diabetes mellitus
    • CHASE, H., BUTLER-SIMON, N., GARG, S., McDUFFIE, M., HOOPS, S., and O'BRIEN, D. (1990). A trial of nicotinamide in newly diagnosed patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 33, 444-446.
    • (1990) Diabetologia , vol.33 , pp. 444-446
    • Chase, H.1    Butler-Simon, N.2    Garg, S.3    McDuffie, M.4    Hoops, S.5    O'Brien, D.6
  • 27
    • 0026543134 scopus 로고
    • Double-blind randomized trial of nicotinamide on early-onset diabetes
    • LEWIS, C., CANAFAX, D., SPRAFKA, J., and BARBOSA, J. (1992). Double-blind randomized trial of nicotinamide on early-onset diabetes. Diabetes Care 15, 121-123.
    • (1992) Diabetes Care , vol.15 , pp. 121-123
    • Lewis, C.1    Canafax, D.2    Sprafka, J.3    Barbosa, J.4
  • 29
    • 0019762336 scopus 로고
    • Adult and juvenile rheumatoid arthritis: Current epidemiologic concepts
    • HOCHBERG, M.C. (1981). Adult and juvenile rheumatoid arthritis: current epidemiologic concepts. Epidemiol. Rev. 3, 27-44.
    • (1981) Epidemiol. Rev. , vol.3 , pp. 27-44
    • Hochberg, M.C.1
  • 30
    • 0023179033 scopus 로고
    • Long-term outcome of treating rheumatoid arthritis: Results after 20 years
    • SCOTT, D.L., SYMMONS, D.P., COULTON, B.L., and POPERT, A.J. (1987). Long-term outcome of treating rheumatoid arthritis: results after 20 years. Lancet 1, 1108-1111.
    • (1987) Lancet , vol.1 , pp. 1108-1111
    • Scott, D.L.1    Symmons, D.P.2    Coulton, B.L.3    Popert, A.J.4
  • 31
    • 0028105830 scopus 로고
    • Prediction of long-term mortality in patients with rheumatoid arthritis according to simple questionnaire and joint count, measures
    • PINCUS, T., BROOKS, R.H., and CALLAHAN, L.F. (1994). Prediction of long-term mortality in patients with rheumatoid arthritis according to simple questionnaire and joint count, measures. Ann. Intern. Med. 120, 26-34.
    • (1994) Ann. Intern. Med. , vol.120 , pp. 26-34
    • Pincus, T.1    Brooks, R.H.2    Callahan, L.F.3
  • 34
    • 0025080342 scopus 로고
    • Termination of slow acting antirheumatic therapy in rheumatoid arthritis: A 14-year prospective evaluation of 1017 consecutive starts
    • WOLFE, F., HAWLEY, D.J., and CATHEY, M.A. (1990). Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective evaluation of 1017 consecutive starts. J. Rheumatol. 17, 994-1002.
    • (1990) J. Rheumatol. , vol.17 , pp. 994-1002
    • Wolfe, F.1    Hawley, D.J.2    Cathey, M.A.3
  • 35
    • 0026766850 scopus 로고
    • Life table analysis of 879 treatment episodes with slow acting antirheumatic drugs in community rheumatology practice
    • published erratum appears in J. Rheumatol. 1992;19:1998
    • MORAND, E.F., McCLOUD, P.I., and LITTLEJOHN, G.O. (1992). Life table analysis of 879 treatment episodes with slow acting antirheumatic drugs in community rheumatology practice [published erratum appears in J. Rheumatol. 1992;19:1998]. J. Rheumatol. 19, 704-708.
    • (1992) J. Rheumatol. , vol.19 , pp. 704-708
    • Morand, E.F.1    McCloud, P.I.2    Littlejohn, G.O.3
  • 36
    • 0030000725 scopus 로고    scopus 로고
    • Guidelines for monitoring drug therapy in rheumatoid arthritis
    • AMERICAN COLLEGE OF RHEUMATOLOGY AD HOC COMMITTEE ON CLINICAL GUIDELINES. (1996). Guidelines for monitoring drug therapy in rheumatoid arthritis. Arthritis Rheum. 39, 723-731.
    • (1996) Arthritis Rheum. , vol.39 , pp. 723-731
  • 38
    • 0028143211 scopus 로고
    • Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
    • ELLIOTT, M.J., MAINI, R.N., FELDMANN, M., KALDEN, J.R., ANTONI, C., SMOLEN, J.S., LEEB, B., BREEDVELD, F.C., MACFARLANE, J.D., BIJL, H., et al. (1994). Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 344, 1105-1110.
    • (1994) Lancet , vol.344 , pp. 1105-1110
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3    Kalden, J.R.4    Antoni, C.5    Smolen, J.S.6    Leeb, B.7    Breedveld, F.C.8    Macfarlane, J.D.9    Bijl, H.10
  • 39
    • 0023694150 scopus 로고
    • Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis
    • EASTGATE, J.A., SYMONS, J.A., WOOD, N.C., GRINLINTON, F.M., DI GIOVINE, F.S., and DUFF, G.W. (1988). Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis. Lancet 2, 706-709.
    • (1988) Lancet , vol.2 , pp. 706-709
    • Eastgate, J.A.1    Symons, J.A.2    Wood, N.C.3    Grinlinton, F.M.4    Di Giovine, F.S.5    Duff, G.W.6
  • 40
    • 0026684213 scopus 로고
    • Determination of cytokines in synovial fluids: Correlation with diagnosis and histomorphological characteristics of synovial tissue
    • KAHLE, P., SAAL, J., SCHAUDT, K., ZACHER, J., FRITZ, P., and PAWELEC, G. (1992). Determination of cytokines in synovial fluids: correlation with diagnosis and histomorphological characteristics of synovial tissue. Ann. Rheum. Dis. 51, 731-734.
    • (1992) Ann. Rheum. Dis. , vol.51 , pp. 731-734
    • Kahle, P.1    Saal, J.2    Schaudt, K.3    Zacher, J.4    Fritz, P.5    Pawelec, G.6
  • 41
    • 0022492018 scopus 로고
    • Enhanced interleukin 1 generation by monocytes in vitro is temporally linked to an early event in the onset of exacerbation of rheumatoid arthritis
    • SHORE, A., JAGLAL, S., and KEYSTONE, E.C. (1986). Enhanced interleukin 1 generation by monocytes in vitro is temporally linked to an early event in the onset of exacerbation of rheumatoid arthritis. Clin. Exp. Immunol. 65, 293-302.
    • (1986) Clin. Exp. Immunol. , vol.65 , pp. 293-302
    • Shore, A.1    Jaglal, S.2    Keystone, E.C.3
  • 42
    • 0343907263 scopus 로고    scopus 로고
    • Comparative cytokine gene expression in synovial tissue of early rheumatoid arthritis and seronegative spondyloarthropathies
    • CANETE, J.D., LLENA, J., COLLADO, A., SANMARTI, R., GAYA, A., GRATACOS, J., BLAY, M., and MUNOZ-GOMEZ, J. (1997). Comparative cytokine gene expression in synovial tissue of early rheumatoid arthritis and seronegative spondyloarthropathies. Br. J. Rheumatol. 36, 38-42.
    • (1997) Br. J. Rheumatol. , vol.36 , pp. 38-42
    • Canete, J.D.1    Llena, J.2    Collado, A.3    Sanmarti, R.4    Gaya, A.5    Gratacos, J.6    Blay, M.7    Munoz-Gomez, J.8
  • 43
    • 0023914715 scopus 로고
    • Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction
    • MIYASAKA, N., SATO, K., GOTO, M., SASANO, M., NATSUYAMA, M., INOUE, K., and NISHIOKA, K. (1988). Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction. Arthritis Rheum. 31, 480-486.
    • (1988) Arthritis Rheum , vol.31 , pp. 480-486
    • Miyasaka, N.1    Sato, K.2    Goto, M.3    Sasano, M.4    Natsuyama, M.5    Inoue, K.6    Nishioka, K.7
  • 44
    • 0031939315 scopus 로고    scopus 로고
    • Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes
    • SASAKI, K., HATTORI, T., FUJISAWA, T., TAKAHASHI, K., INOUE, H., and TAKIGAWA, M. (1998). Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J. Biochem. 123, 431-439.
    • (1998) J. Biochem. , vol.123 , pp. 431-439
    • Sasaki, K.1    Hattori, T.2    Fujisawa, T.3    Takahashi, K.4    Inoue, H.5    Takigawa, M.6
  • 45
    • 0030795025 scopus 로고    scopus 로고
    • In vitro modulation of cytokine, cytokine inhibitor, and prostaglandin E release from blood mononuclear cells and synovial fibroblasts by antirheumatic drugs
    • SEITZ, M., LOETSCHER, P., DEWALD, B., TOWBIN, H., and BAGGIOLINI, M. (1997). In vitro modulation of cytokine, cytokine inhibitor, and prostaglandin E release from blood mononuclear cells and synovial fibroblasts by antirheumatic drugs. J. Rheumatol. 24, 1471-1476.
    • (1997) J. Rheumatol. , vol.24 , pp. 1471-1476
    • Seitz, M.1    Loetscher, P.2    Dewald, B.3    Towbin, H.4    Baggiolini, M.5
  • 47
    • 0002466558 scopus 로고
    • Interferon alpha/beta, gene structure and regulation
    • S. Baron, D.H. Coppenhaver, F. Dianzani, W.R. Fleischmann, T.K. Hughes, G.R. Klimpel, D.W. Niesel, G.J. Stanton, and S.K. Tyring (eds.) Galveston, TX: University of Texas Press
    • DRON, M., and TOVEY, M. (I992). Interferon alpha/beta, gene structure and regulation. In: Interferon: Principles and Medical Applications. S. Baron, D.H. Coppenhaver, F. Dianzani, W.R. Fleischmann, T.K. Hughes, G.R. Klimpel, D.W. Niesel, G.J. Stanton, and S.K. Tyring (eds.) Galveston, TX: University of Texas Press, pp. 33-45.
    • (1992) Interferon: Principles and Medical Applications , pp. 33-45
    • Dron, M.1    Tovey, M.2
  • 48
    • 0017715086 scopus 로고
    • Evaluation of the effects of interferon and interferon inducers on the immune response
    • JOHNSON, H.M., and BARON, S. (1977). Evaluation of the effects of interferon and interferon inducers on the immune response. Pharmacol. Ther. 1, 349-367.
    • (1977) Pharmacol. Ther. , vol.1 , pp. 349-367
    • Johnson, H.M.1    Baron, S.2
  • 49
    • 0023477128 scopus 로고
    • Human interferons: Structure and function
    • ZOON, K.C. (1987). Human interferons: structure and function. Interferon 9, 1-12.
    • (1987) Interferon , vol.9 , pp. 1-12
    • Zoon, K.C.1
  • 50
    • 0002218492 scopus 로고
    • Interferons: Protein structure
    • S. Baron, F. Dianzani, G.J. Stanton, and W.R. Fleischmann (eds.) Austin, TX: University of Texas Press
    • RASHIDBAIGI, A., and PESTKA, S. (1987). Interferons: Protein structure. In: Interferon System. S. Baron, F. Dianzani, G.J. Stanton, and W.R. Fleischmann (eds.) Austin, TX: University of Texas Press, pp. 149-168.
    • (1987) Interferon System , pp. 149-168
    • Rashidbaigi, A.1    Pestka, S.2
  • 51
    • 0028944489 scopus 로고
    • α and β interferons and their receptor and their friends and relations
    • UZE, G., LUTFALLA, G., and KNUDSON, K.E. (1995). α and β Interferons and their receptor and their friends and relations. J. Interferon Cytokine Res. 15, 3-26.
    • (1995) J. Interferon Cytokine Res. , vol.15 , pp. 3-26
    • Uze, G.1    Lutfalla, G.2    Knudson, K.E.3
  • 52
    • 0020988538 scopus 로고
    • Interferon receptors
    • I. Gresser (ed.) New York: Academic Press
    • AGUET, M., and MOGENSEN, K.E. (1983). Interferon receptors. In: Interferons. I. Gresser (ed.) New York: Academic Press, pp. 1-22.
    • (1983) Interferons , pp. 1-22
    • Aguet, M.1    Mogensen, K.E.2
  • 53
    • 0030460065 scopus 로고    scopus 로고
    • Oral cytokine administration
    • ROLLWAGEN, R., and BAQAR, S. (1996). Oral cytokine administration. Immunol. Today 17, 548-550.
    • (1996) Immunol. Today , vol.17 , pp. 548-550
    • Rollwagen, R.1    Baqar, S.2
  • 55
    • 0026043814 scopus 로고
    • Absorption of cytokines via the oropharyngeal associated lymphoid tissues - Does an unorthodox route improve the therapeutic index of interferon?
    • BOCCI, V. (1991). Absorption of cytokines via the oropharyngeal associated lymphoid tissues - does an unorthodox route improve the therapeutic index of interferon? Clin. Pharmacokinet. 21, 411-417.
    • (1991) Clin. Pharmacokinet. , vol.21 , pp. 411-417
    • Bocci, V.1
  • 56
    • 0024587987 scopus 로고
    • Overview of the mucosal immune system
    • BRANDTZAEG, P. (1989). Overview of the mucosal immune system. Curr. Top. Microbiol. Immunol. 146, 13-28.
    • (1989) Curr. Top. Microbiol. Immunol. , vol.146 , pp. 13-28
    • Brandtzaeg, P.1
  • 57
    • 0020646923 scopus 로고
    • Immunosuppression caused by antigen feeding II. Suppressor T cells mask Peyer's patch B cell priming to orally administered antigen
    • MACDONALD, T.T. (1983). Immunosuppression caused by antigen feeding II. Suppressor T cells mask Peyer's patch B cell priming to orally administered antigen. Eur. J. Immunol. 13, 138-142.
    • (1983) Eur. J. Immunol. , vol.13 , pp. 138-142
    • Macdonald, T.T.1
  • 58
    • 0021233780 scopus 로고
    • Immunologic suppression after oral administration of antigen. III. Activation of suppressor-inducer cells in the Peyer's patches
    • MATTINGLY, J.A. (1984). Immunologic suppression after oral administration of antigen. III. Activation of suppressor-inducer cells in the Peyer's patches. Cell. Immunol. 86, 46-52.
    • (1984) Cell. Immunol. , vol.86 , pp. 46-52
    • Mattingly, J.A.1
  • 59
    • 0025356871 scopus 로고
    • The downregulation of IFN-α receptors in human lymphoblastoid cells: Relation of cellular responsiveness to antiproliferative action of IFN-α
    • PFEFFER, L.M., and DONNER, D.D. (1990). The downregulation of IFN-α receptors in human lymphoblastoid cells: relation of cellular responsiveness to antiproliferative action of IFN-α. Cancer Res. 50, 2654-2657.
    • (1990) Cancer Res. , vol.50 , pp. 2654-2657
    • Pfeffer, L.M.1    Donner, D.D.2
  • 60
    • 0026337403 scopus 로고
    • Transmembrane signalling by interferon-α
    • PFEFFER, L.M., and COLAMONICI, O.R. (1991). Transmembrane signalling by interferon-α. Pharmacol. Ther. 52, 149-151.
    • (1991) Pharmacol. Ther. , vol.52 , pp. 149-151
    • Pfeffer, L.M.1    Colamonici, O.R.2
  • 61
    • 0026746424 scopus 로고
    • Orally administered interferons exert their white blood cell suppressive effects via a novel mechanism
    • FLEISCHMANN, W.R., Jr., KOREN, S., and FLEISCHMANN, C.M. (1992). Orally administered interferons exert their white blood cell suppressive effects via a novel mechanism. Proc. Soc. Exp. Biol. Med. 201, 200-207.
    • (1992) Proc. Soc. Exp. Biol. Med. , vol.201 , pp. 200-207
    • Fleischmann W.R., Jr.1    Koren, S.2    Fleischmann, C.M.3
  • 63
    • 0015794874 scopus 로고
    • Circulating interferon in rabbits after administration of human interferon by different routes
    • CANTELL, K., and PYHALA, L. (1973). Circulating interferon in rabbits after administration of human interferon by different routes. J. Gen. Virol. 20, 97-104.
    • (1973) J. Gen. Virol. , vol.20 , pp. 97-104
    • Cantell, K.1    Pyhala, L.2
  • 64
    • 0021952777 scopus 로고
    • Pharmacokinetics of recombinant leukocyte A interferon following various routes and modes of administration to the dog
    • GIBSON, D.M., COTLER, S., SPIEGEL, H.E., and COLBURN, W.A. (1985). Pharmacokinetics of recombinant leukocyte A interferon following various routes and modes of administration to the dog. J. Interferon Res. 5, 403-408.
    • (1985) J. Interferon Res. , vol.5 , pp. 403-408
    • Gibson, D.M.1    Cotler, S.2    Spiegel, H.E.3    Colburn, W.A.4
  • 65
    • 0021251277 scopus 로고
    • Pharmacokinetics of recombinant alpha A interferon following I.V. infusion and bolus, I.M., and P.O. administrations to African green monkeys
    • WILLS, R.J., SPIEGEL, H.E., and SOIKE, K.F. (1984). Pharmacokinetics of recombinant alpha A interferon following I.V. infusion and bolus, I.M., and P.O. administrations to African green monkeys. J. Interferon Res. 4, 399-409.
    • (1984) J. Interferon Res. , vol.4 , pp. 399-409
    • Wills, R.J.1    Spiegel, H.E.2    Soike, K.F.3
  • 66
    • 0001613208 scopus 로고
    • Mx protein: Function and mechanism of action
    • S. Baron, D.H. Coppenhaver, F. Dianzani, W.R. Fleischmann, T.K. Hughes, G.R. Klimpel, D.W. Niesel, G.J. Stanton, and S.K. Tyring (eds.) Galveston, TX: University of Texas Press
    • HORISBERGER, M.A. (1992). Mx protein: function and mechanism of action. In: Interferon: Principles and Medical Applications. S. Baron, D.H. Coppenhaver, F. Dianzani, W.R. Fleischmann, T.K. Hughes, G.R. Klimpel, D.W. Niesel, G.J. Stanton, and S.K. Tyring (eds.) Galveston, TX: University of Texas Press, pp. 215-224.
    • (1992) Interferon: Principles and Medical Applications , pp. 215-224
    • Horisberger, M.A.1
  • 67
    • 0028274170 scopus 로고
    • MxA gene expression after live vires vaccination: A sensitive marker for endogenous type I interferon
    • ROERS, A., HOCHKEPPEL, H., HORISBERGER, M., HOVANESSIAN, A., and HALLER, O. (1994). MxA gene expression after live vires vaccination: a sensitive marker for endogenous type I interferon. J. Infect. Dis. 169, 807-813.
    • (1994) J. Infect. Dis. , vol.169 , pp. 807-813
    • Roers, A.1    Hochkeppel, H.2    Horisberger, M.3    Hovanessian, A.4    Haller, O.5
  • 68
    • 0029985565 scopus 로고    scopus 로고
    • Oral administration of IFN-alpha is superior to subcutaneous administration of IFN-alpha in the suppression of chronic relapsing experimental autoimmune encephalomyelitis
    • BROD, S.A., and KHAN, M. (1996). Oral administration of IFN-alpha is superior to subcutaneous administration of IFN-alpha in the suppression of chronic relapsing experimental autoimmune encephalomyelitis. J. Autoimmun. 9, 11-20.
    • (1996) J. Autoimmun. , vol.9 , pp. 11-20
    • Brod, S.A.1    Khan, M.2
  • 69
    • 0033019248 scopus 로고    scopus 로고
    • Ingested interferon alpha induces Mx mRNA
    • BROD, S.A., NELSON, L., JIN, R., and WOLINSKY, J.S. (1999). Ingested interferon alpha induces Mx mRNA. Cytokine 11, 492-499.
    • (1999) Cytokine , vol.11 , pp. 492-499
    • Brod, S.A.1    Nelson, L.2    Jin, R.3    Wolinsky, J.S.4
  • 70
    • 0030498666 scopus 로고    scopus 로고
    • IFN-β1b decreases the migration of T lymphocytes in vitro - Effects on matrix metalloproteinase-9
    • STUVE, O., DOOLEY. N., UHM, H., ANTEL, J., FRANCIS, G., WILLIAMS, G., and YONG, V. (1996). IFN-β1b decreases the migration of T lymphocytes in vitro - effects on matrix metalloproteinase-9. Ann. Neurol. 40, 853-863.
    • (1996) Ann. Neurol. , vol.40 , pp. 853-863
    • Stuve, O.1    Dooley, N.2    Uhm, H.3    Antel, J.4    Francis, G.5    Williams, G.6    Yong, V.7
  • 71
    • 0032880358 scopus 로고    scopus 로고
    • Migratory behavior of lymphocytes isolated from multiple sclerosis patients: Effects of interferon beta-1b therapy
    • UHM, J.H., DOOLEY, N.P., STUVE, O., FRANCIS, G.S., DUQUETTE, P., ANTEL, J.P., and YONG, V.W. (1999). Migratory behavior of lymphocytes isolated from multiple sclerosis patients: effects of interferon beta-1b therapy. Ann. Neurol. 46, 319-324.
    • (1999) Ann. Neurol. , vol.46 , pp. 319-324
    • Uhm, J.H.1    Dooley, N.P.2    Stuve, O.3    Francis, G.S.4    Duquette, P.5    Antel, J.P.6    Yong, V.W.7
  • 72
    • 0028936221 scopus 로고
    • The interferons: Biological effects, mechanism of action, and use in multiple sclerosis
    • WEINSTOCK-GUTTMANN, B., RANSAHOFF, R.M., KINKEL, R.P., and RUDICK, R.A. (1995). The interferons: biological effects, mechanism of action, and use in multiple sclerosis. Ann. Neurol. 37, 7-15.
    • (1995) Ann. Neurol. , vol.37 , pp. 7-15
    • Weinstock-Guttmann, B.1    Ransahoff, R.M.2    Kinkel, R.P.3    Rudick, R.A.4
  • 73
    • 0035845612 scopus 로고    scopus 로고
    • Ingested IFN-α: Results of a pilot study in relapsing-remitting multiple sclerosis (RRMS)
    • BROD, S., LINDSEY, J., VRIESENDORP, F., AHN, C., NARAYANA, P., and WOLINSKY, J. (2001). Ingested IFN-α: results of a pilot study in relapsing-remitting multiple sclerosis (RRMS). Neurology 57, 845-852.
    • (2001) Neurology , vol.57 , pp. 845-852
    • Brod, S.1    Lindsey, J.2    Vriesendorp, F.3    Ahn, C.4    Narayana, P.5    Wolinsky, J.6
  • 74
    • 0034117395 scopus 로고    scopus 로고
    • Adoptive transfer from interferon-alpha-fed mice is associated with inhibition of active experimental autoimmune encephalomyelitis by decreasing recipient tumor necrosis factor-alpha secretion
    • BROD, S.A., KHAN, M., NELSON, L.D., DECUIR, B., MALONE, M., and HENNINGER, E. (2000). Adoptive transfer from interferon-alpha-fed mice is associated with inhibition of active experimental autoimmune encephalomyelitis by decreasing recipient tumor necrosis factor-alpha secretion. J. Immunother. 23, 235-245.
    • (2000) J. Immunother. , vol.23 , pp. 235-245
    • Brod, S.A.1    Khan, M.2    Nelson, L.D.3    Decuir, B.4    Malone, M.5    Henninger, E.6
  • 76
    • 0029091751 scopus 로고
    • Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft
    • RABINOVITCH, A., SUAREZ-PINZON, W.L., SORENSEN, O., BLEACKLEY, R.C., POWER, R.F., and RAJOTTE, R.V. (1995). Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft. Transplantation 60, 368-374.
    • (1995) Transplantation , vol.60 , pp. 368-374
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3    Bleackley, R.C.4    Power, R.F.5    Rajotte, R.V.6
  • 77
    • 0029810079 scopus 로고    scopus 로고
    • Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10
    • FAUST, A., ROTHE, H., SCHADE, U., LAMPETER, E., and KOLB, H. (1996). Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10. Transplantation 62, 648-652.
    • (1996) Transplantation , vol.62 , pp. 648-652
    • Faust, A.1    Rothe, H.2    Schade, U.3    Lampeter, E.4    Kolb, H.5
  • 78
    • 0028964995 scopus 로고
    • Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type I interferons
    • BROD, S.A., SCOTT, M., BURNS, D.K., and PHILLIPS, J.T. (1995). Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type I interferons. J. Interferon Cytokine Res. 15, 115-122.
    • (1995) J. Interferon Cytokine Res. , vol.15 , pp. 115-122
    • Brod, S.A.1    Scott, M.2    Burns, D.K.3    Phillips, J.T.4
  • 80
    • 0030454489 scopus 로고    scopus 로고
    • Oral administration of type I interferon modulates the course of experimental allergic neuritis
    • VRIESENDORP, F.J., FLYNN, R.E., KHAN, M., PAPPOLLA, M.A., and BROD, S.A. (1996). Oral administration of type I interferon modulates the course of experimental allergic neuritis. Autoimmunity 24, 157-165.
    • (1996) Autoimmunity , vol.24 , pp. 157-165
    • Vriesendorp, F.J.1    Flynn, R.E.2    Khan, M.3    Pappolla, M.A.4    Brod, S.A.5
  • 81
    • 0022358735 scopus 로고
    • Chronic relapsing experimental allergic encephalomyelitis in the lewis rat
    • FEUER, C., PRENTICE, D.E., and CAMMISULI, S. (1985). Chronic relapsing experimental allergic encephalomyelitis in the lewis rat. J. Neuroimmunol. 10, 159-166.
    • (1985) J. Neuroimmunol. , vol.10 , pp. 159-166
    • Feuer, C.1    Prentice, D.E.2    Cammisuli, S.3
  • 82
    • 0017670674 scopus 로고
    • Animal models for multiple sclerosis: Chronic experimental allergic encephalomyelitis in inbred guinea pigs
    • RAINE, C.S., and STONE, S.H. (1977). Animal models for multiple sclerosis: chronic experimental allergic encephalomyelitis in inbred guinea pigs. NY State J. Med. 77, 1693-1696.
    • (1977) NY State J. Med. , vol.77 , pp. 1693-1696
    • Raine, C.S.1    Stone, S.H.2
  • 83
    • 0017452304 scopus 로고
    • Chronic relapsing experimental allergic encephalomyelitis: An experimental model of multiple sclerosis
    • WISNEWSKI, H.M., and KEITH, A.B. (1977). Chronic relapsing experimental allergic encephalomyelitis: an experimental model of multiple sclerosis. Ann. Neurol. 1, 144-148.
    • (1977) Ann. Neurol. , vol.1 , pp. 144-148
    • Wisnewski, H.M.1    Keith, A.B.2
  • 84
    • 0028236020 scopus 로고
    • Suppression of relapsing experimental autoimmune encephalomyelitis in the SJL/J mouse by oral administration of type I interferons
    • BROD, S.A., and BURNS, D.K. (1994). Suppression of relapsing experimental autoimmune encephalomyelitis in the SJL/J mouse by oral administration of type I interferons. Neurology 44, 1144-1148.
    • (1994) Neurology , vol.44 , pp. 1144-1148
    • Brod, S.A.1    Burns, D.K.2
  • 85
    • 0024334434 scopus 로고
    • Structure-function studies of interferons-α: Amino acid substitutions at the conserved residue tyrosine 123 in human interferons-α
    • McINNES, M., CHAMBERS, P.J., CHEETHAM, B.F., BEILHARZ, M.W., and TYMMS, M.J. (1989). Structure-function studies of interferons-α: amino acid substitutions at the conserved residue tyrosine 123 in human interferons-α. J. Interferon Res. 9, 305-314.
    • (1989) J. Interferon Res. , vol.9 , pp. 305-314
    • McInnes, M.1    Chambers, P.J.2    Cheetham, B.F.3    Beilharz, M.W.4    Tymms, M.J.5
  • 86
    • 0023298866 scopus 로고
    • Single amino acid changes that render human IFN-α2 biologically active on mouse cells
    • WEBER, H., VALENZUELA, D., LUJGER, G., GUBLER, M., and WEISSMAN, C. (1987). Single amino acid changes that render human IFN-α2 biologically active on mouse cells. EMBO J. 6, 591-598.
    • (1987) EMBO J. , vol.6 , pp. 591-598
    • Weber, H.1    Valenzuela, D.2    Lujger, G.3    Gubler, M.4    Weissman, C.5
  • 87
    • 0028903315 scopus 로고
    • Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis
    • BROD, S.A., KHAN, M., KERMAN, R.H., and PAPPOLLA, M. (1995). Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 58, 61-69.
    • (1995) J. Neuroimmunol. , vol.58 , pp. 61-69
    • Brod, S.A.1    Khan, M.2    Kerman, R.H.3    Pappolla, M.4
  • 88
    • 0021948231 scopus 로고
    • Adoptive transfer of murine relapsing experimental autoimmune encephalomyelitis
    • LUBLIN, F. (1985). Adoptive transfer of murine relapsing experimental autoimmune encephalomyelitis. Ann. Neurol. 17, 188-190.
    • (1985) Ann. Neurol. , vol.17 , pp. 188-190
    • Lublin, F.1
  • 89
    • 0020036035 scopus 로고
    • Passive transfer of experimental allergic encephalomyelitis in the Lewis rat with activated spleen cells: Differential activation with mitogens
    • PETERS, B.A., and HINRICHS, D.J. (1982). Passive transfer of experimental allergic encephalomyelitis in the Lewis rat with activated spleen cells: differential activation with mitogens. Cell. Immunol. 69, 175-185.
    • (1982) Cell. Immunol. , vol.69 , pp. 175-185
    • Peters, B.A.1    Hinrichs, D.J.2
  • 90
    • 0026027162 scopus 로고
    • Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer demyelinating relapsing experimental autoimmune encephalomyelitis
    • WHITHAM, R.H., BOURDETTE, D.N., HASHIM, G.A., HERNDON, R.M., ILG, R.C., VANDENBARK, A.A., and OFFNER, H. (1991). Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer demyelinating relapsing experimental autoimmune encephalomyelitis. J. Immunol. 146, 101-107.
    • (1991) J. Immunol. , vol.146 , pp. 101-107
    • Whitham, R.H.1    Bourdette, D.N.2    Hashim, G.A.3    Herndon, R.M.4    Ilg, R.C.5    Vandenbark, A.A.6    Offner, H.7
  • 91
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
    • UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group
    • PATY, D.W., and LI, D.K. (1993). Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group. Neurology 43, 662-667.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.2
  • 92
    • 0030777027 scopus 로고    scopus 로고
    • High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats
    • DIAB, A., ZHU, J., XIAO, B., MUSTAFA, M., and LINK, H. (1997). High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats. J. Neuropathol. Exp. Neurol. 56, 641-650.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 641-650
    • Diab, A.1    Zhu, J.2    Xiao, B.3    Mustafa, M.4    Link, H.5
  • 93
    • 0030248470 scopus 로고    scopus 로고
    • Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: Persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta
    • ISSAZADEH, S., LORENTZEN, J., MUSTAFA, M., HOJEBERG, B., MUSSENER, A., and OLSSON, T. (1996). Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta. J. Neuroimmunol. 69, 103-115.
    • (1996) J. Neuroimmunol. , vol.69 , pp. 103-115
    • Issazadeh, S.1    Lorentzen, J.2    Mustafa, M.3    Hojeberg, B.4    Mussener, A.5    Olsson, T.6
  • 94
    • 0031463988 scopus 로고    scopus 로고
    • Interferon-beta not only inhibits interleukin-1beta and tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells
    • COCLET-NINIM, J., DAYER, J.M., and BURGER, D. (1997). Interferon-beta not only inhibits interleukin-1beta and tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells. Eur. Cytokine Netw. 8, 345-349.
    • (1997) Eur. Cytokine Netw. , vol.8 , pp. 345-349
    • Coclet-Ninim, J.1    Dayer, J.M.2    Burger, D.3
  • 95
    • 0026781817 scopus 로고
    • Type I interferons (IFN-alpha and -beta) suppress cytotoxin (tumor necrosis factor-alpha and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cell
    • ABU-KHABAR, K.S., ARMSTRONG, J.A., and HO, M. (1992). Type I interferons (IFN-alpha and -beta) suppress cytotoxin (tumor necrosis factor-alpha and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cell. J. Leukocyte Biol. 52, 165-172.
    • (1992) J. Leukocyte Biol. , vol.52 , pp. 165-172
    • Abu-Khabar, K.S.1    Armstrong, J.A.2    Ho, M.3
  • 96
    • 0028985427 scopus 로고
    • Interferon-alpha induces circulating tumor necrosis factor receptor p55 in humans
    • TILG, H., VOGEL, W., and DINARELLO, C.A. (1995). Interferon-alpha induces circulating tumor necrosis factor receptor p55 in humans. Blood 85, 433-435.
    • (1995) Blood , vol.85 , pp. 433-435
    • Tilg, H.1    Vogel, W.2    Dinarello, C.A.3
  • 98
    • 0036554140 scopus 로고    scopus 로고
    • Interferon-alpha as an immunotherapeutic protein
    • BRASSARD, D.L., GRACE, M.J., and BORDENS, R.W. (2002). Interferon-alpha as an immunotherapeutic protein. J. Leukocyte Biol. 71, 565-581.
    • (2002) J. Leukocyte Biol. , vol.71 , pp. 565-581
    • Brassard, D.L.1    Grace, M.J.2    Bordens, R.W.3
  • 99
    • 0034803591 scopus 로고    scopus 로고
    • Th1/th2 type cytokines in hepatitis B patients treated with interferon-alpha
    • XING. T., ZHANG, L., LU, Q., HOU, J., FENG, X., and LUO, K. (2001). Th1/th2 type cytokines in hepatitis B patients treated with interferon-alpha. Chin. Med. J. (Engl.) 114, 921-924.
    • (2001) Chin. Med. J. (Engl.) , vol.114 , pp. 921-924
    • Xing, T.1    Zhang, L.2    Lu, Q.3    Hou, J.4    Feng, X.5    Luo, K.6
  • 100
    • 0034843855 scopus 로고    scopus 로고
    • Interferon-alpha drives T cell-mediated immunopathology in the intestine
    • MONTELEONE, G., PENDER, S.L., WATHEN, N.C., and MACDONALD, T.T. (2001). Interferon-alpha drives T cell-mediated immunopathology in the intestine. Eur. J. Immunol. 31, 2247-2255.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2247-2255
    • Monteleone, G.1    Pender, S.L.2    Wathen, N.C.3    Macdonald, T.T.4
  • 102
    • 0034720549 scopus 로고    scopus 로고
    • Ingested interferon-alpha prevents allograft islet transplant rejection
    • BROD, S.A., KATZ, S., PHAN, T., and STEPKOWSKI, S. (2000). Ingested interferon-alpha prevents allograft islet transplant rejection. Transplantation 69, 2162-2166.
    • (2000) Transplantation , vol.69 , pp. 2162-2166
    • Brod, S.A.1    Katz, S.2    Phan, T.3    Stepkowski, S.4
  • 104
    • 0027966060 scopus 로고
    • The present knowledge of the inflammatory process and the inflammatory mediators
    • LEIRISALO-REPO, M. (1994). The present knowledge of the inflammatory process and the inflammatory mediators. Pharmacol. Toxicol. 75, 1-3.
    • (1994) Pharmacol. Toxicol. , vol.75 , pp. 1-3
    • Leirisalo-Repo, M.1
  • 106
    • 0027957152 scopus 로고
    • Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway
    • WECHSLER, A., GORDON, M., DENDORFER, U., and LECLAIR, K. (1994). Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. J. Immunol. 1531, 2515-2523.
    • (1994) J. Immunol. , vol.1531 , pp. 2515-2523
    • Wechsler, A.1    Gordon, M.2    Dendorfer, U.3    Leclair, K.4
  • 107
    • 0030904612 scopus 로고    scopus 로고
    • Elevated cytokine messenger RNA levels in the peripheral blood of patients with rheumatoid arthritis suggest different degrees of myeloid cell activation
    • SCHULZE-KOOPS, H., DAVIS, L.S., KAVANAUGH, A.F., and LIPSKY, P.E. (1997). Elevated cytokine messenger RNA levels in the peripheral blood of patients with rheumatoid arthritis suggest different degrees of myeloid cell activation. Arthritis Rheum. 40, 639-647.
    • (1997) Arthritis Rheum. , vol.40 , pp. 639-647
    • Schulze-Koops, H.1    Davis, L.S.2    Kavanaugh, A.F.3    Lipsky, P.E.4
  • 110
    • 0025318862 scopus 로고
    • Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function
    • DAYNES, R.A., ARANEO, B.A., DOWELL, T.A., HUANG, K., and DUDLEY, D. (1990). Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function. J. Exp. Med. 171, 979-996.
    • (1990) J. Exp. Med. , vol.171 , pp. 979-996
    • Daynes, R.A.1    Araneo, B.A.2    Dowell, T.A.3    Huang, K.4    Dudley, D.5
  • 111
    • 0023895986 scopus 로고
    • Roles of interferon produced in physiological conditions. A speculative review
    • BOCCI, V. (1988). Roles of interferon produced in physiological conditions. A speculative review. Immunology 64, 1-9.
    • (1988) Immunology , vol.64 , pp. 1-9
    • Bocci, V.1
  • 112
    • 0031900178 scopus 로고    scopus 로고
    • Single-blinded controlled trial of low-dose oral IFN-alpha for the treatment of xerostomia in patients with Sjögren's syndrome
    • SHIOZAWA, S., TANAKA, Y., and SHIOZAWA, K. (1998). Single-blinded controlled trial of low-dose oral IFN-alpha for the treatment of xerostomia in patients with Sjögren's syndrome. J. Interferon Cytokine Res. 18, 255-262.
    • (1998) J. Interferon Cytokine Res. , vol.18 , pp. 255-262
    • Shiozawa, S.1    Tanaka, Y.2    Shiozawa, K.3
  • 113
    • 0033174272 scopus 로고    scopus 로고
    • Treatment of primary Sjögren's syndrome with low-dose natural human interferon-alpha administered by the oral mucosal route: A phase II clinical trial
    • IFN Protocol Study Group
    • SHIP, J.A., FOX, P.C., MICHALEK, J.E., CUMMINS, M.J., and RICHARDS, A.B. (1999). Treatment of primary Sjögren's syndrome with low-dose natural human interferon-alpha administered by the oral mucosal route: a phase II clinical trial. IFN Protocol Study Group. J. Interferon Cytokine Res. 19, 943-951.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 943-951
    • Ship, J.A.1    Fox, P.C.2    Michalek, J.E.3    Cummins, M.J.4    Richards, A.B.5
  • 114
    • 0032817561 scopus 로고    scopus 로고
    • Efficacy of low-dose oral use of type I interferon in cytomegalovirus infections in vivo
    • BOSIO, E., BEILHARZ, M.W., WATSON, M.W., and LAWSON, C.M. (1999). Efficacy of low-dose oral use of type I interferon in cytomegalovirus infections in vivo. J. Interferon Cytokine Res. 19, 869-876.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 869-876
    • Bosio, E.1    Beilharz, M.W.2    Watson, M.W.3    Lawson, C.M.4
  • 115
    • 0032839875 scopus 로고    scopus 로고
    • Suppression of late asthmatic response by low-dose oral administration of interferon-beta in the guinea pig model of asthma
    • SATOH, Y., KASAMA, K., KUWABARA, M., YIMIN, DIAO, H.Y., NAKAJIMA, H., KOHANAWA, M., and MINAGAWA, T. (1999). Suppression of late asthmatic response by low-dose oral administration of interferon-beta in the guinea pig model of asthma. J. Interferon Cytokine Res. 19, 887-894.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 887-894
    • Satoh, Y.1    Kasama, K.2    Kuwabara, M.3    Yimin4    Diao, H.Y.5    Nakajima, H.6    Kohanawa, M.7    Minagawa, T.8
  • 116
    • 0003084570 scopus 로고    scopus 로고
    • Regulation of angiogenesis by type I interferon
    • FIDLER, I. (2000). Regulation of angiogenesis by type I interferon. Eur. Cyt. Netw. 11, 96.
    • (2000) Eur. Cyt. Netw. , vol.11 , pp. 96
    • Fidler, I.1
  • 118
    • 0003144648 scopus 로고    scopus 로고
    • The effects of IL-6 and LPS on the expression of SOCS by enterocytes
    • OGLE, C.K., and GUO, X. (2000). The effects of IL-6 and LPS on the expression of SOCS by enterocytes. Eur. Cyt. Netw. 11, 46.
    • (2000) Eur. Cyt. Netw. , vol.11 , pp. 46
    • Ogle, C.K.1    Guo, X.2
  • 119
    • 0032567353 scopus 로고    scopus 로고
    • The suppressor of cytokine signaling (SOCS) 1 and OCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
    • SONG, M.M., and SHUAI, K. (1998). The suppressor of cytokine signaling (SOCS) 1 and OCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273, 35056-35062.
    • (1998) J. Biol. Chem. , vol.273 , pp. 35056-35062
    • Song, M.M.1    Shuai, K.2
  • 121
    • 0027361154 scopus 로고
    • Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: Effect on remission duration and survival - Cancer and Leukemia Group B study 8583
    • OZER, H., GEORGE, S.L., SCHIFFER, C.A., RAO, K., RAO, P.N., WURSTER-HILL, D.H., ARTHUR, D.D., POWELL, B., GOTTLIEB, A., PETERSON, B.A., et al. (1993). Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583. Blood 82, 2975-2984.
    • (1993) Blood , vol.82 , pp. 2975-2984
    • Ozer, H.1    George, S.L.2    Schiffer, C.A.3    Rao, K.4    Rao, P.N.5    Wurster-Hill, D.H.6    Arthur, D.D.7    Powell, B.8    Gottlieb, A.9    Peterson, B.A.10
  • 122
    • 0033372623 scopus 로고    scopus 로고
    • Available options for treatment of interferon nonresponders
    • BACON, B.R. (1999). Available options for treatment of interferon nonresponders. Am. J. Med. 107, 67S-70S.
    • (1999) Am. J. Med. , vol.107
    • Bacon, B.R.1
  • 123
    • 0033849496 scopus 로고    scopus 로고
    • Contrasting responses to interferon beta-1b treatment in relapsing-remitting multiple sclerosis: Does baseline interleukin-12p35 messenger RNA predict the efficacy of treatment?
    • VAN BOXEL-DEZAIRE, A.H., VAN TRIGT-HOFF, S.C., KILLESTEIN, J., SCHRIJVER, H.M., VAN HOUWELINGEN, J.C., POLMAN, C.H., and NAGELKERKEN, L. (2000). Contrasting responses to interferon beta-1b treatment in relapsing-remitting multiple sclerosis: does baseline interleukin-12p35 messenger RNA predict the efficacy of treatment? Ann. Neurol. 48, 313-322.
    • (2000) Ann. Neurol. , vol.48 , pp. 313-322
    • Van Boxel-Dezaire, A.H.1    Van Trigt-Hoff, S.C.2    Killestein, J.3    Schrijver, H.M.4    Van Houwelingen, J.C.5    Polman, C.H.6    Nagelkerken, L.7
  • 125
    • 0034544374 scopus 로고    scopus 로고
    • Expression of HuIFN-alphaR2 chain of type I interferon receptor in human hepatocellular carcinoma and non-cancerous tissues
    • TAKAYAMA, A., YANO, H., OGASAWARA, S., HIGAKI, K., and KOJIRO, M. (2000). Expression of HuIFN-alphaR2 chain of type I interferon receptor in human hepatocellular carcinoma and non-cancerous tissues. Int. J. Mol. Med. 6, 621-627.
    • (2000) Int. J. Mol. Med. , vol.6 , pp. 621-627
    • Takayama, A.1    Yano, H.2    Ogasawara, S.3    Higaki, K.4    Kojiro, M.5
  • 126
    • 0032030169 scopus 로고    scopus 로고
    • The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: Effects on JAK-Stat activation and receptor down-regulation
    • BASU, L., YANG, C.H., MURTI, A., GARCIA, J.V., CROZE, E., CONSTANTINESCU, S.N., MULLERSMAN, J.E., and PFEFFER, L.M. (1998). The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: effects on JAK-Stat activation and receptor down-regulation. Virology 242, 14-21.
    • (1998) Virology , vol.242 , pp. 14-21
    • Basu, L.1    Yang, C.H.2    Murti, A.3    Garcia, J.V.4    Croze, E.5    Constantinescu, S.N.6    Mullersman, J.E.7    Pfeffer, L.M.8
  • 127
    • 0025669818 scopus 로고
    • Treatment of rotavirus infection in neonate and weanling pigs using natural human interferon alpha
    • LECCE, J.G., CUMMINS, J.M., and RICHARDS, A.B. (1990). Treatment of rotavirus infection in neonate and weanling pigs using natural human interferon alpha. J. Mol. Biother. 2, 211-216.
    • (1990) J. Mol. Biother. , vol.2 , pp. 211-216
    • Lecce, J.G.1    Cummins, J.M.2    Richards, A.B.3
  • 132
    • 0027732797 scopus 로고
    • Oral therapy with human interferon alpha in calves experimentally injected with infectious bovine rhinotracheitis virus
    • CUMMINS, J.M., HUTCHESON, D.P., CUMMINS, M.J., GEORGIADES, J.A., and RICHARDS, A.B. (1993). Oral therapy with human interferon alpha in calves experimentally injected with infectious bovine rhinotracheitis virus. Arch. Immunol. Ther. Exp. (Warsz.) 41, 193-197.
    • (1993) Arch. Immunol. Ther. Exp. (Warsz.) , vol.41 , pp. 193-197
    • Cummins, J.M.1    Hutcheson, D.P.2    Cummins, M.J.3    Georgiades, J.A.4    Richards, A.B.5
  • 134
    • 0026561074 scopus 로고
    • Low-dose oral natural human interferon-alpha in 29 patients with HIV-1 infection: A double-blind, randomized, placebo-controlled trial
    • KAISER, G., JAEGER, H., BIRKMANN, J., POPPINGER, J., CUMMINS, J., and GALLMEIER, W. (1992). Low-dose oral natural human interferon-alpha in 29 patients with HIV-1 infection: a double-blind, randomized, placebo-controlled trial. AIDS 6, 563-569.
    • (1992) AIDS , vol.6 , pp. 563-569
    • Kaiser, G.1    Jaeger, H.2    Birkmann, J.3    Poppinger, J.4    Cummins, J.5    Gallmeier, W.6
  • 135
  • 137
    • 0031716564 scopus 로고    scopus 로고
    • Oral-mucosal administration of IFN-alpha potentiates immune response in mice
    • In Process Citation
    • NAGAO, Y., YAMASHIRO, K., HARA, N., HORISAWA, Y., KATO, K., and UEMURA, A. (1998). Oral-mucosal administration of IFN-alpha potentiates immune response in mice [In Process Citation]. J. Interferon Cytokine Res. 18, 661-666.
    • (1998) J. Interferon Cytokine Res. , vol.18 , pp. 661-666
    • Nagao, Y.1    Yamashiro, K.2    Hara, N.3    Horisawa, Y.4    Kato, K.5    Uemura, A.6
  • 138
    • 0032840891 scopus 로고    scopus 로고
    • Interferon action on avian viruses. I. Oral administration of chicken interferon-alpha ameliorates Newcastle disease
    • MARCUS, P.I., VAN DER HEIDE, L., and SEKELLICK, M.J. (1999). Interferon action on avian viruses. I. Oral administration of chicken interferon-alpha ameliorates Newcastle disease. J. Interferon Cytokine Res. 19, 881-885.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 881-885
    • Marcus, P.I.1    Van Der Heide, L.2    Sekellick, M.J.3
  • 139
    • 0033017851 scopus 로고    scopus 로고
    • Oromucosal interferon therapy: Marked antiviral and antitumor activity
    • TOVEY, M.G., and MAURY, C. (1999). Oromucosal interferon therapy: marked antiviral and antitumor activity. J. Interferon Cytokine Res. 19, 145-155.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 145-155
    • Tovey, M.G.1    Maury, C.2
  • 140
    • 22244491347 scopus 로고    scopus 로고
    • Deep-lung delivery of proteins
    • PATTON, J. (1998). Deep-lung delivery of proteins. Modern Drug Deliv. 1, 19-28.
    • (1998) Modern Drug Deliv. , vol.1 , pp. 19-28
    • Patton, J.1
  • 141
    • 0024407508 scopus 로고
    • Pharmacokinetics and toxicity of inhaled human interferon-alpha in patients with lung cancer
    • KINNULA, V., MATTSON, K., and CANTELL, K. (1989). Pharmacokinetics and toxicity of inhaled human interferon-alpha in patients with lung cancer. J. Interferon Res. 9, 419-423.
    • (1989) J. Interferon Res. , vol.9 , pp. 419-423
    • Kinnula, V.1    Mattson, K.2    Cantell, K.3
  • 143
    • 0029005118 scopus 로고
    • Immune tolerance and protection against allergic sensitization
    • HOLT, P.G. (1995). Immune tolerance and protection against allergic sensitization. Allergy, 50, 34-36.
    • (1995) Allergy , vol.50 , pp. 34-36
    • Holt, P.G.1
  • 144
    • 0030202910 scopus 로고    scopus 로고
    • Immunoregulation of the allergic reaction in the respiratory tract
    • HOLT, P.G. (1996). Immunoregulation of the allergic reaction in the respiratory tract. Eur. Respir. J. 22(Suppl.), 85s-89s.
    • (1996) Eur. Respir. J. , vol.22 , Issue.SUPPL.
    • Holt, P.G.1
  • 145
    • 0002519643 scopus 로고    scopus 로고
    • Delivery of biotherapeutics by inhalation aerosol
    • A.L. Adjei and P.K. Gupta (eds.) New York: Marcel Dekker
    • NIVEN. R. (1997). Delivery of biotherapeutics by inhalation aerosol. In: Inhalation Delivery of Therapeutic Peptides and Proteins. A.L. Adjei and P.K. Gupta (eds.) New York: Marcel Dekker, pp. 151-231.
    • (1997) Inhalation Delivery of Therapeutic Peptides and Proteins , pp. 151-231
    • Niven, R.1
  • 146
    • 4243546231 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacodynamics of a recombinant human interferon beta 1a following oral administration in healthy male volunteers
    • TRINCHARD-LUGAN, I., BUCLIN, T., LAPOINTE, K., SPERTINI, F., BIOLLAZ, J., FRANCIS, G., MUNAFO, A., and YTHIER, A. (2002). Safety, tolerability, and pharmacodynamics of a recombinant human interferon beta 1a following oral administration in healthy male volunteers. Neurology 58, A491.
    • (2002) Neurology , vol.58
    • Trinchard-Lugan, I.1    Buclin, T.2    Lapointe, K.3    Spertini, F.4    Biollaz, J.5    Francis, G.6    Munafo, A.7    Ythier, A.8
  • 147
    • 0002376956 scopus 로고    scopus 로고
    • Clinical trial of oral interferon beta 1a (r/beneferon) in relapsing remitting MS
    • POLMAN, C., KAPPOS, L., POZZILLI, C., DAHLKE, F., SANDBRINK, R., and BARKHOF, F. (2001). Clinical trial of oral interferon beta 1a (r/beneferon) in relapsing remitting MS. Mult. Scler. 7(Suppl. 11), S10.
    • (2001) Mult. Scler. , vol.7 , Issue.SUPPL. 11
    • Polman, C.1    Kappos, L.2    Pozzilli, C.3    Dahlke, F.4    Sandbrink, R.5    Barkhof, F.6
  • 148
    • 0026720880 scopus 로고
    • The clinical application of the interferons: A review
    • NSW Therapeutic Assessment Group
    • STUART-HARRIS, R.C., LAUCHLAN, R., and DAY, R. (1992). The clinical application of the interferons: a review. NSW Therapeutic Assessment Group. Med. J. Aust. 156, 869-872.
    • (1992) Med. J. Aust. , vol.156 , pp. 869-872
    • Stuart-Harris, R.C.1    Lauchlan, R.2    Day, R.3
  • 149
    • 0023099032 scopus 로고
    • Clinical overview of alpha interferon. Studies and future directions
    • SPIEGEL, R.J. (1987). Clinical overview of alpha interferon. Studies and future directions. Cancer 59, 626-631.
    • (1987) Cancer , vol.59 , pp. 626-631
    • Spiegel, R.J.1
  • 151
    • 0036022693 scopus 로고    scopus 로고
    • Spotlight on peginterferon-alpha-2a (40KD) in chronic hepatitis C
    • PERRY, C.M., and JARVIS, B. (2002). Spotlight on peginterferon-alpha-2a (40KD) in chronic hepatitis C. BioDrugs 16, 213-217.
    • (2002) BioDrugs , vol.16 , pp. 213-217
    • Perry, C.M.1    Jarvis, B.2
  • 152
    • 0029420586 scopus 로고
    • Interferon alpha treatment of relapsing-remitting multiple sclerosis: Long-term study of the correlations between clinical and magnetic resonance imaging results and effects on the immune function
    • DURELLI, L., BONGIOANNI, M.R., CAVALLO, R., FERRERO, B., FERRI, R., VERDUN, E., BRADAC, G.B., RIVA, A., GEUNA, M., BERGAMINI, L., et al. (1995). Interferon alpha treatment of relapsing-remitting multiple sclerosis: long-term study of the correlations between clinical and magnetic resonance imaging results and effects on the immune function. Mult. Scler. 1, S32-37.
    • (1995) Mult. Scler. , vol.1
    • Durelli, L.1    Bongioanni, M.R.2    Cavallo, R.3    Ferrero, B.4    Ferri, R.5    Verdun, E.6    Bradac, G.B.7    Riva, A.8    Geuna, M.9    Bergamini, L.10
  • 153
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS (PREVENTION OF RELAPSES AND DISABILITY BY INTERFERON BETA-1A SUBCUTANEOUSLY IN MULTIPLE SCLEROSIS) STUDY GROUP. (1998). Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 352, 1498-1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 155
    • 0032417696 scopus 로고    scopus 로고
    • Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays
    • DER, S.D., ZHOU, A., WILLIAMS, B.R., and SILVERMAN, R.H. (1998). Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc. Natl. Acad. Sci. USA 95, 15623-15628.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15623-15628
    • Der, S.D.1    Zhou, A.2    Williams, B.R.3    Silverman, R.H.4
  • 157
    • 0029076226 scopus 로고
    • The IFN pregnancy recognition hormone IFN-tau blocks both development and super-antigen reactivation of experimental allergic encephalomyelitis without associated toxicity
    • SOOS, J.M., SUBRAMANIAM, P.S., HOBEIKA, A.C., SCHIFFENBAUER, J., and JOHNSON, H.M. (1995). The IFN pregnancy recognition hormone IFN-tau blocks both development and super-antigen reactivation of experimental allergic encephalomyelitis without associated toxicity. J. Immunol. 155, 2747-2753.
    • (1995) J. Immunol. , vol.155 , pp. 2747-2753
    • Soos, J.M.1    Subramaniam, P.S.2    Hobeika, A.C.3    Schiffenbauer, J.4    Johnson, H.M.5
  • 158
    • 0030894174 scopus 로고    scopus 로고
    • CD4 T suppressor cells mediate interferon tau protection against experimental allergic encephalomyelitis
    • MUJTABA, M.G., SOOS, J.M., and JOHNSON, H.M. (1997). CD4 T suppressor cells mediate interferon tau protection against experimental allergic encephalomyelitis. J. Neuroimmunol. 75, 35-42.
    • (1997) J. Neuroimmunol. , vol.75 , pp. 35-42
    • Mujtaba, M.G.1    Soos, J.M.2    Johnson, H.M.3
  • 159
    • 0031456603 scopus 로고    scopus 로고
    • The antiproliferative and antiviral activities of IFN-tau variants in human cells
    • ALEXENKO, A.P., LEAMAN, D.W., LI, J., and ROBERTS, R.M. (1997). The antiproliferative and antiviral activities of IFN-tau variants in human cells. J. Interferon Cytokine Res. 17, 769-779.
    • (1997) J. Interferon Cytokine Res. , vol.17 , pp. 769-779
    • Alexenko, A.P.1    Leaman, D.W.2    Li, J.3    Roberts, R.M.4
  • 160
    • 0029420676 scopus 로고
    • Human interferon omega - A review
    • ADOLF, G.R. (1995). Human interferon omega - a review. Mult. Scler. 1(Suppl. 1) S44-47.
    • (1995) Mult. Scler. , vol.1 , Issue.SUPPL. 1
    • Adolf, G.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.