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Volumn , Issue 4, 2003, Pages

Molecular mechanisms of irradiation-induced apoptosis

Author keywords

Apaf 1; Apoptosis; Bax; Bcl 2; Death receptors; DNA chip; DNA microarray; Fas; FasL; Gene expression; Genomics; Irradiation; Review; Systems biology; Transcription activation

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BCL 2;

EID: 0345826544     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/927     Document Type: Review
Times cited : (40)

References (120)
  • 1
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B.B. & S.J. Elledge: The DNA damage response: putting checkpoints in perspective. Nature 408, 433-9 (2000)
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 2
    • 0034641963 scopus 로고    scopus 로고
    • Defying death after DNA damage
    • Rich, T., R.L. Allen & A.H. Wyllie: Defying death after DNA damage. Nature 407, 777-83 (2000)
    • (2000) Nature , vol.407 , pp. 777-783
    • Rich, T.1    Allen, R.L.2    Wyllie, A.H.3
  • 3
    • 0033593572 scopus 로고    scopus 로고
    • Cell Death in Development
    • Vaux, D.L. & S.J. Korsmeyer: Cell Death in Development. Cell 96, 245-254 (1999)
    • (1999) Cell , vol.96 , pp. 245-254
    • Vaux, D.L.1    Korsmeyer, S.J.2
  • 4
    • 0033119367 scopus 로고    scopus 로고
    • Genetic control of programmed cell death in the nematode Caenorhabditis elegans
    • Horvitz, H.R.: Genetic control of programmed cell death in the nematode Caenorhabditis elegans. Cancer Res 59, 1701s-1706s. (1999)
    • (1999) Cancer Res , vol.59
    • Horvitz, H.R.1
  • 5
    • 0032440288 scopus 로고    scopus 로고
    • Mechanisms and control of programmed cell death in invertebrates
    • Bergmann, A., J. Agapite & H. Steller: Mechanisms and control of programmed cell death in invertebrates. Oncogene 17, 3215-3223 (1998)
    • (1998) Oncogene , vol.17 , pp. 3215-3223
    • Bergmann, A.1    Agapite, J.2    Steller, H.3
  • 7
    • 0025255636 scopus 로고
    • The Caenorhabditis elegans Genes ced-3 and ced-4 Act Cell Autonomously to Cause Programmed Cell Death
    • Yuan, J. & H.R. Horvitz: The Caenorhabditis elegans Genes ced-3 and ced-4 Act Cell Autonomously to Cause Programmed Cell Death. Developmental Biol. 138, 33-41 (1990)
    • (1990) Developmental Biol. , vol.138 , pp. 33-41
    • Yuan, J.1    Horvitz, H.R.2
  • 8
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    • Yuan, J., S. Shaham, S. Ledoux, H.M. Ellis & H.R. Horvitz: The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75, 641-52. (1993)
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 9
    • 0028147070 scopus 로고
    • Programmed cell death in Caenorhabditis elegans
    • Hengartner, M.O. & H.R. Horvitz: Programmed cell death in Caenorhabditis elegans. Curr Opin Genet Dev 4, 581-6. (1994)
    • (1994) Curr Opin Genet Dev , vol.4 , pp. 581-586
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 10
    • 0031918223 scopus 로고    scopus 로고
    • BCL-2 family: Regulators of cell death
    • Chao, D.T. & S.J. Korsmeyer: BCL-2 family: regulators of cell death. Annu Rev Immunol 16, 395-419. (1998)
    • (1998) Annu Rev Immunol , vol.16 , pp. 395-419
    • Chao, D.T.1    Korsmeyer, S.J.2
  • 11
    • 0035146929 scopus 로고    scopus 로고
    • Life-or-death decisions by the Bcl-2 protein family
    • Adams, J.M. & S. Cory: Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci 26, 61-6. (2001)
    • (2001) Trends Biochem Sci , vol.26 , pp. 61-66
    • Adams, J.M.1    Cory, S.2
  • 12
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou, H., W.J. Henzel, X. Liu, A. Lutschg & X. Wang: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-13. (1997)
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 13
    • 0033179212 scopus 로고    scopus 로고
    • An exegesis of IAPs: Salvation and surprises from BIR motifs
    • Miller, L.K.: An exegesis of IAPs: salvation and surprises from BIR motifs. Trends Cell Biol 9, 323-8. (1999)
    • (1999) Trends Cell Biol , vol.9 , pp. 323-328
    • Miller, L.K.1
  • 14
    • 0033724694 scopus 로고    scopus 로고
    • Understanding IAP function and regulation: A view from Drosophila
    • Hay, B.A.: Understanding IAP function and regulation: a view from Drosophila. Cell Death Differ 7, 1045-56. (2000)
    • (2000) Cell Death Differ , vol.7 , pp. 1045-1056
    • Hay, B.A.1
  • 15
    • 0034282432 scopus 로고    scopus 로고
    • The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
    • Huang, H., C.A. Joazeiro, E. Bonfoco, S. Kamada, J.D. Leverson & T. Hunter: The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. J Biol Chem 275, 26661-4. (2000)
    • (2000) J Biol Chem , vol.275 , pp. 26661-26664
    • Huang, H.1    Joazeiro, C.A.2    Bonfoco, E.3    Kamada, S.4    Leverson, J.D.5    Hunter, T.6
  • 17
    • 0029161958 scopus 로고
    • The head involution defective gene of Drosophila melanogaster functions in programmed cell death
    • Grether, M.E., J.M. Abrams, J. Agapite, K. White & H. Steller: The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes & Dev. 9, 1694-1708. (1995)
    • (1995) Genes & Dev. , vol.9 , pp. 1694-1708
    • Grether, M.E.1    Abrams, J.M.2    Agapite, J.3    White, K.4    Steller, H.5
  • 18
    • 0029742260 scopus 로고    scopus 로고
    • grim, a novel cell death gene in Drosophila
    • Chen, P., W. Nordstrom, B. Gish & J.M. Abrams: grim, a novel cell death gene in Drosophila. Genes Dev. 10, 1773-1782 (1996)
    • (1996) Genes Dev. , vol.10 , pp. 1773-1782
    • Chen, P.1    Nordstrom, W.2    Gish, B.3    Abrams, J.M.4
  • 21
    • 0037154014 scopus 로고    scopus 로고
    • The Damage-Responsive Drosophila Gene sickle Encodes a Novel IAP Binding Protein Similar to but Distinct from reaper, grim, and hid
    • Christich, A., S. Kauppila, P. Chen, N. Sogame, S.I. Ho & J.M. Abrams: The Damage-Responsive Drosophila Gene sickle Encodes a Novel IAP Binding Protein Similar to but Distinct from reaper, grim, and hid. Curr Biol 12, 137-40. (2002)
    • (2002) Curr Biol , vol.12 , pp. 137-140
    • Christich, A.1    Kauppila, S.2    Chen, P.3    Sogame, N.4    Ho, S.I.5    Abrams, J.M.6
  • 22
    • 0034886271 scopus 로고    scopus 로고
    • Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides
    • Wu, J.W., A.E. Cocina, J. Chai, B.A. Hay & Y. Shi: Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol Cell 8, 95-104. (2001)
    • (2001) Mol Cell , vol.8 , pp. 95-104
    • Wu, J.W.1    Cocina, A.E.2    Chai, J.3    Hay, B.A.4    Shi, Y.5
  • 23
    • 0030906521 scopus 로고    scopus 로고
    • Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins
    • Harvey, A., B. AP & M. LK: Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of- apoptosis proteins. Mol Cell Biol 17(5), 2835-2843. (1997)
    • (1997) Mol Cell Biol , vol.17 , Issue.5 , pp. 2835-2843
    • Harvey, A.1    Ap, B.2    Lk, M.3
  • 24
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du, C., M. Fang, Y. Li, L. Li & X. Wang: Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102, 33-42 (2000)
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 25
    • 0034710649 scopus 로고    scopus 로고
    • Structural and biochemical basis of apoptotic activation by Smac/DIABLO
    • Chai, J., C. Du, J.W. Wu, S. Kyin, X. Wang & Y. Shi: Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 406, 855-62 (2000)
    • (2000) Nature , vol.406 , pp. 855-862
    • Chai, J.1    Du, C.2    Wu, J.W.3    Kyin, S.4    Wang, X.5    Shi, Y.6
  • 27
    • 0034785591 scopus 로고    scopus 로고
    • A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
    • Suzuki, Y., Y. Imai, H. Nakayama, K. Takahashi, K. Takio & R. Takahashi: A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8, 613-21. (2001)
    • (2001) Mol Cell , vol.8 , pp. 613-621
    • Suzuki, Y.1    Imai, Y.2    Nakayama, H.3    Takahashi, K.4    Takio, K.5    Takahashi, R.6
  • 29
    • 0027281373 scopus 로고
    • A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
    • Itoh, N. & S. Nagata: A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 268, 10932-7. (1993)
    • (1993) J Biol Chem , vol.268 , pp. 10932-10937
    • Itoh, N.1    Nagata, S.2
  • 30
    • 0028238410 scopus 로고
    • Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells
    • Daniel, P.T. & P.H. Krammer: Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells. J Immunol 152, 5624-32. (1994)
    • (1994) J Immunol , vol.152 , pp. 5624-5632
    • Daniel, P.T.1    Krammer, P.H.2
  • 31
    • 0034536743 scopus 로고    scopus 로고
    • Regulation of death receptor-mediated apoptosis pathways
    • Schmitz, I., S. Kirchhoff & P.H. Krammer: Regulation of death receptor-mediated apoptosis pathways. Int J Biochem Cell Biol 32, 1123-36. (2000)
    • (2000) Int J Biochem Cell Biol , vol.32 , pp. 1123-1136
    • Schmitz, I.1    Kirchhoff, S.2    Krammer, P.H.3
  • 32
    • 0033396491 scopus 로고    scopus 로고
    • Fas ligand-induced apoptosis
    • Nagata, S.: Fas ligand-induced apoptosis. Annu Rev Genet 33, 29-55. (1999)
    • (1999) Annu Rev Genet , vol.33 , pp. 29-55
    • Nagata, S.1
  • 33
    • 0029007855 scopus 로고
    • The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    • Hsu, H., J. Xiong & D.V. Goeddel: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81, 495-504. (1995)
    • (1995) Cell , vol.81 , pp. 495-504
    • Hsu, H.1    Xiong, J.2    Goeddel, D.V.3
  • 34
    • 0029026548 scopus 로고
    • FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
    • Chinnaiyan, A.M., K. O'Rourke, M. Tewari & V.M. Dixit: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505-12 (1995)
    • (1995) Cell , vol.81 , pp. 505-512
    • Chinnaiyan, A.M.1    O'Rourke, K.2    Tewari, M.3    Dixit, V.M.4
  • 35
    • 0031615875 scopus 로고    scopus 로고
    • Autoproteolytic activation of pro-caspases by oligomerization
    • Yang, X., H.Y. Chang & D. Baltimore: Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell 1, 319-25. (1998)
    • (1998) Mol Cell , vol.1 , pp. 319-325
    • Yang, X.1    Chang, H.Y.2    Baltimore, D.3
  • 37
    • 0033231548 scopus 로고    scopus 로고
    • HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis
    • Zhou, L., Z. Song, J. Tittel & H. Steller: HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. Mol Cell 4, 745-55. (1999)
    • (1999) Mol Cell , vol.4 , pp. 745-755
    • Zhou, L.1    Song, Z.2    Tittel, J.3    Steller, H.4
  • 38
    • 0033231614 scopus 로고    scopus 로고
    • Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4- Related caspase activator
    • Kanuka, H., K. Sawamoto, N. Inohara, K. Matsuno, H. Okano & M. Miura: Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4- related caspase activator. Mol Cell 4, 757-69 (1999)
    • (1999) Mol Cell , vol.4 , pp. 757-769
    • Kanuka, H.1    Sawamoto, K.2    Inohara, N.3    Matsuno, K.4    Okano, H.5    Miura, M.6
  • 39
    • 0033193863 scopus 로고    scopus 로고
    • Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
    • Rodriguez, A., H. Oliver, H. Zou, P. Chen, X. Wang & J.M. Abrams: Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol 1, 272-9 (1999)
    • (1999) Nat Cell Biol , vol.1 , pp. 272-279
    • Rodriguez, A.1    Oliver, H.2    Zou, H.3    Chen, P.4    Wang, X.5    Abrams, J.M.6
  • 41
    • 0034193520 scopus 로고    scopus 로고
    • The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
    • Brachmann, C.B., O.W. Jassim, B.D. Wachsmuth & R.L. Cagan: The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation. Curr Biol 10, 547-50 (2000)
    • (2000) Curr Biol , vol.10 , pp. 547-550
    • Brachmann, C.B.1    Jassim, O.W.2    Wachsmuth, B.D.3    Cagan, R.L.4
  • 42
    • 0034613376 scopus 로고    scopus 로고
    • dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD
    • Hu, S. & X. Yang: dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. J Biol Chem 275, 30761-4. (2000)
    • (2000) J Biol Chem , vol.275 , pp. 30761-30764
    • Hu, S.1    Yang, X.2
  • 44
    • 0034698097 scopus 로고    scopus 로고
    • Deterin, a new inhibitor of apoptosis from Drosophila melanogaster
    • Jones, G., D. Jones, L. Zhou, H. Steller & Y. Chu: Deterin, a new inhibitor of apoptosis from Drosophila melanogaster. J Biol Chem 275, 22157-65 (2000)
    • (2000) J Biol Chem , vol.275 , pp. 22157-22165
    • Jones, G.1    Jones, D.2    Zhou, L.3    Steller, H.4    Chu, Y.5
  • 45
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li, H., H. Zhu, C.J. Xu & J. Yuan: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491-501. (1998)
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 46
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo, X., I. Budihardjo, H. Zou, C. Slaughter & X. Wang: Bid, A Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-490 (1998)
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 47
    • 0035803568 scopus 로고    scopus 로고
    • Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
    • Adrain, C., E.M. Creagh & S.J. Martin: Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. Embo J 20, 6627-36. (2001)
    • (2001) Embo J , vol.20 , pp. 6627-6636
    • Adrain, C.1    Creagh, E.M.2    Martin, S.J.3
  • 48
    • 0036205587 scopus 로고    scopus 로고
    • Mechanisms of Caspase Activation and Inhibition during Apoptosis
    • Shi, Y.: Mechanisms of Caspase Activation and Inhibition during Apoptosis. Mol Cell 9, 459-70. (2002)
    • (2002) Mol Cell , vol.9 , pp. 459-470
    • Shi, Y.1
  • 50
    • 0034700491 scopus 로고    scopus 로고
    • Structural basis of IAP recognition by Smac/DIABLO
    • Wu, G., J. Chai, T.L. Suber, J.W. Wu, C. Du, X. Wang & Y. Shi: Structural basis of IAP recognition by Smac/DIABLO. Nature 408, 1008-12. (2000)
    • (2000) Nature , vol.408 , pp. 1008-1012
    • Wu, G.1    Chai, J.2    Suber, T.L.3    Wu, J.W.4    Du, C.5    Wang, X.6    Shi, Y.7
  • 52
    • 0034677545 scopus 로고    scopus 로고
    • DNA damage-related gene expression as biomarkers to assess cellular response after gamma irradiation of a human lymphoblastoid cell line
    • Bishay, K., K. Ory, J. Lebeau, C. Levalois, M.F. Olivier & S. Chevillard: DNA damage-related gene expression as biomarkers to assess cellular response after gamma irradiation of a human lymphoblastoid cell line. Oncogene 19, 916-23. (2000)
    • (2000) Oncogene , vol.19 , pp. 916-923
    • Bishay, K.1    Ory, K.2    Lebeau, J.3    Levalois, C.4    Olivier, M.F.5    Chevillard, S.6
  • 53
    • 0033888469 scopus 로고    scopus 로고
    • Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin
    • Ouhtit, A., H.K. Muller, D.W. Davis, S.E. Ullrich, D. McConkey & H.N. Ananthaswamy: Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol 156, 201-7. (2000)
    • (2000) Am J Pathol , vol.156 , pp. 201-207
    • Ouhtit, A.1    Muller, H.K.2    Davis, D.W.3    Ullrich, S.E.4    McConkey, D.5    Ananthaswamy, H.N.6
  • 55
    • 0034710543 scopus 로고    scopus 로고
    • Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death
    • Holcik, M., C. Yeh, R.G. Korneluk & T. Chow: Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death. Oncogene 19, 4174-7. (2000)
    • (2000) Oncogene , vol.19 , pp. 4174-4177
    • Holcik, M.1    Yeh, C.2    Korneluk, R.G.3    Chow, T.4
  • 56
    • 0030959304 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation required for anti-apoptosis function
    • Ito, T., X. Deng, B. Carr & W.S. May: Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 272, 11671-3. (1997)
    • (1997) J Biol Chem , vol.272 , pp. 11671-11673
    • Ito, T.1    Deng, X.2    Carr, B.3    May, W.S.4
  • 57
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • Yamamoto, K., H. Ichijo & S.J. Korsmeyer: BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19, 8469-78. (1999)
    • (1999) Mol Cell Biol , vol.19 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 58
    • 0034607655 scopus 로고    scopus 로고
    • Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
    • Yang, Y., S. Fang, J.P. Jensen, A.M. Weissman & J.D. Ashwell: Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288, 874-7. (2000)
    • (2000) Science , vol.288 , pp. 874-877
    • Yang, Y.1    Fang, S.2    Jensen, J.P.3    Weissman, A.M.4    Ashwell, J.D.5
  • 59
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
    • Li, P., D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri & X. Wang: Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade. Cell 91, 479-489 (1997)
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 60
    • 0006470452 scopus 로고    scopus 로고
    • Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses
    • Amundson, S.A., M. Bittner, Y. Chen, J. Trent, P. Meltzer & A.J. Fornace, Jr.: Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18, 3666-72. (1999)
    • (1999) Oncogene , vol.18 , pp. 3666-3672
    • Amundson, S.A.1    Bittner, M.2    Chen, Y.3    Trent, J.4    Meltzer, P.5    Fornace Jr., A.J.6
  • 61
    • 0035797473 scopus 로고    scopus 로고
    • Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
    • Burns, T.F., E.J. Bernhard & W.S. El-Deiry: Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 20, 4601-12. (2001)
    • (2001) Oncogene , vol.20 , pp. 4601-4612
    • Burns, T.F.1    Bernhard, E.J.2    El-Deiry, W.S.3
  • 62
    • 0032772492 scopus 로고    scopus 로고
    • Radiation-induced apoptosis and gene expression in neonatal kidney and testis with and without protein synthesis inhibition
    • Gobe, G.C., B. Harmon, J. Leighton & D.J. Allan: Radiation-induced apoptosis and gene expression in neonatal kidney and testis with and without protein synthesis inhibition. Int J Radiat Biol 75, 973-83. (1999)
    • (1999) Int J Radiat Biol , vol.75 , pp. 973-983
    • Gobe, G.C.1    Harmon, B.2    Leighton, J.3    Allan, D.J.4
  • 64
    • 0032833645 scopus 로고    scopus 로고
    • Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis
    • Granville, D.J., J.R. Shaw, S. Leong, C.M. Carthy, P. Margaron, D.W. Hunt & B.M. McManus: Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis. Am J Pathol 155, 1021-5. (1999)
    • (1999) Am J Pathol , vol.155 , pp. 1021-1025
    • Granville, D.J.1    Shaw, J.R.2    Leong, S.3    Carthy, C.M.4    Margaron, P.5    Hunt, D.W.6    McManus, B.M.7
  • 66
    • 0035876483 scopus 로고    scopus 로고
    • BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
    • Zong, W.X., T. Lindsten, A.J. Ross, G.R. MacGregor & C.B. Thompson: BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15, 1481-6. (2001)
    • (2001) Genes Dev , vol.15 , pp. 1481-1486
    • Zong, W.X.1    Lindsten, T.2    Ross, A.J.3    MacGregor, G.R.4    Thompson, C.B.5
  • 68
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T. & J.C. Reed: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299 (1995)
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 69
    • 0034667482 scopus 로고    scopus 로고
    • Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells
    • Gong, B. & A. Almasan: Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells. Cancer Res 60, 5754-60. (2000)
    • (2000) Cancer Res , vol.60 , pp. 5754-5760
    • Gong, B.1    Almasan, A.2
  • 71
    • 0033529717 scopus 로고    scopus 로고
    • The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene
    • Conradt, B. & H.R. Horvitz: The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. Cell 98, 317-27. (1999)
    • (1999) Cell , vol.98 , pp. 317-327
    • Conradt, B.1    Horvitz, H.R.2
  • 73
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis, R.J.: Signal transduction by the JNK group of MAP kinases. Cell 103, 239-52. (2000)
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 77
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • Zha, J., H. Harada, E. Yang, J. Jockel & S.J. Korsmeyer: Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell 87, 619-28. (1996)
    • (1996) Cell , vol.87 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 79
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., M. Dickens, J. Raingeaud, R.J. Davis & M.E. Greenberg: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-31 (1995)
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 80
    • 0035921686 scopus 로고    scopus 로고
    • Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation
    • Dunkern, T.R., G. Fritz & B. Kaina: Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation. Oncogene 20, 6026-38. (2001)
    • (2001) Oncogene , vol.20 , pp. 6026-6038
    • Dunkern, T.R.1    Fritz, G.2    Kaina, B.3
  • 81
    • 0034632668 scopus 로고    scopus 로고
    • Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine
    • Pritchard, D.M., C. Print, L. O'Reilly, J.M. Adams, C.S. Potten & J.A. Hickman: Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine. Oncogene 19, 3955-9. (2000)
    • (2000) Oncogene , vol.19 , pp. 3955-3959
    • Pritchard, D.M.1    Print, C.2    O'Reilly, L.3    Adams, J.M.4    Potten, C.S.5    Hickman, J.A.6
  • 82
    • 0033518139 scopus 로고    scopus 로고
    • Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: Investigations of the mechanistic determinants of epithelial apoptosis in vivo
    • Pritchard, D.M., C.S. Potten, S.J. Korsmeyer, S. Roberts & J.A. Hickman: Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 18, 7287-93. (1999)
    • (1999) Oncogene , vol.18 , pp. 7287-7293
    • Pritchard, D.M.1    Potten, C.S.2    Korsmeyer, S.J.3    Roberts, S.4    Hickman, J.A.5
  • 89
    • 0035879884 scopus 로고    scopus 로고
    • Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells
    • Shinoura, N., S. Sakurai, A. Asai, T. Kirino & H. Hamada: Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells. Int J Cancer 93, 252-61. (2001)
    • (2001) Int J Cancer , vol.93 , pp. 252-261
    • Shinoura, N.1    Sakurai, S.2    Asai, A.3    Kirino, T.4    Hamada, H.5
  • 90
    • 0030925639 scopus 로고    scopus 로고
    • Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor P35 to prevent programmed cell death
    • Manji, G.A., R.R. Hozak, D.J. LaCount & P.D. Friesen: Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor P35 to prevent programmed cell death. J Virol 71, 4509-16. (1997)
    • (1997) J Virol , vol.71 , pp. 4509-4516
    • Manji, G.A.1    Hozak, R.R.2    Lacount, D.J.3    Friesen, P.D.4
  • 91
    • 0034667372 scopus 로고    scopus 로고
    • Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells
    • Sasaki, H., Y. Sheng, F. Kotsuji & B.K. Tsang: Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res 60, 5659-66. (2000)
    • (2000) Cancer Res , vol.60 , pp. 5659-5666
    • Sasaki, H.1    Sheng, Y.2    Kotsuji, F.3    Tsang, B.K.4
  • 92
    • 0032582662 scopus 로고    scopus 로고
    • The Drosophila Gene hid Is a Direct Molecular Target of Ras-Dependent Survival Signaling
    • Bergmann, A., J. Agapite, K. McCall & H. Steller: The Drosophila Gene hid Is a Direct Molecular Target of Ras-Dependent Survival Signaling. Cell 95, 331-341. (1998)
    • (1998) Cell , vol.95 , pp. 331-341
    • Bergmann, A.1    Agapite, J.2    McCall, K.3    Steller, H.4
  • 93
    • 0034737292 scopus 로고    scopus 로고
    • Drosophila p53 binds a damage response element at the reaper locus
    • Brodsky, M.H., W. Nordstrom, G. Tsang, E. Kwan, G.M. Rubin & J.M. Abrams: Drosophila p53 binds a damage response element at the reaper locus. Cell 101, 103-13. (2000)
    • (2000) Cell , vol.101 , pp. 103-113
    • Brodsky, M.H.1    Nordstrom, W.2    Tsang, G.3    Kwan, E.4    Rubin, G.M.5    Abrams, J.M.6
  • 95
    • 0030868999 scopus 로고    scopus 로고
    • Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
    • Rehemtulla, A., C.A. Hamilton, A.M. Chinnaiyan & V.M. Dixit: Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1) J Biol Chem 272, 25783-6. (1997)
    • (1997) J Biol Chem , vol.272 , pp. 25783-25786
    • Rehemtulla, A.1    Hamilton, C.A.2    Chinnaiyan, A.M.3    Dixit, V.M.4
  • 96
    • 0034598751 scopus 로고    scopus 로고
    • Tissue and cell-specific expression of the p53-target genes: Bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice
    • Bouvard, V., T. Zaitchouk, M. Vacher, A. Duthu, M. Canivet, C. Choisy-Rossi, M. Nieruchalski & E. May: Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice. Oncogene 19, 649-60. (2000)
    • (2000) Oncogene , vol.19 , pp. 649-660
    • Bouvard, V.1    Zaitchouk, T.2    Vacher, M.3    Duthu, A.4    Canivet, M.5    Choisy-Rossi, C.6    Nieruchalski, M.7    May, E.8
  • 97
    • 0031803217 scopus 로고    scopus 로고
    • Fas/Fas ligand interactions are involved in ultraviolet-B-induced human lymphocyte apoptosis
    • Caricchio, R., E.A. Reap & P.L. Cohen: Fas/Fas ligand interactions are involved in ultraviolet-B-induced human lymphocyte apoptosis. J Immunol 161, 241-51. (1998)
    • (1998) J Immunol , vol.161 , pp. 241-251
    • Caricchio, R.1    Reap, E.A.2    Cohen, P.L.3
  • 100
    • 0008805915 scopus 로고    scopus 로고
    • Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction
    • Gross, S., A. Knebel, T. Tenev, A. Neininger, M. Gaestel, P. Herrlich & F.D. Bohmer: Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction. J Biol Chem 274, 26378-86 (1999)
    • (1999) J Biol Chem , vol.274 , pp. 26378-26386
    • Gross, S.1    Knebel, A.2    Tenev, T.3    Neininger, A.4    Gaestel, M.5    Herrlich, P.6    Bohmer, F.D.7
  • 102
    • 0034660614 scopus 로고    scopus 로고
    • p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression
    • Ivanov, V.N. & Z. Ronai: p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression. Oncogene 19, 3003-12. (2000)
    • (2000) Oncogene , vol.19 , pp. 3003-3012
    • Ivanov, V.N.1    Ronai, Z.2
  • 103
    • 0032014073 scopus 로고    scopus 로고
    • DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
    • Kasibhatla, S., T. Brunner, L. Genestier, F. Echeverri, A. Mahboubi & D.R. Green: DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1. Mol Cell 1, 543-51. (1998)
    • (1998) Mol Cell , vol.1 , pp. 543-551
    • Kasibhatla, S.1    Brunner, T.2    Genestier, L.3    Echeverri, F.4    Mahboubi, A.5    Green, D.R.6
  • 104
    • 0031943921 scopus 로고    scopus 로고
    • Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L
    • Aragane, Y., D. Kulms, D. Metze, G. Wilkes, B. Poppelmann, T.A. Luger & T. Schwarz: Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J Cell Biol 140, 171-82. (1998)
    • (1998) J Cell Biol , vol.140 , pp. 171-182
    • Aragane, Y.1    Kulms, D.2    Metze, D.3    Wilkes, G.4    Poppelmann, B.5    Luger, T.A.6    Schwarz, T.7
  • 106
    • 0035901966 scopus 로고    scopus 로고
    • Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells
    • Yount, G.L., G. Afshar, S. Ries, M. Korn, N. Shalev, D. Basila, F. McCormick & D.A. Haas-Kogan: Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells. Oncogene 20, 2826-35. (2001)
    • (2001) Oncogene , vol.20 , pp. 2826-2835
    • Yount, G.L.1    Afshar, G.2    Ries, S.3    Korn, M.4    Shalev, N.5    Basila, D.6    McCormick, F.7    Haas-Kogan, D.A.8
  • 107
    • 0034855629 scopus 로고    scopus 로고
    • Ultraviolet Light (UV) Regulation of the TNF Family Decoy Receptors DcR2 and DcR3 in Human Keratinocytes
    • Maeda, T., C. Hao & V.A. Tron: Ultraviolet Light (UV) Regulation of the TNF Family Decoy Receptors DcR2 and DcR3 in Human Keratinocytes. J Cutan Med Surg 5, 294-8. (2001)
    • (2001) J Cutan Med Surg , vol.5 , pp. 294-298
    • Maeda, T.1    Hao, C.2    Tron, V.A.3
  • 109
    • 0035895540 scopus 로고    scopus 로고
    • Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons
    • Aravind, L., V.M. Dixit & E.V. Koonin: Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science 291, 1279-84. (2001)
    • (2001) Science , vol.291 , pp. 1279-1284
    • Aravind, L.1    Dixit, V.M.2    Koonin, E.V.3
  • 112
    • 0032537851 scopus 로고    scopus 로고
    • E2F-1-induced p53-independent apoptosis in transgenic mice
    • Holmberg, C., K. Helin, M. Sehested & O. Karlstrom: E2F-1-induced p53-independent apoptosis in transgenic mice. Oncogene 17, 143-55. (1998)
    • (1998) Oncogene , vol.17 , pp. 143-155
    • Holmberg, C.1    Helin, K.2    Sehested, M.3    Karlstrom, O.4
  • 114
    • 0035837405 scopus 로고    scopus 로고
    • Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage
    • Jin, S., F. Fan, W. Fan, H. Zhao, T. Tong, P. Blanck, I. Alomo, B. Rajasekaran & Q. Zhan: Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage. Oncogene 20, 2683-90. (2001)
    • (2001) Oncogene , vol.20 , pp. 2683-2690
    • Jin, S.1    Fan, F.2    Fan, W.3    Zhao, H.4    Tong, T.5    Blanck, P.6    Alomo, I.7    Rajasekaran, B.8    Zhan, Q.9
  • 115
    • 0030689782 scopus 로고    scopus 로고
    • The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo
    • Reinke, V. & G. Lozano: The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo. Oncogene 15, 1527-34 (1997)
    • (1997) Oncogene , vol.15 , pp. 1527-1534
    • Reinke, V.1    Lozano, G.2
  • 116
    • 0030871457 scopus 로고    scopus 로고
    • p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32beta
    • Fuchs, E.J., K.A. McKenna & A. Bedi: p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32beta. Cancer Res 57, 2550-4. (1997)
    • (1997) Cancer Res , vol.57 , pp. 2550-2554
    • Fuchs, E.J.1    McKenna, K.A.2    Bedi, A.3
  • 119
    • 0031828874 scopus 로고    scopus 로고
    • p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes
    • Tron, V.A., M.J. Trotter, L. Tang, M. Krajewska, J.C. Reed, V.C. Ho & G. Li: p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes. Am J Pathol 153, 579-85 (1998)
    • (1998) Am J Pathol , vol.153 , pp. 579-585
    • Tron, V.A.1    Trotter, M.J.2    Tang, L.3    Krajewska, M.4    Reed, J.C.5    Ho, V.C.6    Li, G.7


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