The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from Reaper, Grim, and Hid

Current Biology

Volumn 12, Issue 2, 2002, Pages 137-140

  Christich, Anna ^a   Kauppila, Saila ^a   Chen, Po ^a   Sogame, Naoko ^a   Ho, Su Inn ^a   Abrams, John M ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXAPODA; INTRACISTERNAL A-PARTICLES; MAMMALIA;

DROSOPHILA PROTEIN; GRIM PROTEIN, DROSOPHILA; INSECT PROTEIN; NEUROPEPTIDE; PEPTIDE; REAPER PROTEIN, DROSOPHILA; SICKLE PROTEIN, DROSOPHILA; WRINKLED PROTEIN, DROSOPHILA;

AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; ARTICLE; CHEMISTRY; DROSOPHILA; GENETICS; MOLECULAR GENETICS; PRENATAL DEVELOPMENT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; DROSOPHILA; DROSOPHILA PROTEINS; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PEPTIDES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037154014     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00658-3     Document Type: Article

References (24)

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3. Grim, a novel cell death gene in drosophila
4. The head involution defective gene of Drosophila melanogaster functions in programmed cell death
5. Genetic control of programmed cell death in Drosophila
6. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
7. DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9
8. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts IAP-caspase interaction
9. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif
10. HtrA2 promotes cell death through its serine protease activity and its ability to antagonise inhibitor of apoptosis proteins
11. Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins Hid and Grim
12. Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides
13. The RHG motifs of Drosophila reaper and grim are important for their distinct cell death-inducing abilities
14. Activation of the reaper gene during ectopic cell killing in drosophila
15. Drosophila p53 binds a damage response element at the reaper locus
16. Dredd, a novel effector of the apoptosis activators Reaper, Grim, and Hid in Drosophila
17. Programmed cell death during Drosophila embryogenesis
18. Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides
19. Sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein
20. Drosophila sickle is a novel grim-reaper cell death activator
21. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
22. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
23. Structural basis of IAP recognition by Smac/DIABLO
24. Structural and biochemical basis of apoptotic activation by Smac/DIABLO