Sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein

Current Biology

Volumn 12, Issue 2, 2002, Pages 125-130

  Srinivasula, Srinivasa M ^a   Datta, Pinaki ^a   Kobayashi, Masatomo ^a   Wu, Jia Wei ^b   Fujioka, Miki ^a   Hegde, Ramesh ^a   Zhang, ZhiJia ^a   Mukattash, Rula ^a   Fernandes Alnemri, Teresa ^a   Shi, Yigong ^b   Jaynes, James B ^a   Alnemri, Emad S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXAPODA; INTRACISTERNAL A-PARTICLES; MAMMALIA;

DROSOPHILA PROTEIN; GRIM PROTEIN, DROSOPHILA; INSECT PROTEIN; NEUROPEPTIDE; PEPTIDE; REAPER PROTEIN, DROSOPHILA; SICKLE PROTEIN, DROSOPHILA; WRINKLED PROTEIN, DROSOPHILA;

AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DROSOPHILA; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PRENATAL DEVELOPMENT; PROTEIN BINDING; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELLS, CULTURED; CLONING, MOLECULAR; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0037154010     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00657-1     Document Type: Article

References (22)

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2. IAP family proteins - Suppressors of apoptosis
3. An emerging blueprint for apoptosis in Drosophila
4. Understanding IAP function and regulation: A view from Drosophila
5. A structural view of mitochondria-mediated apoptosis
6. Genetic control of programmed cell death in Drosophila
7. The head involution defective gene of Drosophila melanogaster functions in programmed cell death
8. Grim, a novel cell death gene in Drosophila
9. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
10. Smac, a mitochondrial protein that promotes Cytochrome c-dependent Caspase activation by eliminating IAP inhibition
11. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
12. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts IAP-caspase interaction
13. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif
14. HtrA2 promotes cell death through its serine protease activity and its ability to antagonise inhibitor of apoptosis proteins
15. Structural analysis of a functional DIAP1 fragment bound to Grim and Hid peptides
16. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
17. Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs)
18. The proapoptotic function of Drosophila Hid is conserved in mammalian cells
19. Programmed cell death during Drosophila embryogenesis
20. Apoptosis in late stage Drosophila nurse cells does not require genes within the H99 deficiency
21. The damage-responsive Drosophila gene Sickle encodes a novel IAP binding protein similar to but distinct from Reaper, Grim and Hid
22. Drosophila sickle is a novel grim-reaper cell death activator