Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-β by phosphatidylinositol 3-kinase/ Akt-dependent suppression of the activation of Smad3 but not Smad2

Journal of Biological Chemistry

Volumn 278, Issue 40, 2003, Pages 38342-38351

  Song, Kyung ^a   Cornelius, Susan C ^a   Reiss, Michael ^b   Danielpour, David ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c Ireland Cancer Ctr Res Labs   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; GROWTH KINETICS; INSULIN;

GROWTH FACTORS;

ENZYME KINETICS;

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CARCINOGENICITY; CELL STRAIN; CELL STRAIN NRP 152; CONTROLLED STUDY; CROSS LINKING; DOWN REGULATION; DOWNSTREAM PROCESSING; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MALE; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REPORTER GENE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CROSS-LINKING REAGENTS; DNA FRAGMENTATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; GENES, REPORTER; INSULIN-LIKE GROWTH FACTOR I; LIGANDS; LUCIFERASES; MALE; PHOSPHORIC MONOESTER HYDROLASES; PROMOTER REGIONS (GENETICS); PROSTATE; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; SIGNAL TRANSDUCTION; SIROLIMUS; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MAMMALIA;

EID: 0141532196     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304583200     Document Type: Article

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