Cellular function of p70(S6K): A role in regulating cell motility

Immunology and Cell Biology

Volumn 78, Issue 4, 2000, Pages 447-451

  Berven, L A ^a   Crouch, M F ^a  

^a Biology and Environment   (Australia)

Author keywords

Cytoskeleton; Migration; P70(S6K)

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; WORTMANNIN; RIBOSOME PROTEIN; S6 KINASE;

CELL FUNCTION; CELL MIGRATION; CELL MOTILITY; CONFERENCE PAPER; ENZYME ACTIVITY; IMMUNE RESPONSE; METASTASIS; PROTEIN SYNTHESIS; RIBOSOME; TUMOR IMMUNOLOGY; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CELL MOTION; CELL STRAIN 3T3; CYTOSKELETON; METABOLISM; MOUSE; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

MAMMALIA;

3T3 CELLS; ANIMALS; CELL CYCLE; CELL MOVEMENT; CYTOSKELETON; MICE; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEINS; SIGNAL TRANSDUCTION;

EID: 0033624269     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.2000.00928.x     Document Type: Conference Paper

References (42)

1. Signaling by distinct classes of phosphoinositide 3-kinases
2. Phosphoinositide kinases
3. Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit
4. Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits
5. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
6. Signal characteristics of G protein-transactivated EGF receptor
7. Roles of non-catalytic subunits in Gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma
8. Signaling inositol polyphosphate-5-phosphatase Characterization of activity and effect of GRB2 association
9. The role of phosphoinositide 3-kinase lipid products in cell function
10. Characterization of S6K2, a novel kinase homologous to S6K1
11. Disruption of the p70 (s6k) /p85 (s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
12. Ribosomal S6 kinase signaling and the control of translation
13. Regulation of the p70, S6 kinase by phosphorylation in vivo: Analysis using site-specific anti-phosphopeptide antibodies
14. An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase
15. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
16. Phosphorylation and activation of p70s6k by PDK1
17. The regulation and activities of the multi-functional serine/threonine kinase Akt/PKB
18. P70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex
19. Cdc2-cyclin B phosphorylates p70, S6 kinase on Ser411 at mitosis
20. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
21. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
22. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
23. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
24. Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation
25. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin-associated protein
26. Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP.2A) and p21-activated kinase-PP. 2A
27. Molecular mechanisms for the control of translation by insulin
28. The 70 kDa S6 kinase: Regulation of a kinase with multiple roles in mitogenic signalling
29. Nuclear localization of p85s6k: Functional requirement for entry into S phase
30. P70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation, J
31. Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
32. Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase
33. Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70 (S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts
34. Tumor invasion: Role of growth factor-induced cell motility
35. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1
36. Nitric oxide donors selectively potentiate thrombin-stimulated p70 (S6k) activity and morphological changes in Swiss 3T3 cells
37. On the mechanisms of cortical actin flow and its role in cytoskeletal organisation of fibroblasts
38. Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton
39. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
40. The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton
41. Monocyte adhesion and spreading on human endothelial cells is dependent on Rhoregulated receptor clustering
42. Insulin induces epidermal growth factor (EGF) receptor clustering and potentiates EGF-stimulated DNA synthesis in Swiss 3T3 cells: A mechanism for costimulation in mitogenic synergy