-
2
-
-
0035929353
-
Switching and signalling at the telomere
-
Blackburn EH: Switching and signalling at the telomere. Cell (2001) 106(6):661-673.
-
(2001)
Cell
, vol.106
, Issue.6
, pp. 661-673
-
-
Blackburn, E.H.1
-
4
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature (1990) 345(6274):458-460.
-
(1990)
Nature
, vol.345
, Issue.6274
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
5
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
note
-
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich RL, Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 266(5193):2011-2015. Reports the discovery that telomerase is expressed in the overwhelming majority of tumors.
-
(1994)
Science
, vol.266
, Issue.5193
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.C.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, R.L.9
Shay, J.W.10
-
6
-
-
0030745448
-
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
-
Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S et al: hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 90(4):785-795.
-
(1997)
Cell
, vol.90
, Issue.4
, pp. 785-795
-
-
Meyerson, M.1
Counter, C.M.2
Eaton, E.N.3
Ellisen, L.W.4
Steiner, P.5
Caddle, S.D.6
Ziaugra, L.7
Beijersbergen, R.L.8
Davidoff, M.J.9
Liu, Q.10
Bacchetti, S.11
-
7
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR: Telomerase catalytic subunit homologs from fission yeast and human. Science (1997) 277(5328):955-959.
-
(1997)
Science
, vol.277
, Issue.5328
, pp. 955-959
-
-
Nakamura, T.M.1
Morin, G.B.2
Chapman, K.B.3
Weinrich, S.L.4
Andrews, W.H.5
Lingner, J.6
Harley, C.B.7
Cech, T.R.8
-
8
-
-
0034614637
-
The hallmarks of cancer
-
note
-
Hanahan D, Weinberg RA: The hallmarks of cancer. Cell (2000) 100(1):57-70. A key survey of the molecular origins of human cancer, highlighting the role of telomere maintenance and telomerase.
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
9
-
-
0036720448
-
Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumours
-
Tomoda R, Seto M, Tsumuki H, Iida K, Yamazaki T, Sonoda J, Matsumine A, Uchida A: Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumours. Cancer (2002) 95(5):1127-1133.
-
(2002)
Cancer
, vol.95
, Issue.5
, pp. 1127-1133
-
-
Tomoda, R.1
Seto, M.2
Tsumuki, H.3
Iida, K.4
Yamazaki, T.5
Sonoda, J.6
Matsumine, A.7
Uchida, A.8
-
10
-
-
0033672470
-
Telomere maintenance by recombination in human cells
-
Dunham MA, Neumann AA, Fasching CL, Reddel RR: Telomere maintenance by recombination in human cells. Nat Genet (2000) 26(4):447-450.
-
(2000)
Nat Genet
, vol.26
, Issue.4
, pp. 447-450
-
-
Dunham, M.A.1
Neumann, A.A.2
Fasching, C.L.3
Reddel, R.R.4
-
11
-
-
0032828652
-
Inhibition of telomerase limits the growth of human cancer cells
-
note
-
Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, Beijersbergen RL, Knoll JHM, Meyerson M, Weinberg RA: Inhibition of telomerase limits the growth of human cancer cells. Nat Med (1999) 5(10):1164-1170. Demonstration of proof-of-principle, that inhibition of telomerase by means of a dominant-negative mutant results in senescence and telomere shortening.
-
(1999)
Nat Med
, vol.5
, Issue.10
, pp. 1164-1170
-
-
Hahn, W.C.1
Stewart, S.A.2
Brooks, M.W.3
York, S.G.4
Eaton, E.5
Kurachi, A.6
Beijersbergen, R.L.7
Knoll, J.H.M.8
Meyerson, M.9
Weinberg, R.A.10
-
12
-
-
0033455559
-
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
-
note
-
Herbert BS, Pitts AE, Baker SI, Hamilton SE, Wright WE, Shay JW, Corey DR: Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA (1999) 96(25):14276-14281. Study of antisense binding to the hTR template, demonstrating that this results in telomere shortening in cancer cells.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, Issue.25
, pp. 14276-14281
-
-
Herbert, B.S.1
Pitts, A.E.2
Baker, S.I.3
Hamilton, S.E.4
Wright, W.E.5
Shay, J.W.6
Corey, D.R.7
-
13
-
-
18544364628
-
Mechanism of human telomerase inhibition by BIBR 1532, a synthetic, non-nucleosidic drug candidate
-
Pascolo E, Wenz C, Lingner J, Hauel N, Priepke H, Kaufmann I, Garin-Chesa P, Rettig WJ, Damm K, Schnapp A: Mechanism of human telomerase inhibition by BIBR 1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem (2002) 277(18):15566-15572.
-
(2002)
J Biol Chem
, vol.277
, Issue.18
, pp. 15566-15572
-
-
Pascolo, E.1
Wenz, C.2
Lingner, J.3
Hauel, N.4
Priepke, H.5
Kaufmann, I.6
Garin-Chesa, P.7
Rettig, W.J.8
Damm, K.9
Schnapp, A.10
-
14
-
-
0037424713
-
Inhibition of telomerase by BIBR 1532 and related analogues
-
Barma DK, Elayadi A, Falck JR, Corey DR: Inhibition of telomerase by BIBR 1532 and related analogues. Bioorg Med Chem Lett (2003) 13(7):1333-1336.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, Issue.7
, pp. 1333-1336
-
-
Barma, D.K.1
Elayadi, A.2
Falck, J.R.3
Corey, D.R.4
-
15
-
-
0036782884
-
Telomerase: A target for cancer therapeutics
-
Shay JW, Wright WE: Telomerase: A target for cancer therapeutics. Cancer Cell (2002) 2(4):257-265.
-
(2002)
Cancer Cell
, vol.2
, Issue.4
, pp. 257-265
-
-
Shay, J.W.1
Wright, W.E.2
-
16
-
-
0035812845
-
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
-
Hemann MT, Strong MA, Hao LY, Greider CW: The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell (2001) 107(1):67-77.
-
(2001)
Cell
, vol.107
, Issue.1
, pp. 67-77
-
-
Hemann, M.T.1
Strong, M.A.2
Hao, L.Y.3
Greider, C.W.4
-
17
-
-
0031949642
-
Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3′-azido-3′-deoxythymidine
-
Melana SM, Holland JF, Pogo BG: Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3′-azido-3′-deoxythymidine. Clin Cancer Res (1998) 4(3):693-696.
-
(1998)
Clin Cancer Res
, vol.4
, Issue.3
, pp. 693-696
-
-
Melana, S.M.1
Holland, J.F.2
Pogo, B.G.3
-
18
-
-
0028222581
-
The effect of nucleoside analogs on telomerase and telomeres in Tetrahymena
-
Strahl C, Blackburn E: The effect of nucleoside analogs on telomerase and telomeres in Tetrahymena. Nucleic Acids Res (1994) 22(6):893-900.
-
(1994)
Nucleic Acids Res
, vol.22
, Issue.6
, pp. 893-900
-
-
Strahl, C.1
Blackburn, E.2
-
19
-
-
0033153293
-
Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines
-
Murkami J, Nagai N, Shigemasa K, Ohama K: Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines. Eur J Cancer (1999) 35(6):1027-1034.
-
(1999)
Eur J Cancer
, vol.35
, Issue.6
, pp. 1027-1034
-
-
Murkami, J.1
Nagai, N.2
Shigemasa, K.3
Ohama, K.4
-
20
-
-
0035572933
-
Inhibition of human telomerase by 7-deaza-2′-deoxyguanosine nucleoside triphosphate analogs: Potent inhibition by 6-thio-7-deaza-2′-deoxyguanosine 5′-triphosphate
-
Fletcher TM, Cathers BE, Ravikumar KS, Mamiya BM, Kerwin SM: Inhibition of human telomerase by 7-deaza-2′-deoxyguanosine nucleoside triphosphate analogs: Potent inhibition by 6-thio-7-deaza-2′-deoxyguanosine 5′-triphosphate. Bioorg Chem (2001) 29(1):36-55.
-
(2001)
Bioorg Chem
, vol.29
, Issue.1
, pp. 36-55
-
-
Fletcher, T.M.1
Cathers, B.E.2
Ravikumar, K.S.3
Mamiya, B.M.4
Kerwin, S.M.5
-
21
-
-
0038069024
-
Potent inhibition of human telomerase by nitrostyrene derivatives
-
Kim JH, Kim JH, Lee GE, Lee JE, Chung IK: Potent inhibition of human telomerase by nitrostyrene derivatives. Mol Pharmacol (2003) 63(5):1117-1124.
-
(2003)
Mol Pharmacol
, vol.63
, Issue.5
, pp. 1117-1124
-
-
Kim, J.H.1
Kim, J.H.2
Lee, G.E.3
Lee, J.E.4
Chung, I.K.5
-
22
-
-
0042346283
-
Quinoxaline derivative: A potent telomerase inhibitor leading to cellular senescence of human cancer cells
-
doi:10.1042/BJ20030363
-
Kim JH, Kim JH, Lee GE, Kim SW, Chung IK: Quinoxaline derivative: A potent telomerase inhibitor leading to cellular senescence of human cancer cells. Biochem J (2003): doi:10.1042/BJ20030363.
-
(2003)
Biochem J
-
-
Kim, J.H.1
Kim, J.H.2
Lee, G.E.3
Kim, S.W.4
Chung, I.K.5
-
23
-
-
0035870755
-
Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: Effect of length, phosphorothioate substitution and time inside cells
-
Elayadi AN, Demieville A, Wancewicz EV, Monia BP, Corey DR: Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: Effect of length, phosphorothioate substitution and time inside cells. Nucleic Acids Res (2001) 29(8):1683-1689.
-
(2001)
Nucleic Acids Res
, vol.29
, Issue.8
, pp. 1683-1689
-
-
Elayadi, A.N.1
Demieville, A.2
Wancewicz, E.V.3
Monia, B.P.4
Corey, D.R.5
-
24
-
-
0037289331
-
Telomerase inhibitors: A new option for chemotherapy
-
note
-
Chen Z, Corey DR: Telomerase inhibitors: A new option for chemotherapy. Adv Cancer Res (2003) 87:31-58. A thoughtful review on telomerase inhibition, analyzing the clinical potential of antisense oligonucleotides.
-
(2003)
Adv Cancer Res
, vol.87
, pp. 31-58
-
-
Chen, Z.1
Corey, D.R.2
-
25
-
-
0037028047
-
Telomerase inhibition, telomere shortening and decreased cell proliferation by cell permeable 2′-O-methoxyethyl oligonucleotides
-
Chen Z, Monia BP, Corey DR: Telomerase inhibition, telomere shortening and decreased cell proliferation by cell permeable 2′-O-methoxyethyl oligonucleotides. J Med Chem (2002) 45(25):5423-5425.
-
(2002)
J Med Chem
, vol.45
, Issue.25
, pp. 5423-5425
-
-
Chen, Z.1
Monia, B.P.2
Corey, D.R.3
-
26
-
-
0036019380
-
2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells
-
Yatabe N, Wang Z, Inoue M: 2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells. Cancer Gene Ther (2002) 9(7):624-630.
-
(2002)
Cancer Gene Ther
, vol.9
, Issue.7
, pp. 624-630
-
-
Yatabe, N.1
Wang, Z.2
Inoue, M.3
-
27
-
-
0034933876
-
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
-
Kim MM, Rivera MA, Botchkina IL, Shalaby R, Thor AD, Blackburn EH: A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation. Proc Natl Acad Sci USA (2001) 98(14):7982-7987.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.14
, pp. 7982-7987
-
-
Kim, M.M.1
Rivera, M.A.2
Botchkina, I.L.3
Shalaby, R.4
Thor, A.D.5
Blackburn, E.H.6
-
28
-
-
0035409880
-
Human telomerase reverse transcriptase antisense treatment downregulates the viability of prostate cancer cells in vitro
-
Schindler A, Fiedler U, Meye A, Schmidt U, Fussel S, Pilarsky C, Herrmann J, Wirth MP: Human telomerase reverse transcriptase antisense treatment downregulates the viability of prostate cancer cells in vitro. Int J Oncol (2001) 19(1):25-30.
-
(2001)
Int J Oncol
, vol.19
, Issue.1
, pp. 25-30
-
-
Schindler, A.1
Fiedler, U.2
Meye, A.3
Schmidt, U.4
Fussel, S.5
Pilarsky, C.6
Herrmann, J.7
Wirth, M.P.8
-
29
-
-
0037339080
-
Antisense hTERT inhibits thyroid cancer cell growth
-
Teng L, Specht MC, Barden CB, Fahey TJ: Antisense hTERT inhibits thyroid cancer cell growth. J Clin Endocrinol Metab (2003) 88(3):1362-1366.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, Issue.3
, pp. 1362-1366
-
-
Teng, L.1
Specht, M.C.2
Barden, C.B.3
Fahey, T.J.4
-
30
-
-
0033519311
-
Inhibition of human telomerase by PNA-cationic peptide conjugates
-
Harrison JG, Frier C, Laurant R, Dennis R, Raney KD, Balasubramanian S: Inhibition of human telomerase by PNA-cationic peptide conjugates. Bioorg Med Chem Lett (1999) 9(9):1273-1278.
-
(1999)
Bioorg Med Chem Lett
, vol.9
, Issue.9
, pp. 1273-1278
-
-
Harrison, J.G.1
Frier, C.2
Laurant, R.3
Dennis, R.4
Raney, K.D.5
Balasubramanian, S.6
-
31
-
-
0034709645
-
The 5′-end of hTERT mRNA is a good target for hammerhead ribozyme to suppress telomerase activity
-
Yokoyama Y, Takahashi Y, Shinohara A, Wan X, Takahashi S, Niwa K, Tamaya T: The 5′-end of hTERT mRNA is a good target for hammerhead ribozyme to suppress telomerase activity. Biochem Biophys Res Commun (2000) 273(1):316-321.
-
(2000)
Biochem Biophys Res Commun
, vol.273
, Issue.1
, pp. 316-321
-
-
Yokoyama, Y.1
Takahashi, Y.2
Shinohara, A.3
Wan, X.4
Takahashi, S.5
Niwa, K.6
Tamaya, T.7
-
32
-
-
0032403264
-
Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells
-
Yokoyama Y, Takahashi Y, Shinohara A, Lian Z, Wan X, Niwa K, Tamaya T: Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells. Cancer Res (1998) 58(23):5406-5410.
-
(1998)
Cancer Res
, vol.58
, Issue.23
, pp. 5406-5410
-
-
Yokoyama, Y.1
Takahashi, Y.2
Shinohara, A.3
Lian, Z.4
Wan, X.5
Niwa, K.6
Tamaya, T.7
-
33
-
-
0032580369
-
Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis
-
Kondo Y, Kondo S, Tanaka Y, Haqqi T, Barna BP, Cowell JK: Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis. Oncogene (1998) 16(17):2243-2248.
-
(1998)
Oncogene
, vol.16
, Issue.17
, pp. 2243-2248
-
-
Kondo, Y.1
Kondo, S.2
Tanaka, Y.3
Haqqi, T.4
Barna, B.P.5
Cowell, J.K.6
-
34
-
-
0035853058
-
Telomere dysfunction alters the chemotherapeutic profile of transformed cells
-
Lee KH, Rudolph KL, Ju YJ, Greenberg RA, Cannizzaro L, Chin L, Weiler SR, DePinho RA: Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proc Natl Acad Sci USA (2001) 98(6):3381-3386.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.6
, pp. 3381-3386
-
-
Lee, K.H.1
Rudolph, K.L.2
Ju, Y.J.3
Greenberg, R.A.4
Cannizzaro, L.5
Chin, L.6
Weiler, S.R.7
DePinho, R.A.8
-
35
-
-
0037350830
-
Telomerase inhibition enhances apoptosis in human acute leukaemia cells: Possibility of antitelomerase therapy
-
Nakajima A, Tauchi T, Sashida G, Sumi M, Abe K, Yamamoto K, Ohyashiki JH, Ohyashiki K: Telomerase inhibition enhances apoptosis in human acute leukaemia cells: Possibility of antitelomerase therapy. Leukemia (2003) 17(3):560-567.
-
(2003)
Leukemia
, vol.17
, Issue.3
, pp. 560-567
-
-
Nakajima, A.1
Tauchi, T.2
Sashida, G.3
Sumi, M.4
Abe, K.5
Yamamoto, K.6
Ohyashiki, J.H.7
Ohyashiki, K.8
-
36
-
-
0033815904
-
Attenuation of human telomerase activity does not increase sensitivity of human melanoma cells to anticancer agents
-
Folini M, De Marco C, Orlandi L, Daidone MG, Zaffaroni N: Attenuation of human telomerase activity does not increase sensitivity of human melanoma cells to anticancer agents. Eur J Cancer (2000) 36(16):2137-2145.
-
(2000)
Eur J Cancer
, vol.36
, Issue.16
, pp. 2137-2145
-
-
Folini, M.1
De Marco, C.2
Orlandi, L.3
Daidone, M.G.4
Zaffaroni, N.5
-
37
-
-
0035300424
-
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
-
Ludwig A, Saretzki G, Holm PS, Tiemann F, Lorenz M, Emrich T, Harley CB, Von Zglinicki T: Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res (2001) 61(7):3053-3061.
-
(2001)
Cancer Res
, vol.61
, Issue.7
, pp. 3053-3061
-
-
Ludwig, A.1
Saretzki, G.2
Holm, P.S.3
Tiemann, F.4
Lorenz, M.5
Emrich, T.6
Harley, C.B.7
Von Zglinicki, T.8
-
39
-
-
0037442701
-
Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo
-
Naasani I, Oh-Hashi F, Oh-Hara T, Feng WY, Johnston J, Chan K, Tsuruo T: Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res (2003) 63(4):824-830.
-
(2003)
Cancer Res
, vol.63
, Issue.4
, pp. 824-830
-
-
Naasani, I.1
Oh-Hashi, F.2
Oh-Hara, T.3
Feng, W.Y.4
Johnston, J.5
Chan, K.6
Tsuruo, T.7
-
40
-
-
0037044179
-
Curcumin inhibits telomerase activity through telomerase reverse transcriptase in MCF-7 breast cancer cell line
-
Ramachandran C, Fonseca HB, Jhabvala P, Escalon EA, Melnick SJ: Curcumin inhibits telomerase activity through telomerase reverse transcriptase in MCF-7 breast cancer cell line. Cancer Lett (2002) 184(1):1-6.
-
(2002)
Cancer Lett
, vol.184
, Issue.1
, pp. 1-6
-
-
Ramachandran, C.1
Fonseca, H.B.2
Jhabvala, P.3
Escalon, E.A.4
Melnick, S.J.5
-
41
-
-
0035344036
-
Indomethacin and telomerase activity in tumour growth retardation
-
Lonnroth C, Andersson M, Lundholm K: Indomethacin and telomerase activity in tumour growth retardation. Int J Oncol (2001) 18(5):929-937.
-
(2001)
Int J Oncol
, vol.18
, Issue.5
, pp. 929-937
-
-
Lonnroth, C.1
Andersson, M.2
Lundholm, K.3
-
42
-
-
0035018021
-
G-quadruplex DNA structures - Variations on a theme
-
Simonsson T: G-quadruplex DNA structures - Variations on a theme. Biol Chem (2001) 382(40):621-628.
-
(2001)
Biol Chem
, vol.382
, Issue.40
, pp. 621-628
-
-
Simonsson, T.1
-
44
-
-
0037142071
-
Crystal structure of parallel quadruplexes from human telomeric DNA
-
note
-
Parkinson GN, Lee MHP, Neidle S: Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 417(6891):876-876-880. Crystal structure analyses of human quadruplexes demonstrates that under physiological conditions they unexpectedly assume an arrangement with all strands in a parallel orientation.
-
(2002)
Nature
, vol.417
, Issue.6891
, pp. 876-880
-
-
Parkinson, G.N.1
Lee, M.H.P.2
Neidle, S.3
-
45
-
-
0035902465
-
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
-
Schffitzel C, Berger I, Postberg J, Hanes J, Lipps HJ, Plückthun A: In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei. Proc Natl Acad Sci USA (2001) 98(15):8572-8577.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.15
, pp. 8572-8577
-
-
Schaffitzel, C.1
Berger, I.2
Postberg, J.3
Hanes, J.4
Lipps, H.J.5
Plückthun, A.6
-
46
-
-
0037423728
-
Structure of a G-quadruplex-ligand complex
-
Haider SM, Parkinson GN, Neidle S: Structure of a G-quadruplex-ligand complex. J Mol Biol (2003) 326(1):117-125.
-
(2003)
J Mol Biol
, vol.326
, Issue.1
, pp. 117-125
-
-
Haider, S.M.1
Parkinson, G.N.2
Neidle, S.3
-
47
-
-
0037427245
-
Structure of the first parallel DNA quadruplex-drug complex
-
Clark GR, Pytel PD, Squire CJ, Neidle S: Structure of the first parallel DNA quadruplex-drug complex. J Am Chem Soc 125(14):4066-4067.
-
(2003)
J Am Chem Soc
, vol.125
, Issue.14
, pp. 4066-4067
-
-
Clark, G.R.1
Pytel, P.D.2
Squire, C.J.3
Neidle, S.4
-
48
-
-
0030786928
-
Inhibition of human telomerase by a G-quadruplex-interactive compound
-
note
-
Sun D, Thompson B, Cathers BE, Salazar M, Kerwin SM, Trent JO, Jenkins TC, Neidle S, Hurley LH: Inhibition of human telomerase by a G-quadruplex-interactive compound. J Med Chem (1997) 40(14):2113-2116. The first report that quadruplex-binding ligands can inhibit telomerase, demonstrating that disubstituted amidoanthraquinones have micromolar potency.
-
(1997)
J Med Chem
, vol.40
, Issue.14
, pp. 2113-2116
-
-
Sun, D.1
Thompson, B.2
Cathers, B.E.3
Salazar, M.4
Kerwin, S.M.5
Trent, J.O.6
Jenkins, T.C.7
Neidle, S.8
Hurley, L.H.9
-
49
-
-
0033530113
-
Human telomerase inhibition by substituted acridine derivatives
-
Harrison RJ, Gowan SM, Kelland LR, Neidle S: Human telomerase inhibition by substituted acridine derivatives. Bioorg Med Chem Lett (1999) 9(17):2463-2468.
-
(1999)
Bioorg Med Chem Lett
, vol.9
, Issue.17
, pp. 2463-2468
-
-
Harrison, R.J.1
Gowan, S.M.2
Kelland, L.R.3
Neidle, S.4
-
50
-
-
0035942270
-
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
-
note
-
Read MA, Harrison RJ, Romagnoli B, Tanious FA, Gowan SH, Reszka AP, Wilson WD, Kelland LR, Neidle S: Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors. Proc Natl Acad Sci USA (2001) 98(9):4844-4849. Rational structure approaches were used to design ligands with enhanced selectivity for the human 22mer G-quadruplex, and increased selectivity and potency for telomerase inhibition.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.9
, pp. 4844-4849
-
-
Read, M.A.1
Harrison, R.J.2
Romagnoli, B.3
Tanious, F.A.4
Gowan, S.H.5
Reszka, A.P.6
Wilson, W.D.7
Kelland, L.R.8
Neidle, S.9
-
51
-
-
18244384536
-
Interaction of an acridine dimer with DNA quadruplex structures
-
Alberti P, Ren J, Teulade-Fichou MP, Guittat L, Riou J-F, Chaires J, Hélène C, Vigneron J-P, Lehn J-M, Mergny J-L: Interaction of an acridine dimer with DNA quadruplex structures. J Biomol Struct Dyn (2001) 19(3):505-513.
-
(2001)
J Biomol Struct Dyn
, vol.19
, Issue.3
, pp. 505-513
-
-
Alberti, P.1
Ren, J.2
Teulade-Fichou, M.P.3
Guittat, L.4
Riou, J.-F.5
Chaires, J.6
Hélène, C.7
Vigneron, J.-P.8
Lehn, J.-M.9
Mergny, J.-L.10
-
52
-
-
0035853164
-
Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay
-
note
-
Mergny J-L, Lacroix L, Teulade-Fichou M-P, Hounsou C, Guittat L, Hoarau M, Arimondo PB, Vigneron J-P, Lehn J-M, Riou J-F, Garestier T et al: Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay. Proc Natl Acad Sci USA (2001) 98(6):3062-3067. Describes the use of fluorescence-based assays to find new quadruplex-binding ligands.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.6
, pp. 3062-3067
-
-
Mergny, J.-L.1
Lacroix, L.2
Teulade-Fichou, M.-P.3
Hounsou, C.4
Guittat, L.5
Hoarau, M.6
Arimondo, P.B.7
Vigneron, J.-P.8
Lehn, J.-M.9
Riou, J.-F.10
Garestier, T.11
-
53
-
-
0242684479
-
Selective recognition of G-quadruplex telomeric DNA by a bis(quinacridine) macrocycle
-
Teulade-Fichou M-P, Carrasco C, Guittat L, Bailly C, Alberti P, Mergny J-L, David A, Lehn J-M, Wilson WD: Selective recognition of G-quadruplex telomeric DNA by a bis(quinacridine) macrocycle. J Am Chem Soc (2003) 125(16):4732-4740.
-
(2003)
J Am Chem Soc
, vol.125
, Issue.16
, pp. 4732-4740
-
-
Teulade-Fichou, M.-P.1
Carrasco, C.2
Guittat, L.3
Bailly, C.4
Alberti, P.5
Mergny, J.-L.6
David, A.7
Lehn, J.-M.8
Wilson, W.D.9
-
54
-
-
0037041260
-
Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase
-
Alberti P, Schmitt P, Nguyen C-H, Rivalle C, Hoarau M, Grierson DS, Mergny J-L: Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase. Bioorg Med Chem Lett (2002) 12(7):1071-1074.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, Issue.7
, pp. 1071-1074
-
-
Alberti, P.1
Schmitt, P.2
Nguyen, C.-H.3
Rivalle, C.4
Hoarau, M.5
Grierson, D.S.6
Mergny, J.-L.7
-
55
-
-
0035282707
-
Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes
-
Koeppel F, Riou J-F, Laoui A, Mailliet P, Arimondo PB, Labit D, Petitgenet O, Hélène C, Mergny J-L: Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes. Nucleic Acids Res (2001) 29(5):1087-1096.
-
(2001)
Nucleic Acids Res
, vol.29
, Issue.5
, pp. 1087-1096
-
-
Koeppel, F.1
Riou, J.-F.2
Laoui, A.3
Mailliet, P.4
Arimondo, P.B.5
Labit, D.6
Petitgenet, O.7
Hélène, C.8
Mergny, J.-L.9
-
56
-
-
0037022658
-
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
-
note
-
Riou JF, Guittat L, Mailliet P, Laoui A, Renou E, Petitgenet O, Megnin-Chanet F, Hélène C, Mergny JL: Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proc Natl Acad Sci USA (2002) 99(5):2672-2677. The first demonstration that G-quadruplex ligands affects telomere length and cell growth in cancer cells.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.5
, pp. 2672-2677
-
-
Riou, J.F.1
Guittat, L.2
Mailliet, P.3
Laoui, A.4
Renou, E.5
Petitgenet, O.6
Megnin-Chanet, F.7
Hélène, C.8
Mergny, J.L.9
-
57
-
-
0034760505
-
Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
-
Gowan SM, Heald R, Stevens MFG, Kelland LR: Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes. Mol Pharmacol (2001) 60(5):981-988.
-
(2001)
Mol Pharmacol
, vol.60
, Issue.5
, pp. 981-988
-
-
Gowan, S.M.1
Heald, R.2
Stevens, M.F.G.3
Kelland, L.R.4
-
58
-
-
0036241599
-
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity
-
note
-
Gowan SM, Harrison JR, Patterson L, Valenti M, Read MA, Neidle S, Kelland LR: A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol (2002) 61(5):1154-1162. Demonstration of senescence and antitumor activity by a potent trisubstituted acridine G-quadruplex ligand.
-
(2002)
Mol Pharmacol
, vol.61
, Issue.5
, pp. 1154-1162
-
-
Gowan, S.M.1
Harrison, J.R.2
Patterson, L.3
Valenti, M.4
Read, M.A.5
Neidle, S.6
Kelland, L.R.7
-
59
-
-
0039129145
-
Accelerated assembly of G-quadruplex structures by a small molecule
-
Han H, Cliff CL, Hurley LH: Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry (1999) 38(22):6981-6986.
-
(1999)
Biochemistry
, vol.38
, Issue.22
, pp. 6981-6986
-
-
Han, H.1
Cliff, C.L.2
Hurley, L.H.3
-
60
-
-
0037119783
-
Perylene diimides with different side chains are selective in inducing different G-quadruplex DNA structures and in inhibiting telomerase
-
Rossetti L, Franceschin M, Bianco A, Ortaggi G, Savino M: Perylene diimides with different side chains are selective in inducing different G-quadruplex DNA structures and in inhibiting telomerase. Bioorg Med Chem Lett (2002) 12(18):2527-2533.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, Issue.18
, pp. 2527-2533
-
-
Rossetti, L.1
Franceschin, M.2
Bianco, A.3
Ortaggi, G.4
Savino, M.5
-
61
-
-
0037434540
-
Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes
-
Kim M-Y, Duan W, Gleason-Guzman M, Hurley LH: Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes. J Med Chem (2003) 46(4):571-583.
-
(2003)
J Med Chem
, vol.46
, Issue.4
, pp. 571-583
-
-
Kim, M.-Y.1
Duan, W.2
Gleason-Guzman, M.3
Hurley, L.H.4
-
62
-
-
0033083378
-
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells
-
Izbicka E, Wheelhouse RT, Raymond E, Davidson KK, Lawrence RA, Sun D, Windle BE, Hurley LH, Von Hoff DD: Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Res (1999) 59(3):639-644.
-
(1999)
Cancer Res
, vol.59
, Issue.3
, pp. 639-644
-
-
Izbicka, E.1
Wheelhouse, R.T.2
Raymond, E.3
Davidson, K.K.4
Lawrence, R.A.5
Sun, D.6
Windle, B.E.7
Hurley, L.H.8
Von Hoff, D.D.9
-
63
-
-
0036597090
-
The cationic porphyrin TMPyP4 down-regulates c-myc and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo
-
Grand CL, Han H, Munoz RM, Weitman S, Von Hoff DD, Hurley LH, Bearss DJ: The cationic porphyrin TMPyP4 down-regulates c-myc and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo. Mol Cancer Ther (2002) 1(8):565-573.
-
(2002)
Mol Cancer Ther
, vol.1
, Issue.8
, pp. 565-573
-
-
Grand, C.L.1
Han, H.2
Munoz, R.M.3
Weitman, S.4
Von Hoff, D.D.5
Hurley, L.H.6
Bearss, D.J.7
-
64
-
-
0037015078
-
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-Myc transcription
-
note
-
Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH: Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-Myc transcription. Proc Natl Acad Sci USA (2002) 99(18):11593-11598. Proof that quadruplexes can be formed from promoter sequences, and that this can be enhanced by ligand binding as a specific means of downregulating transcription.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.18
, pp. 11593-11598
-
-
Siddiqui-Jain, A.1
Grand, C.L.2
Bearss, D.J.3
Hurley, L.H.4
-
65
-
-
0035857396
-
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus
-
note
-
Shin-Ya K, Wierzba K, Matsuo K, Ohtani T, Yamada Y, Furihata K, Hayakawa Y, Seto H: Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J Am Chem Soc (2001) 123(6):1262-1263. Discovery of a novel, highly potent new class of telomerase inhibitor.
-
(2001)
J Am Chem Soc
, vol.123
, Issue.6
, pp. 1262-1263
-
-
Shin-Ya, K.1
Wierzba, K.2
Matsuo, K.3
Ohtani, T.4
Yamada, Y.5
Furihata, K.6
Hayakawa, Y.7
Seto, H.8
-
66
-
-
0037070575
-
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
-
Kim M-Y, Vankayalapati H, Shin-Ya K, Wierzba K, Hurley LH: Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex. J Am Chem Soc (2002) 124(10):2098-2099.
-
(2002)
J Am Chem Soc
, vol.124
, Issue.10
, pp. 2098-2099
-
-
Kim, M.-Y.1
Vankayalapati, H.2
Shin-Ya, K.3
Wierzba, K.4
Hurley, L.H.5
-
67
-
-
0038150335
-
The design of G-quadruplex ligands as telomerase inhibitors
-
Cuesta J, Read MA, Neidle S: The design of G-quadruplex ligands as telomerase inhibitors. Mini Rev Med Chem (2003) 3(1):11-21.
-
(2003)
Mini Rev Med Chem
, vol.3
, Issue.1
, pp. 11-21
-
-
Cuesta, J.1
Read, M.A.2
Neidle, S.3
-
68
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffiths JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, De Lange T: Mammalian telomeres end in a large duplex loop. Cell (1999) 97(4):503-514.
-
(1999)
Cell
, vol.97
, Issue.4
, pp. 503-514
-
-
Griffiths, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
De Lange, T.7
-
69
-
-
0037382414
-
Erosion of the telomeric single-strand overhang at replicative senescence
-
Stewart SA, Ben-Porath I, Carey VJ, O'Conner BE, Hahn WC, Weinberg RA. Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 33(4):492-496.
-
(2003)
Nat Genet
, vol.33
, Issue.4
, pp. 492-496
-
-
Stewart, S.A.1
Ben-Porath, I.2
Carey, V.J.3
O'Conner, B.E.4
Hahn, W.C.5
Weinberg, R.A.6
-
70
-
-
0037457987
-
Evidence that exposure of the telomere 3′ overhang sequence induces senescence
-
Li GZ, Eller MS, Firoozabadi R, Gilchrest BA: Evidence that exposure of the telomere 3′ overhang sequence induces senescence. Proc Natl Acad Sci USA (2003) 100(2):527-531.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.2
, pp. 527-531
-
-
Li, G.Z.1
Eller, M.S.2
Firoozabadi, R.3
Gilchrest, B.A.4
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