Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo

Cancer Research

Volumn 63, Issue 4, 2003, Pages 824-830

  Naasani, Imad ^a,b,c,d   Oh hashi, Fujiko ^a   Oh hara, Tomoko ^a   Feng, Wan Yong ^c   Johnston, Jeffrey ^c   Chan, Kenneth ^c   Tsuruo, Takashi ^a,b  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c OHIO STATE UNIVERSITY   (United States)

^d BioCrystal Ltd   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHOCYANIN; CATECHIN; ELLAGIC ACID; EPICATECHIN; EPIGALLOCATECHIN GALLATE; FLAVONE DERIVATIVE; GALLIC ACID; MYRICETIN; POLYPHENOL; PRODRUG; PYROGALLOL; QUERCETIN; TELOMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEVERAGE; CANCER; CANCER GROWTH; CANCER INCIDENCE; CANCER INHIBITION; CONTROLLED STUDY; DIET; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; FOOD INTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TEA; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATECHIN; CELL DIVISION; COLONIC NEOPLASMS; ENZYME INHIBITORS; FEMALE; FLAVONOIDS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; OSTEOSARCOMA; PHENOLS; POLYMERS; TELOMERASE; TUMOR CELLS, CULTURED; U937 CELLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0037442701     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Yang, C. S., Landau, J. M., Huang, M. T., and Newmark, H. L. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr., 21: 381-406, 2001.
2. Murakami, A., Nakamura, Y., Torikai, K., Tanaka, T., Koshiba, T., Koshimizu, K., Kuwahara, S., Takahashi, Y., Ogawa, K., Yano, M., Tokuda, H., Nishino, H., Mimaki, Y., Sashida, Y., Kitanaka, S., and Ohigashi, H. Inhibitory effect of citrus nobiletin on phorbot ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Res., 60: 5059-5066, 2000.
3. Imai, K., Suga, K., and Nakachi, K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev. Med., 26: 769-775, 1997.
4. Caltagirone, S., Rossi, C., Poggi, A., Ranelletti, F. O., Natali, P. G., Brunetti, M., Aiello, F. B., and Piantelli, M. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int. J. Cancer. 87: 595-600, 2000.
5. Caderni, G., Remy, S., Cheynier, V., Morozzi, G., and Dolara, P. Effect of complex polyphenols on colon carcinogenesis. Eur, J. Nutr., 38: 126-132, 1999.
6. Waladkhani, A. R., and Clemens, M. R. Effect of dietary phytochemicals on cancer development. Int. J. Mol. Med., 1: 747-753, 1998.
7. Webb, T. Green tea experiments in lab, clinic yield mixed results. J. Natl. Cancer Inst., 92: 1038-1039, 2000.
8. Kono, S., Ikeda, M., Tokudome, S., and Kutratsune, M. A case-control study of gastric cancer and diet in northern Kyushu. Jpn. J. Cancer Res., 79: 1067-1074, 1988.
9. Gao, Y. T., McLaughlin, J. K., Blot, W. J., Ji, B. T., Dai, Q., and Fraumeni, J. F., Jr. Reduced risk of esophageal cancer associated with green tea consumption. J. Natl. Cancer Inst., 86: 855-858, 1994.
10. Ji, B. T., Chow, W. H., Hsing, A. W., McLaughlin, J. K., Dai, Q., Gao, Y. T., Blot, W. J., and Fraumeni, J. F. Jr. Green tea consumption and the risk of pancreatic and colorectal cancers. Int. J. Cancer. 70: 255-258, 1997.
11. Zhang. M., Binns, C. W., and Lee. A. H. Tea consumption and ovarian cancer risk: a case-control study in China. Cancer Epidemiol. Biomark. Prev., 11: 713-718, 2002.
12. Suganuma, M., Okabe, S., Sueoka, N., Sueoka, E., Matsuyama, S., Imai, K., Nakachi, K., and Fujiki, H. Green tea and cancer chemoprevention. Mutat. Res., 428: 339-344, 1999.
13. Naasani, I., Seimiya, H., and Tsuruo, T. Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins Biochem. Biophys. Res. Commun., 249: 391-396, 1998.
14. McEachern, M. J., Krauskopf, A., and Blackburn, E. H. Telomeres and their control. Annu. Rev. Genet., 34: 331-358, 2000.
15. Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E. Extension of life-span by introduction of telomerase into normal human cells. Science (Wash. DC), 279: 349-352, 1998.
16. Yang, J., Chang, E., Cherry, A. M., Bangs, C. D., Oei, Y., Bodnar, A., Bronstein, A., Chiu, C. P., and Herron, G. S. Human endothelial cell life extension by telomerase expression. J. Biol. Chem., 274: 26141-26148, 1999.
17. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Wash. DC), 266: 2011-2015, 1994.
18. Hiyama, E., Hiyama, K., Yokoyama, T., Matsuura, Y., Piatyszek, M. A., and Shay, J. W. Correlating telomerase activity levels with human neuroblastoma outcomes. Nat. Med., 1: 249-255, 1995.
19. Fujiwara, M., Okayasu, I., Takemura, T., Tanaka, I., Masuda, R., Furuhata, Y., Noji, M., Oritsu, M., Kato, M., and Oshimura, M. Telomerase activity significantly correlates with chromosome alterations, cell differentiation, and proliferation in lung adenocarcinomas. Mod. Pathol., 13: 723-729, 2000.
20. Fu, W., Begley, J. G., Killen, M. W., and Mattson, M. P. Anti-apoptotic role of telomerase in pheochromocytoma cells. J. Biol. Chem., 274: 7264-7271, 1999.
21. Zhu, J., Wang, H., Bishop, J. M., and Blackburn, E. H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA, 96, 3723-3728, 1999.
22. Xiang, H., Wang, J., Mao, Y. W., and Li, D. W. hTERT can function with rabbit telomerase RNA: regulation of gene expression and attenuation of apoptosis. Biochem. Biophys. Res. Commun., 278: 503-510, 2000.
23. Akiyama, M., Yamada, O., Kanda, N., Akita, S., Kawano, T., Ohno, T., Mizoguchi, H., Eto, Y., Anderson, K. C., and Yamada, H. Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors. Cancer Lett., 178: 187-197, 2002.
24. Herbert, B. S., Wright, A. C., Passons, C. M., Wright, W. E., Ali, I. U., Kopelovich, L., and Shay, J. W. Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells. J. Natl. Cancer Inst., 93: 39-45, 2001.
25. Naasani, I., Seimiya, H., Yamori, T., and Tsuruo, T. FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer Res., 59: 4004-4011, 1999.
26. Piskula, M. K., and Terao, J. Accumulation of (-)-epicatechin metabolites in rat plasma after oral administration and distribution of conjugation enzymes in rat tissues. J. Nutr., 128: 1172-1178, 1998.
27. Chen, L., Lee, M. J., Li, H., and Yang, C. S. Absorption, distribution, elimination of tea polyphenols in rats. Drug Metab. Dispos., 25: 1045-1050, 1997.
28. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O., and Peacocke, M. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA, 92: 9363-9367, 1995.
29. Feng, J., Funk, W. D., Wang, S. S., Weinrich, S. L., Avilion, A. A., Chiu, C. P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., Le, S., West, M. D., Harley, C. B., Andrews, W. H., Greider, C. W., and Villiponteau, B. The RNA component of human telomerase. Science (Wash. DC), 269: 1236-1241, 1995.
30. , Scalbert, A., and Williamson, G. Dietary intake and bioavailability of polyphenols. J. Nutr., 130: 2073S-2085S, 2000.
31. Valcic, S., Burr, J. A., Timmermann, B. N., and Liebler, D. C. Antioxidant chemistry of green tea catechins. New oxidation products of (-)-epigallocatechin gallate and (-)-epigallocatechin from their reactions with peroxyl radicals. Chem. Res. Toxicol. 13: 801-810, 2000.
32. Donovan, J. L., Bell, J. R., Kasim-Karakas, S., German, J. B., Walzem, R. L., Hansen, R. J., and Waterhouse, A. L. Catechin is present as metabolites in human plasma after consumption of red wine. J. Nutr. 129: 1662-1668, 1999.
33. Zhu, Q. Y., Zhang, A., Tsang, D., Huang, Y., and Chen, Z. Y. Stability of Green Tea Catechins. J. Agric. Food Chem., 45: 4624-4628, 1997.
34. Ketsawatsakul, U., Whiteman, M., and Halliwell, B. A reevaluation of the peroxynitrite scavenging activity of some dietary phenolics. Biochem. Biophys. Res. Commun., 279: 692-699, 2000.
35. Henson, J. D., Neumann, A. A., Yeager, T. R., and Reddel, R. R. Alternative lengthening of telomeres in mammalian cells. Oncogene, 21: 598-610, 2002.
36. Mergny, J. L., Riou, J. F., Mailliet, P., Teulade-Fichou, M. P., and Gilson, E. Natural and pharmacological regulation of telomerase. Nucleic Acids Res., 30: 839-865, 2002.
37. Hodes, R. Molecular targeting of cancer: telomeres as targets. Proc. Natl. Acad. Sci. USA. 98: 7649-7651, 2001.
38. Cao, Y., and Cao, R. Angiogenesis inhibited by drinking tea. Nature (Lond.), 398: 381, 1999.
39. Hanahan, D., and Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86: 353-364, 1996.
40. Ferrara, N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am. J. Physiol. Cell Physiol., 280: C1358-1366, 2001.
41. Jones, M. K., Wang, H., Peskar, B. M., Levin, E., Itani, R. M., Sarfeh, I. J., and Tarnawski, A. S. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat. Med., 5: 1418-1423, 1999.
42. Mukhtar, H., and Ahmad, N. Tea polyphenols: prevention of cancer and optimizing health. Am. J. Clin. Nutr., 71: 1698S-702S, 2000.
43. Seimiya, H., Oh-hara, T., Suzuki, T., Naasani, I., Shimazaki, T., Tsuchiya, K., and Tsuruo, T. Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-199. Mol. Cancer Ther., 1: 657-665, 2002.