Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells

Biochemical Journal

Volumn 373, Issue 2, 2003, Pages 523-529

  Kim, Jun Hyun ^a   Kim, Joo Hee ^a   Lee, Gun Eui ^a   Kim, Sang Woong ^b   Chung, In Kwon ^a  

^a Yonsei University   (South Korea)

^b LeadGenex Inc   (South Korea)

Author keywords

Anti cancer agent; Chemical small molecule library; Inhibitor; Senescence; Telomerase; Telomere

Indexed keywords

CHEMOTHERAPY; DNA; RNA; TUMORS;

HUMAN CANCER CELLS;

CELLS;

2,3,7 TRICHLORO 5 NITROQUINOXALINE; ANTINEOPLASTIC AGENT; CELL DNA; DNA POLYMERASE; QUINOXALINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA POLYMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CELL AGING; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; TELOMERE;

BETA-GALACTOSIDASE; BINDING SITES; BREAST NEOPLASMS; CELL AGING; CELL DIVISION; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; DNA-DIRECTED RNA POLYMERASES; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; KINETICS; PHENOTYPE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; QUINOXALINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TELOMERASE; TELOMERE; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0042346283     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030363     Document Type: Article

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