2-5a antisense therapy directed against human telomerase rna inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells

Cancer Gene Therapy

Volumn 9, Issue 7, 2002, Pages 624-630

  Yatabe, Noriyuki ^a   Kyo, Satoru ^a   Kondo, Seiji ^b   Kanaya, Taro ^a   Wang, Zhuo ^a   Maida, Yoshiko ^a   Takakura, Masahiro ^a   Nakamura, Mitsuhiro ^a   Tanaka, Masaaki ^a   Inoue, Masaki ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Antisense oligonucleotide; Cervical cancer; Gene therapy; HTR; Telomerase

Indexed keywords

ADENOSINE PHOSPHATE; ANTISENSE OLIGONUCLEOTIDE; CASPASE; CASPASE INHIBITOR; LIPOFECTAMINE; RNA; TELOMERASE; OLIGONUCLEOTIDE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE THERAPY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TELOMERE; UTERINE CERVIX CANCER; CELL CULTURE; CELL SURVIVAL; DRUG ANTAGONISM; FEMALE; FLOW CYTOMETRY; GENETIC TRANSFECTION; GENETICS; METABOLISM; METHODOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TIME; UTERINE CERVIX TUMOR;

APOPTOSIS; BLOTTING, SOUTHERN; CELL SURVIVAL; CERVIX NEOPLASMS; FEMALE; FLOW CYTOMETRY; GENE THERAPY; HUMAN; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SUPPORT, NON-U.S. GOV'T; TELOMERASE; TELOMERE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; HUMANS; UTERINE CERVICAL NEOPLASMS;

EID: 0036019380     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700479     Document Type: Article

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