Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3'-azido-3'-deoxythymidine

Clinical Cancer Research

Volumn 4, Issue 3, 1998, Pages 693-696

  Melana, Stella M ^a   Holland, James F ^a   Pogo, Beatriz G T ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE; ZIDOVUDINE;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; BREAST; BREAST NEOPLASMS; CELL DIVISION; CELL LINE; CELL SURVIVAL; CLONE CELLS; FEMALE; HUMANS; TELOMERASE; TUMOR CELLS, CULTURED; ZIDOVUDINE;

EID: 0031949642     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Izuta, I., Saneyoshi, M., Sakurai, T., Suzuki, M., Kojima, K., and Yoshida, S. The 5′-triphosphates of 3′-azido-3′-deoxythymidine and 2′, 3′ dideoxynucleosides inhibit DNA polymerase γ by different mechanisms. Biochem. Bhiophys. Res. Commun., 179: 776-785, 1991.
2. Olivero. O., and Poirier, M. Preferential incorporation of 3′-azido 2′,3′-dideoxythymidine into telomeric DNA and Z DNA-containing regions of Chinese hamster ovary cells. Mol. Carcinog., 8: 81-88, 1993.
3. Falcone, A., Lencioni, M., Bunetti, I., Pfanner, E., Allegrini, G., Antonuzzo, A., Andreuccetti, M., Malvaldi, G., Danesi, R., Del Tacca, M., and Conte, P. F. Maximum tolerable doses of intravenous zidovudine in combination with 5-fluorouracil and leucovorin in metastatic colorectal cancer patients. Ann. Oncol., 8: 539-545, 1997.
4. Posner, M. R., Darnowski, J. W., Calabresi, P., Brunetti, I., Corvese, D., Curt, G., Cummings, F. J., Clark, J., Browne, M. J. Beitz, J., and Weitberg, A. B. Oral zidovudine, continuous-infusion fluorouracil, and oral leucovorin calcium: a Phase I study. J. Natl. Cancer Inst., 82: 1710-1714, 1990.
5. Posner, M. R., Darnowski, J. W., Weitberg, A. B., Dudley, M. N., Corvese, B. A., Cummings. F. J., Clark, J., Murray, C, Clendennin, N., Bigley, J., and Calabresi, P. High-dose intravenous zidovudine with 5-fluorouracil and leucovorin. Cancer (Phila.), 70: 2929-2934, 1992.
6. Beitz, J. G., Darnowski, J. W., Cummings, F. J., Browne, M., Clark, J., Bigley, J., and Weitberg, A. A Phase I and pharmacologic analysis of fluorouracil + leucovorin combined with infused high-dose zidovudine. Proc. Am. Assoc. Cancer Res., 33: 427, 1992.
7. Posner, M., Darnowski, J., Tessitore, J., Bigley, J., Parker, L., Stuart, K., and Huberman, M. A Phase I trial of high dose, intravenous zidovudine (AZT) and 5-fluorouracil/leucovorin (FUra/L). Proc. Am. Soc. Clin. Oncol., 12: 162, 1993.
8. Anand, A., Ellis, M., Tessitore, J. Huberman, M., Parker, L. M., Stuart, K., and Posner, M. A Phase I study of intermittent high-dose zidovudine. 5-fluorouracil leucovorin and cisplatin. Proc. Am. Soc. Clin. Oncol.. 14: 481, 1995.
9. Kim, N. W., Piatszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay. J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 266: 2011-2015, 1994.
10. Pressacco, J., and Erlichman, C. Combination studies with 3′-azido3′deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects. Biochem. Pharmacol., 46: 1989-1997, 1993.
11. Strahl, C., and Blackburn, E. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol. Cell. Biol., 16: 53-65, 1996.
12. Soule, H. D., Vazquez, J., Long, A., Albert, S., and Brennan, M. Human cell line from a breast carcinoma J. Natl. Cancer Inst., 51: 1409-1416. 1973.
13. Keydar, I., Chen, L., Karby, S., Weiss, F. R., Delarea, J., Radu, M., Chaitchick. S., and Brenner, H. J. Establishment and characterization of a cell line of human breast carcinoma origin. Eur. J. Cancer, 15: 659-670. 1979.
14. Soule, H. P., Maloney, T., Wolman, S., Peterson, W., Brentz, R., McGrath, C. M., Russo, J., Pauley, R., Jones, R., and Brooks, S. C. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-1O. Cancer Res., 50: 6087-6094, 1990.
15. Engel, L., Young, N., Tralka, T., Lippman, M., O'Brien, S., and Joyce, M. Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. Cancer Res., 38: 3352-3364, 1978.
16. McAteer, J. A., and Davis, J. Basic cell culture technique and the maintenance of cell lines. In: J. M. Davis (ed.), Basic Cell Culture: A Practical Approach, pp. 93-145. New York: IRL Press at Oxford University Press.
17. Piatyszek, M. A., Kim, N. W., Weinrich, S. L., Hiyama, K., Wright, W. E., and Shay, J. W. Detection of telomerase activity in human cells and tumors. Telomeric repeat amplification protocol (TRAP). Methods Cell Sci., 17: 1-15, 1995.
18. Broccoli, D., Young, J. W., and de Lange, T. Telomerase activity in normal and malignant hematopoeitic cells. Proc. Natl. Acad. Sci. USA, 92: 9082-9086, 1995.
19. Mazumder, A., Cooney, D., Agbaria, R., Gupta, M., and Pommier, Y. Inhibition of human immunodeficiency virus type 1 integrase by 3′-azido-3′-deoxythymidylate. Proc. Natl. Acad. Sci. USA, 91: 5771-5775, 1994.
20. Lewis, W., and Dalakas, M. Mitochondrial toxicity of antiviral drugs. Nat. Med., 1: 417-420, 1995.
21. Jacobsson, B., Britton, S., He, Q., Karlsson, A., and Ericksson, S. Decreased thymidine kinase levels in peripheral blood cells from HIV-seropositive individuals: implications for zidovudine metabolism. AIDS Res. Hum. Retroviruses, 11: 805-811, 1995.
22. Wu S., Liu X., Solorzano, M. M., Kwock. R., and Avramis, V. I. Development of zidovudine (AZT) resistance in Jurkat cell is associated with decreased expression of the thymidine kinase (TK) gene and hypermethylation of the 5′ end of human TK gene. J. Acquired Immune Defic. Syndr. Hum. Retrovirol., 8: 1-9, 1995.
23. McGrath, C. M., Grant, P. M., Soule, H. D., Glancy, T., and Rich, M. A. Replication of oncornavirus-like particle in human breast carcinoma cell line, MCF-7. Nature (Lond.), 252: 247-250, 1972.
24. Patience, C., Simpson, G. R., Colletta, A. A., Welch, H. M., Weiss, R. A., and Boyd, M. T. Human endogenous retrovirus expression and reverse transcriptase activity in the T47D mammary carcinoma cell line. J. Virol., 70: 2654-2657, 1996.
25. Wang, Y., Holland, J. F., Bleiweiss, I. K., Melana, S., Liu, X., Pelisson, I., Cantarella, A., Stellrecht, K., Mani, S., and Pogo, B. G. T. Detection of mammary tumor virus env gene-like sequences in human breast cancer. Cancer Res., 55: 5173-5179, 1995.
26. Hiyama, E., Gollahon, L., Kataoka, T., Kuroi, K., Yokoyama, T., Gazdar, A. F., Hiyama, K., Piatyszek, M. A., and Shay, J. W. Telomerase activity in human breast tumors. J. Natl. Cancer Inst., 88: 116-122, 1996.
27. Bednarek, A. K., Sabin, A., Brenner, A. J., Johnston, D. A., and Aldaz, M. C. Analysis of telomerase activity levels in breast cancer: positive detection at the in situ breast carcinoma stage. Clin. Cancer Res., 3: 11-16, 1997.
28. Lavie, A., Schlichting. I., Vetter, I. R., Konrad, M., Reinstein, J., and Goody, R. S. The bottleneck in AZT activation. Nat. Med., 3: 922-924, 1997.
29. Faraoni, I., Turriziani, M., Masci, G., De Vecchis, L., Shay, J. W., Bonmassar, E., and Graziani, G. Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro. Clin. Cancer Res., 3: 579-585, 1997.
30. Wagner, C. R. et al. Potent growth inhibitory activity of zidovudine on cultured breast cancer cells and rat mammary tumors. Cancer Res., 57: 2341-2347, 1997.