메뉴 건너뛰기




Volumn 55, Issue 1, 2003, Pages 51-64

Molecular mechanisms of hepatitis C virus, potential therapeutic targets;Mecanismos moleculares del virus de la hepatitis C, potenciales blancos terapéuticos

Author keywords

Hepatitis C; Hepatitis C virus (HCV); IRES; Protein translation; Recombinant DNA

Indexed keywords

ANTIVIRUS AGENT; DNA VACCINE; PEGINTERFERON ALPHA2A; PROTEINASE INHIBITOR; RECOMBINANT ALPHA INTERFERON; RECOMBINANT PROTEIN; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN; VIRUS RNA;

EID: 0038076230     PISSN: 00348376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (117)
  • 1
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo QL, Kuo GF, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989; 244: 359-62.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.F.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 3
    • 0030931156 scopus 로고    scopus 로고
    • Hepatitis C and hepatocellular carcinoma
    • Di Bisceglie AM. Hepatitis C and hepatocellular carcinoma. Hepatology 1997; 26: S34-S38.
    • (1997) Hepatology , vol.26
    • Di Bisceglie, A.M.1
  • 4
    • 0028047147 scopus 로고
    • Does hepatitis C virus cause hepatocellular carcinoma?
    • Blum HE. Does hepatitis C virus cause hepatocellular carcinoma? Hepatology 1994; 19: 251-5.
    • (1994) Hepatology , vol.19 , pp. 251-255
    • Blum, H.E.1
  • 5
    • 0035120818 scopus 로고    scopus 로고
    • Combination of interferon and ribavirin in chronic hepatitis C: Re-treatment of nonresponders to interferon
    • Di Bisceglie AM, Thompson J, Smith-Wilkaitis N, Brunt EM, Bacon BR. Combination of interferon and ribavirin in chronic hepatitis C: re-treatment of nonresponders to interferon. Hepatology 2001; 33: 704-7.
    • (2001) Hepatology , vol.33 , pp. 704-707
    • Di Bisceglie, A.M.1    Thompson, J.2    Smith-Wilkaitis, N.3    Brunt, E.M.4    Bacon, B.R.5
  • 6
    • 0015754157 scopus 로고
    • Hepatitis A: Detection by immune electron microscopy of a viruslike antigen associated with acute illness
    • Feinstone SM, Kapikian AZ, Purceli RH. Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness. Science 1973; 182: 1026-8.
    • (1973) Science , vol.182 , pp. 1026-1028
    • Feinstone, S.M.1    Kapikian, A.Z.2    Purceli, R.H.3
  • 8
    • 0020549362 scopus 로고
    • Non-A, non-B hepatitis in chimpanzees: Interference with acute hepatitis A virus and chronic hepatitis B virus infections
    • Bradley DW, Maynard JE, McCaustland KA, Murphy BL, Cook EH, Ebert JW. Non-A, non-B hepatitis in chimpanzees: interference with acute hepatitis A virus and chronic hepatitis B virus infections. J Med Virol 1983; 11: 207-13.
    • (1983) J. Med. Virol. , vol.11 , pp. 207-213
    • Bradley, D.W.1    Maynard, J.E.2    McCaustland, K.A.3    Murphy, B.L.4    Cook, E.H.5    Ebert, J.W.6
  • 10
    • 0021992766 scopus 로고
    • Posttransfusion non-A, non-B hepatitis in chimpanzees. Physicochemical evidence that the tubule-forming agent is a small, enveloped virus
    • Bradley DW, McCaustland KA, Cook EH, Schable CA, Ebert JW, Maynard JE. Posttransfusion non-A, non-B hepatitis in chimpanzees. Physicochemical evidence that the tubule-forming agent is a small, enveloped virus. Gastroenterology 1985; 88: 773-9.
    • (1985) Gastroenterology , vol.88 , pp. 773-779
    • Bradley, D.W.1    McCaustland, K.A.2    Cook, E.H.3    Schable, C.A.4    Ebert, J.W.5    Maynard, J.E.6
  • 12
    • 0024511734 scopus 로고
    • An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
    • Kuo G, Choo QL, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, et al. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 1989; 244: 362-4.
    • (1989) Science , vol.244 , pp. 362-364
    • Kuo, G.1    Choo, Q.L.2    Alter, H.J.3    Gitnick, G.L.4    Redeker, A.G.5    Purcell, R.H.6
  • 13
    • 0030024527 scopus 로고    scopus 로고
    • Evolutionary relationship of hepatitis C, pesti-, flavi-, plant-viruses, and newly discovered GB hepatitis agents
    • Ohba K, Mizokami M, Lau JY, Orito E, Ikeo K, Gojobori T. Evolutionary relationship of hepatitis C, pesti-, flavi-, plant-viruses, and newly discovered GB hepatitis agents. FEBS Lett 1996; 378: 232-4.
    • (1996) FEBS Lett. , vol.378 , pp. 232-234
    • Ohba, K.1    Mizokami, M.2    Lau, J.Y.3    Orito, E.4    Ikeo, K.5    Gojobori, T.6
  • 14
    • 0032408707 scopus 로고    scopus 로고
    • Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: Proposals for standardization. International Committee on Virus Taxonomy
    • Robertson B, Myers G, Howard C, Brettin T, Bukh J, Gaschen B, et al. Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization. International Committee on Virus Taxonomy. Arch Virol 1998; 143: 2493-503.
    • (1998) Arch. Virol. , vol.143 , pp. 2493-2503
    • Robertson, B.1    Myers, G.2    Howard, C.3    Brettin, T.4    Bukh, J.5    Gaschen, B.6
  • 15
    • 13244300646 scopus 로고    scopus 로고
    • Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent
    • Linnen J, Wages J Jr., Zhang-Keck ZY, Fry KE, Krawczynski KZ, Alter H, et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science 1996; 271: 505-8.
    • (1996) Science , vol.271 , pp. 505-508
    • Linnen, J.1    Wages J., Jr.2    Zhang-Keck, Z.Y.3    Fry, K.E.4    Krawczynski, K.Z.5    Alter, H.6
  • 17
    • 0034747214 scopus 로고    scopus 로고
    • Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication
    • Friebe P, Lohmann V, Krieger N, Bartenschlager R. Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication. J Virol 2001; 75: 12047-57.
    • (2001) J. Virol. , vol.75 , pp. 12047-12057
    • Friebe, P.1    Lohmann, V.2    Krieger, N.3    Bartenschlager, R.4
  • 18
    • 0036094885 scopus 로고    scopus 로고
    • Genetic analysis of sequences in the 3′ nontranslated region of hepatitis C virus that are important for RNA replication
    • Friebe P, Bartenschlager R. Genetic analysis of sequences in the 3′ nontranslated region of hepatitis C virus that are important for RNA replication. J Virol 2002; 76: 5326-38.
    • (2002) J. Virol. , vol.76 , pp. 5326-5338
    • Friebe, P.1    Bartenschlager, R.2
  • 20
    • 0029956389 scopus 로고    scopus 로고
    • Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry
    • Pestova TV, Hellen CU, Shatsky IN. Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry. Mol Cell Biol 1996; 16: 6859-69.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 6859-6869
    • Pestova, T.V.1    Hellen, C.U.2    Shatsky, I.N.3
  • 21
    • 0027414062 scopus 로고
    • Characterization of the hepatitis C virus-encoded serine proteinase: Determination of proteinase-dependent polyprotein cleavage sites
    • Grakoui A, McCourt DW, Wychowski C, Feinstone SM, Rice CM. Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J Virol 1993; 67: 2832-43.
    • (1993) J. Virol. , vol.67 , pp. 2832-2843
    • Grakoui, A.1    McCourt, D.W.2    Wychowski, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 22
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui A, Wychowski C, Lin C, Feinstone SM, Rice CM. Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol 1993; 67: 1385-95.
    • (1993) J. Virol. , vol.67 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 23
    • 0035955558 scopus 로고    scopus 로고
    • Recent advances in the molecular biology of hepatitis C virus
    • Rosenberg S. Recent advances in the molecular biology of hepatitis C virus. J Mol Biol 2001; 313: 451-64.
    • (2001) J. Mol. Biol. , vol.313 , pp. 451-464
    • Rosenberg, S.1
  • 24
    • 0034713462 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes immortalization of primary human hepatocytes
    • Ray RB, Meyer K, Ray R. Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology 2000; 271: 197-204.
    • (2000) Virology , vol.271 , pp. 197-204
    • Ray, R.B.1    Meyer, K.2    Ray, R.3
  • 25
    • 0033061215 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappa B activation
    • Marusawa H, Hijikata M, Chiba T, Shimotohno K. Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappa B activation. J Virol 1999; 73: 4713-20.
    • (1999) J. Virol. , vol.73 , pp. 4713-4720
    • Marusawa, H.1    Hijikata, M.2    Chiba, T.3    Shimotohno, K.4
  • 26
    • 0033541960 scopus 로고    scopus 로고
    • Hepatitis C virus core protein interacts with a human DEAD box protein DDX3
    • Owsianka AM, Patel AH. Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. Virology 1999; 257: 330-40.
    • (1999) Virology , vol.257 , pp. 330-340
    • Owsianka, A.M.1    Patel, A.H.2
  • 27
    • 0036058267 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line
    • Erhardt A, Hassan M, Heintges T, Haussinger D. Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line. Virology 2002; 292: 272-84.
    • (2002) Virology , vol.292 , pp. 272-284
    • Erhardt, A.1    Hassan, M.2    Heintges, T.3    Haussinger, D.4
  • 28
    • 0033945531 scopus 로고    scopus 로고
    • Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1
    • Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. J Virol 2000; 74: 1736-41.
    • (2000) J. Virol. , vol.74 , pp. 1736-1741
    • Aoki, H.1    Hayashi, J.2    Moriyama, M.3    Arakawa, Y.4    Hino, O.5
  • 29
    • 0033863120 scopus 로고    scopus 로고
    • Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer
    • Kato N, Yoshida H, Kioko Ono-Nita S, Kato J, Goto T, Otsuka M, et al. Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer. Hepatology 2000; 32: 405-12.
    • (2000) Hepatology , vol.32 , pp. 405-412
    • Kato, N.1    Yoshida, H.2    Kioko Ono-Nita, S.3    Kato, J.4    Goto, T.5    Otsuka, M.6
  • 30
    • 0029860266 scopus 로고    scopus 로고
    • Hypervariable region sequence in cryoglobulin-associated hepatitis C virus in sera of patients with chronic hepatitis C: Relationship to antibody response against hypervariable region genome
    • Aiyama T, Yoshioka K, Okumura A, Takayanagi M, Iwata K, Ishikawa T, et al. Hypervariable region sequence in cryoglobulin-associated hepatitis C virus in sera of patients with chronic hepatitis C: relationship to antibody response against hypervariable region genome. Hepatology 1996; 24: 1346-50.
    • (1996) Hepatology , vol.24 , pp. 1346-1350
    • Aiyama, T.1    Yoshioka, K.2    Okumura, A.3    Takayanagi, M.4    Iwata, K.5    Ishikawa, T.6
  • 31
    • 0034646996 scopus 로고    scopus 로고
    • The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
    • Farci P, Shimoda A, Coiana A, Diaz G, Peddis G, Melpolder JC, et al. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science 2000; 288: 339-44.
    • (2000) Science , vol.288 , pp. 339-344
    • Farci, P.1    Shimoda, A.2    Coiana, A.3    Diaz, G.4    Peddis, G.5    Melpolder, J.C.6
  • 33
    • 0033516497 scopus 로고    scopus 로고
    • Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
    • Taylor DR, Shi ST, Romano PR, Barber GN, Lai MM. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 1999; 285: 107-10.
    • (1999) Science , vol.285 , pp. 107-110
    • Taylor, D.R.1    Shi, S.T.2    Romano, P.R.3    Barber, G.N.4    Lai, M.M.5
  • 34
    • 0027287798 scopus 로고
    • Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    • Bartenschlager R, Ahlborn-Laake L, Mous J, Jacobsen H. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol 1993; 67: 3835-44.
    • (1993) J. Virol. , vol.67 , pp. 3835-3844
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 35
    • 0032974384 scopus 로고    scopus 로고
    • The NS3/4A proteinase of the hepatitis C virus: Unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
    • Bartenschlager R. The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy. J Virol Hepat 1999; 6: 165-81.
    • (1999) J. Virol. Hepat. , vol.6 , pp. 165-181
    • Bartenschlager, R.1
  • 36
    • 0034629363 scopus 로고    scopus 로고
    • Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes
    • Di Marco S, Rizzi M, Volpari C, Walsh MA, Narjes F, Colarusso S, et al. Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes. J Biol Chem 2000; 275: 7152-7.
    • (2000) J. Biol. Chem. , vol.275 , pp. 7152-7157
    • Di Marco, S.1    Rizzi, M.2    Volpari, C.3    Walsh, M.A.4    Narjes, F.5    Colarusso, S.6
  • 38
    • 0032938224 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth
    • Ghosh AK, Steele R, Meyer K, Ray R, Ray RB. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. Journal of General Virology 1999; 80: 1179-83.
    • (1999) Journal of General Virology , vol.80 , pp. 1179-1183
    • Ghosh, A.K.1    Steele, R.2    Meyer, K.3    Ray, R.4    Ray, R.B.5
  • 39
    • 0029742568 scopus 로고    scopus 로고
    • Interferon sensitivity determining sequence of the hepatitis C virus genome
    • Miyamura T. Interferon sensitivity determining sequence of the hepatitis C virus genome. Hepatology 1996; 24: 460-1.
    • (1996) Hepatology , vol.24 , pp. 460-461
    • Miyamura, T.1
  • 40
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
    • Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 1996; 334: 77-81.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 77-81
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6
  • 41
    • 0029161576 scopus 로고
    • Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
    • Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96: 224-30.
    • (1995) J. Clin. Invest. , vol.96 , pp. 224-230
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6
  • 42
    • 0031658197 scopus 로고    scopus 로고
    • Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein
    • Fukuma T, Enomoto N, Marumo F, Sato C. Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein. Hepatology 1998; 28: 1147-53.
    • (1998) Hepatology , vol.28 , pp. 1147-1153
    • Fukuma, T.1    Enomoto, N.2    Marumo, F.3    Sato, C.4
  • 43
    • 0034080813 scopus 로고    scopus 로고
    • Lack of clinical evidence for involvement of hepatitis C virus interferon-alpha sensitivity-determining region variability in RNA-dependent protein kinase-mediated cellular antiviral responses
    • Mihm S, Monazahian M, Grethe S, Meier V, Thomssen R, Ramadori G. Lack of clinical evidence for involvement of hepatitis C virus interferon-alpha sensitivity-determining region variability in RNA-dependent protein kinase-mediated cellular antiviral responses. J Med Virol 2000; 61: 29-36.
    • (2000) J. Med. Virol. , vol.61 , pp. 29-36
    • Mihm, S.1    Monazahian, M.2    Grethe, S.3    Meier, V.4    Thomssen, R.5    Ramadori, G.6
  • 44
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale MJ Jr., Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE, et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 1997; 230: 217-27.
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale M.J., Jr.1    Korth, M.J.2    Tang, N.M.3    Tan, S.L.4    Hopkins, D.A.5    Dever, T.E.6
  • 45
    • 17144463221 scopus 로고    scopus 로고
    • Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: Molecular mechanisms of kinase regulation
    • Gale M Jr., Blakely CM, Kwieciszewski B, Tan SL, Dossett M, Tang NM, et al. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol Cell Biol 1998; 18: 5208-18.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 5208-5218
    • Gale M., Jr.1    Blakely, C.M.2    Kwieciszewski, B.3    Tan, S.L.4    Dossett, M.5    Tang, N.M.6
  • 46
    • 0242422098 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis
    • Francois C, Duverlie G. Rebouillat D, Khorsi H, Castelain S, Blum HE, et al. Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis. Journal of Virol 2000; 74: 5587-96.
    • (2000) Journal of Virol. , vol.74 , pp. 5587-5596
    • Francois, C.1    Duverlie, G.2    Rebouillat, D.3    Khorsi, H.4    Castelain, S.5    Blum, H.E.6
  • 48
    • 0033692476 scopus 로고    scopus 로고
    • Recent advances in the analysis of HCV NS5B RNA-dependent RNA polymerase
    • Lesburg CA, Radfar RF, Weber PC. Recent advances in the analysis of HCV NS5B RNA-dependent RNA polymerase. Curr Opin Investig Drugs 2000; 1: 289-96.
    • (2000) Curr. Opin. Investig. Drugs , vol.1 , pp. 289-296
    • Lesburg, C.A.1    Radfar, R.F.2    Weber, P.C.3
  • 49
    • 0036194639 scopus 로고    scopus 로고
    • Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase
    • Wang QM, Hockman MA, Staschke KF, Johnson RB, Case KA, Lu JF, et al. Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase. J Virol 2002;76:3865-72.
    • (2002) J. Virol. , vol.76 , pp. 3865-3872
    • Wang, Q.M.1    Hockman, M.A.2    Staschke, K.F.3    Johnson, R.B.4    Case, K.A.5    Lu, J.F.6
  • 50
    • 0032530621 scopus 로고    scopus 로고
    • Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus
    • Lohmann V, Roos A, Korner F, Koch JO, Bartenschlager R. Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus. Virology 1998; 249: 108-18.
    • (1998) Virology , vol.249 , pp. 108-118
    • Lohmann, V.1    Roos, A.2    Korner, F.3    Koch, J.O.4    Bartenschlager, R.5
  • 51
    • 0037016676 scopus 로고    scopus 로고
    • Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase
    • Moradpour D, Bieck E, Hugle T, Wels W, Wu JZ, Hong Z, et al. Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem 2002; 277: 593-601.
    • (2002) J. Biol. Chem. , vol.277 , pp. 593-601
    • Moradpour, D.1    Bieck, E.2    Hugle, T.3    Wels, W.4    Wu, J.Z.5    Hong, Z.6
  • 52
    • 0035021347 scopus 로고    scopus 로고
    • Characterization of monoclonal antibodies that specifically recognize the palm subdomain of hepatitis C virus nonstructural protein 5B polymerase
    • Ingravallo P, Lahser F, Xia E, Sodowich B, Lai VC, Hong Z, et al. Characterization of monoclonal antibodies that specifically recognize the palm subdomain of hepatitis C virus nonstructural protein 5B polymerase. Virus Res 2001; 75: 179-87.
    • (2001) Virus Res. , vol.75 , pp. 179-187
    • Ingravallo, P.1    Lahser, F.2    Xia, E.3    Sodowich, B.4    Lai, V.C.5    Hong, Z.6
  • 53
    • 0033794684 scopus 로고    scopus 로고
    • The effects of the conserved extreme 3′ end sequence of hepatitis C virus (HCV) RNA on the in vitro stabilization and translation of the HCV RNA genome
    • Fang JW, Moyer RW. The effects of the conserved extreme 3′ end sequence of hepatitis C virus (HCV) RNA on the in vitro stabilization and translation of the HCV RNA genome. J Hepatol 2000; 33: 632-9.
    • (2000) J. Hepatol. , vol.33 , pp. 632-639
    • Fang, J.W.1    Moyer, R.W.2
  • 54
    • 0033515094 scopus 로고    scopus 로고
    • In vivo analysis of the 3′ untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone
    • Yanagi M, St Claire M, Emerson SU, Purcell RH, Bukh J. In vivo analysis of the 3′ untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone. Proc Natl Acad Sci USA 1999; 96: 2291-5.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2291-2295
    • Yanagi, M.1    St Claire, M.2    Emerson, S.U.3    Purcell, R.H.4    Bukh, J.5
  • 55
    • 0033224562 scopus 로고    scopus 로고
    • The molecular biology of hepatitis C virus. Genotypes and quasispecies
    • Forns X, Bukh J. The molecular biology of hepatitis C virus. Genotypes and quasispecies. Clin Liver Dis 1999; 3: 693-716.
    • (1999) Clin. Liver Dis. , vol.3 , pp. 693-716
    • Forns, X.1    Bukh, J.2
  • 57
    • 84991184625 scopus 로고
    • Degree of diversity of hepatitis C virus quasispecies and progression of liver disease
    • Honda M, Kaneko S, Sakai A, Unoura M, Murakami S, Kobayashi K. Degree of diversity of hepatitis C virus quasispecies and progression of liver disease. Hepatology 1994; 20: 1144-51.
    • (1994) Hepatology , vol.20 , pp. 1144-1151
    • Honda, M.1    Kaneko, S.2    Sakai, A.3    Unoura, M.4    Murakami, S.5    Kobayashi, K.6
  • 58
    • 0026726857 scopus 로고
    • Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: Variability and stability
    • Okamoto H, Kojima M, Okada S, Yoshizawa H, Iizuka H, Tanaka T, et al. Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology 1992; 190: 894-9.
    • (1992) Virology , vol.190 , pp. 894-899
    • Okamoto, H.1    Kojima, M.2    Okada, S.3    Yoshizawa, H.4    Iizuka, H.5    Tanaka, T.6
  • 59
    • 0035678574 scopus 로고    scopus 로고
    • Hepatitis C virus genotyping: Clinical implications and methods
    • Nolte FS. Hepatitis C virus genotyping: Clinical implications and methods. Mol Diagn 2001; 6: 265-77.
    • (2001) Mol. Diagn. , vol.6 , pp. 265-277
    • Nolte, F.S.1
  • 62
    • 0028304599 scopus 로고
    • Diagnostic and clinical implications of the different genotypes of hepatitis C virus
    • Bukh J, Miller RH. Diagnostic and clinical implications of the different genotypes of hepatitis C virus. Hepatology 1994; 20: 256-9.
    • (1994) Hepatology , vol.20 , pp. 256-259
    • Bukh, J.1    Miller, R.H.2
  • 63
    • 0034772636 scopus 로고    scopus 로고
    • Hepatitis C virus. The importance of viral heterogeneity
    • Farci P. Hepatitis C virus. The importance of viral heterogeneity. Clin Liver Dis 2001; 5: 895-916.
    • (2001) Clin. Liver Dis. , vol.5 , pp. 895-916
    • Farci, P.1
  • 65
    • 0026036931 scopus 로고
    • Detection of hepatitis C viral RNA by the polymerase chain reaction
    • Lucey M, Traber PG. Detection of hepatitis C viral RNA by the polymerase chain reaction. Hepatology 1991;13: 193-5.
    • (1991) Hepatology , vol.13 , pp. 193-195
    • Lucey, M.1    Traber, P.G.2
  • 66
    • 0033025269 scopus 로고    scopus 로고
    • Comparative evaluation of hepatitis C virus RNA quantitation by branched DNA, NASBA, and monitor assays
    • Lunel F, Cresta P, Vitour D, Payan C, Dumont B, Frangeul L, et al. Comparative evaluation of hepatitis C virus RNA quantitation by branched DNA, NASBA, and monitor assays. Hepatology 1999; 29: 528-35.
    • (1999) Hepatology , vol.29 , pp. 528-535
    • Lunel, F.1    Cresta, P.2    Vitour, D.3    Payan, C.4    Dumont, B.5    Frangeul, L.6
  • 67
    • 0027220727 scopus 로고
    • Detection of serum hepatitis C virus RNA in HCV antibody-seropositive volunteer blood donors
    • McGuinness PH, Bishop GA, Lien A, Wiley B, Parsons C, McCaughan GW. Detection of serum hepatitis C virus RNA in HCV antibody-seropositive volunteer blood donors. Hepatology 1993; 18: 485-90.
    • (1993) Hepatology , vol.18 , pp. 485-490
    • McGuinness, P.H.1    Bishop, G.A.2    Lien, A.3    Wiley, B.4    Parsons, C.5    McCaughan, G.W.6
  • 68
    • 0031807165 scopus 로고    scopus 로고
    • Does the hepatitis C virus replicate in cells of the hematopoietic lineage?
    • Negro F, Levrero M. Does the hepatitis C virus replicate in cells of the hematopoietic lineage? Hepatology 1998; 28: 261-4.
    • (1998) Hepatology , vol.28 , pp. 261-264
    • Negro, F.1    Levrero, M.2
  • 69
    • 0033589745 scopus 로고    scopus 로고
    • Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis
    • Ramratnam B, Bonhoeffer S, Binley J, Hurley A, Zhang L, Mittler J, et al. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 1999; 354: 1782-5.
    • (1999) Lancet , vol.354 , pp. 1782-1785
    • Ramratnam, B.1    Bonhoeffer, S.2    Binley, J.3    Hurley, A.4    Zhang, L.5    Mittler, J.6
  • 70
    • 0033607281 scopus 로고    scopus 로고
    • Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor
    • Agnello V, Abel G, Elfahal M, Knight GB, Zhang QX. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci USA 1999; 96: 12766-71.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12766-12771
    • Agnello, V.1    Abel, G.2    Elfahal, M.3    Knight, G.B.4    Zhang, Q.X.5
  • 73
    • 0029817885 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus replication in cloned cells obtained from a human T-cell leukemia virus type 1-infected cell line, MT-2
    • Mizutani T, Kato N, Saito S, Ikeda M, Sugiyama K, Shimotohno K. Characterization of hepatitis C virus replication in cloned cells obtained from a human T-cell leukemia virus type 1-infected cell line, MT-2. J Virol 1996; 70: 7219-23.
    • (1996) J. Virol. , vol.70 , pp. 7219-7223
    • Mizutani, T.1    Kato, N.2    Saito, S.3    Ikeda, M.4    Sugiyama, K.5    Shimotohno, K.6
  • 74
    • 0029940724 scopus 로고    scopus 로고
    • Characterization of long-term cultures of hepatitis C virus
    • Nakajima N, Hijikata M, Yoshikura H, Shimizu YK. Characterization of long-term cultures of hepatitis C virus. J Virol 1996; 70: 3325-9.
    • (1996) J. Virol. , vol.70 , pp. 3325-3329
    • Nakajima, N.1    Hijikata, M.2    Yoshikura, H.3    Shimizu, Y.K.4
  • 75
    • 0031714336 scopus 로고    scopus 로고
    • In vitro infection of adult normal human hepatocytes in primary culture by hepatitis C virus
    • Fournier C, Sureau C, Coste J, Ducos J, Pageaux G, Larrey D, et al. In vitro infection of adult normal human hepatocytes in primary culture by hepatitis C virus. J Gen Virol 1998; 79: 2367-74.
    • (1998) J. Gen. Virol. , vol.79 , pp. 2367-2374
    • Fournier, C.1    Sureau, C.2    Coste, J.3    Ducos, J.4    Pageaux, G.5    Larrey, D.6
  • 76
    • 0037196583 scopus 로고    scopus 로고
    • In vitro models for hepatitis C
    • Bartenschlager R. In vitro models for hepatitis C. Virus Res 2002; 82: 25-32.
    • (2002) Virus Res. , vol.82 , pp. 25-32
    • Bartenschlager, R.1
  • 77
    • 0031862855 scopus 로고    scopus 로고
    • Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins
    • Moradpour D, Kary P, Rice CM, Blum HE. Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins. Hepatology 1998; 28: 192-201.
    • (1998) Hepatology , vol.28 , pp. 192-201
    • Moradpour, D.1    Kary, P.2    Rice, C.M.3    Blum, H.E.4
  • 78
    • 0035002162 scopus 로고    scopus 로고
    • Inducible model to study negative strand RNA synthesis and assembly of hepatitis C virus from a full-length cDNA clone
    • Myung J, Khalap N, Kalkeri G, Garry R, Dash S. Inducible model to study negative strand RNA synthesis and assembly of hepatitis C virus from a full-length cDNA clone. J Virol Methods 2001; 94: 55-67.
    • (2001) J. Virol. Methods , vol.94 , pp. 55-67
    • Myung, J.1    Khalap, N.2    Kalkeri, G.3    Garry, R.4    Dash, S.5
  • 79
    • 0034964795 scopus 로고    scopus 로고
    • Infectious cDNA clone of the hepatitis C virus genotype 1 prototype sequence
    • Lanford RE, Lee H, Chavez D, Guerra B, Brasky KM. Infectious cDNA clone of the hepatitis C virus genotype 1 prototype sequence. J Gen Viral 2001; 82: 1291-7.
    • (2001) J. Gen. Virol. , vol.82 , pp. 1291-1297
    • Lanford, R.E.1    Lee, H.2    Chavez, D.3    Guerra, B.4    Brasky, K.M.5
  • 80
    • 0028961384 scopus 로고
    • Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV
    • Yoo BJ, Selby MJ, Choe J, Sub BS, Choi SH, Joh JS, et al. Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV. J Virol 1995; 69: 32-8.
    • (1995) J. Virol. , vol.69 , pp. 32-38
    • Yoo, B.J.1    Selby, M.J.2    Choe, J.3    Sub, B.S.4    Choi, S.H.5    Joh, J.S.6
  • 82
    • 0034466886 scopus 로고    scopus 로고
    • Development of a primary tamarin hepatocyte culture system for GB virus-B: A surrogate model for hepatitis C virus
    • Beames B, Chavez D, Guerra B, Notvall L, Brasky KM, Lanford RE. Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus. J Viral 2000; 74: 11764-72.
    • (2000) J. Virol. , vol.74 , pp. 11764-11772
    • Beames, B.1    Chavez, D.2    Guerra, B.3    Notvall, L.4    Brasky, K.M.5    Lanford, R.E.6
  • 83
    • 0027959912 scopus 로고
    • Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a
    • Okamoto H, Mishiro S, Tokita H, Tsuda F, Miyakawa Y, Mayumi M. Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a. Hepatology 1994; 20: 1131-6.
    • (1994) Hepatology , vol.20 , pp. 1131-1136
    • Okamoto, H.1    Mishiro, S.2    Tokita, H.3    Tsuda, F.4    Miyakawa, Y.5    Mayumi, M.6
  • 86
    • 0036346427 scopus 로고    scopus 로고
    • Advances in model systems for hepatitis C virus research
    • Lanford RE, Bigger C. Advances in model systems for hepatitis C virus research. Virology 2002; 293: 1-9.
    • (2002) Virology , vol.293 , pp. 1-9
    • Lanford, R.E.1    Bigger, C.2
  • 87
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight KJ, Kolykhalov AA, Rice CM. Efficient initiation of HCV RNA replication in cell culture. Science 2000; 290: 1972-4.
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 88
    • 0036196022 scopus 로고    scopus 로고
    • Persistent and transient replication of full-length hepatitis C virus genomes in cell culture
    • Pietschmann T, Lehmann V, Kaul A, Krieger N, Rinck G, Rutter G, et al. Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol 2002; 76: 4008-21.
    • (2002) J. Virol. , vol.76 , pp. 4008-4021
    • Pietschmann, T.1    Lehmann, V.2    Kaul, A.3    Krieger, N.4    Rinck, G.5    Rutter, G.6
  • 89
    • 0036240477 scopus 로고    scopus 로고
    • Mechanism of action of ribavirin in the combination treatment of chronic HCV infection
    • Lau JY, Tam RC, Liang TJ, Hong Z. Mechanism of action of ribavirin in the combination treatment of chronic HCV infection. Hepatology 2002; 35: 1002-9.
    • (2002) Hepatology , vol.35 , pp. 1002-1009
    • Lau, J.Y.1    Tam, R.C.2    Liang, T.J.3    Hong, Z.4
  • 91
    • 0033844251 scopus 로고    scopus 로고
    • A dose-ranging study of pegylated interferon alfa-2b and ribavirin in chronic hepatitis C
    • The Hepatitis C Intervention Therapy Group
    • Glue P, Rouzier-Panis R, Raffanel C, Sabo R, Gupta SK, Salfi M, et al. A dose-ranging study of pegylated interferon alfa-2b and ribavirin in chronic hepatitis C. The Hepatitis C Intervention Therapy Group. Hepatology 2000; 32: 647-53.
    • (2000) Hepatology , vol.32 , pp. 647-653
    • Glue, P.1    Rouzier-Panis, R.2    Raffanel, C.3    Sabo, R.4    Gupta, S.K.5    Salfi, M.6
  • 92
    • 0026584974 scopus 로고
    • Genetic structure and heterogeneity of hepatitis C virus: A vaccine impediment?
    • Daugherty D. Genetic structure and heterogeneity of hepatitis C virus: a vaccine impediment? Hepatology 1992; 15: 739-41.
    • (1992) Hepatology , vol.15 , pp. 739-741
    • Daugherty, D.1
  • 93
    • 0030796292 scopus 로고    scopus 로고
    • Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires
    • Dimasi N, Martin F, Volpari C, Brunetti M, Biasiol G, Altamura S, et al. Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires. J Virol 1997; 71: 7461-9.
    • (1997) J. Virol. , vol.71 , pp. 7461-7469
    • Dimasi, N.1    Martin, F.2    Volpari, C.3    Brunetti, M.4    Biasiol, G.5    Altamura, S.6
  • 94
    • 0037041216 scopus 로고    scopus 로고
    • Azapeptides as inhibitors of the hepatitis C virus NS3 scrine protease
    • Zhang RF, Durkin JP, Windsor WT. Azapeptides as inhibitors of the hepatitis C virus NS3 scrine protease. Bioorg Med Chem Lett 2002; 12: 1005-8.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 1005-1008
    • Zhang, R.F.1    Durkin, J.P.2    Windsor, W.T.3
  • 95
    • 0035738231 scopus 로고    scopus 로고
    • Inhibition of the bovine viral diarrhoea virus NS3 serine protease by a boron-modified peptidyl mimetic of its natural substrate
    • Bukhtiyarova MF, Rizzo CJ, Kettner CA, Korant BD, Scarnati HT, King RW. Inhibition of the bovine viral diarrhoea virus NS3 serine protease by a boron-modified peptidyl mimetic of its natural substrate. Antivir Chem Chemother 2001;12: 367-73.
    • (2001) Antivir. Chem. Chemother. , vol.12 , pp. 367-373
    • Bukhtiyarova, M.F.1    Rizzo, C.J.2    Kettner, C.A.3    Korant, B.D.4    Scarnati, H.T.5    King, R.W.6
  • 96
    • 0029996016 scopus 로고    scopus 로고
    • Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes
    • Hanecak R, Brown-Driver V, Fox MC, Azad RF, Furusako S, Nozaki C, et al. Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes. J Virol 1996; 70: 5203-12.
    • (1996) J. Virol. , vol.70 , pp. 5203-5212
    • Hanecak, R.1    Brown-Driver, V.2    Fox, M.C.3    Azad, R.F.4    Furusako, S.5    Nozaki, C.6
  • 97
    • 0028303251 scopus 로고
    • Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence
    • Wakita T, Wands JR. Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence. J Biol Chem 1994; 269: 14205-10.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14205-14210
    • Wakita, T.1    Wands, J.R.2
  • 98
    • 0036545533 scopus 로고    scopus 로고
    • The hepatitis C virus internal ribosome-entry site: A new target for antiviral research
    • Gallego J, Varani G. The hepatitis C virus internal ribosome-entry site: a new target for antiviral research. Biochem Soc Trans 2002; 30: 140-6.
    • (2002) Biochem. Soc. Trans. , vol.30 , pp. 140-146
    • Gallego, J.1    Varani, G.2
  • 99
    • 0032876683 scopus 로고    scopus 로고
    • Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
    • Lesburg CA, Cable MB, Ferrari E, Hong Z, Mannarino AF, Weber PC. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol 1999; 6: 937-43.
    • (1999) Nat. Struct. Biol. , vol.6 , pp. 937-943
    • Lesburg, C.A.1    Cable, M.B.2    Ferrari, E.3    Hong, Z.4    Mannarino, A.F.5    Weber, P.C.6
  • 101
    • 0036304311 scopus 로고    scopus 로고
    • Viremia and immunogenicity in nonhuman primates of a tetravalent yellow fever-dengue chimeric vaccine: Genetic reconstructions, dose adjustment, and antibody responses against wild-type dengue virus isolates
    • Guirakhoo F, Pugachev K, Arroyo J, Miller C, Zhang ZX, Weltzin R, et al, Viremia and immunogenicity in nonhuman primates of a tetravalent yellow fever-dengue chimeric vaccine: genetic reconstructions, dose adjustment, and antibody responses against wild-type dengue virus isolates. Virology 2002; 298: 146-59.
    • (2002) Virology , vol.298 , pp. 146-159
    • Guirakhoo, F.1    Pugachev, K.2    Arroyo, J.3    Miller, C.4    Zhang, Z.X.5    Weltzin, R.6
  • 102
    • 0034915714 scopus 로고    scopus 로고
    • Hepatitis C virus-like particles induce virus-specific humoral and cellular immune responses in mice
    • Lechmann M, Murata K, Satoi J, Vergalla J, Baumert TF, Liang TJ. Hepatitis C virus-like particles induce virus-specific humoral and cellular immune responses in mice. Hepatology 2001; 34: 417-23.
    • (2001) Hepatology , vol.34 , pp. 417-423
    • Lechmann, M.1    Murata, K.2    Satoi, J.3    Vergalla, J.4    Baumert, T.F.5    Liang, T.J.6
  • 103
    • 0034663387 scopus 로고    scopus 로고
    • Characterization of modified hepatitis C virus E2 proteins expressed on the cell surface
    • Forns X, Allander T, Rohwer-Nutter P, Bukh J. Characterization of modified hepatitis C virus E2 proteins expressed on the cell surface. Virology 2000; 274: 75-85.
    • (2000) Virology , vol.274 , pp. 75-85
    • Forns, X.1    Allander, T.2    Rohwer-Nutter, P.3    Bukh, J.4
  • 104
    • 0037055970 scopus 로고    scopus 로고
    • DNA-based vaccination against hepatitis C virus (HCV): Effect of expressing different forms of HCV E2 protein and use of CpG-optimized vectors in mice
    • Ma X, Forns X, Gutierrez R, Mushahwar I, Wu T, Payette P, et al. DNA-based vaccination against hepatitis C virus (HCV): effect of expressing different forms of HCV E2 protein and use of CpG-optimized vectors in mice. Vaccine 2002; 20: 3263.
    • (2002) Vaccine , vol.20 , pp. 3263
    • Ma, X.1    Forns, X.2    Gutierrez, R.3    Mushahwar, I.4    Wu, T.5    Payette, P.6
  • 105
    • 0033848911 scopus 로고    scopus 로고
    • Vaccination of chimpanzees with plasmid DNA encoding the hepatitis C virus (HCV) envelope E2 protein modified the infection after challenge with homologous monoclonal HCV
    • Forns X, Payette PJ, Ma X, Satterfield W, Eder G, Mushahwar IK, et al. Vaccination of chimpanzees with plasmid DNA encoding the hepatitis C virus (HCV) envelope E2 protein modified the infection after challenge with homologous monoclonal HCV. Hepatology 2000; 32: 618-25.
    • (2000) Hepatology , vol.32 , pp. 618-625
    • Forns, X.1    Payette, P.J.2    Ma, X.3    Satterfield, W.4    Eder, G.5    Mushahwar, I.K.6
  • 106
    • 0033848911 scopus 로고    scopus 로고
    • Vaccination of chimpanzees with plasmid DNA encoding the hepatitis C virus (HCV) envelope E2 protein modified the infection after challenge with homologous monoclonal HCV
    • Forns X, Payette PJ, Ma X, Satterfield W, Eder G, Mushahwar IK, et al. Vaccination of chimpanzees with plasmid DNA encoding the hepatitis C virus (HCV) envelope E2 protein modified the infection after challenge with homologous monoclonal HCV. Hepatology 2000; 32: 618-25.
    • (2000) Hepatology , vol.32 , pp. 618-625
    • Forns, X.1    Payette, P.J.2    Ma, X.3    Satterfield, W.4    Eder, G.5    Mushahwar, I.K.6
  • 107
    • 0036733784 scopus 로고    scopus 로고
    • DNA-based immuno-therapy: Potential for treatment of chronic viral hepatitis?
    • Beckebaum S, Cicinnati VR, Gerken G. DNA-based immuno-therapy: potential for treatment of chronic viral hepatitis? Rev Med Virol 2002; 12: 297-319.
    • (2002) Rev. Med. Virol. , vol.12 , pp. 297-319
    • Beckebaum, S.1    Cicinnati, V.R.2    Gerken, G.3
  • 109
    • 0034886079 scopus 로고    scopus 로고
    • DNA vaccines for hepatitis C virus
    • Brinster CF, Inchauspe G. DNA vaccines for hepatitis C virus. Intervirology 2001; 44: 143-53.
    • (2001) Intervirology , vol.44 , pp. 143-153
    • Brinster, C.F.1    Inchauspe, G.2
  • 110
    • 0035824669 scopus 로고    scopus 로고
    • In vitro characterization of a purified NS2/3 protease variant of hepatitis C virus
    • Thibeault D, Maurice R, Pilote L, Lamarre D, Pause A. In vitro characterization of a purified NS2/3 protease variant of hepatitis C virus. J Biol Chem 2001; 276: 46678-84.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46678-46684
    • Thibeault, D.1    Maurice, R.2    Pilote, L.3    Lamarre, D.4    Pause, A.5
  • 111
    • 0031888452 scopus 로고    scopus 로고
    • Crystallization and preliminary X-ray crystallographic analysis of the helicase domain of hepatitis C virus NS3 protein
    • Kang LW, Cho HS, Cha SS, Chung KM, Back SH, Jang SK, et al. Crystallization and preliminary X-ray crystallographic analysis of the helicase domain of hepatitis C virus NS3 protein. Acta Crystallogr D Biol Crystallogr 1998; 54: 121-3.
    • (1998) Acta Crystallogr. D Biol. Crystallogr. , vol.54 , pp. 121-123
    • Kang, L.W.1    Cho, H.S.2    Cha, S.S.3    Chung, K.M.4    Back, S.H.5    Jang, S.K.6
  • 113
    • 0030719462 scopus 로고    scopus 로고
    • Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA
    • Kumar PK, Machida K, Urvil PT, Kakiuchi N, Vishnuvardhan D, Shimotohno K, et al. Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA. Virology 1997; 237: 270-82.
    • (1997) Virology , vol.237 , pp. 270-282
    • Kumar, P.K.1    Machida, K.2    Urvil, P.T.3    Kakiuchi, N.4    Vishnuvardhan, D.5    Shimotohno, K.6
  • 114
    • 17544378561 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV poliovirus using synthetic stabilized ribozymes
    • Macejak DG, Jensen KL, Jamison SF, Domenico K, Roberts EC, Chaudhary N, et al. Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV poliovirus using synthetic stabilized ribozymes. Hepatology 2000; 31: 769-76.
    • (2000) Hepatology , vol.31 , pp. 769-776
    • Macejak, D.G.1    Jensen, K.L.2    Jamison, S.F.3    Domenico, K.4    Roberts, E.C.5    Chaudhary, N.6
  • 115
    • 0032995650 scopus 로고    scopus 로고
    • Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV-vaccinia virus recombinant
    • Zhang H, Hanecak R, Brown-Driver V, Azad R, Conklin B, Fox MC, et al. Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV-vaccinia virus recombinant. Antimicrob Agents Chemother 1999; 43: 347-53.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 347-353
    • Zhang, H.1    Hanecak, R.2    Brown-Driver, V.3    Azad, R.4    Conklin, B.5    Fox, M.C.6
  • 116
    • 0033224562 scopus 로고    scopus 로고
    • The molecular biology of hepatitis C virus. Genotypes and quasispecies
    • Forns X, Bukh J. The molecular biology of hepatitis C virus. Genotypes and quasispecies. Clin Liver Dis 1999; 3: 693-716.
    • (1999) Clin. Liver Dis. , vol.3 , pp. 693-716
    • Forns, X.1    Bukh, J.2
  • 117
    • 0035003885 scopus 로고    scopus 로고
    • Down-regulation of translation driven by hepatitis C virus internal ribosomal entry site by the 3′ untranslated region of RNA
    • Murakami K, Abe M, Kageyama T, Kamoshita N, Nomoto A. Down-regulation of translation driven by hepatitis C virus internal ribosomal entry site by the 3′ untranslated region of RNA. Arch Viral 2001; 146: 729-41.
    • (2001) Arch. Virol. , vol.146 , pp. 729-741
    • Murakami, K.1    Abe, M.2    Kageyama, T.3    Kamoshita, N.4    Nomoto, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.