The RNA aptamer-binding site of hepatitis C virus NS3 protease

Biochemical and Biophysical Research Communications

Volumn 279, Issue 2, 2000, Pages 557-562

  Hwang, Joonsung ^a,b   Fauzi, Hamid ^a   Fukuda, Kotaro ^a   Sekiya, Satoru ^a,b   Kakiuchi, Nobuko ^a   Shimotohno, Kunitada ^c   Taira, Kazunari ^d   Kusakabe, Isao ^b   Nishikawa, Satoshi ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; APTAMER; DNA; POLYPROTEIN; PROTEINASE; RNA;

ARTICLE; BINDING SITE; DNA SEQUENCE; ENZYME INHIBITION; HEPATITIS C VIRUS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE;

EID: 0034694918     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4007     Document Type: Article

References (18)

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4. Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA
5. Isolation and characterization of RNA aptamers specific for the hepatitis C virus NS3 protease
6. Expression of highly active recombinant NS3 protease domain of hepatitis C virus in E. coli
7. Bacterial expression and analysis of cleavage activity of HCV serine proteinase using recombinant and synthetic substrate
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10. Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition
11. Selection of a RNA aptamer that binds to human activated protein C and inhibits its protease function
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14. Functional mapping of the surface residues of human thrombin
15. Structural basis for the anticoagulant activity of the thrombinthrombomodulin complex
16. The clot thickens: Clues provided by thrombin structure
17. The 2.8 A crystal structure of Gla-domainless activated protein C
18. Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase