The NS3/4A proteinase of the hepatitis C virus: Unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

Journal of Viral Hepatitis

Volumn 6, Issue 3, 1999, Pages 165-181

  Bartenschlager, R ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

HCV replication; HCV specific antiviral therapy; HCV specific drug targets; Hepatitis C virus; NS3 4A proteinase; Three dimensional structure of NS3 4A HCV proteinase

Indexed keywords

PHENANTHRENE DERIVATIVE; PROTEINASE; SERINE PROTEINASE INHIBITOR; THIAZOLIDINE DERIVATIVE;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; CHRONIC LIVER DISEASE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STRUCTURE; GENE EXPRESSION REGULATION; GENOME; HEPATITIS C VIRUS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; HEPACIVIRUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN CONFORMATION; RNA HELICASES; SERINE ENDOPEPTIDASES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0032974384     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.1999.00152.x     Document Type: Review

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