Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes

Journal of Biological Chemistry

Volumn 275, Issue 10, 2000, Pages 7152-7157

  Di Marco, Stefania ^a   Rizzi, Menico ^b   Volpari, Cinzia ^a   Walsh, Martin A ^a   Narjes, Frank ^a   Colarusso, Stefania ^a   De Francesco, Raffaele ^a   Matassa, Victor G ^a   Sollazzo, Maurizio ^a  

^a IRBM   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; VIRUS PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLIZATION; HEPACIVIRUS; HYDROGEN BONDING; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0034629363     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.10.7152     Document Type: Article

References (25)

1. Weiland, O. (1994) FEMS Microbiol. Rev. 14, 279-288
2. Bartenschlager, R. (1997) Intervirology 40, 378-393
3. Kim, J. L., Morgenstern, K. A., Lin, C., Fox, T., Dwyer, M. D., Landro, J. A., Chambers, S. P., Markland, W., Lepre, C. A., O'Malley, E. T., Harbeson, S. L., Rice, C. M., Murcko, M. A., Caron, P. R., and Thomson, J. A. (1996) Cell 87, 343-355
4. Yan, Y., Li, Y., Munshi, S., Sardana, V., Cole, J. L., Sardana, M., Steinkuehler, C., Tomei, L., De Francesco, R., Kuo, L. C., and Chen, Z. (1998) Protein Sci. 7, 837-847
5. Narjes, F., Brunetti, M., Colarusso, S., Gerlach, B., Koch, U., Biasol, G., Fattori, D., De Francesco, R., Matassa, V. G., and Steinkühler, C. (2000) Biochemistry 39, 1849-1861
6. De Francesco, R., Urbani, A., Nardi, M. C., Tomei, L., Steinkühler, C., and Tramontano, A. (1996) Biochemistry 35, 13282-13287
7. Steinkühler, C., Biasol, G., Brunetti, M., Urbani, A., Koch, U., Cortese, R., Pessi, A., and De Francesco, R. (1998) Biochemistry 37, 8899-8905
8. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
9. Collaborative Computational Project, Number 4 (1994) Acta Crystallogr. D 50, 760-763
10. Navaza, J. (1994) Acta Crystallogr. A 50, 157-163
11. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. D 53, 240-255
12. Lamzin, V. S., and Wilson, K. S. (1997) Methods Enzymol. 277, 269-305
13. Brünger, A. T. (1992) Nature 355, 472-475
14. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119
15. Urbani, A., Biasol., G., Brunetti, M., Volpari, C., Di Marco, S., Sollazzo, M., Orru', S., Dal Piaz, F., Casbarra, A., Pucci, P., Nardi, C., Gallinari, P., De Francesco, R., and Steinkühler, C. (1999) Biochemistry 38, 5206-5215
16. Chen, Z., Li, Y., Mulichak, A. M., Lewis, S., and Shafer, J. A. (1995) Arch. Biochem. Biophys. 322, 198-203
17. Walter, J., and Bode, W. (1983) Hoppe-Seyler's Z. Physiol. Chem. 364, 949-959
18. Tanizawa, K., Kanaoka, Y., Wos, J. D., and Lawson, W. (1985) Biol. Chem. Hoppe-Seyler 366, 871-878
19. Kuhn, P., Knapp, M., Soltis, S. M., Ganshaw, G., Thoene, M., and Bott, R. (1998) Biochemistry 37, 13446-13452
20. Martin, T. W., and Derewenda, Z. S. (1999) Nat. Struct. Biol. 6, 403-406
21. Love, R. A., Parge, H. E., Wickersham, J. A., Hostomsky, Z., Habuka, N., Moomaw, E. W., Adachi, T., and Hostomska, Z. (1996) Cell 87, 331-342
22. Barbato, G., Cicero, D. O., Nardi, M. C., Steinkühler, C., Cortese, R., De Francesco, R., and Bazzo, R. (1999) J. Mol. Bill. 289, 371-384
23. Ingallinella, P., Altamura, S., Bianchi, E., Taliani, M., Ingenito, R., Cortese, R., De Francesco, R., Steinkühler, C., and Pessi, A. (1998) Biochemistry 37, 8906-8914
24. Esnouf, R. M. (1997) J. Mol. Graph. 15, 132-134
25. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291