Inhibition of the bovine viral diarrhoea virus NS3 serine protease by a boron-modified peptidyl mimetic of its natural substrate

Antiviral Chemistry and Chemotherapy

Volumn 12, Issue 6, 2001, Pages 367-373

  Bukhtiyarova, Marina ^a   Rizzo, Christopher J ^a   Kettner, Charles A ^a   Korant, Bruce D ^a   Scarnati, Helen T ^a   King, Robert W ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Antiviral; BVDV; NS3; Peptidyl mimetic; Protease

Indexed keywords

ANTIVIRUS AGENT; BORON DERIVATIVE; DPC AB914400; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BOVINE VIRAL DIARRHEA VIRUS; ENZYME INHIBITION; IC 50; MOLECULAR CLONING; NONHUMAN; PESTIVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035738231     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020101200607     Document Type: Article

References (13)

1. Mechanism of action of a pestivirus antiviral compound
2. Efficient initiation of HCV RNA replication in cell culture
3. Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus
4. Bovine viral diarrhea virus genomic organization
5. Inhibition of the serine proteases, leukocyte elastase, pancreatic elastase, cathepsin G, and by peptide boronic acids
6. 2-Phenylethaneboronic acid, a possible transition-state analog for chymotrypsin
7. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
8. Inducible model to study negative strand RNA synthesis and assembly of hepatitis C virus from a full-length cDNA clone
9. Flaviviridae: The viruses and their replication
10. NS3 serine protease of bovine viral diarrhea virus: Characterization of active site residues, NS4A cofactor domain, and protease-cofactor interactions
11. Pestiviruses
12. Pestivirus gene expression: Protein p80 of bovine viral diarrhea virus is a protease involved in polyprotein processing