The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9

EMBO Journal

Volumn 20, Issue 15, 2001, Pages 4076-4087

  Piddini, Eugenia ^a   Schmid, Johannes A ^b   De Martin, Rainer ^b   Dotti, Carlos G ^a,c  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Actin; Cell morphology; GTPases; Kinesin; Microtubules

Indexed keywords

GUANOSINE TRIPHOSPHATASE; KINESIN; PROTEIN KIF9; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SHAPE; CELL SPREADING; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; GENE EXPRESSION; MICROFILAMENT; MICROTUBULE; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ACTINS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CELL MEMBRANE; CELL SIZE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOSKELETON; DNA, COMPLEMENTARY; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMEDIATE-EARLY PROTEINS; KINESIN; MEMBRANE PROTEINS; MICROFILAMENTS; MICROTUBULES; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; PRECIPITIN TESTS; RAS PROTEINS; SACCHAROMYCES CEREVISIAE; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0035422395     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.15.4076     Document Type: Article

References (37)

1. A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase
2. The Ras-related protein Rad associates with the cytoskeleton in a non-lipid-dependent manner
3. The GTPase superfamily: Conserved structure and molecular mechanism
4. Transcriptional activation of a Ras-like gene (kir) by oncogenic tyrosine kinases
5. Kir, a novel Ras-family G-protein, induces invasive pseudohyphal growth in Saccharomyces cerevisiae
6. Interaction of a Golgi-associated kinesin-like protein with Rab6
7. Tools of the trade: Use of dominant-inhibitory mutants of Ras-family GTPases
8. Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding protein family repressed by lipopolysaccharide stimulation
9. Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
10. Calmodulin binds to and inhibits GTP binding of the Ras-like GTPase Kir/Gem
11. The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac-signaling pathways in cells
12. Rat hippocampal neurons in low density
13. Kinesin and dynein superfamily proteins in organelle transport and cell division
14. Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor
15. A simple and rapid method for screening transformant yeast colonies using PCR
16. Coiled coils: New structures and new functions
17. Predicting coiled coils from protein sequences
18. Gem: An induced, immediate early protein belonging to the Ras family
19. Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II
20. Effects of phosphorylation on function of the Rad GTPase
21. The MAP kinase, MLK2, colocalizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
22. Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome
23. Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport
24. Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization
25. Rad: A member of the Ras family overexpressed in muscle of type II diabetic humans
26. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costa12
27. Systematic variation in gene expression patterns in human cancer cell lines
28. KIF2β, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation
29. Dynamics of NFκB and IκBα studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNA by fluorescence resonance energy transfer
30. Costa12, a novel kinesin-related protein in the hedgehog signaling pathway
31. Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis
32. Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23
33. Gem, a GTP-binding protein from mitogen-stimulated T cells, is induced in endothelial cells upon activation by inflammatory cytokines
34. Positive feedback interactions between microtubule and actin dynamics during cell motility
35. Characterization of Rad, a new member of Ras/GTPase superfamily and its regulation by a unique GTPase-activating protein (GAP)-like activity
36. Rad, a novel Ras-related GTPase, interacts with skeletal muscle β-tropomyosin
37. Interaction of the Ras-related protein associated with diabetes Rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation