Elongation factor-1α is a novel substrate of Rho-associated kinase

Biochemical and Biophysical Research Communications

Volumn 278, Issue 1, 2000, Pages 72-78

  Izawa, Tetsuyuki ^a,b   Fukata, Yuko ^c   Kimura, Toshihide ^a   Iwamatsu, Akihiro ^d   Dohi, Kazuhiro ^b   Kaibuchi, Kozo ^a,c  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KIRIN BREWERY CO LTD   (Japan)

Author keywords

EF 1 ; F actin; Myosin binding subunit of myosin phosphatase; Rho; Rho kinase

Indexed keywords

ELONGATION FACTOR 1ALPHA; F ACTIN; GUANOSINE TRIPHOSPHATASE; MYOSIN; MYOSIN LIGHT CHAIN; POLYPEPTIDE; RHO KINASE;

ANIMAL TISSUE; ARTICLE; CELL ADHESION; CYTOSKELETON; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; LIVER CYTOSOL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0034638596     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3772     Document Type: Article

References (48)

1. Regulation and function of the Rho subfamily of small GTPases
2. Rho GTPases and signaling networks
3. Rho GTPases and the actin cytoskeleton
4. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
5. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
6. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
7. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
8. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
9. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
10. The p160 RhoA-binding kinase ROKa is a member of a kinase family and is involved in the reorganization of the cytoskeleton
11. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
12. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
13. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
14. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
15. p160 RhoA-binding kinase ROKa induces neurite retraction
16. Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase
17. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
18. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
19. Association of the myosin-binding subunit of myosin phosphatase and moesin: Dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase
20. Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase
21. Phosphorylation of moesin by Rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures
22. Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility
23. Eukaryotic protein elongation factors
24. Isolation of an abundant 50,000-dalton actin filament bundling protein from Dictyostelium amoebae
25. Identification of an actin-binding protein from Dictyostelium as elongation factor 1a
26. Actin crosslinking protein EF-1 a of Dictyostelium discoideum has a unique bonding rule that allows square-packed bundles
27. Microtubule severing by elongation factor 1 alpha
28. Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma
29. Identification of a putative target for Rho as a serine-threonine kinase, PKN
30. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase during cell migration and cytokinesis
31. Purification of muscle actin
32. Phosphorylation of collapsin response mediator protein-2 by Rho-kinase
33. S-carboxymethylation of proteins transferred onto polyvinylidene difluoride membranes followed by in situ protease digestion and amino acid microsequencing
34. Sequence patterns produced by incomplete enzymatic digestion or one-step Edman degradation of peptide mixtures as probes for protein database searches
35. Identification of a novel β-catenin-interacting protein
36. Identification of AF-6 and canoe as putative targets for Ras
37. pH regulation of the F-actin binding properties of Dictyostelium elongation factor 1 alpha
38. Properties of two isoforms of human blood platelet alpha-actinin
39. Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase
40. Structure of the actin-myosin complex and its implications for muscle contraction
41. F-actin sequesters elongation factor 1alpha from interaction with aminoacyl-tRNA in a pH-dependent reaction
42. The cytoskeleton and mRNA localization
43. mRNA and cytoskeletal filaments
44. Sequences responsible for intracellular localization of beta-actin messenger RNA also affect cell phenotype
45. Beta-actin mRNA localization is regulated by signal transduction mechanisms
46. Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae
47. Interaction of Rho1p target Bni1p with F-actin-binding elongation factor 1alpha: Implication in Rho1p-regulated reorganization of the actin cytoskeleton in Saccharomyces cerevisiae
48. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization