Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils

Journal of Experimental Medicine

Volumn 183, Issue 6, 1996, Pages 2437-2448

  Ponath, Paul D ^a   Qin, Shixin ^a   Post, Theodore W ^b   Wang, Juan ^a   Wu, Lijun ^a   Gerard, Norma P ^b   Newman, Walter ^a   Gerard, Craig ^b,c   Mackay, Charles R ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE;

AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; B CELL LYMPHOMA; BINDING AFFINITY; CHEMOTAXIS; GENE EXPRESSION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR CLONING; NORTHERN BLOTTING; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CHEMOKINES, CC; CHEMOTACTIC FACTORS, EOSINOPHIL; CHEMOTAXIS, LEUKOCYTE; CLONING, MOLECULAR; CONSERVED SEQUENCE; CYTOKINES; DNA PRIMERS; EOSINOPHILS; HUMANS; LYMPHOMA, B-CELL; MACROPHAGE INFLAMMATORY PROTEIN-1; MICE; MOLECULAR SEQUENCE DATA; MONOCYTE CHEMOATTRACTANT PROTEINS; MONOKINES; POLYMERASE CHAIN REACTION; RANTES; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0029898807     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.6.2437     Document Type: Article

References (76)

1. Baggiolini, M., B. Dewald, and B. Moser. 1994. IL-8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55:97-179.
2. Oppenheim, J.J., C.O. Zachariae, N. Mukaida, and K. Matsushima. 1991. Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu. Rev. Immunol. 9: 617-648.
3. Miller, M.D., and M.S. Krangel. 1992. Biology and biochemistry ot the chemokines: a family ot chemotactic and inflammatory cytokines. Crit. Rev. Immunol. 12:17-46.
4. Jose, P.J., D.A. Griffiths-Johnson, P.D. Collins, D.T. Walsh, R. Moqbel, N.F. Totty, O. Truong, J.J. Hsuan, and T.J. Williams. 1994. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J. Exp. Med. 179:881-887.
5. Ponath, P.D., S. Qin, D.J. Ringler, I. Clark-Lewis, J. Wang, N. Kassam, H. Smith, X. Shi, J.-A. Gonzalo, W. Newman et al. 1996. Cloning of the human eosinophil chemoattractant, eotaxin: expression, receptor binding and functional properties provide a mechanism for the selective recruitment of eosinophils. J. Clin. Invest. 97:604-612.
6. Kelner, G.S., J. Kennedy, K.B. Bacon, S. Kleyensteuber, D.A. Largaespada, N.A. Jenkins, N.G. Copeland, J.F. Bazan, K.W. Moore, T.J. Schall, and A. Zlotnick. 1994. Lymphotactin: a novel cytokine which represents a new class of chemokine. Science (Wash. DC). 266:1395-1399.
7. Broaddus, V.C., A.M. Boylan, J.M. Hoeffel, K.J. Kim, M. Sadick, A. Chuntharapai, and C.A. Hebert. 1994. Neutralization of IL-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy. J. Immunol. 152:2960-2967.
8. Mulligan, M.S., M.L. Jones, M.A. Bolanowski, M.P. Baganoff, C.L. Deppeler, D.M. Meyers, U.S. Ryan, and P.A. Ward. 1993. Inhibition of lung inflammatory reactions in rats by an anti-human IL-8 antibody. J. Immunol. 150:5585-5595.
9. Sekido, N., N. Mukaida, A. Harada, I. Nakanishi, Y. Watanabe, and K. Matsushima. 1993. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature (Lond.). 365:654-657.
10. Cacalano, G., J. Lee, K. Kikly, A.M. Ryan, S. Pitts-Meek, B. Hultgren, W.I. Wood, and M.W. Moore. 1994. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science (Wash. DC). 265:682-684.
11. Cook, D.N., M.A. Beck, T.M. Coffman, S.L. Kirby, J.F. Sheridan, I.B. Pragnell, and O. Smithies. 1995. Requirement of MIP-1α for an inflammatory response to viral infection. Science (Wash. DC). 269:1583-1585.
12. Lukacs, N.W., R.M. Strieter, C.L. Shaklee, S.W. Chensue, and S.L. Kunkel. 1995. Macrophage inflammatory protein-1 alpha influences eosinophil recruitment in antigen-specific airway inflammation. Eur. J. Immunol. 25:245-251.
13. Flory, C.M., M.L. Jones, and J.S. Warren. 1993. Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein 1. Lab. Invest. 69:396-404.
14. Rand, M.L., J.S. Warren, W. Newman, and D.J. Ringler. 1996. Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1 Am. J. Path. 148:855-864.
15. Murphy, P.M., and H.L. Tiffany. 1991. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science (Wash. DC). 253:1280-1283.
16. Beckman, M.P., W.E. Munger, C. Kozlosky, T. VandenBos, V. Price, S. Lyman, N.P. Gerard, C. Gerard, and D.P. Cerretti. 1991. Molecular characterization of the interleukin-8 receptor. Biochem. Biophys. Res. Commun. 179:784-789.
17. Holmes, W.E., J. Lee, W.J. Kuang, G.C. Rice, and W.I. Wood. 1991. Structure and functional expression of a human interleukin-8 receptor. Science (Wash. DC). 253:1278-1280.
18. Neote, K., D. DiGregorio, J.Y. Mak, R. Horuk, and T.J. Schall. 1993. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell. 72:415-425.
19. Gao, J.L., D.B. Kuhns, H.L. Tiffany, D. McDermott, X. Li, U. Francke, and P.M. Murphy. 1993. Structure and functional expression of the human macrophage inflammatory protein 1 α/RANTES receptor. J. Exp. Med. 177:1421-1427.
20. Charo, I.F., S.J. Myers, A. Herman, C. Franci, A.J. Connolly, and S.R. Coughlin. 1994. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Nat. Acad. Sci. USA. 91:2752-2756.
21. Myers, S.J., L.M. Wong, and I.F. Charo. 1995. Signal transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embyonic kidney cells. J. Biol. Chem. 270:5786-5792.
22. Power, C.A., A. Myer, K. Nemeth, K.B. Bacon, A.J. Hoogewerf, A.E.I. Proudfoot, and T.N.C. Wells. 1995. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J. Biol. Chem. 270:19495-19500.
23. Gerard, C., and N.P. Gerard. 1994. The pro-inflammatory seven-transmembrane segment receptors of the leukocyte. Curr. Opin. Immunol. 6:140-145.
24. Gerard, C., and N.P. Gerard. 1994. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12:775-808.
25. Weller, P.F. 1992. Roles of eosinophils in allergy. Curr. Opin. Immunol. 4:782-787.
26. Gleich, G.J., C.R. Adolphson, and K.M. Leiferman. 1993. The biology of the eosinophilic leukocyte. Annu. Rev. Med. 44:85-101.
27. Kay, A.B., and C.J. Corrigan. 1992. Asthma. Eosinophils and neutrophils. Br. Med. Bull. 48:51-64.
28. Busse, W.W., and J.B. Sedgwick. 1992. Eosinophils in asthma. Ann. Allergy. 68:286-290.
29. Wardlaw, A.J., R. Moqbel, O. Cromwell, and A.B. Kay. 1986. Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. J. Clin. Invest. 78:1701-1706.
30. Gerard, N.P., M.K. Hodges, J.M. Drazen, P.F. Weller, and C. Gerard. 1989. Characterization of a receptor for C5a anaphylatoxin on human eosinophils. J. Biol. Chem. 264:1760-1765.
31. Rand, T.H., W.W. Cruikshank, D.M. Center, and P.F. Weller. 1991. CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration. J. Exp. Med. 173: 1521-1528.
32. Rot, A., M. Krieger, T. Brunner, S.C. Bischoff, T.J. Schall, and C.A. Dahinden. 1992. RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes. J. Exp. Med. 176:1489-1495.
33. Dahinden, C.A., T. Geiser, T. Brunner, V. von Tscharner, D. Caput, P. Ferrara, A. Minty, and M. Baggiolini. 1994. Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine. J. Exp. Med. 179:751-756.
34. Kameyoshi, Y., A. Dorschner, A.I. Mallet, E. Christophers, and J.M. Schroder. 1992. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J. Exp. Med. 176:587-592.
35. Baggiolini, M., and C.A. Dahinden. 1994. CC chemokines in allergic inflammation. Immunol. Today. 15:127-133.
36. Gonzalo, J.-A., G.-Q. Jia, V. Aguirre, D. Friend, A.J. Coyle, N.A. Jenkins, G.-S. Lin, H. Katz, A. Lichtman, N. Copeland et al. 1996. Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but is not restricted to a Th2-type response. Immunity. 4:1-14.
37. Bradley, B.L., M. Azzawi, M. Jacobson, B. Assoufi, J.V. Collins, A.-M. Irani, L.B. Schwartz, S.R. Durham, P.K. Jeffery, and A.B. Kay. 1991. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 88:661-674.
38. Bousquet, J., P. Chanez, J.Y. Lacoste, G. Barneon, M.N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and P.-B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
39. Wardlaw, A.J., S. Dunnette, G.J. Gleich, J.V. Collins, and A.B. Kay 1988. Eosinophils and mast cells in bronchial lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am. Rev. Respir. Dis. 137:62-69.
40. Jeffery, P.K., A.J. Wardlaw, F.C. Nelson, J.V. Collins, and A.B. Kay. 1989. Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am. Rev. Respir. Dis. 140:1745-1753.
41. Rothenburg, M.E., A.D. Luster, C.M. Lilly, J.M. Drazen, and P. Leder. 1995. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J. Exp. Med. 181:1211-1216.
42. Jose, P.J., I.M. Adcock, D.A. Griffiths-Johnson, N. Berkman, T.N. Wells, T.J. Williams, and C.A. Power. 1994. Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs. Biochem. Biophys. Res. Commun. 205:788-794.
43. Griffiths. J.H., P.D. Collins, A.G. Rossi, P.J. Jose, and T.J. Williams. 1993. The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem. Biophys. Res. Commun. 197:1167-1172.
44. Sambrook, J., E.F. Fritsch, and T. Maniatis, editors. 1989. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
45. Ponath, P.D., D. Fass, H.-C. Liou, L.H. Glimcher, and J.L. Strominger. 1993. The regulatory gene, hXBP-1, and its target, HLA-SR, utilize both common and distinct regulatory elements and protein complexes. J. Biol. Chem. 268:17074-17082.
46. Palermo, D.P., M.E. DeGraaf, K.R. Marotti, E. Rehberg, and L. E. Post. 1991. Production of analytical quantities or recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. J. Biotech. 19:35-47.
47. Coligan, J.E., A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. 1992. Current Protocols in Immunology. John Wiley & Sons, Inc., New York. p. 2.5.4.
48. Clark-Lewis, I., B. Moser, A. Walz, M. Baggiolini, G.J. Scott, and R. Aebersold. 1991. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. Biochemistry. 30:3128-3135.
49. Van Riper, G., S. Siciliano, P.A. Fischer, R. Meurer, M.S. Springer, and H. Rosen. 1993. Characterization and species distribution of high affinity GTP-coupled receptors for human RANTES and monocyte chemoattractant protein 1. J. Exp. Med. 177:851-856.
50. Woodgett, J.R., K.L. Gould, and T. Hunter. 1986. Substrate specifity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. Eur. J. Biochem. 161:177-184.
51. Kishimoto, A., K. Nishiyama, H. Nakanishi, Y. Uratsuji, H. Normura, Y. Takeyama, and Y. Nishizuka. 1985. Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3′:5′-monophosphate-dependent protein kinase. J. Biol. Chem. 260:12492-12499.
52. Haribabu, B., and R. Snyderman. 1993. Identification of additional members of human G protein-coupled receptor kinase multigene family. Proc. Natl. Acad. Sci. USA. 90:9398-9402.
53. Kunapuli, P., and J.L. Benovic. 1993. Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. Proc. Natl. Acad. Sci. USA. 90:5588-5594.
54. Benovic, J.L., and J. Gomez. 1993. Molecular cloning and expression of GKR6. J. Biol. Chem. 268:19521-19527.
55. Gerard, N.P., L. Bao, H. Xiao-Ping, R.L. Eddy, T.B. Shows, and C. Gerard. 1993. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. Biochemistry. 32:1243-1250.
56. Murphy, P.M., H.L. Tiffany, D. McDermott, and S.K. Ahuja. 1993. Sequence and organization of the human N-formyl peptide receptor-encoding gene. Gene. 133:285-290.
57. Ahuja, S.K., A. Shetty, H.L. Tiffany, and P.M. Murphy. 1994. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and 13. J. Biol. Chem. 269:26381-26389.
58. Sprenger, H., A.R. Lloyd, R.G. Meyer, J.A. Johnston, and D.J. Kelvin. 1994. Genomic structure, characterization, and identification of the promoter of the human IL-8 receptor A gene J. Immunol. 153:2524-2532.
59. Sprenger, H., A.R. Lloyd, L.L. Lautens, T.I. Bonner, and D.J. Kelvin. 1994. Structure, genomic organization, and expression of the human interleukin-8 receptor B gene. J. Biol. Chem. 269:11065-11072.
60. Combadiere, C., S.K. Ahuja, and P.M. Murphy. 1995. Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270:16491-16494.
61. Combadiere, C., S.K. Ahuja, and P.M. Murphy. 1995. Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270:30235 [erratum].
62. Kunz, D., N.P. Gerard, and C. Gerard. 1992. The human leukocyte platelet-activating factor receptor, cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. J. Biol. Chem. 267:9101-9106.
63. Honda, S., J.J. Campbell, D.P. Andrew, B. Engelhardt, B.A. Butcher, R.A. Warnock, R.D. Ye, and E.C. Butcher. 1994. Ligand-induced adhesion to activated endothelium and to vascular cell adhesion molecule-1 in lymphocytes transfected with the N-formyl peptide receptor. J. Immunol. 152:4026-4035.
64. Simon, M.I., M.P. Strathmann, and N. Gautam. 1991. Diversity of G proteins in signal transduction. Science (Wash. DC). 252:802-808.
65. + T cells. Science (Wash. DC). 270:1811-1815.
66. Ebisawa, M., T. Yamada, C. Bickel, D. Klunk, and R.P. Schleimer. 1994. Eosinophil transendothelial migration induced by cytokines. III. Effect of the chemokine RANTES. J. Immunol. 153:2153-2160.
67. 2+- and Calcineurin-dependent recycling of an integrin to the front of the migrating neutrophils. Nature (Lond.). 376:75-79.
68. Mandeville, J.T., R.N. Ghosh, and F.R. Maxfield. 1995. Intracellular calcium levels correlate with speed and persistent forward motion in migrating neutrophils. Biophys. J. 68: 1207-1217.
69. Camps, M., A. Carozzi, P. Schnabel, A. Scheer, P.J. Parker, and P. Gierschik. 1992. Isoenzyme-selective stimulation of phospholipase C-beta 2 by G-protein beta gamma-subunits. Nature (Lond.). 360:684-686.
70. Amatruda, T.T., N.P. Gerard, G. Gerard, and M.I. Simon. 1993. Specific interactions of chemoattractant factor receptors with G-proteins. J. Biol. Chem. 268:10139-10144.
71. Meurer, R., G.V. Ripper, W. Feeney, P. Cunningham, D. Hora, Jr., M.S. Springer, D.E. MacIntyre, and H. Rosen. 1993. Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 α, or human interleukin 8. J. Exp. Med. 178:1913-1921.
72. Ernst, C.A., Y.J. Zhang, P.R. Hancock, B.J. Rutledge, C.L. Corless, and B.J. Rollins. 1994. Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. J. Immunol. 152:3541-3549.
73. Moser, B., C. Schumacher, V. von Tscharner, I. Clark-Lewis, and M. Baggiolini. 1991. Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils. J. Biol. Chem. 266:10666-10671.
74. Post, T.W., C.R. Bozic, M.E. Rothenberg, A.D. Luster, N. Gerard, and C. Gerard. 1995. Molecular characterization of two murine eosinophil β chemokine receptors. J. Immunol. 155:5299-5305.
75. Ben-Baruch, A., L. Xu, P.R. Young, K.M. Bengali, J.J. Oppenheim, and J.M. Wang. 1995. Monocyte chemotactic protein-3 (MCP-3) interacts with multiple leukocyte receptors. J. Biol. Chem. 270:22123-22128.
76. Boring, L., J. Gosling, F.S. Monteclaro, A.J. Lusis, C.-L. Tsou, and I.F. Charo. 1996. Molecular cloning and functional expression of murine JE (MCP-1) and MIP-1α receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J. Biol. Chem. In press.