A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum

Journal of Experimental Medicine

Volumn 191, Issue 1, 2000, Pages 171-179

  Lüttichau, Hans R ^a,b   Stine, Johnny ^c   Bocsen, Thomas P ^a   Johnsen, Anders H ^d   Chantry, David ^c   Gerstoft, Jan ^b   Schwartz, Thue W ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Department of Infectious Diseases   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d University of Copenhagen   (Denmark)

Author keywords

Chemokine receptors; Chemokines; Dendritic cells; Kaposi sarcoma associated herpesvirus; Monocytes

Indexed keywords

BETA CHEMOKINE; CHEMOKINE RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 2; RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL INVASION; CELL STRAIN COS1; CHEMOTAXIS; CHO CELL; CONTROLLED STUDY; DENDRITIC CELL; EMBRYO; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; MOLLUSCIPOXVIRUS; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CHEMOKINES; CHEMOKINES, CC; CHEMOTAXIS; CHO CELLS; COS CELLS; CRICETINAE; HUMANS; MOLECULAR SEQUENCE DATA; MOLLUSCUM CONTAGIOSUM VIRUS; RECEPTORS, CHEMOKINE; VIRAL PROTEINS;

EID: 0034598341     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.1.171     Document Type: Article

References (51)

1. Viac, J., and Y. Chardonnet. 1990. Immunocompetent cells and epithelial cell modifications in molluscum contagiosum. J. Cutan. Pathol. 17:202-205.
2. Heng, M.C., M.E. Steuer, A. Levy, S. McMahon, M. Richman, S.G. Allen, and B. Blackhart. 1989. Lack of host cellular immune response in eruptive molluscum contagiosum. Am. J. Dematopathol. 11:248-254.
3. Bhawan, J., Y. Dayal, and A.K. Bhan. 1986. Langerhans cells in molluscum contagiosum, verruca vulgaris, plantar wart, and condyloma acuminatum. J. Am. Acad. Dermatol. 15:645-649.
4. Senkevich, T.G., J.J. Bugert, J.R. Sisler, E.V. Koonin, G. Darai, and B. Moss. 1996. Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes. Science. 273:813-816.
5. Baggiolini, M. 1998. Chemokines and leukocyte traffic. Nature. 392:565-568.
6. Rollins, B.J. 1997. Chemokines. Blood. 90:909-928.
7. Zlotnik, A., J. Morales, and J.A. Hedrick. 1999. Recent advances in chemokines and chemokine receptors. Crit. Rev. Immunol. 19:1-47.
8. McFadden, G., and D. Kelvin. 1997. New strategies for chemokine inhibition and modulation. Biochem. Pharmacol. 54:1271-1280.
9. Dairaghi, D.J., D.R. Greaves, and T.J. Schall. 1998. Abduction of chemokine elements by herpesviruses. Semin. Virol. 8:377-385.
10. Wells, T.N.C., and T.W. Schwartz. 1997. Plagiarism of the host immune system: lessons about chemokine immunology from viruses. Curr. Opin. Biotechnol. 8:741-748.
11. Ahuja, S.K., and P.M. Murphy. 1999. Viral mimicry of chemokines and chemokine receptors. In Chemokines in Disease. C.A. Herbert, editor. Humana Press Inc., Totowa, NJ. 235-251.
12. Stine, J.T., D. Chantry, and P.W. Gray. 1999. Virally encoded chemokines and chemokine receptors: genetic embezzlement of host DNA. In Chemokines. A. Mantovani, editor. Karger AG, Basel, Switzerland. 161-180.
13. Gao, J.-L., and P.M. Murphy. 1994. Human cytomegalovirus open reading frame US28 encodes a functional B chemokine receptor. J. Biol. Chem. 269:28539-28542.
14. Chee, M.S., S.C. Satchwell, E. Preddie, K.M. Weston, and B.G. Barrell. 1990. Human cytomegalovirus encodes three G protein-coupled receptor homologues. Natture. 344:774-777.
15. Gompels, U.A., J. Nicholas, G. Lawrence, M. Jones, B.J. Thomson, M.E.D. Martin, S. Efstathiou, M. Craxton, and H.A. Macaulay. 1995. The DNA sequence of human herpes virus-6: structure, coding content, and genome evolution. Virology. 209:29-51.
16. Isegawa, Y., Z. Ping, K. Nakano, N. Sugimoto, and K. Yamanishi. 1998. Human herpesvirus 6 open reading frame U12 encodes a functional B-chemokine receptor. J. Virol. 72: 6104-6112.
17. Nicholas, J. 1996. Determination and analysis of the complete nucleotide sequence of human herpesvirus 7. J. Virol. 70:5975-5989.
18. Arvanitakis, L., E. Geras-Raaka, A. Varma, M.C. Gershengorn, and E. Cesarman. 1997. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature. 385:347-350.
19. Birkenbach, M., K. Josefsen, R. Yalamanchili, G. Lenoir, and E. Kieff. 1993. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67:2209-2220.
20. + T cells. J. Virol. 68:5326-5329.
21. Bais, C., B. Santomasso, O. Coso, L. Arvanitakis, E.G. Raaka, J.S. Gutkind, A.S. Asch, E. Cesarman, M.C. Gershengorn, and E.A. Mesri. 1998. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature. 391:86-89.
22. Rosenkilde, M.M., T.N. Kledal, H. Bräuner-Osborne, and T.W. Schwartz. 1999. Agonist and inverse agonist for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. J. Biol. Chem. 274:956-961.
23. Kledal, T.N., M.M. Rosenkilde, and T.W. Schwartz. 1998. Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28. FEBS Lett. 441: 209-214.
24. Cha, T.-A., E. Tom, G.W. Kemble, G.M. Duke, E.S. Mocarski, and R.R. Spaete. 1996. Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains. J. Virol. 70:78-83.
25. Penfold, M.E.T., D.J. Dairaghi, G.M. Duke, N. Saederup, E.S. Mocarski, G.W. Kemble, and T.J. Schall. 1999. Cytomegalovirus encodes a potent alpha chemokine. Proc. Natl. Acad Sci. USA. 96:9839-9844.
26. Zou, P., Y. Isegawa, K. Nakano, M. Haque, Y. Horiguchi. and K. Yamanishi. 1999. Human herpesvirus 6 open reading frame U83 encodes a functional chemokine. J. Virol. 73: 5926-5933.
27. Kledal, T.N., M.M. Rosenkilde, F. Coulin, G. Simmons, A.H. Johnsen, S. Alouani, C.A. Power, H.R. Luttichau, J. Gerstoft P.R. Clapham, et al. 1997. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 277:1656-1659.
28. 3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II. J. Exp. Med. 188:193-198.
29. Endres, M.J., C.G. Garlisi, H. Xiao, L. Shan, and J.A. Hedrick. 1999. The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8 J. Exp. Med. 189:1993-1998.
30. Dairaghi, D.J., R.A. Fan, B.E. McMaster, M.R. Hanley, and T.J. Schall. 1999. HHV8-encoded vMIP-1 selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J. Biol. Chem. 274:21569-21574.
31. Boshoff, C., Y. Endo, P.D. Collins, Y. Takeuchi, J.D. Reeves, V.L. Schweickart, M.A. Siam, T. Sasaki, T.J. Williams, P.W. Gray, et al. 1997. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science. 278: 290-294.
32. Damon, I., P.M. Murphy, and B. Moss. 1998. Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog. Proc. Natl. Acad. Sci. USA 95:64036407.
33. Johansen, T.E., M.S. Scholler, S. Tolstroy, and T.W. Shcwartz. 1990. Biosynthesis of peptide precursors and protease inhibitors using new constitutive and inducible eukaryotic expression vectors. FEBS Lett. 267:289-294.
34. Maggi, C.A., and I.W. Schwartz. 1997. The dual nature of the tachykinin NK1 recptor. Trends Pharmacol. Sci. 18:351-356.
35. Moser, H., B. Dewald, L. Barella, C. Schumacher, M. Baggiolini, and I. Clark-Lewis. 1993. Interleukin-8 antagonists generated by N-terminal modification. J. Biol. Chem. 268: 7125-7128.
36. Zhang, Y.J., B.J. Rutledge, and B.J. Rollins. 1994. Structure/ activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. J. Biol. Chem. 269:15918-1 5924.
37. 2-terminal residues. J. Exp. Med. 181: 631-640.
38. Simmons, G., P.R. Clapham, L. Picard, R.E. Offord, M.M. Rosenkilde, T.W. Schwartz, R. Buser, T.N.C. Wells, and A.E.I. Proudfoot. 1997. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science. 276:276-279.
39. Krathwohl. M.D., R. Hromas, D.R. Brown, H.E. Broxmeyer, and K.M. Fife. 1997. Functional characterization of the C-C-chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2. Proc. Natl. Acad. Sci. USA. 94:9875-9880.
40. Horuk, R. J. Hesselgesser, Y. Zhou, D. Faulds, M. Halks-Miller, S. Harvey, D. Taub, M. Samson, M. Parmentier, J. Rucker, et al. 1998. The CC chemokine 1-309 inhibits CCR8-dependent infection by diverse HIV-1 strains. J. Biol. Chem. 273:386-391.
41. Miller, M.D., and M.S. Krangel. 1992. The human cytokine 1-309 is a monocyte chemoattractant. Proc. Natl. Acad. Sci. USA. 89:2950-2954.
42. D'Ambrosio, D., A. Iellem, R. Bonecchi, D. Mazzeo, S. Sozzani, A. Mantovani, and F. Sinigaglia. 1998. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 161:5111-5115.
43. Zingoni, A., H. Soto, J.A. Hedrick, A. Stoppacciaro, J.A. Storlazzi, F. Sinigaglia, D. D'Ambrosio, A. O'Garra, D. Robinson, M. Rocchi, et al. 1998. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J. Immunol. 161:547-551.
44. Miller, M.D., S. Hata, R. De Waal Malefyt, and M.S. Krangel. 1989. A novel polypeptide secreted by activated human T lymphocytes. J. Immunol. 143:2907-2916.
45. Selvan, R.S., L.-J. Zhou, and M.S. Krangel. 1997. Regulation of 1-309 gene expression human monocytes by endogenous interleukin-1. Eur. J. Immunol. 27:687-694.
46. Selvan, R.S. J.H. Butterfield, and M.S. Krangel. 1994. Expression of multiple chemokine genes by a human mast cell leukemia. J. Biol. Chem. 269.13893-13898.
47. Geissmann, F., C. Prost, J.-P. Monnet, M. Dy, N. Brousse, and O. Hermine. 1998. Transforming growth factor B1. in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic langerhans cells. J. Exp. Med. 187:961-966.
48. Randolph, G.J., S. Beaulieu, S. Lebecque, R.M. Steinman, and W.A. Mullers. 1998. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science. 282:480-483.
49. Geras-Raaka, E., A. Varma, I. Clark-Lewis, and M.C. Gershengorn. 1998. Kaposi's sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-1α inhibit signaling by KSHV G protein-coupled receptor, Biochem. Biophys. Res. Commun. 253:725-727.
50. Sozzani, S., W. Luini, G. Bianchi, P. Allavena, T.N.C. Wells, M. Napolitano, G. Bernardini, A. Vecchi, D. D'Ambrosio, D. Mazzeo, et al. 1998. The viral chemokine macrophage in flammatory protein-II is a selective Th2 chemoattractant. Blood. 92:4036-4039.
51. LiWang, A.C., J.J. Cao, H. Zheng, Z. Lu, S.C. Peiper, and P.J. LiWang. 1999. Dynamics study on the anti-human immunodeficiency virus chemokine viral macrophage-inflammatory protein-II (VMIP-II) reveals a fully monomeric protein. Biochemistry. 38:442-453.