Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration

Journal of Biological Chemistry

Volumn 273, Issue 17, 1998, Pages 10095-10098

  White, John R ^a   Lee, Judithann M ^a   Young, Peter R ^a   Hertzberg, Robert P ^a   Jurewicz, Anthony J ^a   Chaikin, Margery A ^a   Widdowson, Katherine ^a   Foley, James J ^a   Martin, Lenox D ^a   Griswold, Don E ^a   Sarau, Henry M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; COMPLEMENT COMPONENT C5A; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; INTERLEUKIN 8 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING COMPETITION; CALCIUM MOBILIZATION; CELL SPECIFICITY; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY CELL; LEUKOCYTE ACTIVATION; MEDIATOR RELEASE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NORMAL HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT;

ANIMALS; CHEMOTAXIS, LEUKOCYTE; CHO CELLS; CRICETINAE; HUMANS; INTERLEUKIN-8; NEUTROPHILS; PHENYLUREA COMPOUNDS; RABBITS; RECEPTORS, CHEMOKINE; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-8B; RECOMBINANT PROTEINS;

EID: 0032562614     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.17.10095     Document Type: Article

References (41)

1. Rot, A., Hub, E., Middleton, J., Pons, F., Rabeck, C., Thierer, K., Wintle, J., Wolff, B., Zsak, M., and Dukor, P. (1996) J. Leukocyte Biol. 59, 39-44
2. Detmers, P. A., Lo, S. K., Olsen-Egbert, E., Walz, A., Baggiolini, M., and Cohn, Z. A. (1990) J. Exp. Med. 171, 1155-1162
3. Holmes, W. E., Lee, J., Kuang, W. J., Rice, G. C., and Wood, W. I. (1991) Science 253, 1278-1280
4. Murphy, P. M., and Tiffany, H. L. (1991) Science 253, 1280-1283
5. Hebert, C. A., Vitangcol, R. V., and Baker, J. B. (1991) J. Biol. Chem. 266, 18989-18994
6. Chuntharapai, A., Lee, J., Hebert, C. A., and Kim, K. J. (1994) J. Immunol. 153, 5682-5688
7. Xu, L., Kelvin, D. J., Ye, G. Q., Taub, D. D., Ben Baruch, A., Oppenheim, J. J., and Wang, J. M. (1995) J. Leukocyte Biol. 57, 335-342
8. Santamaria-Babi, L. F., Moser, B., Perez-Soler, M. T., Moser, R., Loetscher, P., Villiger, B., Blaser, K., and Hauser, C. (1996) Eur. J. Immunol. 26, 2056-2061
9. Quan, J. M., Martin, T. R., Rosenberg, G. B., Foster, D. C., Whitmore, T., and Goodman, R. B. (1996) Biochem. Biophys. Res. Commun. 219, 405-411
10. Chuntharapai, A., and Kim, K. J. (1995) J. Immunol. 155, 2587-2594
11. Hammond, M. E., Lapointe, G. R., Feucht, P. H., Hilt, S., Gallegos, C. A., Gordon, C. A., Giedlin, M. A., Mullenbach, G., and Tekamp Olson, P. (1995) J. Immunol. 155, 1428-1433
12. Larsen, C. G., Thomsen, M. K., Gesser, B., Thomsen, P. D., Deleuran, B. W., Nowak, J., Skodt, V., Thomsen, H. K., Deleuran, M., Thestrup Pedersen, K., Harada, A., Matsushima, K., and Menne, T. (1995) J. Immunol. 155, 2151-2157
13. Broaddus, V. C., Boylan, A. M., Hoeffel, J. M., Kim, K. J., Sadick, M., Chuntharapai, A., and Hebert, C. A. (1994) J. Immunol. 152, 2960-2967
14. Sekido, N., Mukaida, N., Harada, A., Nakanishi, I., Watanabe, Y., and Matsushima, K. (1993) Nature 365, 654-657
15. Vedder, N. B., Winn, R. K., Rice, C. L., Chi, E. Y., Arfors, K. E., and Harlan, J. M. (1988) J. Clin. Invest. 81, 939-944
16. Mulligan, M. S., Varani, J., Dame, M. K., Lane, C. L., Smith, C. W., Anderson, D. C., and Ward, P. A. (1991) J. Clin. Invest. 88, 1396-1406
17. Cacalano, G., Lee, J., Kikly, K., Ryan, A. M., Pitts Meek, S., Hultgren, B., Wood, W. I., and Moore, M. W. (1994) Science 265, 682-684
18. Kraft, A. S., and Anderson, W. B. (1983) Nature 301, 621-623
19. Rollins, T. E., Siciliano, S., and Springer, M. S. (1988) J. Biol. Chem. 263, 520-526
20. Lane, T. A., Lamkin, G. E., and Windle, B. E. (1981) Blood 58, 228-236
21. Boehm, J. C., Gleason, J. G., Pendrak, I., Sarau, H. M., Schmidt, D. B., Foley, J. J., and Kingsbury, W. D. (1993) J. Med. Chem. 36, 3333-3340
22. Hay, D. W., Muccitelli, R. M., Vickery Clark, L. M., Novak, L. S., Osborn, R. R., Gleason, J. G., Yodis, L. A., Saverino, C. M., Eckardt, R. D., Sarau, H. M., Wasserman, M. A., Torphy, T. J., and Newton, J. F. (1991) Pulm. Pharmacol. 4, 177-189
23. Widdowson, K. L., Veber, D. F., Nie, H., Jurewicz, A. J., Foley, J. J., Sarau, H. M., Lee, J., and White, J. R. (1998) in Peptides Escom (Ramage, R., ed) Leiden, The Netherlands, in press
24. Ferrante, A., and Thong, Y. H. (1982) J. Immunol. Methods 48, 81-85
25. Berkhout, T. A., Sarau, H., Moores, K., White, J. R., Elshourbagy, N., Appelbaum, E., Reape, T. J., Brawner, M., Makwana, J., Foley, J. J., Schmidt, D. B., Imburgia, C., McNulty, D., Matthews, J., O'Donnell, K., O'Shannessy, D., Scott, M., Groot, P. H. E., and Macphee, C. (1997) J. Biol. Chem. 272, 16404-16410
26. Bignold, L. P., and Ferrante, A. (1987) J. Immunol. Methods 96, 29-33
27. Griswold, D. E., Martin, L., Ventre, J., Meunier, L., and Perry, L. (1991) J. Pharmacol. Methods 25, 319-328
28. Mueller, S. G., White, J. R., Schraw, W. P., Lam, V., and Richmond, A. (1997) J. Biol. Chem. 272, 8207-8214
29. Suzuki, H., Prado, G. N., Wilkinson, N., and Navarro, J. (1994) J. Biol. Chem. 269, 18263-18266
30. Motosugi, H., Graham, L., Noblitt, T. W., Doyle, N. A., Quinlan, W. M., Li, Y., and Doerschuk, C. M. (1996) Am. J. Pathol. 149, 963-973
31. Doerschuk, C. M. (1992) Am. J. Respir. Cell Mol. Biol. 7, 140-148
32. Laterveer, L., Lindley, I. J., Heemskerk, D. P., Camps, J. A., Pauwels, E. K., Willemze, R., and Fibbe, W. E. (1996) Blood 87, 781-788
33. Jones, S. A., Dewald, B., Clark-Lewis, I., and Baggiolini, M. (1997) J. Biol. Chem 272, 16166-16169
34. Emonds Alt, X., Vilain, P., Goulaouic, P., Proietto, V., Van Broeck, D., Advenier, C., Naline, E., Neliat, G., Le Fur, G., and Breliere, J. C. (1992) Life Sci. 50, PL101-PL106
35. Brooks, D. P., Fredrickson, T. A., Weinstock, J., Ruffolo, R. R., Jr., Edwards, R. M., and Gellai, M. (1992) Naunyn Schmiedebergs Arch. Pharmacol. 345, 673-678
36. Clozel, M., Breu, V., Burri, K., Cassal, J. M., Fischli, W., Gray, G. A., Hirth, G., Loffler, B. M., Muller, M., Neidhart, W., and Ramuz, H. (1993) Nature 365, 759-761
37. Lanza, T. J., Durette, P. L., Rollins, T., Siciliano, S., Cianciarulo, D. N., Kobayashi, S. V., Caldwell, C. G., Springer, M. S., and Hagmann, W. K. (1992) J. Med. Chem. 35, 252-258
38. Grau, G. E., Mili, N., Lou, J. N., Morel, D. R., Ricou, B., Lucas, R., and Suter, P. M. (1996) Lab. Invest. 74, 761-770
39. Marini, M., Vittori, E., Hollemborg, J., and Mattoli, S. (1992) J. Allergy Clin. Immunol. 89, 1001-1009
40. Nakamura, H., Abe, S., Shibata, Y., Sata, M., Kato, S., Saito, H., Hino, T., Takahashi, H., and Tomoike, H. (1997) Int. Arch. Allergy Immunol. 112, 157-162
41. Khair, O. A., Davies, R. J., and Devalia, J. L. (1996) Eur. Respir. J. 9, 1913-1922