Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5

Blood

Volumn 97, Issue 7, 2001, Pages 1920-1924

  Ogilvie, Patricia ^b   Bardi, Giuseppe ^b   Clark Lewis, Ian ^b   Baggiolini, Marco ^b   Uguccioni, Mariagrazia ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 AGONIST; EOTAXIN; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; LEUKOCYTE FUNCTION; MONOCYTE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING;

EID: 0035313370     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.7.1920     Document Type: Article

References (25)

1. The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo
2. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes
3. Cloning, expression, and characterization of the human eosinophil eotaxin receptor
4. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils
5. High expression of the chemokine receptor CCR3 in human blood basophils - Role in activation by eotaxin, MCP-4, and other chemokines
6. Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils
7. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
8. Eotaxin: A VIC (very important chemokine) of allergic inflammation?
9. Eotaxin: From an eosinophilic chemokine to a major regulator of allergic reactions
10. IL-4 induces eotaxin: A possible mechanism of selective eosinophil recruitment in helminth infection and atopy
11. Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts
12. Interleukin (IL)4 and IL-13 act on human lung fibroblasts - Implication in asthma
13. Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells
14. Production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α by inflammatory granuloma fibroblasts
15. - T cells induces monocyte chemoattractant protein-1 in early listeriosis
16. Expression and regulation of monocyte chemoattractant protein-1 by human eosinophils
17. Chemokine receptor usage by human eosinophils - The importance of CCR3 demonstrated using an antagonistic monoclonal antibody
18. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide 2
19. Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding
20. Rapid killing of actinomycin D-treated tumor cells by human mononuclear cells, I: Effectors belong to the monocyte-macrophage lineage
21. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1α and MIP-1β on human monocytes
22. Ion channels in human neutrophils activated by a rise in free cytosoric calcium concentration
23. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist
24. Chemokines and their receptors in lymphocyte traffic and HIV infection
25. 2+ mobilization, and enzyme release