Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors

Chirality

Volumn 15, Issue 2, 2003, Pages 167-179

  Johansen, Tommy N ^a   Greenwood, Jeremy R ^a   Frydenvang, Karla ^a   Madsen, Ulf ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Asymmetric synthesis; Bioisosterism; Chiral HPLC; Docking experiments; Enantiopharmacology; Excitatory amino acids; Resolution; Stereoselectivity; X ray crystallography

Indexed keywords

2 AMINO 2 (3 HYDROXY 5 METHYL 4 ISOXAZOLYL)ACETIC ACID; 2 AMINO 3 (3 HYDROXY 1,2,5 THIADIAZOL 4 YL)PROPIONIC ACID; 2 AMINO 3 (3 HYDROXY 5 PHENYL 4 ISOXAZOLYL)PROPIONIC ACID; 2 AMINO 3 [3 HYDROXY 5 (2 PYRIDYL)ISOXAZOL 4 YL]PROPIONIC ACID; 2 FURYL 2 AMINO 3 (3 HYDROXY 5 METHYL 4 ISOXAZOLYL)PROPIONIC ACID; 4 [3 (2 NAPHTHYL)ALLYL]GLUTAMIC ACID; 5 (2 METHYLTETRAZOLYL) 2 AMINO (3 HYDROXY 5 METHYL 4 ISOXAZOLYL)PROPIONIC ACID; 5 TETRAZOLYL GLYCINE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; 6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ALPHA AMINO 5 TERT BUTYL 3 HYDROXY 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR AGONIST; DOCKING PROTEIN; DOMOIC ACID; EXCITATORY AMINO ACID; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; HOMOIBOTENIC ACID; IBOTENIC ACID; IONOTROPIC RECEPTOR; ISOXAZOLE DERIVATIVE; KAINIC ACID RECEPTOR AGONIST; LY 395153; NEUROTRANSMITTER; RECEPTOR SUBTYPE; TALAMPANEL; THIO 2 AMINO (3 HYDROXY 5 METHYL 4 ISOXAZOLYL)PROPIONIC ACID; THIO ALPHA AMINO 5 TERT BUTYL 3 HYDROXY 4 ISOXAZOLEPROPIONIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; WILLARDINE;

CENTRAL NERVOUS SYSTEM; CHEMICAL STRUCTURE; CHIRAL CHROMATOGRAPHY; CHIRALITY; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DEGENERATIVE DISEASE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; HUMANS; KAINIC ACID; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; RECEPTORS, KAINIC ACID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037261506     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.10177     Document Type: Review

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