Facilitation of glutamate receptors reverses an age-associated memory impairment in rats

Synapse

Volumn 22, Issue 4, 1996, Pages 332-337

  Granger, Richard ^a   Deadwyler, Sam ^b   Davis, Mike ^a   Moskovitz, Brian ^a   Kessler, Markus ^a   Rogers, Gary ^c   Lynch, Gary ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c Cortex Pharmaceuticals Inc ^*  (United States)

Author keywords

Age related memory impairment; Aging; Glutamate receptors; Memory

Indexed keywords

GLUTAMATE RECEPTOR;

AGING; ANIMAL EXPERIMENT; ARTICLE; EXCITATORY POSTSYNAPTIC POTENTIAL; FACILITATION; FOREBRAIN; LONG TERM POTENTIATION; MALE; MEMORY CONSOLIDATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SENILITY;

AGE FACTORS; AGING; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MAZE LEARNING; MEMORY; RATS; RECEPTORS, GLUTAMATE; TIME FACTORS;

EID: 0029916627     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199604)22:4<332::AID-SYN4>3.0.CO;2-C     Document Type: Article

References (22)

1. Arai, A., Silberg, J., and Lynch, G. (1995) Differences in the refractory properties of two distinct inhibitory circuitries in field CA1 of the hippocampus. Brain Res., in press.
2. Bahr, B., Godshall, A., Hall, R., and Lynch, G. (.1992) Mouse telencephalon exhibits an age-related decrease in glutamate (ampa) receptors but no change in nerve terminal markers. Brain Res., 589:320-326.
3. Craik, F. (1977) Age differences in human memory. In: Handbook of the Psychology of Aging. Birren, J., and Schaie, K., ed. Van Nostrand Reinhold, New York.
4. Crook, T. and West, R. (1990) Name recall performance across the adult life span. Br. J. Psychol., 81:335-349
5. Crook, T., Larrabee, G., and Youngjohn, J. (1990) Diagnosis and assessment of age-associated memory impairment. Clin. Neuropharmacol., 13:S81-S91.
6. Goudsmit, E., Van De Poll, N., and Swaab, D. (1990). Testosterone fails to reverse spatial memory decline in aged rats and impairs retention in young and middle aged animals. Behav. Neural Biol., 53:6-20.
7. Granger, R., Staubli, U., Davis, M., Perez, Y., Nilsson, L., Rogers, G., and Lynch, G. (1993) A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning dependent task. Synapse, 15:326-329.
8. Hampson, R., Heyser, C., and Deadwyler, S. (1993b) Hippocampal cell firing correlates of delayed match to sample performance in the rat. Behav. Neurosci., 107:715-739.
9. Hampson, R., Bunn, T., Byrd, D., and Deadwyler, S. (1993a) Modeling of spatial vs behavioral firing of hippocampal complex sipke cells. Soc. Neurosci. Abst., 19:1608.
10. Hampson, R., Byrd, D., and Deadwyler, S. (1994) Population analyses reveal that rat hippocampus encodes both spatial and task-specific information during delayed non match to sample tasks. Soc. Neuroscience Abst., 20:430.
11. Huppert, F., and Kopelman, M. (1989). Rates of forgetting in normal ageing: A comparison with dementia. Neuropsychologia, 27: 849-860.
12. Kadar, T., Silbermann, M., Brandeis, R., and Levy, A. (1990b) Age-related structural changes in the cholinergic components within the central nervous system, ii. Working memory impairment and its relation to hippocampal muscarinic receptors. Mech. Aging Dev., 55:139-149.
13. Kadar, T., Silbermann, M., Brandeis, R., and Levy, A. (1990a) Age-related structural changes in the rat hippocampus: correlation with working memory deficiency. Brain Res., 512:113-120.
14. Landfield, P., and Lynch, G. (1977) Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-impaired rats. J. Gerontol., 32:523-533.
15. Magnusson, K., and Cotman, C. (1993). Age-related changes in exeitatory amino acid receptors in two mouse strains. Neurobiol. Aging, 14:197-206.
16. Masliah, E., Mallory, M., Hansen, L., DeTeresa, R., and Terry, R. (1993) Quantitative synaptic alterations in the human neocortex during normal aging. Neurology, 43:192-197.
17. Moore, C., Browning, M., and Rose, G. (1993) Hippocampal plasticity induced by primed burst, but not long-term potentiation, stimulation is impaired in area cal of aged fischer 344 rats. Hippocampus, 3:57-66.
18. Staubli, U., Perez, Y., Xu, F., Rogers, G., Ingvar, M., Stone-Elander, S., and Lynch, G. (1994a) Centrally active modulators of glutamate (ampa) receptors facilitate the induction of LTP in vivo. Proc. Natl. Acad. Sci. U.S.A., 91:11158-11162.
19. Staubli, U., Rogers, G., and Lynch, G. (1994b) Facilitation of glutamate receptors enhances memory. Proc. Natl. Acad. Sci , 91:777-781.
20. Thomas, J., Fozard, J., and Waugh, N. (1977) Age-related differences in naming latency. Am. J. Psychol., 90:499-509.
21. Weiss, C., and Thompson, R. (1991) The effects of age on eyeblink conditioning in the freely moving fischer-344 rat. Neurobiol. Aging, 12:249-254.
22. Wenk, G., Walker, L., Price, D., and Cork, L. (1991) Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys. Neurobiol. Aging, 12:93-98.