Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties

Journal of Medicinal Chemistry

Volumn 44, Issue 26, 2001, Pages 4501-4504

  Campiani, G ^a   Morelli, E ^b   Nacci, V ^a   Fattorusso, C ^b   Ramunno, A ^a   Novellino, E ^b   Greenwood, J ^c   Liljefors, T ^c   Griffiths, R ^d   Sinclair, C ^d   Reavy, H ^d   Kristensen, A S ^c   Pickering, D S ^c   Schousboe, A ^c   Cagnotto, A ^e   Fumagalli, E ^e   Mennini, T ^e  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR AGONIST; CPW 399; CPW 405; CYCLOTHIAZIDE; EXCITATORY AMINO ACID RECEPTOR; FLUOROWILLARDIINE; GLUTAMATE RECEPTOR; KAINIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NIFEDIPINE; UNCLASSIFIED DRUG; WILLARDIINE;

ANIMAL CELL; ARTICLE; BINDING SITE; BRAIN MEMBRANE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GRANULE CELL; LIGAND BINDING; MOLECULAR MODEL; NEUROPHARMACOLOGY; NEUROTOXICITY; NONHUMAN; OOCYTE; RAT; RECEPTOR DOWN REGULATION; XENOPUS LAEVIS;

ALANINE; ANIMALS; BRAIN; CELL DEATH; CELL LINE; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; LIGANDS; MICE; MODELS, MOLECULAR; NEURONS; OOCYTES; PYRIMIDINES; PYRIMIDINONES; RADIOLIGAND ASSAY; RATS; RECEPTORS, AMPA; RECOMBINANT PROTEINS; STEREOISOMERISM; XENOPUS LAEVIS;

EID: 0035924219     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm015552m     Document Type: Article

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