AMPA receptor agonists: Resolution, configurational assignment, and pharmacology of (+)-(S)- and (-)-(R)-2-amino-3-[3-hydroxy-5-(2-pyridyl)- isoxazol-4-yl]-propionic acid (2-Py-AMPA)

Chirality

Volumn 9, Issue 3, 1997, Pages 274-280

  Johansen, Tommy N ^a   Ebert, Bjarke ^a   Falch, Erik ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

AMPA receptor affinity; AMPA receptor agonism; chiral HPLC; circular dichroism; configurational assignment; electrophysiology; enantiomeric purity; resolution

Indexed keywords

2 AMINO 3 (3 HYDROXY 5 PHENYLISOXAZOL 4 YL)PROPIONIC ACID; 2 AMINO 3 [3 HYDROXY 5 (2 PYRIDYL)ISOXAZOL 4 YL]PROPIONIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALANINE; ANIMALS; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; EXCITATORY AMINO ACID AGONISTS; ISOXAZOLES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, AMPA; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0030915716     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:3<274::AID-CHIR12>3.0.CO;2-K     Document Type: Article

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