Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors

Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2001, Pages 1051-1059

  Madsen, U ^a   Brauner Osborne H ^a   Frydenvang, K ^a   Hvene, L ^a   Johansen, T N ^a   Nielsen, B ^a   Sanchez C ^b   Stensbol T B ^a   Bischoff, F ^a   Krogsgaard Larsen, P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (3 HYDROXY 4 PENTYL 5 ISOXAZOLYL)PROPIONIC ACID; 2 AMINO 3 (3 HYDROXY 4 PHENYL 5 ISOXAZOLYL)PROPIONIC ACID; 2 AMINO 3 (3 HYDROXY 5 ISOXAZOLYL)PROPIONIC ACID DERIVATIVE; 2 AMINO 3 (4 HEPTYL 3 HYDROXY 5 ISOXAZOLYL)PROPIONIC ACID; 2 AMINO 3 (4 HEXYL 3 HYDROXY 5 ISOXAZOLYL)PROPIONIC ACID; 3 ISOXAZOLOLAMINO ACID DERIVATIVE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; IBOTENIC ACID; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CONTROLLED STUDY; CONVULSION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS; ANIMALS; ANTICONVULSANTS; CEREBRAL CORTEX; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; ISOXAZOLES; LIGANDS; MALE; MICE; PROPIONIC ACIDS; RADIOLIGAND ASSAY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035966866     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000441t     Document Type: Article

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