[3H]N-2-(4-(N-Benzamido)phenyl)propyl-2-propanesulfonamide: A novel AMPA receptor potentiator and radioligand [2]

Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2001, Pages 302-304

  Zarrinmayeh, H ^a   Bleakman, D ^a   Gates, M R ^a   Yu, H ^a   Zimmerman, D M ^a   Ornstein, P L ^a   McKennon, T ^a   Arnold, M B ^a   Wheeler, W J ^a   Skolnick, P ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; IONOTROPIC RECEPTOR; AMPA RECEPTOR; BENZAMIDE DERIVATIVE; LIGAND; N 2 (4 (N BENZAMIDO)PHENYL)PROPYL 2 PROPANESULFONAMIDE; N-2-(4-(N-BENZAMIDO)PHENYL)PROPYL-2-PROPANESULFONAMIDE; SULFONAMIDE; TRITIUM;

DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LEARNING; LETTER; MEMORY; NERVE CELL PLASTICITY; NEUROTRANSMISSION; ANIMAL; ARTICLE; BRAIN CORTEX; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PATCH CLAMP; PHYSIOLOGY; PURKINJE CELL; RAT; SYNTHESIS;

ANIMALS; BENZAMIDES; CEREBRAL CORTEX; LIGANDS; PATCH-CLAMP TECHNIQUES; PURKINJE CELLS; RATS; RECEPTORS, AMPA; SULFONAMIDES; TRITIUM;

EID: 0035242037     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000462n     Document Type: Letter

References (14)

1. Neurotransmitter receptors II: AMPA and kainate receptors
2. New developments in the molecular pharmacology of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors
3. Structural determinants of allosteric regulation in alternatively spliced AMPA receptors
4. Single-hannel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition
5. AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate
6. A synaptic model of memory: Long-term potentiation in the hippocampus
7. 3H]AMPA binding in rat hippocampus
8. Modulating excitatory synaptic neurotransmission: Potent treatment of neurological disease?
9. Therapeutic potential of AMPA receptor ligands in neurological disorders
10. Modulating of AMPA/kinate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus
11. Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) receptors
12. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: Stereospecificity and selectivity profiles
13. (2S, 4R)-4-Methylglutamic acid (SYM 2081): A selective, high affinity ligand for kainate receptors
14. Allosteric regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors by thiocyanate and cyclothiazide at a common modulatory site distinct from that of 2,3-benodiazepines